CN1365688A - Nano medicine 'Ertong Qingfei' and its preparing process - Google Patents
Nano medicine 'Ertong Qingfei' and its preparing process Download PDFInfo
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- CN1365688A CN1365688A CN 01100631 CN01100631A CN1365688A CN 1365688 A CN1365688 A CN 1365688A CN 01100631 CN01100631 CN 01100631 CN 01100631 A CN01100631 A CN 01100631A CN 1365688 A CN1365688 A CN 1365688A
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Abstract
A nanometre medicine "Ertong Qingfei" is prepared from the nanometre powders of 22 Chinese-medicinal materials including ephedra, gypsum, liquorice root, mulberry bark, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of lung heat clearing, reduce phlegm, cough-relieving, cure mainly children's's the exterior tightened by pathogenic windcold, lung meridian expectorant heat, the flushed complexion fever of the body, the cough tachypnea, the abundant expectoration thickness, the nano medicine ' Ertong Qingfei ' of pharyngalgia celostomia the invention still further relates to the method for this medication preparation.
Child's lung heat clearing ball is a kind of classical Chinese patent medicine, mainly contains antibiotic, antiviral, and antitussive and antiasthmatic reduces phlegm, and is analgesic and promote effect such as immunity, is used for children's's the exterior tightened by pathogenic windcold, lung meridian expectorant heat, flushed complexion fever of the body, cough tachypnea, abundant expectoration thickness, pharyngalgia celostomia.But traditional child's lung heat clearing ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Ertong Qingfei ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Ertong Qingfei '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 6-15 part nanometer Semen Armeniacae Amarum (stir-fry) 10-35 part nanometer Gypsum Fibrosum 25-55 part
Nanometer Radix Glycyrrhizae 6-15 part nanometer Cortex Mori (processed with honey) 20-45 part nanometer cortex trichosanthis 20-45 part
Nanometer Radix Scutellariae 25-55 part nano Radix Isatidis 25-55 part nano Juhong 20-45 part
Nanometer Rhizoma Pinelliae Preparatum 20-45 part nanometer Fructus Perillae (stir-fry) 10-35 part nanometer Semen Lepidii (Semen Descurainiae) 6-15 part
Nanometer Bulbus Fritillariae Thunbergii 25-55 part nanometer Folium Perillae 10-35 part nanometric Herbra Asarum 5-15 part
Nanometer Herba Menthae 20-45 part nanometer Folium Eriobotryae (processed with honey) 25-55 part nanometer Rhizoma Cynanchi Stauntonii 20-45 part
Nanometer Radix Peucedani 10-35 part nanometer Rhizoma Acori Graminei 20-45 part nanometer Radix Trichosanthis 20-45 part
Nanometer Lapis Chloriti (forging) 6-18 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 8-12 part nanometer Semen Armeniacae Amarum (stir-fry) 15-25 part nanometer Gypsum Fibrosum 32-48 part
Nanometer Radix Glycyrrhizae 8-12 part nanometer Cortex Mori (processed with honey) 25-35 part nanometer cortex trichosanthis 25-35 part
Nanometer Radix Scutellariae 32-48 part nano Radix Isatidis 32-48 part nano Juhong 25-35 part
Nanometer Rhizoma Pinelliae Preparatum 25-35 part nanometer Fructus Perillae (stir-fry) 15-25 part nanometer Semen Lepidii (Semen Descurainiae) 8-12 part
Nanometer Bulbus Fritillariae Thunbergii 32-48 part nanometer Folium Perillae 15-25 part nanometric Herbra Asarum 6-12 part
Nanometer Herba Menthae 25-35 part nanometer Folium Eriobotryae (processed with honey) 32-48 part nanometer Rhizoma Cynanchi Stauntonii 25-35 part
Nanometer Radix Peucedani 15-25 part nanometer Rhizoma Acori Graminei 25-35 part nanometer Radix Trichosanthis 25-35 part
Nanometer Lapis Chloriti (forging) 8-12 part
The optimum weight proportioning of medicine of the present invention is:
40 parts in 20 parts of nanometer Gypsum Fibrosum of 10 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae (stir-fry)
30 parts of 30 parts of nanometer cortex trichosanthis of 10 parts of nanometer Cortex Mori of nanometer Radix Glycyrrhizae (processed with honey)
30 parts of 40 parts of nano Juhongs of 40 parts of nano Radix Isatidis of nanometer Radix Scutellariae
10 parts of 20 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 30 parts of nanometer Fructus Perillaes of nanometer Rhizoma Pinelliae Preparatum (stir-fry)
8 parts of 20 parts of nanometric Herbra Asarums of 40 parts of nanometer Folium Perillaes of nanometer Bulbus Fritillariae Thunbergii
30 parts of 40 parts of nanometer Rhizoma Cynanchi Stauntoniis of 30 parts of nanometer Folium Eriobotryaes of nanometer Herba Menthae (processed with honey)
30 parts of 30 parts of nanometer Radix Trichosanthis of 20 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Peucedani
10 parts of nanometer Lapis Chloriti (forging)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and the mountain has showed the material that develops to nanoscale now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps;
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Ertong Qingfei ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Ertong Qingfei ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common child's lung heat clearing pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Ertong Qingfei ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as infantile bronchitis, viral pneumonia, bronchopneumonia, pertussis, and clinical efficacy significantly is better than traditional child's lung heat clearing ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method;
40 parts in 20 parts of nanometer Gypsum Fibrosum of 10 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae (stir-fry)
30 parts of 30 parts of nanometer cortex trichosanthis of 10 parts of nanometer Cortex Mori of nanometer Radix Glycyrrhizae (processed with honey)
30 parts of 40 parts of nano Juhongs of 40 parts of nano Radix Isatidis of nanometer Radix Scutellariae
10 parts of 20 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 30 parts of nanometer Fructus Perillaes of nanometer Rhizoma Pinelliae Preparatum (stir-fry)
8 parts of 20 parts of nanometric Herbra Asarums of 40 parts of nanometer Folium Perillaes of nanometer Bulbus Fritillariae Thunbergii
30 parts of 40 parts of nanometer Rhizoma Cynanchi Stauntoniis of 30 parts of nanometer Folium Eriobotryaes of nanometer Herba Menthae (processed with honey)
30 parts of 30 parts of nanometer Radix Trichosanthis of 20 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Peucedani
10 parts of nanometer Lapis Chloriti (forging)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts in 20 parts of nanometer Gypsum Fibrosum of 10 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae (stir-fry)
30 parts of 30 parts of nanometer cortex trichosanthis of 10 parts of nanometer Cortex Mori of nanometer Radix Glycyrrhizae (processed with honey)
30 parts of 40 parts of nano Juhongs of 40 parts of nano Radix Isatidis of nanometer Radix Scutellariae
10 parts of 20 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 30 parts of nanometer Fructus Perillaes of nanometer Rhizoma Pinelliae Preparatum (stir-fry)
8 parts of 20 parts of nanometric Herbra Asarums of 40 parts of nanometer Folium Perillaes of nanometer Bulbus Fritillariae Thunbergii
30 parts of 40 parts of nanometer Rhizoma Cynanchi Stauntoniis of 30 parts of nanometer Folium Eriobotryaes of nanometer Herba Menthae (processed with honey)
30 parts of 30 parts of nanometer Radix Trichosanthis of 20 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Peucedani
10 parts of nanometer Lapis Chloriti (forging)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer child lung heat clearing powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts in 20 parts of nanometer Gypsum Fibrosum of 10 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae (stir-fry)
30 parts of 30 parts of nanometer cortex trichosanthis of 10 parts of nanometer Cortex Mori of nanometer Radix Glycyrrhizae (processed with honey)
30 parts of 40 parts of nano Juhongs of 40 parts of nano Radix Isatidis of nanometer Radix Scutellariae
10 parts of 20 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 30 parts of nanometer Fructus Perillaes of nanometer Rhizoma Pinelliae Preparatum (stir-fry)
8 parts of 20 parts of nanometric Herbra Asarums of 40 parts of nanometer Folium Perillaes of nanometer Bulbus Fritillariae Thunbergii
30 parts of 40 parts of nanometer Rhizoma Cynanchi Stauntoniis of 30 parts of nanometer Folium Eriobotryaes of nanometer Herba Menthae (processed with honey)
30 parts of 30 parts of nanometer Radix Trichosanthis of 20 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Peucedani
10 parts of nanometer Lapis Chloriti (forging)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer child lung heat clearing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Ertong Qingfei ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Ephedrae 8-12 part nanometer Semen Armeniacae Amarum (stir-fry) 15-25 part nanometer Gypsum Fibrosum 32-48 part
Nanometer Radix Glycyrrhizae 8-12 part nanometer Cortex Mori (processed with honey) 25-35 part nanometer cortex trichosanthis 25-35 part
Nanometer Radix Scutellariae 32-48 part nano Radix Isatidis 32-48 part nano Juhong 25-35 part
Nanometer Rhizoma Pinelliae Preparatum 25-35 part nanometer Fructus Perillae (stir-fry) 15-25 part nanometer Semen Lepidii (Semen Descurainiae) 8-12 part
Nanometer Bulbus Fritillariae Thunbergii 32-48 part nanometer Folium Perillae 15-25 part nanometric Herbra Asarum 6-12 part
Nanometer Herba Menthae 25-35 part nanometer Folium Eriobotryae (processed with honey) 32-48 part nanometer Rhizoma Cynanchi Stauntonii 25-35 part
Nanometer Radix Peucedani 15-25 part nanometer Rhizoma Acori Graminei 25-35 part nanometer Radix Trichosanthis 25-35 part
Nanometer Lapis Chloriti (forging) 8-12 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Ertong Qingfei ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 8-12 part nanometer Semen Armeniacae Amarum (stir-fry) 15-25 part nanometer Gypsum Fibrosum 32-48 part
Nanometer Radix Glycyrrhizae 8-12 part nanometer Cortex Mori (processed with honey) 25-35 part nanometer cortex trichosanthis 25-35 part
Nanometer Radix Scutellariae 32-48 part nano Radix Isatidis 32-48 part nano Juhong 25-35 part
Nanometer Rhizoma Pinelliae Preparatum 25-35 part nanometer Fructus Perillae (stir-fry) 15-25 part nanometer Semen Lepidii (Semen Descurainiae) 8-12 part
Nanometer Bulbus Fritillariae Thunbergii 32-48 part nanometer Folium Perillae 15-25 part nanometric Herbra Asarum 6-12 part
Nanometer Herba Menthae 25-35 part nanometer Folium Eriobotryae (processed with honey) 32-48 part nanometer Rhizoma Cynanchi Stauntonii 25-35 part
Nanometer Radix Peucedani 15-25 part nanometer Rhizoma Acori Graminei 25-35 part nanometer Radix Trichosanthis 25-35 part
Nanometer Lapis Chloriti (forging) 8-12 part
3, nano medicine ' Ertong Qingfei ' according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts in 20 parts of nanometer Gypsum Fibrosum of 10 portions of nanometer Semen Armeniacae Amarums of nanometer Herba Ephedrae (stir-fry)
30 parts of 30 parts of nanometer cortex trichosanthis of 10 parts of nanometer Cortex Mori of nanometer Radix Glycyrrhizae (processed with honey)
30 parts of 40 parts of nano Juhongs of 40 parts of nano Radix Isatidis of nanometer Radix Scutellariae
10 parts of 20 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 30 parts of nanometer Fructus Perillaes of nanometer Rhizoma Pinelliae Preparatum (stir-fry)
8 parts of 20 parts of nanometric Herbra Asarums of 40 parts of nanometer Folium Perillaes of nanometer Bulbus Fritillariae Thunbergii
30 parts of 40 parts of nanometer Rhizoma Cynanchi Stauntoniis of 30 parts of nanometer Folium Eriobotryaes of nanometer Herba Menthae (processed with honey)
30 parts of 30 parts of nanometer Radix Trichosanthis of 20 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Peucedani
10 parts of nanometer Lapis Chloriti (forging)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Ertong Qingfei 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Ertong Qingfei 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100631 CN1365688A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Ertong Qingfei' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100631 CN1365688A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Ertong Qingfei' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365688A true CN1365688A (en) | 2002-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100631 Pending CN1365688A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Ertong Qingfei' and its preparing process |
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| CN (1) | CN1365688A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314428C (en) * | 2004-02-02 | 2007-05-09 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN102133319A (en) * | 2011-03-18 | 2011-07-27 | 邴超 | Medicament for relieving asthma and cough and preparation method thereof |
| CN102188133A (en) * | 2011-05-05 | 2011-09-21 | 惠州市欧野科技有限公司 | Health-care pillow for treating chronic bronchitis in old people |
-
2001
- 2001-01-15 CN CN 01100631 patent/CN1365688A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314428C (en) * | 2004-02-02 | 2007-05-09 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN102133319A (en) * | 2011-03-18 | 2011-07-27 | 邴超 | Medicament for relieving asthma and cough and preparation method thereof |
| CN102133319B (en) * | 2011-03-18 | 2012-07-04 | 邴超 | Medicament for relieving asthma and cough and preparation method thereof |
| CN102188133A (en) * | 2011-05-05 | 2011-09-21 | 惠州市欧野科技有限公司 | Health-care pillow for treating chronic bronchitis in old people |
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