CN102133319A - Medicament for relieving asthma and cough and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for relieving asthma and cough and a preparation method thereof, wherein the medicament is mainly prepared from the following Chinese medicines of Chinese ephedra, almond, liquorice, loquat leaves, baical skullcap root, gecko, Chinese yam, radish seed, Chinese caterpillar fungus, the root bark of white mulberry, mandala, dahurian rhododendron leaf, agilawood, ginkgo, walnut kernel and lumbricus in proportions by weight. The medicament disclosed by the invention is a Chinese medicine pill which has the functions of relieving cough, eliminating phlegm and relieving asthma and improving body immunity and has the advantages of low side effect, obvious treatment effect, small size, portability and convenience for oral administration.

Description

Medicine of a kind of antiasthmatic-antitussive and preparation method thereof

Technical field

The present invention relates to medicine of a kind of antiasthmatic-antitussive and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Bronchial asthma is under the high reactive state of bronchus because the narrow disease of extensive air flue spasm that allergen or other factors cause.Clinical exogenous, endogenous of continuing to use at present and Combination three types.The traditional Chinese medical science claims asthma, in thinking latent phlegm is arranged, the sense exopathogen that continues, and inside and outside combined pathogens, mental disorder is handed over resistance, causes lung qi a surname to fall, and is the main pathogenesis of primary disease.

At cold, heat, empty, full mold asthma is dialectical, asthma has the outbreak repeatedly of variable interval, does not prolongedly heal.Visceral-qi changes wind-cold affecting lung or exterior cold and interior heat for it, dyspnea raucous breath, flaring of nares, dyspnea with rapid respiration, expectoration thickness uncomfortable in chest is not well, thin white fur of tongue or Huang, and matter is red, main performance such as floating and rapid pulse on the basis of MAXINGSHIGAN TANG and cortex mori decoction, develops in conjunction with clinical practice and modern medicines achievement in research.Side epheday intermedia, Radix Stephaniae Tetrandrae, the arduous temperature of Cortex Mori have the diaphoresis cold expelling, expelling wind and removing dampness, and inducing diuresis to remove edema, Semen Ginkgo, Semen Juglandis, Semen Armeniacae Amarum, Folium Eriobotryae, warm in nature, go into the lung kidney channel, temperature compensation lung, kidney, are relievingd asthma at improving inspiration by invigorating kidney-QI, eliminating phlegm and stopping cough.Radix Scutellariae, bitter in the mouth cold in nature, the function heat clearing away, dampness is usually used in the allergic disease of doctor trained in Western medicine.Test factually and show, baicalin and baicaligenin contained in the Radix Scutellariae have antiallergic, detoxifcation, anti-acetylcholine effect, the increase and the experimental asthma that can suppress capillary permeability, the release histamine that suppresses mastocyte, effect that strengthens cytophagy and the activation that promotes healthy people's lymphoblast sulfenyl enzyme are still arranged, thereby suppressed the release of anaphylaxis media such as histamine's 5-hydroxy tryptamine.Gecko, Cordyceps are flat, and tonifying the lung void is arranged, invigorating kidney-YANG, the kidney tonifying essence, relieving asthma and cough reduces phlegm, modern pharmacology experiment showed, have expansion bronchus, tranquilizing soporific, effects such as human body immunity improving function, warm in nature, the lowering the adverse-rising QI to subdue asthma of Lignum Aquilariae Resinatum.Pheretima, obey the flat warm dual-purpose of son, Rhizoma Dioscoreae, the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is because of through eliminating indigestion and phlegm therapeutic method to keep the adverse QI flowing downwards Dingchuan.Folium Rhododendri Daurici, Flos Daturae property hardship, Xin Wen is poisonous, and Radix Glycyrrhizae should be concocted and be separated it in addition.

Summary of the invention

The purpose of this invention is to provide medicine of a kind of antiasthmatic-antitussive and preparation method thereof, to solve the deficiency of present medicine, treatment bronchitis, bronchial asthma.

The present invention adopts following technical scheme to achieve these goals:

A kind of medicine of antiasthmatic-antitussive is characterized in that the weight portion of its constitutive material is:

Herba Ephedrae 5-8 part, Semen Armeniacae Amarum 10-15 part, Radix Glycyrrhizae 5-8 part, Folium Eriobotryae 10-15 part, Radix Scutellariae 12-18 part, Gecko 8-12 part, Rhizoma Dioscoreae 10-15 part, Semen Raphani 10-15 part, Cordyceps 8-12 part, Cortex Mori 10-15 part, Flos Daturae 5-8 part, Folium Rhododendri Daurici 8-12 part, Lignum Aquilariae Resinatum 2-4 part, Semen Ginkgo 10-15 part, Semen Juglandis 5-8 part, Pheretima 10-15 part.

The medicine of described antiasthmatic-antitussive is characterized in that its constitutive material weight portion is:

6 parts in Herba Ephedrae, 12 parts in Semen Armeniacae Amarum, 6 parts in Radix Glycyrrhizae, 12 parts of Folium Eriobotryaes, 15 parts of Radix Scutellariaes, 9 parts of Geckos, 12 parts of Rhizoma Dioscoreaes, 12 parts of Semen Raphanis, 9 parts of Cordyceps, 12 parts of Cortex Mori, 6 parts of Flos Daturae, 9 parts of Folium Rhododendri Daurici, 3 parts of Lignum Aquilariae Resinatum, 12 parts of Semen Ginkgoes, 6 parts of Semen Juglandis, 12 parts of Pheretimas.

The preparation method of the medicine of described antiasthmatic-antitussive is characterized in that may further comprise the steps:

(1) take by weighing Gecko, Cordyceps, Semen Armeniacae Amarum, Rhizoma Dioscoreae, Semen Raphani, Semen Ginkgo, Semen Juglandis, eight kinds of medicines of Pheretima by the constitutive material weight portion, clean with clear water then, mix oven dry, grinding and sieving gets medicated powder A;

(2) take by weighing Herba Ephedrae, Radix Glycyrrhizae, Folium Eriobotryae, Radix Scutellariae, Cortex Mori, Flos Daturae, Folium Rhododendri Daurici, eight kinds of medicines of Lignum Aquilariae Resinatum by weight, clean with clear water, add water purification then and soaked 2-3 hour, decocting in water merges decoction liquor, the plaster B of filtering and concentrating;

(3) A, B are merged mix homogeneously and make pill.

Beneficial effect of the present invention:

The present invention is the Chinese medicine pill, improves body immunity, and side effect is little, and curative effect is obvious, and medicine Xiao Yi is portable, and buccal is convenient.

The specific embodiment

Embodiment 1:

Infant: Zhang, the man, 9 years old, the student lived Zhang village village, Huang Ling town, Linquan County, and on March 16th, 2004 went to a doctor.Infant cough, asthma show effect repeatedly 7 years surplus.Check: face of acute ill, nutrition is general, 36.8 ℃ of body temperature, two nasal conchae hypertrophy, hyperemia, two lung wheezing sounds are breathed 53 times/minute with dried moist rale, heart rate 104 times/minute, the rhythm of the heart is neat.Liver, spleen do not touch, the no enlargement of whole body superficial lymph knot.Fluoroscopy of chest: two increased bronchovascular shadows, increase, surplus no abnormal, electrocardiogram is normal.Chemical examination: erythrocyte 5.5 * 10 ¹²/ L, leukocyte 10.8 * 10 ⁹/ L, the eosinophilic granulocyte 19%.

Make a definite diagnosis: allergic bronchial asthma.

Treatment: salmaterol is for Kazon powder inhalant, and each 1 inhales (50mg salmaterol and 500ug fluticasone propionate) every day 2 times, oral antiasthmatic-antitussive ball, and one time 1.5 gram, was obeyed 3 months continuously at every day three times.The instruction infant is suffered from cold less, is taken exercise more, and the back was not seen recurrence in 2 years with examining.

Know from experience: this routine infant, pure-yang constituent is felt clear distemper poison again, cause inhibited pulmonary QI, and asthma is shown effect repeatedly, and by therapy of combining Chinese and Western medicine one all follow-up clothes antiasthmatic-antitussive balls, one time 1.5 gram 3 times on the one, 3 months and fully recover, is followed up a case by regular visits to and was not seen recurrence in 2 years.

Embodiment 2:

Patient Wang, the man, 57 years old, the driver lived residential district, Zhouzhuang, area just outside a city gate town, coughed, panted year surplus in the of 40.

This case on March 11st, 2004 because of heating, cough, uncomfortable in chest, tell sticking expectorant with dyspnea, emergency is gone to a doctor, check: 38.5 ℃ of body temperature, blood pressure 145-90 millimetres of mercury, rapid breathing difficulty, the half the circumference of the sleeve where it joins the shoulder of panting, cyanotic lips, two nasal conchae hypertrophy, hyperemia, bottleneck throat hyperemia, two pulmonary respiration sounds are thick, two lung audibles and dried moist rale and wheezing sound.Heart rate 74 times/minute, heart is no abnormal, and liver, spleen do not touch, and two lower limb do not have edema.X line rabat is as seen: two lung marking are coarse, disorderly, and side of body gap is wide, and the trachea mediastinum is placed in the middle, and podiod is little, and there is a small amount of shade at right lung diaphragm angle, the smooth no adhesion of diaphragmatic surface.Chemical examination: hemoglobin 124g/L, erythrocyte 3.8 * 10 ¹²/ L, leukocyte 13.8 * 10 ⁹/ L, neutrophil cell 69%, lymph are had a liking for cell 43%, and the eosinophilic granulocyte 18%.Electrocardiogram is normal.

Make a definite diagnosis: chronic bronchitis, bronchial asthma, emphysema concurrent infection.

Handle: receive 5 grams for intravenous drip mezlocillin sulbactam, levofloxacin 0.2 gram, every day secondary.Oral antiasthmatic-antitussive ball every day three times, each ball, logotype three days, body temperature is normal.After change oral antiasthmatic-antitussive ball into, every day three times, each ball serve on three months.The patient was in further consultation on June 19 in 2004, and the patient is conscious, and health is fine, and is normal through rabat check pulmonary of X elder generation.The instruction patient closely in two years more to take exercises, and goes into to renew around the winter clothes antiasthmatic-antitussive ball, and every day 1-2 time, each 1 ball serve on three months, follows up a case by regular visits to and does not see recurrence in 3 years.

Embodiment 3:

The Wang, the woman, 17 years old, the student lived Jiang Lou administrative village, senior officer town, Linquan County, cough, excessive phlegm, asthma, dyspnea show effect repeatedly 15 years surplus.

The rapid difficulty of patient respiratory, the half the circumference of the sleeve where it joins the shoulder of panting, uncomfortable in chest, go out profuse sweating, pale complexion, cyanotic lips, can not put down for sleeping in, in emergency prescription on individual diagnosis on August 3rd, 2006.Check: 36.8 ℃ of body temperature, blood pressure 110-70 millimetres of mercury, two lung auscultations, respiratory murmur is thick, and a little dried moist rale is arranged, with prolonged expiration, all the other (1) X ray examinations, visible two lungs increased bronchovascular shadows of marching off into political wilderness, the bright increase of lung field, tabula descends.Chemical examination: hemoglobin 125g/L, erythrocyte 4.2 * 10 ¹²/ L, leukocyte 11.2 * 10 ⁹/ L, the eosinophilic granulocyte 16%.

Make a definite diagnosis: allergic bronchial asthma.

Handle: atomizing sucks breathes heavily the peace inhalant morning, every day three times, one time 20 minutes, oral antiasthmatic-antitussive ball, three times on the one, one time 1 ball, continuous 2 weeks are after remission, change antiasthmatic-antitussive ball every day three times into, one time 1 ball, continuous clothes three months, the instruction patient goes into the winter every year and renews clothes antiasthmatic-antitussive ball 3-4 month.After follow up a case by regular visits to and do not see recurrence in 2 years, Linquan literary composition king brewery work now.

Embodiment 4:

Patient Zheng, the man 49 years old, lives Zheng Lou village, Ying Xian town, Linquan County, JIUYUE in 2007 first visit on the 3rd, cough, asthma show effect surplus in the of 40 year repeatedly, increase the weight of 4 years, annual winter the recurrent cough, uncomfortable in chest, breathe hard, difficulty in walking, can not put down night for sleeping in, just drawn with flat car by the household in JIUYUE in 2007 3 days and accept for medical treatment.Check: painful sickly complexion, facial Mild edema, cyanotic lips, the little Huang of tongue fur, 36.9 ℃ of body temperature, pulse 72 times/minute, blood pressure 138-90 millimetres of mercury, auscultation: two pulmonary respiration sounds are thick, and with dryness, moist rale, two lungs are with wheezing sound, heart rate 70 times/minute, rule is neat, and liver, spleen do not touch, no lower limbs edema.The Chest X-rays of X line, increases slightly at two enhanced lung markings, and podiod is little, and electrocardiogram is normal.Chemical examination: hemoglobin 121g/L, erythrocyte 3.6 * 10 ¹²/ L, leukocyte 18.9 * 10 ⁹/ L, neutrophil cell 84%, lymphocyte 42%, the eosinophilic granulocyte 16%.

Make a definite diagnosis: chronic bronchitis merges bronchial asthma.

Treatment: the antiasthmatic-antitussive ball, one time 1 ball, every day 3 times, in two weeks of nebulae inhalation, after symptom control, one time 1 ball of continuous clothes antiasthmatic-antitussive ball three times on the one, after three months, changes one time 1 ball into, a twice-daily.Renew clothes two months, require the patient to strengthen physical exercise, went into the winter in 1 year to renew clothes antiasthmatic-antitussive ball after three months, follow up a case by regular visits to and do not see recurrence in 2 years.

Claims (3)

1. the medicine of an antiasthmatic-antitussive is characterized in that the weight portion of its constitutive material is:

Herba Ephedrae 5-8 part, Semen Armeniacae Amarum 10-15 part, Radix Glycyrrhizae 5-8 part, Folium Eriobotryae 10-15 part, Radix Scutellariae 12-18 part, Gecko 8-12 part, Rhizoma Dioscoreae 10-15 part, Semen Raphani 10-15 part, Cordyceps 8-12 part, Cortex Mori 10-15 part, Flos Daturae 5-8 part, Folium Rhododendri Daurici 8-12 part, Lignum Aquilariae Resinatum 2-4 part, Semen Ginkgo 10-15 part, Semen Juglandis 5-8 part, Pheretima 10-15 part.

2. the medicine of antiasthmatic-antitussive according to claim 1 is characterized in that its constitutive material weight portion is:

6 parts in Herba Ephedrae, 12 parts in Semen Armeniacae Amarum, 6 parts in Radix Glycyrrhizae, 12 parts of Folium Eriobotryaes, 15 parts of Radix Scutellariaes, 9 parts of Geckos, 12 parts of Rhizoma Dioscoreaes, 12 parts of Semen Raphanis, 9 parts of Cordyceps, 12 parts of Cortex Mori, 6 parts of Flos Daturae, 9 parts of Folium Rhododendri Daurici, 3 parts of Lignum Aquilariae Resinatum, 12 parts of Semen Ginkgoes, 6 parts of Semen Juglandis, 12 parts of Pheretimas.

3. the preparation method of the medicine of claim 1 or 2 described antiasthmatic-antitussives is characterized in that may further comprise the steps:

(1) take by weighing Gecko, Cordyceps, Semen Armeniacae Amarum, Rhizoma Dioscoreae, Semen Raphani, Semen Ginkgo, Semen Juglandis, eight kinds of medicines of Pheretima by the constitutive material weight portion, clean with clear water then, mix oven dry, grinding and sieving gets medicated powder A;

(2) take by weighing Herba Ephedrae, Radix Glycyrrhizae, Folium Eriobotryae, Radix Scutellariae, Cortex Mori, Flos Daturae, Folium Rhododendri Daurici, eight kinds of medicines of Lignum Aquilariae Resinatum by weight, clean with clear water, add water purification then and soaked 2-3 hour, decocting in water merges decoction liquor, the plaster B of filtering and concentrating;

(3) A, B are merged mix homogeneously and make pill.