CN1368200A - Nano medicine 'Emuqingfei' and its preparing process - Google Patents
Nano medicine 'Emuqingfei' and its preparing process Download PDFInfo
- Publication number
- CN1368200A CN1368200A CN 01102533 CN01102533A CN1368200A CN 1368200 A CN1368200 A CN 1368200A CN 01102533 CN01102533 CN 01102533 CN 01102533 A CN01102533 A CN 01102533A CN 1368200 A CN1368200 A CN 1368200A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- medicine
- nanometer radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Ermu Qingfei" for dispelling pathogenic heat of lung is prepared from the nanometre powders of 9 Chinese medicinal materials including tendrilled fritillary bulb, anemarrhena rhizome, rhubarb, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Emuqingfei ' of a kind of removing heat-phlegm, nourishing the lung to arrest cough, the invention still further relates to the method for this medication preparation.
Two female lung heat clearing balls are a kind of classical Chinese patent medicines, mainly contain effects such as removing heat-phlegm, nourishing the lung to arrest cough, are used for cough due to lung-heat, accumulation and obstruction of sputum, the living skin ulcer of mouth and nose, laryngopharynx swelling and pain, constipation, yellowish or reddish urine.But two traditional female lung heat clearing ball disintegrates are slower, absorb not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Emuqingfei ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Emuqingfei '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 100-250 part of nano Sichuan fritillary bulb nanometer Rhizoma Anemarrhenae 30-60 part nano rhubarb 100-250 part
Nanometer Radix Scutellariae 50-150 part nanometer Radix Peucedani 30-65 part nanometer Radix Trichosanthis 50-120 part
Nanometer Radix Platycodonis 50-120 part nanometer Semen Armeniacae Amarum 30-65 part nanometer Cortex Mori 30-65 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 120-200 part of nano Sichuan fritillary bulb nanometer Rhizoma Anemarrhenae 35-55 part nano rhubarb 120-200 part
Nanometer Radix Scutellariae 60-120 part nanometer Radix Peucedani 35-55 part nanometer Radix Trichosanthis 60-100 part
Nanometer Radix Platycodonis 60-100 part nanometer Semen Armeniacae Amarum 35-55 part nanometer Cortex Mori 35-55 part
The optimum weight proportioning of medicine of the present invention is:
160 parts of 40 parts of nano rhubarbs of the female 160 parts of nanometer Rhizoma Anemarrhenaes of nano Sichuan fritillary bulb
80 parts of 40 parts of nanometer Radix Trichosanthis of 80 parts of nanometer Radix Peucedanis of nanometer Radix Scutellariae
40 parts of 40 parts of nanometer Cortex Mori of 80 parts of nanometer Semen Armeniacae Amarums of nanometer Radix Platycodonis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Emuqingfei ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Emuqingfei ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common two female lung heat clearing pill materials are micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Emuqingfei ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough due to lung-heat, accumulation and obstruction of sputum, the living skin ulcer of mouth and nose, laryngopharynx swelling and pain, constipation, yellowish or reddish urine, and clinical efficacy significantly is better than two traditional female lung heat clearing balls.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
160 parts of 40 parts of nano rhubarbs of the female 160 parts of nanometer Rhizoma Anemarrhenaes of nano Sichuan fritillary bulb
80 parts of 40 parts of nanometer Radix Trichosanthis of 80 parts of nanometer Radix Peucedanis of nanometer Radix Scutellariae
40 parts of 40 parts of nanometer Cortex Mori of 80 parts of nanometer Semen Armeniacae Amarums of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
160 parts of 40 parts of nano rhubarbs of the female 160 parts of nanometer Rhizoma Anemarrhenaes of nano Sichuan fritillary bulb
80 parts of 40 parts of nanometer Radix Trichosanthis of 80 parts of nanometer Radix Peucedanis of nanometer Radix Scutellariae
40 parts of 40 parts of nanometer Cortex Mori of 80 parts of nanometer Semen Armeniacae Amarums of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer two female lung heat clearing powder needle injections, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
160 parts of 40 parts of nano rhubarbs of the female 160 parts of nanometer Rhizoma Anemarrhenaes of nano Sichuan fritillary bulb
80 parts of 40 parts of nanometer Radix Trichosanthis of 80 parts of nanometer Radix Peucedanis of nanometer Radix Scutellariae
40 parts of 40 parts of nanometer Cortex Mori of 80 parts of nanometer Semen Armeniacae Amarums of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer two female lung heat clearing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Emuqingfei ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 100-250 part of nano Sichuan fritillary bulb nanometer Rhizoma Anemarrhenae 30-60 part nano rhubarb 100-250 part
Nanometer Radix Scutellariae 50-150 part nanometer Radix Peucedani 30-65 part nanometer Radix Trichosanthis 50-120 part
Nanometer Radix Platycodonis 50-120 part nanometer Semen Armeniacae Amarum 30-65 part nanometer Cortex Mori 30-65 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Emuqingfei ' according to claim 1, wherein the weight proportion of each nano raw material is:
The female 120-200 part of nano Sichuan fritillary bulb nanometer Rhizoma Anemarrhenae 35-55 part nano rhubarb 120-200 part
Nanometer Radix Scutellariae 60-120 part nanometer Radix Peucedani 35-55 part nanometer Radix Trichosanthis 60-100 part
Nanometer Radix Platycodonis 60-100 part nanometer Semen Armeniacae Amarum 35-55 part nanometer Cortex Mori 35-55 part
3, nano medicine ' Emuqingfei ' according to claim 1, wherein the weight proportion of each nano raw material is:
160 parts of 40 parts of nano rhubarbs of the female 160 parts of nanometer Rhizoma Anemarrhenaes of nano Sichuan fritillary bulb
80 parts of 40 parts of nanometer Radix Trichosanthis of 80 parts of nanometer Radix Peucedanis of nanometer Radix Scutellariae
40 parts of 40 parts of nanometer Cortex Mori of 80 parts of nanometer Semen Armeniacae Amarums of nanometer Radix Platycodonis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Emuqingfei 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Emuqingfei 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102533 CN1368200A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Emuqingfei' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102533 CN1368200A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Emuqingfei' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368200A true CN1368200A (en) | 2002-09-11 |
Family
ID=4652794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102533 Pending CN1368200A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Emuqingfei' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368200A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103416550A (en) * | 2013-07-12 | 2013-12-04 | 苏州市天灵中药饮片有限公司 | Health-care tea for clearing heat from throats |
-
2001
- 2001-02-01 CN CN 01102533 patent/CN1368200A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103416550A (en) * | 2013-07-12 | 2013-12-04 | 苏州市天灵中药饮片有限公司 | Health-care tea for clearing heat from throats |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368092A (en) | Nano medicine 'Mahuangzhike' and its preparing process | |
| CN1368200A (en) | Nano medicine 'Emuqingfei' and its preparing process | |
| CN1368206A (en) | Nano medicine 'Zhizi Jinhua' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1365757A (en) | Nano antitussive asthma-relieving medicine and its preparing process | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1366925A (en) | Nano stomach-clearing coptis preparation medicine and preparation method | |
| CN1366893A (en) | Nano qingfei yihuo preparation medicine and preparation method thereof | |
| CN1366894A (en) | Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof | |
| CN1365724A (en) | Nano compound antitussive platycodon root medicine and its preparing process | |
| CN1368265A (en) | Nano medicine 'Xingsu' and its preparing process | |
| CN1364580A (en) | Nano children cough arresting medicine and its preparing method | |
| CN1365766A (en) | Nano medicine 'Wuji' and its preparing process | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1365710A (en) | Nano inflammation-relieving and antitussive medicine and its preparing process | |
| CN1365713A (en) | Nano medicine for treating ulcer and its preparing process | |
| CN1366963A (en) | Nano Ermuansou preparation medicine and preparation method | |
| CN1365705A (en) | Nano medicine 'Xiaoer Huadu' and its preparing process | |
| CN1368276A (en) | Nano medicine 'Zhike Pipa' and its preparing process | |
| CN1364606A (en) | Nano compound loquat leaf medicine and its preparing method | |
| CN1365802A (en) | Nano antitussive loquat medicine and its preparing process | |
| CN1365743A (en) | Nano medicine 'Keyin' and its preparing process | |
| CN1365756A (en) | Nano antitussive medicine 'Juhong' and its preparing process | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1364582A (en) | Nano children heat clearing away and cough arresting medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |