CN1365727A - Nano cinammon twigs medicine and its preparing process - Google Patents
Nano cinammon twigs medicine and its preparing process Download PDFInfo
- Publication number
- CN1365727A CN1365727A CN 01100670 CN01100670A CN1365727A CN 1365727 A CN1365727 A CN 1365727A CN 01100670 CN01100670 CN 01100670 CN 01100670 A CN01100670 A CN 01100670A CN 1365727 A CN1365727 A CN 1365727A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- medicine
- chinese
- chinese crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre cinammon twig medicine is prepared from the nanometer powders of 5 Chinese medicinal materials including cinammon twig, white peony root, ginger, liquorice root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to that a kind of section flesh is delivered, the nano cinammon twigs medicine of harmonizing yingfen and weifen, the invention still further relates to the method for this medication preparation.
The Ramulus Cinnamomi mixture is a kind of classical Chinese patent medicine, mainly contains effects such as cutting flesh is delivered, harmonizing yingfen and weifen, is used for the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, the diseases such as retch, perspiration and aversion to wind of having a headache and fever, have a stuffy nose.But traditional Ramulus Cinnamomi mixture absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano cinammon twigs medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano cinammon twigs medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Ramulus Cinnamomi 160-280 part nanometer Radix Paeoniae Alba 160-280 part nanometer Rhizoma Zingiberis Recens 160-280 part
Nanometer Radix Glycyrrhizae 100-180 part nanometer Fructus Jujubae 160-280 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Ramulus Cinnamomi 180-250 part nanometer Radix Paeoniae Alba 180-250 part nanometer Rhizoma Zingiberis Recens 180-250 part
Nanometer Radix Glycyrrhizae 120-160 part nanometer Fructus Jujubae 180-250 part
The optimum weight proportioning of medicine of the present invention is:
215 parts in 215 portions of nanometer Rhizoma Zingiberis Recenss of 215 parts of nanometer Radix Paeoniae Albas of nanometer Ramulus Cinnamomi
215 parts in 143 portions of nanometer Fructus Jujubaes of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Ramulus Cinnamomi mistura preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano cinammon twigs medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Ramulus Cinnamomi mistura preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of nano cinammon twigs medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, the treatment of conditions such as retch, perspiration and aversion to wind of having a headache and fever, have a stuffy nose, and clinical efficacy significantly is better than traditional Ramulus Cinnamomi mixture.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
215 parts in 215 portions of nanometer Rhizoma Zingiberis Recenss of 215 parts of nanometer Radix Paeoniae Albas of nanometer Ramulus Cinnamomi
215 parts in 143 portions of nanometer Fructus Jujubaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
215 parts in 215 portions of nanometer Rhizoma Zingiberis Recenss of 215 parts of nanometer Radix Paeoniae Albas of nanometer Ramulus Cinnamomi
215 parts in 143 portions of nanometer Fructus Jujubaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Ramulus Cinnamomi powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
215 parts in 215 portions of nanometer Rhizoma Zingiberis Recenss of 215 parts of nanometer Radix Paeoniae Albas of nanometer Ramulus Cinnamomi
215 parts in 143 portions of nanometer Fructus Jujubaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Ramulus Cinnamomi membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano cinammon twigs medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Ramulus Cinnamomi 160-280 part nanometer Radix Paeoniae Alba 160-280 part nanometer Rhizoma Zingiberis Recens 160-280 part
Nanometer Radix Glycyrrhizae 100-180 part nanometer Fructus Jujubae 160-280 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano cinammon twigs medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Ramulus Cinnamomi 180-250 part nanometer Radix Paeoniae Alba 180-250 part nanometer Rhizoma Zingiberis Recens 180-250 part
Nanometer Radix Glycyrrhizae 120-160 part nanometer Fructus Jujubae 180-250 part
3, nano cinammon twigs medicine according to claim 1, wherein the weight proportion of each nano raw material is:
215 parts in 215 portions of nanometer Rhizoma Zingiberis Recenss of 215 parts of nanometer Radix Paeoniae Albas of nanometer Ramulus Cinnamomi
215 parts in 143 portions of nanometer Fructus Jujubaes of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano cinammon twigs medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano cinammon twigs medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100670 CN1365727A (en) | 2001-01-15 | 2001-01-15 | Nano cinammon twigs medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100670 CN1365727A (en) | 2001-01-15 | 2001-01-15 | Nano cinammon twigs medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365727A true CN1365727A (en) | 2002-08-28 |
Family
ID=4651779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100670 Pending CN1365727A (en) | 2001-01-15 | 2001-01-15 | Nano cinammon twigs medicine and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365727A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110935000A (en) * | 2019-12-26 | 2020-03-31 | 九江学院 | Application of cassia twig and magnolia apricot decoction in preparation of medicine for treating infantile indigestion with food retention and fever |
-
2001
- 2001-01-15 CN CN 01100670 patent/CN1365727A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110935000A (en) * | 2019-12-26 | 2020-03-31 | 九江学院 | Application of cassia twig and magnolia apricot decoction in preparation of medicine for treating infantile indigestion with food retention and fever |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1365686A (en) | Nano clove medicine and its preparing process | |
| CN1365727A (en) | Nano cinammon twigs medicine and its preparing process | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1365757A (en) | Nano antitussive asthma-relieving medicine and its preparing process | |
| CN1365778A (en) | Nano medicine 'Qinlian' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1364543A (en) | Nano apricot kernel and perilla antitussive medicine and its preparing method | |
| CN1365703A (en) | Nano medicine for child to induce diaphoresis and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1368341A (en) | Nano medicine 'Pitong' and its preparing process | |
| CN1368213A (en) | Nano medicine 'Desheng' and its preparing process | |
| CN1368117A (en) | Nano medicine for developing infantile intelligence and its preparing process | |
| CN1366978A (en) | Nane common cold-fever-abating preparation medicine and preparation method | |
| CN1366899A (en) | Nano dizziness-clearing preparation medicine and preparation method thereof | |
| CN1366965A (en) | Nano wind-cold Ganmaoning preparation medicine and preparation method | |
| CN1368147A (en) | Nano medicine 'Jianyang' and its preparing process | |
| CN1368276A (en) | Nano medicine 'Zhike Pipa' and its preparing process | |
| CN1368304A (en) | Nano medicine 'Yinchai' and its preparing process | |
| CN1365743A (en) | Nano medicine 'Keyin' and its preparing process | |
| CN1365769A (en) | Nano medicine 'Kanggan' and its preparing process | |
| CN1365745A (en) | Nano 4-component elecampane inula medicine and its preparing process | |
| CN1363306A (en) | Nano compound prunella spike medicine and its preparing process | |
| CN1365785A (en) | Nano medicine 'Anshen Buxin' and its preparing process | |
| CN1368259A (en) | Nano medicine 'Yangweining' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |