CN102895276A - Method for preparing ginseng ganoderma preparation - Google Patents
Method for preparing ginseng ganoderma preparation Download PDFInfo
- Publication number
- CN102895276A CN102895276A CN2012104074804A CN201210407480A CN102895276A CN 102895276 A CN102895276 A CN 102895276A CN 2012104074804 A CN2012104074804 A CN 2012104074804A CN 201210407480 A CN201210407480 A CN 201210407480A CN 102895276 A CN102895276 A CN 102895276A
- Authority
- CN
- China
- Prior art keywords
- ganoderma
- preparation
- ginseng
- clear paste
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a method for preparing ginseng ganoderma preparation. The ginseng ganoderma preparation is made from ginseng, ganoderma and auxiliary materials. According to the invention, the process of the preparation is optimized according to the properties of the drugs in the ginseng ganoderma preparation and the effects of the drugs provided in the formula. Compared with the prior art, the product prepared by the process is higher in active component content and better in clinical efficacy.
Description
Technical field
The present invention relates to a kind of preparation method of ginseng and lucid ganoderma preparation, belong to the field of medicine technology.
Technical background
Body void is that some function of body goes down to some extent, and namely alleged " subhealth state " of doctor trained in Western medicine taken a tonic or nourishing food to build up one's health, regulated and nurse one's health, can further develop as untimely, and be unfavorable to health.Treatment is weak, according to the traditional Chinese medical science " void then auxiliary it, sthenia syndrome requiring purgation, heat then cold it, cold then heat." principle, need by nourishing to adjust deficiency and excess, and need according to each one body constitution and disease in the dialectical body of distinguishing of row nourish, make the negative and positive of qi and blood of body reach new balance, get well.The ginseng and lucid ganoderma capsule is prepared from by Radix Ginseng, Ganoderma and adjuvant.Wherein Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins admittedly take off, invigorating the spleen to benefit the lung, Ganoderma is aided with the merit of invigorating QI and tranquilization, two kinds of medicines are played strengthening the body resistance altogether in the side, the effect of benefiting vital QI for tranquillizing is used for the empty weak disease of waiting of body.Existing method of producing the ginseng and lucid ganoderma capsule generally is to adopt the method for putting down in writing on the drug standard, standard number: WS-11517 (ZD-1517)-2002, in the method for above-mentioned standard record, the Ganoderma water boiling and extraction, Radix Ginseng is pulverized, and method is fairly simple, causes containing in the product a large amount of invalid components and impurity, extracts active ingredients efficient is lower, so that the clinical efficacy of ginseng and lucid ganoderma capsule is not ideal enough.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of preparation method of ginseng and lucid ganoderma preparation.
For solving the problems of the technologies described above, the present invention realizes by the following technical solutions:
A kind of ginseng and lucid ganoderma preparation calculates according to composition by weight, and it is prepared from by Radix Ginseng 300-500 part, Ganoderma 300-500 part and adjuvant.
Specifically, described ginseng and lucid ganoderma preparation calculates according to composition by weight, and it is prepared from by 395 parts of Radix Ginsengs, 400 parts of Ganodermas and adjuvant.
The preparation method of described ginseng and lucid ganoderma preparation is: the ginseng crude drug is cleaned the final vacuum normal temperature drying, and through comminution by gas stream, for subsequent use; Other gets Ganoderma in 60 ℃ of lower crushed after being dried,, filters in 90 ℃ of lower lixiviates with material-water ratio 1:30, and merging filtrate, filtrate is lower concentrated at 60 ℃; Gained Ganoderma clear paste and Radix Ginseng powder mixing add conventional adjuvant again and can make different oral formulations according to conventional method.
Specifically, the preparation method of described ginseng and lucid ganoderma preparation is: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; Gained Ganoderma clear paste and Radix Ginseng powder mixing add conventional adjuvant again and can make different oral formulations according to conventional method.
Described oral formulations is capsule or tablet.
The preparation method of described capsule is: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; The abundant mixed pelletization of starch of gained Ganoderma clear paste and Radix Ginseng powder and the amount of making 10%, cold drying, granulate packs 2 into
#Capsule, check is packed and be get final product.
The preparation method of described tablet is: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; To granulate behind Radix Ginseng powder and the Ganoderma clear paste mixing soft material processed, spray 70% ethanol and adjust pellet moisture, add the Pulvis Talci of the amount of making 5%, 0.5% magnesium stearate mixing, with 14 mesh sieve granulate, tabletting, quality inspection, packing, and get final product.
Ginseng and lucid ganoderma preparation of the present invention is prepared from by Radix Ginseng, Ganoderma and adjuvant.Radix Ginseng is dry root and the rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Sweet, the little hardship of property, tepor; Return spleen, lung, the heart, kidney channel; Radix Ginseng has that strongly invigorating primordial QI, multiple arteries and veins take off admittedly, invigorating the spleen to benefit the lung, promote the production of body fluid and nourish blood and the merit of the Fructus Alpiniae Oxyphyllae of calming the nerves, and is usually used in weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, QI and blood lose must and sexual impotence cold womb etc.Modern chemistry studies show that, the main effective ingredient of Radix Ginseng is ginsenoside and saccharide, and modern pharmacology studies show that, Radix Ginseng can shock, resist myocardial ischemia, arrhythmia, enhancing human body immunity function, promote hemopoietic function, improve substance metabolism etc.Ganoderma is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum(Leyss.ex Fr.) the dry sporophore of Karst. or Ganoderma Ganoderma sinense Zhao.Xu et Zhang.Ganoderma property is sweet, flat; GUIXIN, lung, kidney channel.Effect with invigorating QI and tranquilization, relieving cough and asthma; Be usually used in malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia are losed heart and anorexia.Studies show that in the Ganoderma according to the modern chemistry means and also to contain in addition ergosterol, organic acid, aminoacid etc. mainly take polysaccharide as main; Polysaccharide has antitumor, blood sugar lowering, promotion nucleic acid protein anabolism, the hemopoietic function of improving, strengthens the effects such as immune in the Ganoderma, is the main effective ingredient of Ganoderma.The present invention participates in the people in the Ganoderma prescription, plays altogether strengthening the body resistance, the effect of benefiting vital QI for tranquillizing.
In the prior art, Radix Ginseng adopts conventional drying means, studies discovery through the inventor, and it is the powder of 0.5～1 μ m that Radix Ginseng adopts comminution by gas stream, and its loss of effective components still less.The main pharmacodynamics composition of Ganoderma is ganoderan; The method that the available technology adopting decocting boils is extracted the effective ingredient in the Ganoderma, its extraction ratio is not high, the present invention is prior to 60 ℃ of lower crushed after being dried, cross 300 mesh sieves, again with material-water ratio 1:30 in 90 ℃ of lower lixiviates 2 times, improved the stripping of ganoderan and guaranteed the smooth filtration of extracting solution, described technique Effective Raise the extraction ratio of effective ingredient in the medicine, bioavailability is higher, and clinical efficacy is better, has reached goal of the invention.
The applicant has carried out following experiment, and provable the present invention has effective effect;
Experimental example 1: total saponins and monomer saponin contain quantity research in the varigrained Radix Ginseng powder
1.1 breaking method and powder size
The ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is 1～12 μ m, 0.5～1 μ m, 200～500nm, 200nm, 20～80nm through comminution by gas stream again.Former technique: get Radix Ginseng, clean, chopping in 60 ℃ of dryings, is pulverized, and crosses 60 mesh sieves and gets.
1.2 instrument and reagent
Agilent-1100 high performance liquid chromatograph, KQ-500 medical digital controlled Ultrasound Instrument (Fauna of Kunshan, Jiangsu instrument plant); Acetonitrile (chromatographically pure), pure water (Hangzhou WAHAHA company), ginsenoside's reference substance Rg
1, Re, Rb
1, Rc, Rb
2, Rd(purity 98%, Nat'l Pharmaceutical ﹠ Biological Products Control Institute), other reagent are analytical pure.
1.3 chromatographic condition and method
Chromatographic condition: C18 post, column temperature: 35 ℃, detect wavelength: 203nm, sample size: 20 μ l, mobile phase: acetonitrile (A)-water (B) constant speed gradient elution, flow velocity: 1.6mlmin
-1, elution program: 0～18min, 17.5%A; 18.1～21min, 18.5%A; 21.1～44min, 29%A; 44.1～45min, 40%A; 45.1～55min, 90%A; 55.1～60min, 17.5%A.
Method: precision takes by weighing 6 kinds of each 1.000g of Radix Ginseng powder sample respectively, sample thief 0.5g(is accurate to 0.0001), adopt the cable type extractor according methanol eddy to extract 8h, extracting solution places the evaporating dish water bath with thermostatic control to volatilize, with the dissolving of 30% acetonitrile, be settled in the 10ml volumetric flask, shake up placement, with front usefulness 0.45 μ m membrane filtration, gained filtrate is sample liquid; Precision takes by weighing ginsenoside's reference substance Rg respectively
1, Re, Rb
1, Rc, Rb
2, each 2mg of Rd, place same 2ml volumetric flask, with % acetonitrile ultrasonic dissolution and standardize solution, get reference substance solution.After the researchs such as linear relationship, stability test, replica test, different Radix Ginseng powder extracting solution are contained survey again, the results are shown in Table 1.
1.4 result
Monomer saponin and total saponin content (%) in the different powder samples of table 1
Experimental result shows: the saponin total content of particle diameter in the ginseng submicron powder of 0.5～1 μ m is the highest, and be more much higher than saponin measured quantity in the former technique Radix Ginseng powder.
Experimental example 2: different degrees of grinding are extracted the impact of yield on ganoderan
1.1 material
Chinese medicine grinder and morning and evening tides pulverizer (BFM100B, Jinan Billionpowder Tech﹠ Eng Co., Ltd), Waters600 high performance liquid chromatography, molecular weight are 150,270,410,670, the glucose of 1400kDa (dextran series, Sigma company).
1.2 chromatographic condition
The Waters600 high performance liquid chromatography, column temperature: 35 ℃, mobile phase: 0.1molL
-1Phosphate buffer (Ph7.0), flow velocity: 0.5mlmin, sample size: 20 μ L.
1.3 method
Ganoderma dries to constant weight under 60 ℃, crosses respectively 10 orders (former technique), 40 orders after pulverizing with Chinese medicine grinder, will continue to pulverize with ultrafine crusher in right amount again, crosses 300 orders; Accurately respectively get the REISH 10g of above 3 kinds of different degrees of grinding, add the 250ml distilled water, 100 ℃ are extracted 2h, filter, and filtrate is concentrated into 1/10 volume, and with the centrifugal 20min of 13400g, supernatant is with 0.45 μ m membrane filtration, and filtrate is as test liquid.Take molecular weight as 150,270,410,670, the glucose (dextran series, Sigma company) of 1400kDa is reference.
1.4 result
Testing result shows: the handled polysaccharide yield difference of 40 orders and 10 orders (former technique) is little, and superfine grinding (crossing 300 orders) can significantly improve the extraction ratio of polysaccharide.
Experimental example 3: Ganoderma Study on extraction
The present invention carries out preferably the extraction process of Ganoderma as index take the extraction yield of ganoderan, and technological level factor table sees Table 2, A: liquid ratio, and B: extraction time (h), C: extraction temperature (℃).
Table 2 factor level table
Extract yield as index take ganoderan, adopt orthogonal experiment according to the factor level table Ganoderma extraction process to be carried out preferably the results are shown in Table 3.
Table 3 Orthogonal experiment results
The result shows: extraction temperature extracts having the greatest impact of yield to polysaccharide, and the impact of extraction time is taken second place, and the liquid ratio impact is minimum; The optimal extract process of ganoderan is A
1B
3C
2, that is: material-water ratio is 1:30,90 ℃ of extraction temperatures, extraction time are 3.5h.
Experimental example 4: effect experiment
1 materials and methods
1.1 experimental animal: SD rat, 40, average weight (178.1 ± 3.23) g, male and female half and half.
1.2 instrument and reagent: NXE-1B type cone and plate viscometer (Chengdu Instruement Factory); Generic centrifuge (Anting Scientific Instrument Factory, Shanghai); Thermostatic water bath.
1.3 medicine
Former technique medicine: get Ganoderma, pulverize, decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.25～1.26 (60 ℃); Other gets Radix Ginseng, and is clean, and chopping in 60 ℃ of dryings, is pulverized, and crosses 60 mesh sieves, adds abundant mixing in the Ganoderma clear paste, sieves, and drying incapsulates, and get final product.Get capsule 's content, use physiological saline solution.
Technique medicine of the present invention: according to the method preparation of embodiment 1.Get capsule 's content, use physiological saline solution.
1.4 test method: the SD rat is divided into 4 groups at random, male and female half and half, 10 every group.
1. Normal group: every Mus gavage every day normal saline 1ml/100g; 2. swimming strain modeling group: every Mus gavage every day normal saline 1ml/100g; 3. the swimming strain adds former technique medicine group: every Mus concentration every day is 0.5% former technique drug solution 1ml/100g; 4. the swimming strain adds technique medicine group of the present invention: every Mus concentration every day is 1% technique drug solution 1ml/100g of the present invention, and normal diet is fed.Adopt swimming strain legal system to make the rat model of qi-asthenia.Except Normal group, every day will be 2., 3., 4. organizing rat, to put into water temperature be the thermostatic water bath went swimming of 35cm for (43.0 ± 0.5) ℃, the depth of water, the time that occurs natural subsidence take every rat swims the fatigue proof time as it, when natural subsidence appears in complete group of rat 50%, all stop swimming.14d did not swim on the 15th day continuously, got blood to broken end behind gavage normal saline or the Cordyceps polysaccharide solution 40min, added anticoagulant heparin.Adopt centrifuge with the centrifugal 30min of 3000r/min, income value is packed cell volume.Normal group was measured These parameters according to identical method after giving normal saline 40min on the 15th day.
2 results and analysis
2.1 the impact on model of qi-asthenia SD Rat Erythrocytes hematocrit
Table 1 is on the impact of Rat Erythrocytes hematocrit
Annotate: compare with swimming strain modeling group, * represents P ﹤ 0.05, and * * represents P ﹤ 0.01
Add former technique medicine group relatively with the swimming strain, # represents P ﹤ 0.05
Conclusion: as shown in Table 1, technique medicine of the present invention is better than former technique medicine to the impact of model of qi-asthenia SD Rat Erythrocytes hematocrit.
The specific embodiment:
Embodiment 1:
Prescription: Radix Ginseng 395, Ganoderma 400g.
Technique: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; The abundant mixed pelletization of starch of gained Ganoderma clear paste and Radix Ginseng powder and the amount of making 10%, cold drying, granulate packs 2 into
#Capsule, check, packing namely gets capsule.
Usage and consumption: oral, one time 3,3 times on the one.
Specification: every dress 0.4g.
Embodiment 2:
Prescription: Radix Ginseng 500g, Ganoderma 500g.
Technique: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize as coarse powder first, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; To granulate behind Radix Ginseng powder and the Ganoderma clear paste mixing soft material processed, spray 70% ethanol and adjust pellet moisture, add the Pulvis Talci of the amount of making 5%, 0.5% magnesium stearate mixing, with 14 mesh sieve granulate, tabletting, quality inspection, packing namely gets tablet.
Usage and consumption: oral, one time 3,3 times on the one.
Specification: every 0.4g on chip.
Claims (5)
1. the preparation method of a ginseng and lucid ganoderma preparation, it is characterized in that: described ginseng and lucid ganoderma preparation calculates according to composition by weight, is prepared from by Radix Ginseng 300-500 part, Ganoderma 300-500 part and adjuvant; The preparation method of described ginseng and lucid ganoderma preparation is: the ginseng crude drug is cleaned the final vacuum normal temperature drying, and through comminution by gas stream, for subsequent use; Other gets Ganoderma in 60 ℃ of lower crushed after being dried,, filters in 90 ℃ of lower lixiviates with material-water ratio 1:30, and merging filtrate, filtrate is lower concentrated at 60 ℃; Gained Ganoderma clear paste and Radix Ginseng powder mixing add conventional adjuvant again and can make different oral formulations according to conventional method.
2. the preparation method of ginseng and lucid ganoderma preparation as claimed in claim 1 is characterized in that: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize first and be coarse powder, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; Gained Ganoderma clear paste and Radix Ginseng powder mixing add conventional adjuvant again and can make different oral formulations according to conventional method.
3. the preparation method of ginseng and lucid ganoderma preparation as claimed in claim 1, it is characterized in that: described oral formulations is capsule or tablet.
4. the preparation method of ginseng and lucid ganoderma preparation as claimed in claim 3, it is characterized in that: the preparation method of described capsule is: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize first and be coarse powder, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; The abundant mixed pelletization of starch of gained Ganoderma clear paste and Radix Ginseng powder and the amount of making 10%, cold drying, granulate, the 2# capsule of packing into, check is packed and be get final product.
5. the preparation method of ginseng and lucid ganoderma preparation as claimed in claim 3, it is characterized in that: the preparation method of described tablet is: the ginseng crude drug being cleaned the final vacuum normal temperature drying, pulverize first and be coarse powder, is the granule of 0.5～1 μ m again through comminution by gas stream, for subsequent use; Other gets Ganoderma and crosses 300 orders in 60 ℃ of lower crushed after being dried, and in 90 ℃ of lower lixiviates 2 times, each 3.5h filters with material-water ratio 1:30, merging filtrate, and filtrate is concentrated into relative density under 60 ℃ be 1.25～1.26 clear paste; To granulate behind Radix Ginseng powder and the Ganoderma clear paste mixing soft material processed, spray 70% ethanol and adjust pellet moisture, add the Pulvis Talci of the amount of making 5%, 0.5% magnesium stearate mixing, with 14 mesh sieve granulate, tabletting, quality inspection, packing, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104074804A CN102895276A (en) | 2012-10-23 | 2012-10-23 | Method for preparing ginseng ganoderma preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104074804A CN102895276A (en) | 2012-10-23 | 2012-10-23 | Method for preparing ginseng ganoderma preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102895276A true CN102895276A (en) | 2013-01-30 |
Family
ID=47567962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104074804A Pending CN102895276A (en) | 2012-10-23 | 2012-10-23 | Method for preparing ginseng ganoderma preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102895276A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523788A (en) * | 2014-12-16 | 2015-04-22 | 百花医药集团股份有限公司 | Preparation method of ginseng lucid ganoderma preparation |
| CN108142941A (en) * | 2016-12-03 | 2018-06-12 | 河北以岭医药研究院有限公司 | A kind of health food containing ganoderma lucidum and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274259A (en) * | 2011-07-25 | 2011-12-14 | 江中药业股份有限公司 | Traditional Chinese medicine composition for enhancing immune function of human bodies |
| CN102406669A (en) * | 2011-11-11 | 2012-04-11 | 吉林天强制药有限公司 | Chinese medicine composite and preparation method and medicinal preparation thereof |
-
2012
- 2012-10-23 CN CN2012104074804A patent/CN102895276A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274259A (en) * | 2011-07-25 | 2011-12-14 | 江中药业股份有限公司 | Traditional Chinese medicine composition for enhancing immune function of human bodies |
| CN102406669A (en) * | 2011-11-11 | 2012-04-11 | 吉林天强制药有限公司 | Chinese medicine composite and preparation method and medicinal preparation thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523788A (en) * | 2014-12-16 | 2015-04-22 | 百花医药集团股份有限公司 | Preparation method of ginseng lucid ganoderma preparation |
| CN108142941A (en) * | 2016-12-03 | 2018-06-12 | 河北以岭医药研究院有限公司 | A kind of health food containing ganoderma lucidum and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104666892A (en) | Sealwort and ginseng formula for enhancing immunity and relieving fatigue and preparation method of formula | |
| CN1785284B (en) | Medicinal composition containing flowery knotwood root | |
| CN102362881A (en) | Method for preparing ginkgo and American ginseng preparation | |
| CN112972547A (en) | Traditional Chinese medicine composition for treating qi-blood deficiency syndrome and preparation method and application thereof | |
| CN102422957B (en) | Bawei danshen tea and preparation process thereof | |
| CN103720769A (en) | Traditional Chinese medicinal composition capable of enhancing immunity | |
| CN104997883A (en) | Inonotus obliquus raspberry tree red raspberry composition, inonotus obliquus raspberry tree red raspberry composite oral solution and preparation method and application thereof | |
| CN104055871A (en) | Traditional Chinese medicinal composition for improving sleeping quality and application of traditional Chinese medicinal composition | |
| AU2015345884B2 (en) | Drug or health care product preventing or treating liver and kidney damage-related diseases and use thereof | |
| CN102579836B (en) | Traditional Chinese medical dendrobium huoshanense composition and preparation method thereof | |
| CN101816723B (en) | Sobering up and liver protecting Chinese medicinal preparation and preparation method thereof | |
| CN102973719A (en) | Traditional Chinese medicine health-care food with bowel relaxing function and preparation method thereof | |
| CN102600368B (en) | Pharmaceutical composition, as well as preparation method and application thereof | |
| CN100469377C (en) | Nankang soft capsule for treating prostatitis | |
| CN103689708B (en) | Pine pollen-fragrant solomonseal rhizome liquid beverage | |
| CN107722131A (en) | A kind of total ganoderma spore powder refined polysaccharide with notable adjunct antineoplastic activity and its preparation method and application | |
| CN102895276A (en) | Method for preparing ginseng ganoderma preparation | |
| CN102100737B (en) | Medicinal composition containing general ginsenoside and total salvianolic acid and preparation method thereof | |
| CN104107388B (en) | One kind improves immunity anti-tumor compound Chinese medicine composition and its production and use | |
| CN101897770A (en) | Bone spur capsule and preparation process thereof | |
| CN106928376A (en) | The separation method of skunk bush polysaccharide and its application | |
| CN110664905A (en) | Traditional Chinese medicine preparation for expelling wind and clearing away cold and preparation method thereof | |
| CN104000994A (en) | Preparation method of concentrated six-taste glutinous rehmannia capsule | |
| CN104706708B (en) | Red stilbene ethanol extract prevents and treats application and wherein effective component identification method in hepatic fibrosis medicines in preparation | |
| CN108066494A (en) | A kind of enuresis nocturna frequency effect liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130130 |