CN1362115A - Nano Guilin water melon medicine and its preparation - Google Patents
Nano Guilin water melon medicine and its preparation Download PDFInfo
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- CN1362115A CN1362115A CN 01100167 CN01100167A CN1362115A CN 1362115 A CN1362115 A CN 1362115A CN 01100167 CN01100167 CN 01100167 CN 01100167 A CN01100167 A CN 01100167A CN 1362115 A CN1362115 A CN 1362115A
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Abstract
The present invention discloses a nano Guilin-watermelon preparation medicine. It is made up by using 14 Chinese medicinal materials of nano watermelon frost, nano borax, nano phellodendron, nano coptis, nano scutellaria and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano Guilin water melon preparation medicine of a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
GUILIN XIGUA SHUANG is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is used for laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, acute and chronic pharyngolaryngitis, tonsillitis, stomatitis, oral ulcer, infantile thrush and slight burn and scald and wound hemorrhage.But traditional GUILIN XIGUA SHUANG absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Guilin water melon preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Guilin water melon preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer watermelon crystal 50-500 part nanometer Borax 100-500 part nano phellodendron bark 50-400 part
Nanometer coptis 100-500 part nanometer Radix Scutellariae 50-400 part nanometer Radix Sophorae Tonkinensis 50-500 part
Nanometer Rhizoma Belamcandae 100-600 part nanometer Bulbus Fritillariae Thunbergii 100-500 part nano natural indigo 30-300 part
Nanometer Borneolum Syntheticum 1-10 part nano rhubarb 10-100 part nanometer Fructus Momordicae 50-500 part
Nanometer Radix Glycyrrhizae 10-50 part nanometer Mentholum 1-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer watermelon crystal 100-300 part nanometer Borax 200-400 part nano phellodendron bark 100-300 part
Nanometer coptis 150-400 part nanometer Radix Scutellariae 100-300 part nanometer Radix Sophorae Tonkinensis 100-400 part
Nanometer Rhizoma Belamcandae 200-500 part nanometer Bulbus Fritillariae Thunbergii 200-400 part nano natural indigo 50-200 part
Nanometer Borneolum Syntheticum 3-8 part nano rhubarb 20-50 part nanometer Fructus Momordicae 100-300 part
Nanometer Radix Glycyrrhizae 20-40 part nanometer Mentholum 3-8 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 300 parts of nano phellodendron barks of 150 parts of nanometer Boraxs of nanometer watermelon crystal
150 parts of 200 parts of nanometer Radix Sophorae Tonkinensiss of 250 parts of nanometer Radix Scutellariaes of nanometer coptis
100 parts of 250 parts of nano natural indigos of 300 parts of nanometer Bulbus Fritillariae Thunbergiis of nanometer Rhizoma Belamcandae
150 parts of 30 portions of nanometer Fructus Momordicaes of 5 parts of nano rhubarbs of nanometer Borneolum Syntheticum
5 parts of 30 parts of nanometer Mentholums of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material ...-material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, get Guilin water melon preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Guilin water melon preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common GUILIN XIGUA SHUANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Guilin water melon preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, acute and chronic pharyngolaryngitis, tonsillitis, stomatitis, oral ulcer, treatment of conditions such as infantile thrush and slight burn and scald and wound hemorrhage, clinical efficacy significantly is better than traditional GUILIN XIGUA SHUANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 300 parts of nano phellodendron barks of 150 parts of nanometer Boraxs of nanometer watermelon crystal
150 parts of 200 parts of nanometer Radix Sophorae Tonkinensiss of 250 parts of nanometer Radix Scutellariaes of nanometer coptis
100 parts of 250 parts of nano natural indigos of 300 parts of nanometer Bulbus Fritillariae Thunbergiis of nanometer Rhizoma Belamcandae
150 parts of 30 portions of nanometer Fructus Momordicaes of 5 parts of nano rhubarbs of nanometer Borneolum Syntheticum
5 parts of 30 parts of nanometer Mentholums of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 300 parts of nano phellodendron barks of 150 parts of nanometer Boraxs of nanometer watermelon crystal
150 parts of 200 parts of nanometer Radix Sophorae Tonkinensiss of 250 parts of nanometer Radix Scutellariaes of nanometer coptis
100 parts of 250 parts of nano natural indigos of 300 parts of nanometer Bulbus Fritillariae Thunbergiis of nanometer Rhizoma Belamcandae
150 parts of 30 portions of nanometer Fructus Momordicaes of 5 parts of nano rhubarbs of nanometer Borneolum Syntheticum
5 parts of 30 parts of nanometer Mentholums of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano Guilin water melon frost powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
200 parts of 300 parts of nano phellodendron barks of 150 parts of nanometer Boraxs of nanometer watermelon crystal
150 parts of 200 parts of nanometer Radix Sophorae Tonkinensiss of 250 parts of nanometer Radix Scutellariaes of nanometer coptis
100 parts of 250 parts of nano natural indigos of 300 parts of nanometer Bulbus Fritillariae Thunbergiis of nanometer Rhizoma Belamcandae
150 parts of 30 portions of nanometer Fructus Momordicaes of 5 parts of nano rhubarbs of nanometer Borneolum Syntheticum
5 parts of 30 parts of nanometer Mentholums of nanometer Radix Glycyrrhizae
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano Guilin two melons frost membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: cervical region.
Claims (6)
1, a kind of nano Guilin water melon preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer watermelon crystal 50-500 part nanometer Borax 100-500 part nano phellodendron bark 50-400 part
Nanometer coptis 100-500 part nanometer Radix Scutellariae 50-400 part nanometer Radix Sophorae Tonkinensis 50-500 part
Nanometer Rhizoma Belamcandae 100-600 part nanometer Bulbus Fritillariae Thunbergii 100-500 part nano natural indigo 30-300 part
Nanometer Borneolum Syntheticum 1-10 part nano rhubarb 10-100 part nanometer Fructus Momordicae 50-500 part
Nanometer Radix Glycyrrhizae 10-50 part nanometer Mentholum 1-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Guilin water melon preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer watermelon crystal 100-300 part nanometer Borax 200-400 part nano phellodendron bark 100-300 part
Nanometer coptis 150-400 part nanometer Radix Scutellariae 100-300 part nanometer Radix Sophorae Tonkinensis 100-400 part
Nanometer Rhizoma Belamcandae 200-500 part nanometer Bulbus Fritillariae Thunbergii 200-400 part nano natural indigo 50-200 part
Nanometer Borneolum Syntheticum 3-8 part nano rhubarb 20-50 part nanometer Fructus Momordicae 100-300 part
Nanometer Radix Glycyrrhizae 20-40 part nanometer Mentholum 3-8 part
3, nano Guilin water melon preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 300 parts of nano phellodendron barks of 150 parts of nanometer Boraxs of nanometer watermelon crystal
150 parts of 200 parts of nanometer Radix Sophorae Tonkinensiss of 250 parts of nanometer Radix Scutellariaes of nanometer coptis
100 parts of 250 parts of nano natural indigos of 300 parts of nanometer Bulbus Fritillariae Thunbergiis of nanometer Rhizoma Belamcandae
150 parts of 30 portions of nanometer Fructus Momordicaes of 5 parts of nano rhubarbs of nanometer Borneolum Syntheticum
5 parts of 30 parts of nanometer Mentholums of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Guilin water melon preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Guilin water melon preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 01100167 CN1362115A (en) | 2001-01-04 | 2001-01-04 | Nano Guilin water melon medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100167 CN1362115A (en) | 2001-01-04 | 2001-01-04 | Nano Guilin water melon medicine and its preparation |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396488B (en) * | 2008-10-29 | 2011-06-01 | 宗希阳 | Medicine for treating chronic faucitis |
| CN101278892B (en) * | 2008-05-16 | 2011-12-21 | 广州市薏莉雅生物技术开发有限公司 | Functional cosmetics additive agent and method of producing the same |
| CN104922531A (en) * | 2015-01-25 | 2015-09-23 | 王栋 | Medicament for treating infantile thrush |
| CN105920473A (en) * | 2016-07-12 | 2016-09-07 | 杨高林 | Method for preparing traditional Chinese medicine for treating lung-kidney yin deficiency type chronic pharyngitis and composition thereof |
| CN105943839A (en) * | 2016-07-12 | 2016-09-21 | 杨高林 | Preparation method for traditional Chinese medicinal composition for treating liver depression and phlegm heat type chronic pharyngitis and composition |
| CN105998979A (en) * | 2016-07-12 | 2016-10-12 | 杨高林 | Traditional Chinese medicine composition for treating lung-and-kidney-yin-deficiency-type chronic pharyngitis and method |
| CN106039075A (en) * | 2016-07-12 | 2016-10-26 | 杨高林 | Traditional Chinese medicine composition and method for treating lung and stomach heat accumulated type chronic pharyngitis |
| CN106038955A (en) * | 2016-07-12 | 2016-10-26 | 杨高林 | Preparing method of traditional Chinese medicine treating lung and stomach accumulated heat type chronic pharyngitis and composition of traditional Chinese medicine |
| CN106109895A (en) * | 2016-07-12 | 2016-11-16 | 杨高林 | A kind of Chinese medicine composition treating phlegm stagnation fire type chronic pharyngitis and method |
| CN110907574A (en) * | 2019-11-06 | 2020-03-24 | 桂林三金药业股份有限公司 | Quality control method, quality control spectrogram and construction method of traditional Chinese medicine composition |
-
2001
- 2001-01-04 CN CN 01100167 patent/CN1362115A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278892B (en) * | 2008-05-16 | 2011-12-21 | 广州市薏莉雅生物技术开发有限公司 | Functional cosmetics additive agent and method of producing the same |
| CN101396488B (en) * | 2008-10-29 | 2011-06-01 | 宗希阳 | Medicine for treating chronic faucitis |
| CN104922531A (en) * | 2015-01-25 | 2015-09-23 | 王栋 | Medicament for treating infantile thrush |
| CN105920473A (en) * | 2016-07-12 | 2016-09-07 | 杨高林 | Method for preparing traditional Chinese medicine for treating lung-kidney yin deficiency type chronic pharyngitis and composition thereof |
| CN105943839A (en) * | 2016-07-12 | 2016-09-21 | 杨高林 | Preparation method for traditional Chinese medicinal composition for treating liver depression and phlegm heat type chronic pharyngitis and composition |
| CN105998979A (en) * | 2016-07-12 | 2016-10-12 | 杨高林 | Traditional Chinese medicine composition for treating lung-and-kidney-yin-deficiency-type chronic pharyngitis and method |
| CN106039075A (en) * | 2016-07-12 | 2016-10-26 | 杨高林 | Traditional Chinese medicine composition and method for treating lung and stomach heat accumulated type chronic pharyngitis |
| CN106038955A (en) * | 2016-07-12 | 2016-10-26 | 杨高林 | Preparing method of traditional Chinese medicine treating lung and stomach accumulated heat type chronic pharyngitis and composition of traditional Chinese medicine |
| CN106109895A (en) * | 2016-07-12 | 2016-11-16 | 杨高林 | A kind of Chinese medicine composition treating phlegm stagnation fire type chronic pharyngitis and method |
| CN110907574A (en) * | 2019-11-06 | 2020-03-24 | 桂林三金药业股份有限公司 | Quality control method, quality control spectrogram and construction method of traditional Chinese medicine composition |
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