CN1365781A - Nano medicine 'Ruyi Jinhuang' and its preparing process - Google Patents
Nano medicine 'Ruyi Jinhuang' and its preparing process Download PDFInfo
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- CN1365781A CN1365781A CN 01100882 CN01100882A CN1365781A CN 1365781 A CN1365781 A CN 1365781A CN 01100882 CN01100882 CN 01100882 CN 01100882 A CN01100882 A CN 01100882A CN 1365781 A CN1365781 A CN 1365781A
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Abstract
A nanometre medicine "Ruyijinhuang" is prepared from the nanometre powders of 10 Chinese medicinal materials including turmeric, rhubarb, atractylodes rhizome, phellodendron bark, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Ruyi Jinhuang ' of a kind of heat-clearing and toxic substances removing, dissipating blood stasis knot, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
Ruyi jinhuang powder, ruyi jinhuang san is a kind of classical Chinese patent medicine, mainly contains effects such as antibacterial, antiinflammatory, antiulcer, detoxifcation analgesia, is used for diseases such as erysipelas, body surface sore, abscess, acute mastitis, skin infection and innominate toxic swelling.But traditional ruyi jinhuang powder, ruyi jinhuang san absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Ruyi Jinhuang ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Ruyi Jinhuang '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Curcumae Longae 100-250 nano rhubarb 100-250 part nano phellodendron bark 100-250 part
Nanometer Rhizoma Atractylodis 40-90 part nanometer Cortex Magnoliae Officinalis 40-90 part nanometer Pericarpium Citri Reticulatae 40-95 part
Nanometer Radix Glycyrrhizae 40-90 part nanometer Arisaema Cum Bile 40-90 part nano angelica root 100-250 part
Nanometer Radix Trichosanthis 200-500 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Curcumae Longae 120-200 nano rhubarb 120-200 part nano phellodendron bark 120-200 part
Nanometer Rhizoma Atractylodis 50-80 part nanometer Cortex Magnoliae Officinalis 50-80 part nanometer Pericarpium Citri Reticulatae 50-80 part
Nanometer Radix Glycyrrhizae 50-80 part nanometer Arisaema Cum Bile 50-80 part nano angelica root 120-200 part
Nanometer Radix Trichosanthis 250-400 part
The optimum weight proportioning of medicine of the present invention is:
160 parts of 160 parts of nano phellodendron barks of 160 parts of nano rhubarbs of nanometer Rhizoma Curcumae Longae
64 parts of 64 parts of nanometer Pericarpium Citri Reticulataes of 64 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Atractylodis
160 parts of 64 parts of nano angelica roots of 64 parts of nanometer Arisaema Cum Bile of nanometer Radix Glycyrrhizae
320 parts of nanometer Radix Trichosanthis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Ruyi Jinhuang ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Ruyi Jinhuang ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common ruyi jinhuang powder, ruyi jinhuang san preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Ruyi Jinhuang ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as erysipelas, furuncle, single skin ulcer viral keratitis, cellulitis, mastalgia, lymphadenitis, parotitis, pyogenic paronychia, paronychia, nodular vasculitis, duodenal ulcer, hemorrhoid, and clinical efficacy significantly is better than traditional ruyi jinhuang powder, ruyi jinhuang san.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
160 parts of 160 parts of nano phellodendron barks of 160 parts of nano rhubarbs of nanometer Rhizoma Curcumae Longae
64 parts of 64 parts of nanometer Pericarpium Citri Reticulataes of 64 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Atractylodis
160 parts of 64 parts of nano angelica roots of 64 parts of nanometer Arisaema Cum Bile of nanometer Radix Glycyrrhizae
320 parts of nanometer Radix Trichosanthis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
160 parts of 160 parts of nano phellodendron barks of 160 parts of nano rhubarbs of nanometer Rhizoma Curcumae Longae
64 parts of 64 parts of nanometer Pericarpium Citri Reticulataes of 64 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Atractylodis
160 parts of 64 parts of nano angelica roots of 64 parts of nanometer Arisaema Cum Bile of nanometer Radix Glycyrrhizae
320 parts of nanometer Radix Trichosanthis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making comply with one's wishes golden yellow powder needle injection, every injection content of nanometer is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
160 parts of 160 parts of nano phellodendron barks of 160 parts of nano rhubarbs of nanometer Rhizoma Curcumae Longae
64 parts of 64 parts of nanometer Pericarpium Citri Reticulataes of 64 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Atractylodis
160 parts of 64 parts of nano angelica roots of 64 parts of nanometer Arisaema Cum Bile of nanometer Radix Glycyrrhizae
320 parts of nanometer Radix Trichosanthis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer golden yellow membrane as one wishes, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, chest or affected part.
Claims (6)
1, a kind of nano medicine ' Ruyi Jinhuang ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Curcumae Longae 100-250 nano rhubarb 100-250 part nano phellodendron bark 100-250 part
Nanometer Rhizoma Atractylodis 40-90 part nanometer Cortex Magnoliae Officinalis 40-90 part nanometer Pericarpium Citri Reticulatae 40-95 part
Nanometer Radix Glycyrrhizae 40-90 part nanometer Arisaema Cum Bile 40-90 part nano angelica root 100-250 part
Nanometer Radix Trichosanthis 200-500 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Ruyi Jinhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Curcumae Longae 120-200 nano rhubarb 120-200 part nano phellodendron bark 120-200 part
Nanometer Rhizoma Atractylodis 50-80 part nanometer Cortex Magnoliae Officinalis 50-80 part nanometer Pericarpium Citri Reticulatae 50-80 part
Nanometer Radix Glycyrrhizae 50-80 part nanometer Arisaema Cum Bile 50-80 part nano angelica root 120-200 part
Nanometer Radix Trichosanthis 250-400 part
3, nano medicine ' Ruyi Jinhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
160 parts of 160 parts of nano phellodendron barks of 160 parts of nano rhubarbs of nanometer Rhizoma Curcumae Longae
64 parts of 64 parts of nanometer Pericarpium Citri Reticulataes of 64 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Atractylodis
160 parts of 64 parts of nano angelica roots of 64 parts of nanometer Arisaema Cum Bile of nanometer Radix Glycyrrhizae
320 parts of nanometer Radix Trichosanthis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Ruyi Jinhuang 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Ruyi Jinhuang 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100882 CN1365781A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Ruyi Jinhuang' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100882 CN1365781A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Ruyi Jinhuang' and its preparing process |
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| Publication Number | Publication Date |
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| CN1365781A true CN1365781A (en) | 2002-08-28 |
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| CN 01100882 Pending CN1365781A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Ruyi Jinhuang' and its preparing process |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308030C (en) * | 2003-04-25 | 2007-04-04 | 安徽天洋药业有限公司 | Medicine combination containing valid part of Ruyi Jinhuangsan and its preparing method |
| CN100448436C (en) * | 2002-12-31 | 2009-01-07 | 奥苏尔公司 | Wound dressing |
| CN103599491A (en) * | 2013-11-29 | 2014-02-26 | 苏国仁 | Medicine for treating ulcer and sore yang pattern and preparation method thereof |
| CN103610815A (en) * | 2013-12-16 | 2014-03-05 | 粘芙蓉 | Traditional Chinese medicine for treating phlegmon |
| CN103656416A (en) * | 2013-12-22 | 2014-03-26 | 王雪雁 | Traditional Chinese medicinal composition for treating parotiditis and preparation method thereof |
| CN105287945A (en) * | 2015-12-03 | 2016-02-03 | 林强 | Traditional Chinese medicine for treatment of damp-heat downwards-flowing nodular vasculitis and preparation method thereof |
| CN105816810A (en) * | 2016-04-29 | 2016-08-03 | 王金生 | Hemorrhoids cream for acupoints |
| CN109324138A (en) * | 2018-12-14 | 2019-02-12 | 江苏七0七天然制药有限公司 | A kind of ruyi jinhuang powder, ruyi jinhuang san fingerprint |
-
2001
- 2001-01-19 CN CN 01100882 patent/CN1365781A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100448436C (en) * | 2002-12-31 | 2009-01-07 | 奥苏尔公司 | Wound dressing |
| CN1308030C (en) * | 2003-04-25 | 2007-04-04 | 安徽天洋药业有限公司 | Medicine combination containing valid part of Ruyi Jinhuangsan and its preparing method |
| CN103599491A (en) * | 2013-11-29 | 2014-02-26 | 苏国仁 | Medicine for treating ulcer and sore yang pattern and preparation method thereof |
| CN103610815A (en) * | 2013-12-16 | 2014-03-05 | 粘芙蓉 | Traditional Chinese medicine for treating phlegmon |
| CN103610815B (en) * | 2013-12-16 | 2015-07-29 | 吕豪 | A kind of Chinese medicine for the treatment of cellulitis |
| CN103656416A (en) * | 2013-12-22 | 2014-03-26 | 王雪雁 | Traditional Chinese medicinal composition for treating parotiditis and preparation method thereof |
| CN103656416B (en) * | 2013-12-22 | 2015-08-26 | 王雪雁 | One treats parotitic Chinese medicine composition and preparation method thereof |
| CN105287945A (en) * | 2015-12-03 | 2016-02-03 | 林强 | Traditional Chinese medicine for treatment of damp-heat downwards-flowing nodular vasculitis and preparation method thereof |
| CN105816810A (en) * | 2016-04-29 | 2016-08-03 | 王金生 | Hemorrhoids cream for acupoints |
| CN109324138A (en) * | 2018-12-14 | 2019-02-12 | 江苏七0七天然制药有限公司 | A kind of ruyi jinhuang powder, ruyi jinhuang san fingerprint |
| CN109324138B (en) * | 2018-12-14 | 2021-07-13 | 江苏七0七天然制药有限公司 | Ruyi golden yellow powder fingerprint spectrum establishment method |
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