CN1364580A - Nano children cough arresting medicine and its preparing method - Google Patents
Nano children cough arresting medicine and its preparing method Download PDFInfo
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- CN1364580A CN1364580A CN 01101923 CN01101923A CN1364580A CN 1364580 A CN1364580 A CN 1364580A CN 01101923 CN01101923 CN 01101923 CN 01101923 A CN01101923 A CN 01101923A CN 1364580 A CN1364580 A CN 1364580A
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Abstract
The nano children's cough arresting medicine is prepared with nano figwort, nano lilyturf root, nano almond, nano arisaema with bile, nano perilla seed and other 10 kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of moistening lung and clearing heat, antitussive reduces phlegm, and cures mainly children's's interior-heat fever, the cough with profuse sputum, the nano children cough arresting medicine of abdominal distention constipation the invention still further relates to the method for this medication preparation.
Children's's antitussive ball is a kind of classical Chinese patent medicine, mainly contains the lung moistening heat clearing away, and antitussive effect such as reduce phlegm is used for children's's interior-heat fever, cough with profuse sputum, abdominal distention constipation.But traditional children's's antitussive ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano children cough arresting medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano children cough arresting medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Scrophulariae 36-92 part nanometer 36-92 Radix Ophiopogonis part nanometer Semen Armeniacae Amarum (stir-fry) 36-92 part
Nanometer Arisaema Cum Bile 36-92 part nanometer Fructus Perillae (stir-fry) 18-46 part nanometer Semen Arecae (Jiao) 26-70 part
The female 26-70 part of nanometer Radix Trichosanthis 26-70 part nanometer Folium Perillae 18-46 part nano Sichuan fritillary bulb
Nanometer Rhizoma Anemarrhenae 18-46 part nanometer Semen Trichosanthis (processed with honey) 26-70 part nanometer Radix Glycyrrhizae 26-70 part
Nanometer Radix Platycodonis 26-70 part nanometer Caulis Bambusae In Taenia 26-70 part nanometer Cortex Mori (processed with honey) 26-70 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Scrophulariae 51-77 part nanometer 51-77 Radix Ophiopogonis part nanometer Semen Armeniacae Amarum (stir-fry) 51-77 part
Nanometer Arisaema Cum Bile 51-77 part nanometer Fructus Perillae (stir-fry) 26-38 part nanometer Semen Arecae (Jiao) 38-58 part
The female 38-58 part of nanometer Radix Trichosanthis 38-58 part nanometer Folium Perillae 26-38 part nano Sichuan fritillary bulb
Nanometer Rhizoma Anemarrhenae 26-38 part nanometer Semen Trichosanthis (processed with honey) 38-58 part nanometer Radix Glycyrrhizae 38-58 part
Nanometer Radix Platycodonis 38-58 part nanometer Caulis Bambusae In Taenia 38-58 part nanometer Cortex Mori (processed with honey) 38-58 part
The optimum weight proportioning of medicine of the present invention is:
64 parts of 64 parts of nanometers of nanometer Radix Scrophulariae, 64 portions of nanometer Semen Armeniacae Amarums Radix Ophiopogonis (stir-fry)
48 parts of 32 portions of nanometer Semen Arecaes of 64 parts of nanometer Fructus Perillaes of nanometer Arisaema Cum Bile (stir-fry) (Jiao)
Female 48 parts of 32 parts of nano Sichuan fritillary bulbs of 48 parts of nanometer Folium Perillaes of nanometer Radix Trichosanthis
48 parts in 48 parts of nanometer Radix Glycyrrhizaes of 32 parts of nanometer Semen Trichosanthis of the nanometer Rhizoma Anemarrhenae (processed with honey)
48 parts of nanometer Radix Platycodonis 48 parts of nanometer Cortex Mori of 48 parts of nanometer Caulis Bambusae In Taenia (processed with honey)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the children cough arresting nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano children cough arresting medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common children's's antitussive pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano children cough arresting medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for children's's interior-heat fever, the cough with profuse sputum, and treatment of conditions such as abdominal distention constipation, clinical efficacy significantly is better than traditional children's's antitussive ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
64 parts of 64 parts of nanometers of nanometer Radix Scrophulariae, 64 portions of nanometer Semen Armeniacae Amarums Radix Ophiopogonis (stir-fry)
48 parts of 32 portions of nanometer Semen Arecaes of 64 parts of nanometer Fructus Perillaes of nanometer Arisaema Cum Bile (stir-fry) (Jiao)
Female 48 parts of 32 parts of nano Sichuan fritillary bulbs of 48 parts of nanometer Folium Perillaes of nanometer Radix Trichosanthis
48 parts in 48 parts of nanometer Radix Glycyrrhizaes of 32 parts of nanometer Semen Trichosanthis of the nanometer Rhizoma Anemarrhenae (processed with honey)
48 parts of nanometer Radix Platycodonis 48 parts of nanometer Cortex Mori of 48 parts of nanometer Caulis Bambusae In Taenia (processed with honey)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
64 parts of 64 parts of nanometers of nanometer Radix Scrophulariae, 64 portions of nanometer Semen Armeniacae Amarums Radix Ophiopogonis (stir-fry)
48 parts of 32 portions of nanometer Semen Arecaes of 64 parts of nanometer Fructus Perillaes of nanometer Arisaema Cum Bile (stir-fry) (Jiao)
Female 48 parts of 32 parts of nano Sichuan fritillary bulbs of 48 parts of nanometer Folium Perillaes of nanometer Radix Trichosanthis
48 parts in 48 parts of nanometer Radix Glycyrrhizaes of 32 parts of nanometer Semen Trichosanthis of the nanometer Rhizoma Anemarrhenae (processed with honey)
48 parts of nanometer Radix Platycodonis 48 parts of nanometer Cortex Mori of 48 parts of nanometer Caulis Bambusae In Taenia (processed with honey)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano children's antitussive powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
64 parts of 64 parts of nanometers of nanometer Radix Scrophulariae, 64 portions of nanometer Semen Armeniacae Amarums Radix Ophiopogonis (stir-fry)
48 parts of 32 portions of nanometer Semen Arecaes of 64 parts of nanometer Fructus Perillaes of nanometer Arisaema Cum Bile (stir-fry) (Jiao)
Female 48 parts of 32 parts of nano Sichuan fritillary bulbs of 48 parts of nanometer Folium Perillaes of nanometer Radix Trichosanthis
48 parts in 48 parts of nanometer Radix Glycyrrhizaes of 32 parts of nanometer Semen Trichosanthis of the nanometer Rhizoma Anemarrhenae (processed with honey)
48 parts of nanometer Radix Platycodonis 48 parts of nanometer Cortex Mori of 48 parts of nanometer Caulis Bambusae In Taenia (processed with honey)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano children's antitussive membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano children cough arresting medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Scrophulariae 36-92 part nanometer 36-92 Radix Ophiopogonis part nanometer Semen Armeniacae Amarum (stir-fry) 36-92 part
Nanometer Arisaema Cum Bile 36-92 part nanometer Fructus Perillae (stir-fry) 18-46 part nanometer Semen Arecae (Jiao) 26-70 part
The female 26-70 part of nanometer Radix Trichosanthis 26-70 part nanometer Folium Perillae 18-46 part nano Sichuan fritillary bulb
Nanometer Rhizoma Anemarrhenae 18-46 part nanometer Semen Trichosanthis (processed with honey) 26-70 part nanometer Radix Glycyrrhizae 26-70 part
Nanometer Radix Platycodonis 26-70 part nanometer Caulis Bambusae In Taenia 26-70 part nanometer Cortex Mori (processed with honey) 26-70 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano children cough arresting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Scrophulariae 51-77 part nanometer 51-77 Radix Ophiopogonis part nanometer Semen Armeniacae Amarum (stir-fry) 51-77 part
Nanometer Arisaema Cum Bile 51-77 part nanometer Fructus Perillae (stir-fry) 26-38 part nanometer Semen Arecae (Jiao) 38-58 part
The female 38-58 part of nanometer Radix Trichosanthis 38-58 part nanometer Folium Perillae 26-38 part nano Sichuan fritillary bulb
Nanometer Rhizoma Anemarrhenae 26-38 part nanometer Semen Trichosanthis (processed with honey) 38-58 part nanometer Radix Glycyrrhizae 38-58 part
Nanometer Radix Platycodonis 38-58 part nanometer Caulis Bambusae In Taenia 38-58 part nanometer Cortex Mori (processed with honey) 38-58 part
3, nano children cough arresting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
64 parts of 64 parts of nanometers of nanometer Radix Scrophulariae, 64 portions of nanometer Semen Armeniacae Amarums Radix Ophiopogonis (stir-fry)
48 parts of 32 portions of nanometer Semen Arecaes of 64 parts of nanometer Fructus Perillaes of nanometer Arisaema Cum Bile (stir-fry) (Jiao)
Female 48 parts of 32 parts of nano Sichuan fritillary bulbs of 48 parts of nanometer Folium Perillaes of nanometer Radix Trichosanthis
48 parts in 48 parts of nanometer Radix Glycyrrhizaes of 32 parts of nanometer Semen Trichosanthis of the nanometer Rhizoma Anemarrhenae (processed with honey)
48 parts of nanometer Radix Platycodonis 48 parts of nanometer Cortex Mori of 48 parts of nanometer Caulis Bambusae In Taenia (processed with honey)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano children cough arresting medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano children cough arresting medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101923 CN1364580A (en) | 2001-01-16 | 2001-01-16 | Nano children cough arresting medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101923 CN1364580A (en) | 2001-01-16 | 2001-01-16 | Nano children cough arresting medicine and its preparing method |
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| Publication Number | Publication Date |
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| CN1364580A true CN1364580A (en) | 2002-08-21 |
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| CN 01101923 Pending CN1364580A (en) | 2001-01-16 | 2001-01-16 | Nano children cough arresting medicine and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068626B (en) * | 2009-11-19 | 2012-03-07 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Detection method for infantile cough syrup as Chinese medicine preparation |
| CN104667018A (en) * | 2015-03-20 | 2015-06-03 | 海南葫芦娃制药有限公司 | Granules for relieving cough of child and preparation method of granules |
-
2001
- 2001-01-16 CN CN 01101923 patent/CN1364580A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068626B (en) * | 2009-11-19 | 2012-03-07 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Detection method for infantile cough syrup as Chinese medicine preparation |
| CN104667018A (en) * | 2015-03-20 | 2015-06-03 | 海南葫芦娃制药有限公司 | Granules for relieving cough of child and preparation method of granules |
| CN104667018B (en) * | 2015-03-20 | 2018-02-16 | 海南葫芦娃药业集团股份有限公司 | A kind of children's Cough remedy granules and preparation method thereof |
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