CN1365757A - Nano antitussive asthma-relieving medicine and its preparing process - Google Patents
Nano antitussive asthma-relieving medicine and its preparing process Download PDFInfo
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- CN1365757A CN1365757A CN 01100858 CN01100858A CN1365757A CN 1365757 A CN1365757 A CN 1365757A CN 01100858 CN01100858 CN 01100858 CN 01100858 A CN01100858 A CN 01100858A CN 1365757 A CN1365757 A CN 1365757A
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Abstract
A nanometre medicine "Zhishou Dingchuan" is prepared from the nanometre powders of 4 Chinese medicinal materials including ephedra, bitter apricot kernel, liquorice root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to that a kind of hot cold is led off, the nano antitussive asthma-relieving medicine of clearing lung, relieving asthma, the invention still further relates to the method for this medication preparation.
The relieving cough, relieving asthma oral liquid is a kind of classical Chinese patent medicine, mainly contains effects such as Xin Liang leads off, clearing lung, relieving asthma, is used for that exterior cold and interior heat, fever of the body are thirsty, cough with profuse sputum, dyspnea with rapid and short breath QI rising in reverse order, full vexed, the acute bronchitis of chest and diaphragm.But traditional relieving cough, relieving asthma oral liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antitussive asthma-relieving medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antitussive asthma-relieving medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 600-1500 part nanometer Semen Armeniacae Amarum 600-1500 part
Nanometer Radix Glycyrrhizae 600-1500 part nanometer Gypsum Fibrosum 600-1500 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 800-1200 part nanometer Semen Armeniacae Amarum 800-1200 part
Nanometer Radix Glycyrrhizae 800-1200 part nanometer Gypsum Fibrosum 800-1200 part
The optimum weight proportioning of medicine of the present invention is:
1000 parts of 1000 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae
1000 parts in 1000 parts of nanometer Gypsum Fibrosum of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the antitussive asthma-relieving nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano antitussive asthma-relieving medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common relieving cough, relieving asthma oral liquid formulations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano antitussive asthma-relieving medicine etc. had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for that exterior cold and interior heat, fever of the body are thirsty, full vexed, the acute bronchitis of cough with profuse sputum, dyspnea with rapid and short breath QI rising in reverse order, chest and diaphragm, clinical efficacy significantly is better than traditional relieving cough, relieving asthma oral liquid.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
1000 parts of 1000 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae
1000 parts in 1000 parts of nanometer Gypsum Fibrosum of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
1000 parts of 1000 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae
1000 parts in 1000 parts of nanometer Gypsum Fibrosum of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer relieving cough, relieving asthma powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
1000 parts of 1000 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae
1000 parts in 1000 parts of nanometer Gypsum Fibrosum of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer relieving cough, relieving asthma membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano antitussive asthma-relieving medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Ephedrae 600-1500 part nanometer Semen Armeniacae Amarum 600-1500 part
Nanometer Radix Glycyrrhizae 600-1500 part nanometer Gypsum Fibrosum 600-1500 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antitussive asthma-relieving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 800-1200 part nanometer Semen Armeniacae Amarum 800-1200 part
Nanometer Radix Glycyrrhizae 800-1200 part nanometer Gypsum Fibrosum 800-1200 part
3, nano antitussive asthma-relieving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
1000 parts of 1000 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae
1000 parts in 1000 parts of nanometer Gypsum Fibrosum of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antitussive asthma-relieving medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antitussive asthma-relieving medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100858 CN1365757A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive asthma-relieving medicine and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100858 CN1365757A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive asthma-relieving medicine and its preparing process |
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| CN1365757A true CN1365757A (en) | 2002-08-28 |
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| CN 01100858 Pending CN1365757A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive asthma-relieving medicine and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843682A (en) * | 2010-06-08 | 2010-09-29 | 江西中成药业集团有限公司 | Maxingshigan injecta and preparation method thereof |
| CN103405541A (en) * | 2013-09-02 | 2013-11-27 | 郑州福源动物药业有限公司 | Veterinary ephedra, almond, gypsum and liquoric root granules and preparation method thereof |
| CN105748642A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
-
2001
- 2001-01-19 CN CN 01100858 patent/CN1365757A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843682A (en) * | 2010-06-08 | 2010-09-29 | 江西中成药业集团有限公司 | Maxingshigan injecta and preparation method thereof |
| CN103405541A (en) * | 2013-09-02 | 2013-11-27 | 郑州福源动物药业有限公司 | Veterinary ephedra, almond, gypsum and liquoric root granules and preparation method thereof |
| CN105748642A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
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