CN1365746A - Nano medicine 'Sizheng' and its preparing process - Google Patents
Nano medicine 'Sizheng' and its preparing process Download PDFInfo
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- CN1365746A CN1365746A CN 01100847 CN01100847A CN1365746A CN 1365746 A CN1365746 A CN 1365746A CN 01100847 CN01100847 CN 01100847 CN 01100847 A CN01100847 A CN 01100847A CN 1365746 A CN1365746 A CN 1365746A
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Abstract
A nanometre medicine "Sizheng" is prepared from the nanometre powders of 20 Chinese medicinal materials including agastache rugosa, elsholtzia, perilla leaf, dahurian angelica root, sandal wood, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to that a kind of cold expelling drives away summer heat, dampness removing relieving distension, antidiarrheal preventing or arresting vomiting, cure mainly the nano medicine ' Sizheng ' of flu, the invention still further relates to the method for this medication preparation.
Four positive balls are a kind of classical Chinese patent medicines, mainly contain antibioticly, alleviate smooth muscle spasm, and effects such as function of gallbladder promoting and facilitating digestion function are used for pestilent cold, the fever with aversion to cold of retention of dampness due to stagnation of QI, and a body is sleepy, nausea and vomiting, diseases such as abdominal distention diarrhoea.But four traditional positive ball disintegrates are slower, absorb not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Sizheng ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Sizheng '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Pogostemonis 70-150 part nanometer Herba Moslae 60-120 part nanometer Folium Perillae 60-130 part
Nano angelica root 60-120 part nanometer Lignum Santali Albi 20-45 part nanometer Fructus Chaenomelis 60-130 part
Nanometer Rhizoma Pinelliae Preparatum 60-130 part nanometer Cortex Magnoliae Officinalis 60-130 part nanometer Pericarpium Arecae 60-130 part
Nanometer Pericarpium Citri Reticulatae 60-130 part nanometer Rhizoma Atractylodis Macrocephalae 60-130 part nanometer Radix Platycodonis 60-130 part
Nano Poria 60-130 part nanometer Semen Arecae 20-45 part nanometer Fructus Aurantii 60-130 part
Nanometer Fructus Crataegi 20-45 part nanometer Massa Medicata Fermentata 60-130 part nanometer Fructus Hordei Germinatus 20-45 part
Nanometer Semen Lablab Album 60-130 part nanometer Radix Glycyrrhizae 60-130 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Pogostemonis 80-120 part nanometer Herba Moslae 70-110 part nanometer Folium Perillae 70-110 part
Nano angelica root 70-110 part nanometer Lignum Santali Albi 25-35 part nanometer Fructus Chaenomelis 70-110 part
Nanometer Rhizoma Pinelliae Preparatum 70-110 part nanometer Cortex Magnoliae Officinalis 70-110 part nanometer Pericarpium Arecae 70-110 part
Nanometer Pericarpium Citri Reticulatae 70-110 part nanometer Rhizoma Atractylodis Macrocephalae 70-110 part nanometer Radix Platycodonis 70-110 part
Nano Poria 70-110 part nanometer Semen Arecae 25-35 part nanometer Fructus Aurantii 70-110 part
Nanometer Fructus Crataegi 25-35 part nanometer Massa Medicata Fermentata 70-110 part nanometer Fructus Hordei Germinatus 25-35 part
Nanometer Semen Lablab Album 70-110 part nanometer Radix Glycyrrhizae 70-110 part
The optimum weight proportioning of medicine of the present invention is:
90 parts of 90 parts of nanometer Folium Perillaes of 90 parts of nanometer Herba Moslaes of nanometer Herba Pogostemonis
90 parts of 30 parts of nanometer Fructus Chaenomeliss of 90 parts of nanometer Lignum Santali Albis of nano angelica root
90 parts of 90 parts of nanometer Pericarpium Arecae of 90 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Pinelliae Preparatum
90 parts of 90 parts of nanometer Radix Platycodoniss of 90 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Pericarpium Citri Reticulatae
90 parts of 30 parts of nanometer Fructus Aurantiis of 90 portions of nanometer Semen Arecaes of nano Poria
30 parts in 90 parts of nanometer Fructus Hordei Germinatus of 30 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
90 parts in 90 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Lablab Album
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Sizheng ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Sizheng ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common four positive pill materials are micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Sizheng ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as flu, abdominal distention, diarrhoea and vomiting, and clinical efficacy significantly is better than four traditional positive balls.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
90 parts of 90 parts of nanometer Folium Perillaes of 90 parts of nanometer Herba Moslaes of nanometer Herba Pogostemonis
90 parts of 30 parts of nanometer Fructus Chaenomeliss of 90 parts of nanometer Lignum Santali Albis of nano angelica root
90 parts of 90 parts of nanometer Pericarpium Arecae of 90 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Pinelliae Preparatum
90 parts of 90 parts of nanometer Radix Platycodoniss of 90 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Pericarpium Citri Reticulatae
90 parts of 30 parts of nanometer Fructus Aurantiis of 90 portions of nanometer Semen Arecaes of nano Poria
30 parts in 90 parts of nanometer Fructus Hordei Germinatus of 30 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
90 parts in 90 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
90 parts of 90 parts of nanometer Folium Perillaes of 90 parts of nanometer Herba Moslaes of nanometer Herba Pogostemonis
90 parts of 30 parts of nanometer Fructus Chaenomeliss of 90 parts of nanometer Lignum Santali Albis of nano angelica root
90 parts of 90 parts of nanometer Pericarpium Arecae of 90 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Pinelliae Preparatum
90 parts of 90 parts of nanometer Radix Platycodoniss of 90 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Pericarpium Citri Reticulatae
90 parts of 30 parts of nanometer Fructus Aurantiis of 90 portions of nanometer Semen Arecaes of nano Poria
30 parts in 90 parts of nanometer Fructus Hordei Germinatus of 30 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
90 parts in 90 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer four positive powder needle injections, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
90 parts of 90 parts of nanometer Folium Perillaes of 90 parts of nanometer Herba Moslaes of nanometer Herba Pogostemonis
90 parts of 30 parts of nanometer Fructus Chaenomeliss of 90 parts of nanometer Lignum Santali Albis of nano angelica root
90 parts of 90 parts of nanometer Pericarpium Arecae of 90 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Pinelliae Preparatum
90 parts of 90 parts of nanometer Radix Platycodoniss of 90 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Pericarpium Citri Reticulatae
90 parts of 30 parts of nanometer Fructus Aurantiis of 90 portions of nanometer Semen Arecaes of nano Poria
30 parts in 90 parts of nanometer Fructus Hordei Germinatus of 30 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
90 parts in 90 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer four positive membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Sizheng ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Pogostemonis 70-150 part nanometer Herba Moslae 60-120 part nanometer Folium Perillae 60-130 part
Nano angelica root 60-120 part nanometer Lignum Santali Albi 20-45 part nanometer Fructus Chaenomelis 60-130 part
Nanometer Rhizoma Pinelliae Preparatum 60-130 part nanometer Cortex Magnoliae Officinalis 60-130 part nanometer Pericarpium Arecae 60-130 part
Nanometer Pericarpium Citri Reticulatae 60-130 part nanometer Rhizoma Atractylodis Macrocephalae 60-130 part nanometer Radix Platycodonis 60-130 part
Nano Poria 60-130 part nanometer Semen Arecae 20-45 part nanometer Fructus Aurantii 60-130 part
Nanometer Fructus Crataegi 20-45 part nanometer Massa Medicata Fermentata 60-130 part nanometer Fructus Hordei Germinatus 20-45 part
Nanometer Semen Lablab Album 60-130 part nanometer Radix Glycyrrhizae 60-130 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Sizheng ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Pogostemonis 80-120 part nanometer Herba Moslae 70-110 part nanometer Folium Perillae 70-110 part
Nano angelica root 70-110 part nanometer Lignum Santali Albi 25-35 part nanometer Fructus Chaenomelis 70-110 part
Nanometer Rhizoma Pinelliae Preparatum 70-110 part nanometer Cortex Magnoliae Officinalis 70-110 part nanometer Pericarpium Arecae 70-110 part
Nanometer Pericarpium Citri Reticulatae 70-110 part nanometer Rhizoma Atractylodis Macrocephalae 70-110 part nanometer Radix Platycodonis 70-110 part
Nano Poria 70-110 part nanometer Semen Arecae 25-35 part nanometer Fructus Aurantii 70-110 part
Nanometer Fructus Crataegi 25-35 part nanometer Massa Medicata Fermentata 70-110 part nanometer Fructus Hordei Germinatus 25-35 part
Nanometer Semen Lablab Album 70-110 part nanometer Radix Glycyrrhizae 70-110 part
3, nano medicine ' Sizheng ' according to claim 1, wherein the weight proportion of each nano raw material is:
90 parts of 90 parts of nanometer Folium Perillaes of 90 parts of nanometer Herba Moslaes of nanometer Herba Pogostemonis
90 parts of 30 parts of nanometer Fructus Chaenomeliss of 90 parts of nanometer Lignum Santali Albis of nano angelica root
90 parts of 90 parts of nanometer Pericarpium Arecae of 90 parts of nanometer Cortex Magnoliae Officinalis of nanometer Rhizoma Pinelliae Preparatum
90 parts of 90 parts of nanometer Radix Platycodoniss of 90 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Pericarpium Citri Reticulatae
90 parts of 30 parts of nanometer Fructus Aurantiis of 90 portions of nanometer Semen Arecaes of nano Poria
30 parts in 90 parts of nanometer Fructus Hordei Germinatus of 30 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
90 parts in 90 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Lablab Album
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Sizheng 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Sizheng 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100847 CN1365746A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Sizheng' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100847 CN1365746A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Sizheng' and its preparing process |
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| Publication Number | Publication Date |
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| CN1365746A true CN1365746A (en) | 2002-08-28 |
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| CN 01100847 Pending CN1365746A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Sizheng' and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988872A (en) * | 2012-12-18 | 2013-03-27 | 福州海王金象中药制药有限公司 | Wanyingganhe Tea (used for treating colds, fever, abdominal pain, vomiting and diarrhea and summer diarrhea) preparation process |
| CN106074938A (en) * | 2016-08-04 | 2016-11-09 | 太仓优活生物技术有限公司 | A kind of aid digestion antibacterial Chinese herbal medicines |
| CN106822766A (en) * | 2017-04-10 | 2017-06-13 | 林美嫦 | A kind of traditional Chinese medicinal components of clearing damp invigorating the spleen and preparation method thereof |
-
2001
- 2001-01-19 CN CN 01100847 patent/CN1365746A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988872A (en) * | 2012-12-18 | 2013-03-27 | 福州海王金象中药制药有限公司 | Wanyingganhe Tea (used for treating colds, fever, abdominal pain, vomiting and diarrhea and summer diarrhea) preparation process |
| CN106074938A (en) * | 2016-08-04 | 2016-11-09 | 太仓优活生物技术有限公司 | A kind of aid digestion antibacterial Chinese herbal medicines |
| CN106822766A (en) * | 2017-04-10 | 2017-06-13 | 林美嫦 | A kind of traditional Chinese medicinal components of clearing damp invigorating the spleen and preparation method thereof |
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