CN1362232A - Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation - Google Patents
Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation Download PDFInfo
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- CN1362232A CN1362232A CN 01100731 CN01100731A CN1362232A CN 1362232 A CN1362232 A CN 1362232A CN 01100731 CN01100731 CN 01100731 CN 01100731 A CN01100731 A CN 01100731A CN 1362232 A CN1362232 A CN 1362232A
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Abstract
The present invention discloses a nano Guifu-dihuang preparation medicine. It is made up by using 7 Chinese medicinal materials of nano cooked rehmanis, nano dioscorea, nano cornus, nano poria, nano alisma and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of nanometer osmanthus attached glutinous rehmannia formulation medicine of warming and recuperating the kidney-YANG, the invention still further relates to the method for this medication preparation.
The osmanthus attached glutinous rehmannia sheet is a kind of classical Chinese patent medicine, mainly contains effects such as warming and recuperating the kidney-YANG, be used for that insufficiency of kidney-YANG, the acid of waist knee joint are cold, limbs edema, dysuria or anti-many, phlegm retention is breathed with cough and quench one's thirst.But traditional osmanthus attached glutinous rehmannia sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer osmanthus attached glutinous rehmannia formulation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer osmanthus attached glutinous rehmannia formulation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae Preparata 100-220 part nanometer Rhizoma Dioscoreae 40-120 part nanometer Fructus Corni 40-120 part
Nano Poria 40-80 part nanometer Rhizoma Alismatis 40-80 part nanometer Cortex Cinnamomi 10-30 part
Nanometric Radix Aconiti Lateralis Preparata 10-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae Preparata 130-190 part nanometer Rhizoma Dioscoreae 60-100 part nanometer Fructus Corni 60-100 part
Nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part nanometer Cortex Cinnamomi 15-25 part
Nanometric Radix Aconiti Lateralis Preparata 15-25 part
The optimum weight proportioning of medicine of the present invention is:
80 parts of 80 parts of nanometer Fructus Corni of 160 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
20 parts of 60 parts of nanometer Cortex Cinnamomis of 60 parts of nanometer Rhizoma Alismatis of nano Poria
20 parts of nanometric Radix Aconiti Lateralis Preparatas
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the osmanthus attached glutinous rehmannia formulation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer osmanthus attached glutinous rehmannia formulation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common osmanthus attached glutinous rehmannia tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nanometer osmanthus attached glutinous rehmannia formulation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that insufficiency of kidney-YANG, the acid of waist knee joint are cold, limbs edema, dysuria or anti-many, treatment of conditions such as phlegm retention is breathed with cough and quench one's thirst, and clinical efficacy significantly is better than traditional osmanthus attached glutinous rehmannia sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
80 parts of 80 parts of nanometer Fructus Corni of 160 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
20 parts of 60 parts of nanometer Cortex Cinnamomis of 60 parts of nanometer Rhizoma Alismatis of nano Poria
20 parts of nanometric Radix Aconiti Lateralis Preparatas
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
80 parts of 80 parts of nanometer Fructus Corni of 160 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
20 parts of 60 parts of nanometer Cortex Cinnamomis of 60 parts of nanometer Rhizoma Alismatis of nano Poria
20 parts of nanometric Radix Aconiti Lateralis Preparatas
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer osmanthus attached glutinous rehmannia powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
80 parts of 80 parts of nanometer Fructus Corni of 160 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
20 parts of 60 parts of nanometer Cortex Cinnamomis of 60 parts of nanometer Rhizoma Alismatis of nano Poria
20 parts of nanometric Radix Aconiti Lateralis Preparatas
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer osmanthus attached glutinous rehmannia membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer osmanthus attached glutinous rehmannia formulation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae Preparata 100-220 part nanometer Rhizoma Dioscoreae 40-120 part nanometer Fructus Corni 40-120 part
Nano Poria 40-80 part nanometer Rhizoma Alismatis 40-80 part nanometer Cortex Cinnamomi 10-30 part
Nanometric Radix Aconiti Lateralis Preparata 10-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer osmanthus attached glutinous rehmannia formulation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae Preparata 130-190 part nanometer Rhizoma Dioscoreae 60-100 part nanometer Fructus Corni 60-100 part
Nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part nanometer Cortex Cinnamomi 15-25 part
Nanometric Radix Aconiti Lateralis Preparata 15-25 part
3, nanometer osmanthus attached glutinous rehmannia formulation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
80 parts of 80 parts of nanometer Fructus Corni of 160 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
20 parts of 60 parts of nanometer Cortex Cinnamomis of 60 parts of nanometer Rhizoma Alismatis of nano Poria
20 parts of nanometric Radix Aconiti Lateralis Preparatas
4, according to claim 1 or 2 or 3 described nanometer osmanthus attached glutinous rehmannia formulation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer osmanthus attached glutinous rehmannia formulation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100731 CN1362232A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100731 CN1362232A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation |
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| CN1362232A true CN1362232A (en) | 2002-08-07 |
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| CN 01100731 Pending CN1362232A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406602B (en) * | 2008-11-21 | 2012-04-04 | 汝州市中医院 | Hypoglycemic capsules containing seven ingredients with rehmannia |
| CN104189865A (en) * | 2014-09-26 | 2014-12-10 | 陈维香 | Traditional Chinese medicine preparation for gonitis and preparation method of traditional Chinese medicine preparation |
-
2001
- 2001-01-08 CN CN 01100731 patent/CN1362232A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406602B (en) * | 2008-11-21 | 2012-04-04 | 汝州市中医院 | Hypoglycemic capsules containing seven ingredients with rehmannia |
| CN104189865A (en) * | 2014-09-26 | 2014-12-10 | 陈维香 | Traditional Chinese medicine preparation for gonitis and preparation method of traditional Chinese medicine preparation |
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