CN1365703A - Nano medicine for child to induce diaphoresis and its preparing process - Google Patents
Nano medicine for child to induce diaphoresis and its preparing process Download PDFInfo
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- CN1365703A CN1365703A CN 01100646 CN01100646A CN1365703A CN 1365703 A CN1365703 A CN 1365703A CN 01100646 CN01100646 CN 01100646 CN 01100646 A CN01100646 A CN 01100646A CN 1365703 A CN1365703 A CN 1365703A
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Abstract
A nanometre medicine "Xiaoer Jiebiao" is prepared from the nanometre powders of 10 Chinese medicinal materials including honeysuckle flower, forsythia fruit, arctium fruit, dandelion herb, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages and high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of diffusing lung, relieving exterior syndrome, heat-clearing and toxic substances removing, cure mainly the nano children's that the has some inkling of a cold preparation medicine that induces sweat, the invention still further relates to the method for this medication preparation.
Children's's granule that induces sweat is a kind of classical Chinese patent medicine, mainly contains antiviral, and is analgesic, antiinflammatory, effects such as analgesia, the fever with aversion to cold that is used to have some inkling of a cold, headache cough, nose cold current tears, throat sufferings.Granule absorbs not exclusively but traditional children's is induced sweat, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano children's of the increase evident in efficacy preparation medicine that induces sweat.
The preparation method that another object of the present invention provides this nano children's to induce sweat preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer gold Flos Lonicerae 220.-450 part nanometer Fructus Forsythiae 180-350 part nanometer Fructus Arctii (stir-fry) 150-400 part
Nanometer Herba Taraxaci 200-450 part nanometer Radix Scutellariae 200-450 part nanometer Radix Saposhnikoviae 100-250 part
Nanometer Folium Perillae 100-200 part nanometer Herba Schizonepetae 70-150 part nanometer Radix Puerariae 100-250 part
Nano bezoar 1-5 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer gold Flos Lonicerae 250-350 part nanometer Fructus Forsythiae 200-300 part nanometer Fructus Arctii (stir-fry) 200-300 part
Nanometer Herba Taraxaci 250-350 part nanometer Radix Scutellariae 250-350 part nanometer Radix Saposhnikoviae 120-180 part
Nanometer Folium Perillae 120-180 part nanometer Herba Schizonepetae 80-120 part nanometer Radix Puerariae 120-180 part
Nano bezoar 1-3 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of nanometer gold Flos Lonicerae 250 parts of nanometer Fructus Arctiis of 300 parts of nanometer Fructus Forsythiaes (stir-fry)
150 parts of 300 parts of nanometer Radix Saposhnikoviaes of 300 parts of nanometer Radix Scutellariaes of nanometer Herba Taraxaci
150 parts of 100 parts of nanometer Radix Puerariaes of 150 parts of nanometer Herba Schizonepetaes of nanometer Folium Perillae
1 part of nano bezoar
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, children's's preparation nano powder that induces sweat;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
It is identical that above-mentioned two kinds of methods are made the induce sweat pharmacological effect of preparation medicine of nano children's.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common children's induce sweat the granular preparation material be the micron or the millimeter above particle diameter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the nano children's new drug formulation that the pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution etc. of preparation medicine have no precedent in the past that induces sweat.
The fever with aversion to cold that pharmaceutical preparation of the present invention can be used for having some inkling of a cold, headache cough, the nasal obstruction watery nasal discharge, treatment of conditions such as throat sufferings, clinical efficacy significantly is better than traditional children's granule that induces sweat.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
250 parts of nanometer gold Flos Lonicerae 250 parts of nanometer Fructus Arctiis of 300 parts of nanometer Fructus Forsythiaes (stir-fry)
150 parts of 300 parts of nanometer Radix Saposhnikoviaes of 300 parts of nanometer Radix Scutellariaes of nanometer Herba Taraxaci
150 parts of 100 parts of nanometer Radix Puerariaes of 150 parts of nanometer Herba Schizonepetaes of nanometer Folium Perillae
1 part of nano bezoar
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
250 parts of nanometer gold Flos Lonicerae 250 parts of nanometer Fructus Arctiis of 300 parts of nanometer Fructus Forsythiaes (stir-fry)
150 parts of 300 parts of nanometer Radix Saposhnikoviaes of 300 parts of nanometer Radix Scutellariaes of nanometer Herba Taraxaci
150 parts of 100 parts of nanometer Radix Puerariaes of 150 parts of nanometer Herba Schizonepetaes of nanometer Folium Perillae
1 part of nano bezoar
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making induce sweat powder needle injection, every injection content of nano children's is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
250 parts of nanometer gold Flos Lonicerae 250 parts of nanometer Fructus Arctiis of 300 parts of nanometer Fructus Forsythiaes (stir-fry)
150 parts of 300 parts of nanometer Radix Saposhnikoviaes of 300 parts of nanometer Radix Scutellariaes of nanometer Herba Taraxaci
150 parts of 100 parts of nanometer Radix Puerariaes of 150 parts of nanometer Herba Schizonepetaes of nanometer Folium Perillae
1 part of nano bezoar
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano children's membrane that induces sweat, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano children's preparation medicine that induces sweat is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer gold Flos Lonicerae 220-450 part nanometer Fructus Forsythiae 180-350 part nanometer Fructus Arctii (stir-fry) 150-400 part
Nanometer Herba Taraxaci 200-450 part nanometer Radix Scutellariae 200-450 part nanometer Radix Saposhnikoviae 100-250 part
Nanometer Folium Perillae 100-200 part nanometer Herba Schizonepetae 70-150 part nanometer Radix Puerariae 100-250 part
Nano bezoar 1-5 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the nano children's according to claim 1 preparation medicine that induces sweat, wherein the weight proportion of each nano raw material is:
Nanometer gold Flos Lonicerae 250-350 part nanometer Fructus Forsythiae 200-300 part nanometer Fructus Arctii (stir-fry) 200-300 part
Nanometer Herba Taraxaci 250-350 part nanometer Radix Scutellariae 250-350 part nanometer Radix Saposhnikoviae 120-180 part
Nanometer Folium Perillae 120-180 part nanometer Herba Schizonepetae 80-120 part nanometer Radix Puerariae 120-180 part
Nano bezoar 1-3 part
3, the nano children's according to claim 1 preparation medicine that induces sweat, wherein the weight proportion of each nano raw material is:
250 parts of nanometer gold Flos Lonicerae 250 parts of nanometer Fructus Arctiis of 300 parts of nanometer Fructus Forsythiaes (stir-fry)
150 parts of 300 parts of nanometer Radix Saposhnikoviaes of 300 parts of nanometer Radix Scutellariaes of nanometer Herba Taraxaci
150 parts of 100 parts of nanometer Radix Puerariaes of 150 parts of nanometer Herba Schizonepetaes of nanometer Folium Perillae
1 part of nano bezoar
4, according to claim 1 or the 2 or 3 described nano children's preparation medicine that induces sweat, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the induce sweat pharmaceutical methods of preparation medicine of claim 1 or 2 or 3 described nano children's, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100646 CN1365703A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for child to induce diaphoresis and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100646 CN1365703A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for child to induce diaphoresis and its preparing process |
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| CN1365703A true CN1365703A (en) | 2002-08-28 |
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| CN 01100646 Pending CN1365703A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for child to induce diaphoresis and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409862C (en) * | 2005-03-01 | 2008-08-13 | 重庆大易科技投资有限公司 | Chinese medicinal composition for treating viral infection of upper respiratory tract and preparing process thereof |
| CN1799586B (en) * | 2005-10-13 | 2010-10-13 | 同溢堂药业有限公司 | Cold treating capsule and its preparation method |
| CN103520286A (en) * | 2013-10-15 | 2014-01-22 | 四川好医生药业集团有限公司 | Extraction process of raw medicinal materials of exterior syndrome-relieving particles for children |
-
2001
- 2001-01-15 CN CN 01100646 patent/CN1365703A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409862C (en) * | 2005-03-01 | 2008-08-13 | 重庆大易科技投资有限公司 | Chinese medicinal composition for treating viral infection of upper respiratory tract and preparing process thereof |
| CN1799586B (en) * | 2005-10-13 | 2010-10-13 | 同溢堂药业有限公司 | Cold treating capsule and its preparation method |
| CN103520286A (en) * | 2013-10-15 | 2014-01-22 | 四川好医生药业集团有限公司 | Extraction process of raw medicinal materials of exterior syndrome-relieving particles for children |
| CN103520286B (en) * | 2013-10-15 | 2015-03-04 | 四川好医生药业集团有限公司 | Extraction process of raw medicinal materials of exterior syndrome-relieving particles for children |
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