CN1366899A - Nano dizziness-clearing preparation medicine and preparation method thereof - Google Patents
Nano dizziness-clearing preparation medicine and preparation method thereof Download PDFInfo
- Publication number
- CN1366899A CN1366899A CN 01102038 CN01102038A CN1366899A CN 1366899 A CN1366899 A CN 1366899A CN 01102038 CN01102038 CN 01102038 CN 01102038 A CN01102038 A CN 01102038A CN 1366899 A CN1366899 A CN 1366899A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- dizziness
- chinese
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano dizziness-clearing preparation medicine. It is made up by using the Chinese medicinal materials of nano ligusticum, nano angelica, nano mint, nano schizonepeta spike and nano gypsum as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of diffusing wind heat clearing away, cure mainly the nano dizziness-clearing preparation medicine of wind heat dizziness, dizzy, migraine and general headache, nasal obstruction toothache, the invention still further relates to the method for this medication preparation.
Pill of quenching dizziness is a kind of classical Chinese patent medicine, mainly contain analgesic, analgesia, antiinflammatory, antibiotic, improve effects such as brain microcirculation, cerebral blood flow increasing amount, be used for wind heat dizziness, dizzy, migraine and general headache, nasal obstruction toothache.But traditional pill of quenching dizziness disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano dizziness-clearing preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano dizziness-clearing preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Chuanxiong 120-300 part nano angelica root 120-300 part nanometer Herba Menthae 60-150 part
Nanometer Herba Schizonepetae 60-150 part nanometer Gypsum Fibrosum 60-150 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Chuanxiong 150-250 part nano angelica root 150-250 part nanometer Herba Menthae 80-120 part
Nanometer Herba Schizonepetae 80-120 part nanometer Gypsum Fibrosum 80-120 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 200 parts of nanometer Herba Menthaes of 200 parts of nano angelica roots of nanometer Rhizoma Chuanxiong
100 parts in 100 parts of nanometer Gypsum Fibrosum of nanometer Herba Schizonepetae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the dizziness-clearing preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano dizziness-clearing preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common pill of quenching dizziness preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano dizziness-clearing preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as headache, dizzy, nasal sinusitis, toothache, and clinical efficacy significantly is better than traditional pill of quenching dizziness.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 200 parts of nanometer Herba Menthaes of 200 parts of nano angelica roots of nanometer Rhizoma Chuanxiong
100 parts in 100 parts of nanometer Gypsum Fibrosum of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 200 parts of nanometer Herba Menthaes of 200 parts of nano angelica roots of nanometer Rhizoma Chuanxiong
100 parts in 100 parts of nanometer Gypsum Fibrosum of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano dizziness-clearing powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 200 parts of nanometer Herba Menthaes of 200 parts of nano angelica roots of nanometer Rhizoma Chuanxiong
100 parts in 100 parts of nanometer Gypsum Fibrosum of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder skill good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano dizziness-clearing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano dizziness-clearing preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Chuanxiong 120-300 part nano angelica root 120-300 part nanometer Herba Menthae 60-150 part
Nanometer Herba Schizonepetae 60-150 part nanometer Gypsum Fibrosum 60-150 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano dizziness-clearing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Chuanxiong 150-250 part nano angelica root 150-250 part nanometer Herba Menthae 80-120 part
Nanometer Herba Schizonepetae 80-120 part nanometer Gypsum Fibrosum 80-120 part
3, nano dizziness-clearing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 200 parts of nanometer Herba Menthaes of 200 parts of nano angelica roots of nanometer Rhizoma Chuanxiong
100 parts in 100 parts of nanometer Gypsum Fibrosum of nanometer Herba Schizonepetae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano dizziness-clearing preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano dizziness-clearing preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102038 CN1366899A (en) | 2001-01-22 | 2001-01-22 | Nano dizziness-clearing preparation medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102038 CN1366899A (en) | 2001-01-22 | 2001-01-22 | Nano dizziness-clearing preparation medicine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1366899A true CN1366899A (en) | 2002-09-04 |
Family
ID=4652409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102038 Pending CN1366899A (en) | 2001-01-22 | 2001-01-22 | Nano dizziness-clearing preparation medicine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1366899A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143928A (en) * | 2017-12-29 | 2018-06-12 | 刘建民 | A kind of Chinese medicine for treating migraine |
-
2001
- 2001-01-22 CN CN 01102038 patent/CN1366899A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143928A (en) * | 2017-12-29 | 2018-06-12 | 刘建民 | A kind of Chinese medicine for treating migraine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1364538A (en) | Nano bronchitis treating medicine and its preparing method | |
| CN1368208A (en) | Nano medicine 'Ganfu' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1366899A (en) | Nano dizziness-clearing preparation medicine and preparation method thereof | |
| CN1365757A (en) | Nano antitussive asthma-relieving medicine and its preparing process | |
| CN1366966A (en) | Nano pinellia preparation medicine and preparation method | |
| CN1366978A (en) | Nane common cold-fever-abating preparation medicine and preparation method | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1368217A (en) | Nano medicine 'Cangyi nose drops' and its preparing process | |
| CN1368065A (en) | Nano medicine 'Saixianning' and its preparing process | |
| CN1366965A (en) | Nano wind-cold Ganmaoning preparation medicine and preparation method | |
| CN1365714A (en) | Nano medicine 'Jiufen' and its preparing process | |
| CN1365727A (en) | Nano cinammon twigs medicine and its preparing process | |
| CN1368276A (en) | Nano medicine 'Zhike Pipa' and its preparing process | |
| CN1368218A (en) | Nano compound medicine for treating hepatitides and its preparing process | |
| CN1368304A (en) | Nano medicine 'Yinchai' and its preparing process | |
| CN1362108A (en) | Nano rhinitis-treating drop medicine and its preparation | |
| CN1365768A (en) | Nano 6-component Anxiao medicine and its preparing process | |
| CN1364528A (en) | Nano nephritis treating medicine and its preparing method | |
| CN1362219A (en) | Nano Zhichuanling medicine for treating asthma and its preparation | |
| CN1368147A (en) | Nano medicine 'Jianyang' and its preparing process | |
| CN1368207A (en) | Nano medicine 'Ganshule' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |