CN102106966B - Preparation method of Chinese medicinal composition with functions of supplementing qi and nourishing blood - Google Patents
Preparation method of Chinese medicinal composition with functions of supplementing qi and nourishing blood Download PDFInfo
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- CN102106966B CN102106966B CN2009102435168A CN200910243516A CN102106966B CN 102106966 B CN102106966 B CN 102106966B CN 2009102435168 A CN2009102435168 A CN 2009102435168A CN 200910243516 A CN200910243516 A CN 200910243516A CN 102106966 B CN102106966 B CN 102106966B
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Abstract
The invention discloses a preparation method of a Chinese medicinal composition with functions of supplementing qi and nourishing blood. In the method, the Chinese medicinal composition comprises raw materials of ginseng, milkvetch root, codonopsis pilosula, dwarf lilyturf root, Chinese angelica, cornu cervi pantotrichum, epimedium sagittatus, and the like. The preparation method comprises the following steps of: slicing the cornu cervi pantotrichum, adding water and decocting; filtering and condensing filtrate; adding 3 times of ethanol, precipitating and filtering; recovering the ethanol for later use; fractionally extracting the epimedium sagittatus; fractionally extraction volatile oil of largehead atractylodes; adding water in largehead atractylodes decoction dreg, the codonopsis pilosula, and the like, decocting and combining decoction; filtering, condensing the filtrate until the relative density is 1.19 (20DEG C); combining with the standby liquid; adding 133g of cane sugar and 267g of honey and decocting for 30 minutes; cooling and then adding a proper amount of essence and ethyl p-hydroxybenzoate; and adding the total amount to be 1000ml and uniformly stirring to obtain the Chinese medicinal composition. The Chinese medicinal composition has a remarkable medicinal effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition preparation method, particularly relate to a kind of Chinese medicine composition preparation method with benefiting QI and nourishing blood effect.
Background technology
Prior art discloses prescription and the preparation method of benefiting QI and nourishing blood oral liquid, is respectively:
Prescription:
Radix Ginseng (going reed) 8.3g Radix Astragali 83.4g Radix Codonopsis 75g
50g Radix Angelicae Sinensis 33.3g Rhizoma Atractylodis Macrocephalae Radix Ophiopogonis (stir-fry) 33.3g
Radix Rehmanniae 33.3g Radix Polygoni Multiflori Preparata 30g Fructus Schisandrae Chinensis 25g
Pericarpium Citri Reticulatae 33.3g Cortex Lycii 25g Cornu Cervi Pantotrichum 1.7g
Herba Epimedii 50g
Method for making: the Cornu Cervi Pantotrichum section, decoct with water secondary, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20～1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; 12 flavors such as all the other Radix Codonopsis decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃) and merges with above-mentioned reserve liquid, add sucrose 133g, refined honey 267g, decocted 30 minutes, add essence after the cooling, ethylparaben is an amount of, adjust total amount to 1000ml, stir evenly, and get final product.
The present invention is the improvement to preparation method, and new product has more outstanding drug effect.
Summary of the invention
The object of the invention also is to provide a kind of preparation method with Chinese medicine composition of benefiting QI and nourishing blood effect.
The present invention seeks to be achieved through the following technical solutions:
A kind of preparation method with Chinese medicine composition of benefiting QI and nourishing blood effect:
Choose following crude drug:
Radix Ginseng 2-16 weight portion Radix Astragali 30-160 weight portion Radix Codonopsis 30-120 weight portion
Radix Ophiopogonis 20-100 weight portion Radix Angelicae Sinensis 10-90 weight portion Rhizoma Atractylodis Macrocephalae 10-90 weight portion
Radix Rehmanniae 10-90 weight portion Fructus Schisandrae Chinensis 10-90 weight portion Radix Polygoni Multiflori Preparata 10-90 weight portion
Pericarpium Citri Reticulatae 10-90 weight portion Cortex Lycii 10-90 weight portion Cornu Cervi Pantotrichum 1-9 weight portion
Herba Epimedii 20-120 weight portion;
The Cornu Cervi Pantotrichum section decocts with water 2-4 time, and each 5-10 doubly measures, and 1-3 hour, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 2-5 and doubly measures ethanol, and precipitation filters, and Recycled ethanol is for subsequent use;
The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct each 1-4 hour 2-4 time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil;
Rhizoma Atractylodis Macrocephalae medicinal residues and all the other medical materials decoct with water 2-4 time, and each 1-4 hour, collecting decoction, filter concentrated, merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, make various dosage forms through conventional technique, comprise capsule, drop pill, tablet, granule, gel, oral liquid.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the acceptable adjuvant of pharmacy, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are decided, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The above-mentioned raw materials optimum ratio is:
The Radix Ginseng 14 weight portion Radixs Astragali 40 weight portion Radix Codonopsis 50 weight portions
Radix Ophiopogonis 90 weight portion Radix Angelicae Sinensis, the 20 weight portion Rhizoma Atractylodis Macrocephalaes, 80 weight portions
Radix Rehmanniae 23 weight portion Fructus Schisandrae Chinensis 80 weight portion Radix Polygoni Multiflori Preparatas 20 weight portions
Pericarpium Citri Reticulatae 73 weight portion Cortex Lycii 15 weight portion Cornu Cervi Pantotrichums 7 weight portions
Herba Epimedii 30 weight portions;
The above-mentioned raw materials optimum ratio is:
The Radix Ginseng 4 weight portion Radixs Astragali 130 weight portion Radix Codonopsis 30 weight portions
Radix Ophiopogonis 90 weight portion Radix Angelicae Sinensis, the 15 weight portion Rhizoma Atractylodis Macrocephalaes, 30 weight portions
Radix Rehmanniae 80 weight portion Fructus Schisandrae Chinensis 20 weight portion Radix Polygoni Multiflori Preparatas 80 weight portions
Pericarpium Citri Reticulatae 20 weight portion Cortex Lycii 80 weight portion Cornu Cervi Pantotrichums 3 weight portions
Herba Epimedii 100 weight portions;
The preparation method of Chinese medicine composition oral liquid formulations of the present invention is preferably:
Method for making: Cornu Cervi Pantotrichum section, decoct with water secondary, 8 times of amounts for the first time, 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time; The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; All the other Radix Codonopsis of Rhizoma Atractylodis Macrocephalae medicinal residues etc. ten decoct with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃), merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, add sucrose 133 weight portions, refined honey 267 weight portions, decocted 30 minutes, cooling adds essence afterwards, ethylparaben is an amount of, adjust total amount to 1000 parts by volume, stir evenly, and get final product.
Weight portion/parts by volume is corresponding with g/ml in the compositions of the present invention.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Experimental example 1: on the impact of NIH Phagocytosis By The Peritoneal Macrophages In Mice
1.1 test material
(1) tested medicine: medicine group of the present invention is taken from the preparation of embodiment 1, and every ml is equivalent to crude drug in whole 0.41g, and experiment is in the crude drug amount.Matched group 2: with embodiment 1 prescription, method for making is: the Cornu Cervi Pantotrichum section, decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20～1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; 12 flavors such as all the other Radix Codonopsis decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃) and merges with above-mentioned reserve liquid, add sucrose 133g, refined honey 267g, decocted 30 minutes, add essence after the cooling, ethylparaben is an amount of, adjust total amount to 1000ml, stir evenly, and get final product.
(2) laboratory animal: the NIH mice, the 18-20 gram, the male and female dual-purpose is conventional animals;
(3) 5% chicken erythrocyte (CRBC) are purchased one of commercially available cock, the preparation of this experimental group.
1.2 test method
Get 30 mices, be divided at random 3 groups, 10 every group, male and female half and half, medicine group of the present invention, matched group administration 100mg/kg, every animal gavage every day successive administration 8 days.The 7th day every Mus lumbar injection 0.8% liver glycogen 1ml, the 24hr pneumoretroperitoneum is injected 5% chicken erythrocyte 0.5ml, the cervical vertebra dislocation method is put to death mice behind the 3hr, and lumbar injection A Shi liquid (Alsever ' s) 1ml gets abdominal cavity drop sheet behind the massage abdominal part immediately, 2 of every Mus, incubation 30 minutes dyeed 3-5 minute rinsing, airing with 4% Ji Mu Sa-Switzerland, under oily mirror, count 200 of macrophages for every, be calculated as follows phagocytic percentage and phagocytic index:
1.3 result
Table 1 is on the impact of NIH Turnover of Mouse Peritoneal Macrophages phagocyte phagocytic function (X ± SD)
Annotate: compare with matched group 2 * P＜0.05;
The impact of the osteoporosis rat that experimental example 2 causes dexamethasone
1, test material
Be subjected to reagent: of the present invention group, content: 4.8g crude drug/10ml is the oral liquid of embodiment 1 preparation;
Negative control product: distilled water
Matched group 2: with embodiment 1 prescription, method for making is: the Cornu Cervi Pantotrichum section, decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20～1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; 12 flavors such as all the other Radix Codonopsis decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃) and merges with above-mentioned reserve liquid, add sucrose 133g, refined honey 267g, decocted 30 minutes, add essence after the cooling, ethylparaben is an amount of, adjust total amount to 1000ml, stir evenly, and get final product.
The modeling medicine: dexamethasone injection becomes 2.5mg/ml with normal saline dilution
The SD rat: totally 80, female, hero half and half, the weight of animals: 240-260g, every treated animal number: 20, female, hero half and half.
2. experimental technique
Rat is divided into 4 groups at random, 20 every group, female, male each 10.Be grouped into: (1) matched group 1, (2) of the present invention group, (3) matched group 2, (4) model group; Gastric infusion, every day, gastric infusion was 1 time, successive administration 50 days.The isopyknic distilled water of matched group 2 gavages.From on-test, except matched group 1, all the other each group all gives dexamethasone 2 times in intramuscular injection weekly, and dosage is 2.5mg/kg, 2 dosing intervals 3 days, and one until off-test.In the 14th day of off-test with finish front the 3rd day, the equal lumbar injection of all test group gives quadracycline 30mg/kg.All test group are fasting 12h after last is given approximately.Weigh, get blood, centrifugal, separation of serum is measured calcium, phosphorus content, and with sacrifice of animal.Female, the blood calcium of tom, phosphorus content are calculated separately.
Table 2 is on the impact (mg/dl) of the osteoporosis rat serum paraoxonase content of induced by dexamethasone (X ± SD)
* compare P＜0.05 with model group
Of the present invention group can significantly be improved the calcium level that dexamethasone causes osteoporosis rat, and therefore, present composition oral liquid improves significantly to the equal tool of female and Male Rats with Osteoporosis of induced by dexamethasone.
The extraction experiment of embodiment 3 icariin in epimedium herbs
1. experiment purpose:
Extracting mode is adjusted on basis at existing extraction equipment, take Icariin content as investigating index, adopts different extraction conditions that epimedium herb is extracted, and calculates the whole bag of tricks and extracts the rate of transform.
2. experimental technique:
2.1 medical material processing method:
Contain the flavone compounds such as icariin in the Herba Epimedii.
2.1.1 adopt alcohol extracting method to extract, measure the content of icariin in three extracting solution.
Process the method for Herba Epimedii: get epimedium herb 100g (lot number: 20080504), solvent: adopt respectively 50%, 60%, 70% ethanol; Extraction time: 2h, 1.5h, 1h; Solvent load: 800ml, 600ml, 500ml carries out orthogonal test.
2.1.2 with close extraction Radix Ophiopogonis, measure the content of icariin in three extracting solution.
Process the method for Herba Epimedii: get Herba Epimedii, Radix Ophiopogonis medical material 100g, extract three times.Add for the first time boiling water 2000ml, extract 2h; Add for the second time boiling water 2000ml, extract 1.5h; Add for the third time water 2000ml, extract 1.5h.Solution adopts tap water, and is concentrated, measures content.
2.1.3 adopt burning water to extract, measure the content of icariin in three extracting solution.
Process the method for Herba Epimedii: get epimedium herb 100g (lot number: 20080504), extract three times.Add for the first time boiling water 2000ml, extract 2h; Add for the second time water 2000ml, extract 1.5h; Add for the third time water 2000ml, extract 1.5h.Solution adopts tap water, and is concentrated, measures content.
2.1.4 adopt the aqueous alkali method to extract, measure the content of icariin in three extracting solution.
Process the method for Herba Epimedii: get epimedium herb 50g (lot number: 20080504), use respectively 2%NaOH, 5%NaOH, 5%Na2CO3, twice of 10%Na2CO3 solution extraction.Add for the first time boiling water 2000ml, extract 1.5h; Add for the second time water 2000ml, extract 1h.Concentrated, measure content.
2.2 detection method:
Chromatographic condition and system suitability experiment: be filler with the RP-18 bonded silica gel; Acetonitrile: water (30: 70) is mobile phase; The detection wavelength is 270nm.Theoretical cam curve is calculated by the icariin peak and is not less than 3000.
The icariin reference substance solution: concentration is 1.202 * 10
-4Mg/ml,
The preparation of need testing solution: three concentrated solution supernatant of precision weighing are 1g approximately, is dissolved to Diluted Alcohol in the volumetric flask of 25ml, and weighed weight, supersound process 1h in weighed weight, supplies the weight of less loss with Diluted Alcohol, shake up, and filters, and gets subsequent filtrate, and get final product.
3. experimental data and analysis:
The different sampling points of Herba Epimedii are surveyed the Icariin content difference, and the content in the medical material is not provided
3.1 alcohol reflux extraction method:
For the first time adopt 50% ethanol, consumption 1600ml, extraction time 2h records Icariin content 0.215g, and because the ethanol consumption is too large, all the other orthogonal tests are abandoned.
3.2 with close extraction method Radix Ophiopogonis:
3.3 boiling water reflux extraction:
3.4 aqueous alkali reflux extraction:
Testing result is not found icariin
3.5 conclusion
In the ethanol extraction, find in the practical operation, Herba Epimedii is the leaf class, lighter weight, and volume is larger, and solvent load is excessive, and ethanol extraction cost in commercial production is too large, and therefore suggestion is abandoned.Boil water extraction method: boiling water extraction, Icariin content is high.
4 pairs of stomach solid tumors of experimental example affects on the growth
1. instrument and material
Laboratory animal and tumor strain: Kunming mouse, 8 ages in week, male and female half and half, 18-22g; Experiment tumor strain: MFC (mice model of forestomach JEG-3).
Instrument and reagent: volatile oil extractor, Cyclophosphamide for injection, ethyl acetate, anhydrous sodium sulfate etc., agents useful for same is analytical pure.
2. method and result
2.1 experiment grouping
Get 30 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 3 groups at random, is respectively blank group, cyclophosphamide positive controls, of the present invention group (embodiment 1), 10 every group.
2.2 experimental technique
Under aseptic condition, extract the rear 7d tumor source animal ascites that goes down to posterity, add the physiological saline solution dilution, making its concentration is 2 * 10
6Individual cancerous cell alive.Near underarm region, subcutaneous vaccination, approximately contains 4 * 10 by 0.2ml/ in test Mus right fore
5Individual cancerous cell alive.The administration of dividing into groups next day, successive administration 14 days, except positive controls is intraperitoneal injection (dosage is 30mg/kg), all the other each groups are gastric infusion.Medicine of the present invention is pressed the 80ml/kg administration, and the blank group is with the normal saline gavage with dosage.
2.3 tumor-inhibiting action is observed
Medication the 15th day is taken off cervical vertebra and is put to death mice, peels off the tumor body and takes out the tumor piece, claims tumor heavy, calculates tumour inhibiting rate.Tumour inhibiting rate=(the average tumor of the average tumor weight-experimental group of blank group is heavy)/average tumor of blank group heavy * 100%.
2.4 statistical procedures
Administration group and control group mice tumor weight average adopt SPSS to organize a t check with x ± s significance test.
2.5 result of the test
Of the present invention group of gastric infusion of the results show has the effect that suppresses the gastric cancer tumor.Experimental result sees the following form
Following embodiment all can realize the described effect of above-mentioned experimental example
The specific embodiment
Embodiment 1:
Radix Ginseng (going reed) 8.3g Radix Astragali 83.4g Radix Codonopsis 75g
Radix Ophiopogonis 50g Radix Angelicae Sinensis 33.3g Rhizoma Atractylodis Macrocephalae 33.3g
Radix Rehmanniae 33.3g Fructus Schisandrae Chinensis 25g Radix Polygoni Multiflori Preparata 30g
Pericarpium Citri Reticulatae 33.3g Cortex Lycii 25g Cornu Cervi Pantotrichum 1.7g
Herba Epimedii 50g
Method for making: Cornu Cervi Pantotrichum section, decoct with water secondary, 8 times of amounts for the first time, 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; Rhizoma Atractylodis Macrocephalae medicinal residues and all the other Radix Codonopsis etc. ten decocts with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃), merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, add sucrose 133g, refined honey 267g, decocted 30 minutes, cooling adds essence afterwards, ethylparaben is an amount of, adjust total amount to 1000ml, stir evenly, and get final product; Function cures mainly: benefiting QI and nourishing blood.Be used for physical weakness, the cardiopalmus of breathing hard, lustreless complexion.
Usage and dosage: oral, a 15～20ml, 3 times on the one.
Specification: every 10ml
Embodiment 2: drop pill
Radix Ginseng (going reed) 8.3g Radix Astragali 83.4g Radix Codonopsis 75g
Radix Ophiopogonis 50g Radix Angelicae Sinensis 33.3g Rhizoma Atractylodis Macrocephalae 33.3g
Radix Rehmanniae 33.3g Fructus Schisandrae Chinensis 25g Radix Polygoni Multiflori Preparata 30g
Pericarpium Citri Reticulatae 33.3g Cortex Lycii 25g Cornu Cervi Pantotrichum 1.7g
Herba Epimedii 50g
Method for making: Cornu Cervi Pantotrichum section, decoct with water secondary, 8 times of amounts for the first time, 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; Rhizoma Atractylodis Macrocephalae medicinal residues and all the other Radix Codonopsis etc. ten decocts with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into relative density 1.19 (20 ℃), merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, add the Polyethylene Glycol of whole meltings, stir, from top to bottom, splash into liquid paraffin 133g, and get final product.
Embodiment 3: effervescent
Radix Ginseng 14g Radix Astragali 40g Radix Codonopsis 50g
Radix Ophiopogonis 90g Radix Angelicae Sinensis 20g Rhizoma Atractylodis Macrocephalae 80g
Radix Rehmanniae 23g Fructus Schisandrae Chinensis 80g Radix Polygoni Multiflori Preparata 20g
Pericarpium Citri Reticulatae 73g Cortex Lycii 15g Cornu Cervi Pantotrichum 7g
Herba Epimedii 30g;
Method for making: Cornu Cervi Pantotrichum section, decoct with water secondary, 8 times of amounts for the first time, 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; Rhizoma Atractylodis Macrocephalae medicinal residues and all the other Radix Codonopsis etc. ten decocts with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃), merges with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, and drying under reduced pressure becomes dried cream, be ground into fine powder, add an amount of sodium bicarbonate, citric acid and sucrose 133g, steviosin 26g, granulation, drying adds above-mentioned volatile oil, mixing, make 460g, and get final product.
Embodiment 4: oral liquid
Radix Ginseng 4g Radix Astragali 130g Radix Codonopsis 30g
Radix Ophiopogonis 90g Radix Angelicae Sinensis 15g Rhizoma Atractylodis Macrocephalae 30g
Radix Rehmanniae 80g Fructus Schisandrae Chinensis 20g Radix Polygoni Multiflori Preparata 80g
Pericarpium Citri Reticulatae 20g Cortex Lycii 80g Cornu Cervi Pantotrichum 3g
Herba Epimedii 100g;
Cornu Cervi Pantotrichum section decocts with water secondary, 8 times of amounts for the first time, and 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and filtrate is concentrated into relative density 1.20-1.25 (20 ℃), adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; Rhizoma Atractylodis Macrocephalae medicinal residues and all the other Radix Codonopsis etc. ten decocts with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated into relative density 1.19 (20 ℃), merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, add sucrose 133g, refined honey 267g, decocted 30 minutes, cooling adds essence afterwards, ethylparaben is an amount of, adjust total amount to 1000ml, stir evenly, and get final product.
Claims (7)
1. the preparation method with pharmaceutical composition of benefiting QI and nourishing blood is characterized in that the method comprises the steps:
Choose following crude drug:
The Cornu Cervi Pantotrichum section decocts with water 2-4 time, and each 5-10 doubly measures, and 1-3 hour, collecting decoction filtered, and relative density 1.20-1.25 when filtrate is concentrated into 20 ℃ adds 2-5 and doubly measures ethanol, and precipitation filters, and Recycled ethanol is for subsequent use;
The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct each 1-4 hour 2-4 time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil;
Rhizoma Atractylodis Macrocephalae medicinal residues and all the other medical materials decoct with water 2-4 time, and each 1-4 hour, collecting decoction, filtration is concentrated, merges with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, makes various dosage forms.
2. the method for claim 1 is characterized in that preparation process routinely makes capsule, drop pill, tablet, granule, gel, oral liquid.
3. the method for claim 1 is characterized in that the method is:
Cornu Cervi Pantotrichum section decocts with water secondary, 8 times of amounts for the first time, and 6 times of amounts for the second time, each 3 hours, collecting decoction filtered, and relative density 1.20-1.25 when filtrate is concentrated into 20 ℃ adds 3 times of amount ethanol, and precipitation filters, and Recycled ethanol is for subsequent use; The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct secondary, 3 hours for the first time, 2 hours for the second time; The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil; All the other Radix Codonopsis of Rhizoma Atractylodis Macrocephalae medicinal residues etc. ten decoct with water secondary simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, relative density 1.19 when filtrate was concentrated into 20 ℃, merge with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, add sucrose 133 weight portions, refined honey 267 weight portions, decocted 30 minutes, cooling adds essence afterwards, ethylparaben is an amount of, adjust total amount to 1000 parts by volume, stir evenly, and get final product.
4. the application of Chinese medicine composition in preparation treatment medicine for treating osteoporosis, described Chinese medicine composition is following method preparation:
Choose following crude drug:
The Cornu Cervi Pantotrichum section decocts with water 2-4 time, and each 5-10 doubly measures, and 1-3 hour, collecting decoction filtered, and relative density 1.20-1.25 when filtrate is concentrated into 20 ℃ adds 2-5 and doubly measures ethanol, and precipitation filters, and Recycled ethanol is for subsequent use;
The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct each 1-4 hour 2-4 time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil;
Rhizoma Atractylodis Macrocephalae medicinal residues and all the other medical materials decoct with water 2-4 time, and each 1-4 hour, collecting decoction, filtration is concentrated, merges with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, makes various dosage forms.
5. application as claimed in claim 4 is characterized in that choosing the crude drug of following proportioning:
6. the application of Chinese medicine composition in preparation inhibition gastric cancer medicine, described Chinese medicine composition is following method preparation:
Choose following crude drug:
The Cornu Cervi Pantotrichum section decocts with water 2-4 time, and each 5-10 doubly measures, and 1-3 hour, collecting decoction filtered, and relative density 1.20-1.25 when filtrate is concentrated into 20 ℃ adds 2-5 and doubly measures ethanol, and precipitation filters, and Recycled ethanol is for subsequent use;
The Herba Epimedii boiling water extraction, and be pressed on the medical material with weight, decoct each 1-4 hour 2-4 time;
The Rhizoma Atractylodis Macrocephalae is for subsequent use with extraction by steam distillation volatile oil;
Rhizoma Atractylodis Macrocephalae medicinal residues and all the other medical materials decoct with water 2-4 time, and each 1-4 hour, collecting decoction, filtration is concentrated, merges with above-mentioned reserve liquid, Rhizoma Atractylodis Macrocephalae volatile oil, makes various dosage forms.
7. application as claimed in claim 6 is characterized in that choosing the crude drug of following proportioning:
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