CN1362207A - Nano healthy energy restoring agastachis medicine and its preparation - Google Patents
Nano healthy energy restoring agastachis medicine and its preparation Download PDFInfo
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- CN1362207A CN1362207A CN 01100706 CN01100706A CN1362207A CN 1362207 A CN1362207 A CN 1362207A CN 01100706 CN01100706 CN 01100706 CN 01100706 A CN01100706 A CN 01100706A CN 1362207 A CN1362207 A CN 1362207A
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Abstract
The present invention discloses a nano agastache/patchouli qi-righting preparation medicine. It is made up by using 13 Chinese medicinal materials of nano patchouli, nano perilla leaf, nano angelica, nano ovate atractylodes, nano tangerine peel and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of removing dampness of inducing sweat, regulate the flow of vital energy and in nanometer HUOXIANG ZHENGQI ZHIJI medicine, the invention still further relates to the preparation method of this medicine.
HUOXIANG ZHENGQI WAN is a kind of traditional Chinese patent medicine, mainly contains spasmolytic, analgesia, tell in the town, strengthens cellular immune function, effect such as antibacterial grade, be used for affection of exogenous wind-cold, the internal injury humidity hysteresis, cholera is vomited and diarrhoea, fever with chills, headache, chest and diaphragm is full vexed, epigastric pain, white and greasy fur, and clouds and mists in the mountains subtertian malaria etc. but traditional HUOXIANG ZHENGQI WAN, absorb not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer HUOXIANG ZHENGQI ZHIJI medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer HUOXIANG ZHENGQI ZHIJI medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Pogostemonis 130-170 part nanometer Folium Perillae 30-70 part nano angelica root 30-70 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Pericarpium Citri Reticulatae 80-120 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 80-120 part
Nanometer Cortex Magnoliae Officinalis 80-120 part nano Poria 30-70 part nanometer Radix Platycodonis 80-120 part
Nanometer Radix Glycyrrhizae 80-120 part nanometer Pericarpium Arecae 30-70 part nanometer Fructus Jujubae 20-30 part
Nanometer Rhizoma Zingiberis Recens 10-20 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Pogostemonis 140-160 part nanometer Folium Perillae 40-60 part nano angelica root 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 90-110 part nanometer Pericarpium Citri Reticulatae 90-110 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 90-110 part
Nanometer Cortex Magnoliae Officinalis 90-110 part nano Poria 40-60 part nanometer Radix Platycodonis 90-110 part
Nanometer Radix Glycyrrhizae 90-110 part nanometer Pericarpium Arecae 40-60 part nanometer Fructus Jujubae 22-28 part
Nanometer Rhizoma Zingiberis Recens 12-18 part
The best important proportioning of medicine of the present invention is:
50 parts of 50 parts of nano angelica roots of 150 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
100 parts of 100 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of 100 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Rhizoma Atractylodis Macrocephalae
100 parts of 50 parts of nanometer Radix Platycodoniss of 100 parts of nano Porias of nanometer Cortex Magnoliae Officinalis
25 parts in 50 portions of nanometer Fructus Jujubaes of 100 parts of nanometer Pericarpium Arecae of nanometer Radix Glycyrrhizae
15 parts in nanometer Rhizoma Zingiberis Recens
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the ageratum nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer HUOXIANG ZHENGQI ZHIJI medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common HUOXIANG ZHENGQI WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nanometer HUOXIANG ZHENGQI ZHIJI medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for flu, acute gastroenteritis, and acute and chronic colitis, acidosis, treatments such as tinea corporis dermatitis, clinical efficacy is significantly because traditional HUOXIANG ZHENGQI WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
50 parts of 50 parts of nano angelica roots of 150 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
100 parts of 100 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of 100 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Rhizoma Atractylodis Macrocephalae
100 parts of 50 parts of nanometer Radix Platycodoniss of 100 parts of nano Porias of nanometer Cortex Magnoliae Officinalis
25 parts in 50 portions of nanometer Fructus Jujubaes of 100 parts of nanometer Pericarpium Arecae of nanometer Radix Glycyrrhizae
15 parts in nanometer Rhizoma Zingiberis Recens
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
50 parts of 50 parts of nano angelica roots of 150 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
100 parts of 100 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of 100 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Rhizoma Atractylodis Macrocephalae
100 parts of 50 parts of nanometer Radix Platycodoniss of 100 parts of nano Porias of nanometer Cortex Magnoliae Officinalis
25 parts in 50 portions of nanometer Fructus Jujubaes of 100 parts of nanometer Pericarpium Arecae of nanometer Radix Glycyrrhizae
15 parts in nanometer Rhizoma Zingiberis Recens
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer ageratum powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
50 parts of 50 parts of nano angelica roots of 150 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
100 parts of 100 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of 100 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Rhizoma Atractylodis Macrocephalae
100 parts of 50 parts of nanometer Radix Platycodoniss of 100 parts of nano Porias of nanometer Cortex Magnoliae Officinalis
25 parts in 50 portions of nanometer Fructus Jujubaes of 100 parts of nanometer Pericarpium Arecae of nanometer Radix Glycyrrhizae
15 parts in nanometer Rhizoma Zingiberis Recens
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer ageratum membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nanometer HUOXIANG ZHENGQI ZHIJI medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer Herba Pogostemonis 130-170 part nanometer Folium Perillae 30-70 part nano angelica root 30-70 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Pericarpium Citri Reticulatae 80-120 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 80-120 part
Nanometer Cortex Magnoliae Officinalis 80-120 part nano Poria 30-70 part nanometer Radix Platycodonis 80-120 part
Nanometer Radix Glycyrrhizae 80-120 part nanometer Pericarpium Arecae 30-70 part nanometer Fructus Jujubae 20-30 part
Nanometer Rhizoma Zingiberis Recens 10-20 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer HUOXIANG ZHENGQI ZHIJI medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Pogostemonis 140-160 part nanometer Folium Perillae 40-60 part nano angelica root 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 90-110 part nanometer Pericarpium Citri Reticulatae 90-110 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 90-110 part
Nanometer Cortex Magnoliae Officinalis 90-110 part nano Poria 40-60 part nanometer Radix Platycodonis 90-110 part
Nanometer Radix Glycyrrhizae 90-110 part nanometer Pericarpium Arecae 40-60 part nanometer Fructus Jujubae 22-28 part
Nanometer Rhizoma Zingiberis Recens 12-18 part
3, nanometer HUOXIANG ZHENGQI ZHIJI medicine according to claim 1, wherein the weight proportion of each nano raw material is:
50 parts of 50 parts of nano angelica roots of 150 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
100 parts of 100 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of 100 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Rhizoma Atractylodis Macrocephalae
100 parts of 50 parts of nanometer Radix Platycodoniss of 100 parts of nano Porias of nanometer Cortex Magnoliae Officinalis
25 parts in 50 portions of nanometer Fructus Jujubaes of 100 parts of nanometer Pericarpium Arecae of nanometer Radix Glycyrrhizae
15 parts in nanometer Rhizoma Zingiberis Recens
4, according to claim 1 or 2 or 3 described nanometer HUOXIANG ZHENGQI ZHIJI medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer HUOXIANG ZHENGQI ZHIJI medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100706 CN1362207A (en) | 2001-01-08 | 2001-01-08 | Nano healthy energy restoring agastachis medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100706 CN1362207A (en) | 2001-01-08 | 2001-01-08 | Nano healthy energy restoring agastachis medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670029B (en) * | 2009-08-11 | 2012-03-07 | 太极集团重庆涪陵制药厂有限公司 | Method for distinguishing and measuring contents of perillene and perillaldehyde in giant-hyssop preparation |
| CN102743716A (en) * | 2012-06-07 | 2012-10-24 | 王晓兵 | Traditional Chinese medicine composite oral liquid for treating fever by relieving exterior syndrome with pungent and warm natured traditional Chinese medicines |
| CN103536705A (en) * | 2013-11-08 | 2014-01-29 | 刘艳菊 | Traditional Chinese medicine composition for treating colitis |
-
2001
- 2001-01-08 CN CN 01100706 patent/CN1362207A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670029B (en) * | 2009-08-11 | 2012-03-07 | 太极集团重庆涪陵制药厂有限公司 | Method for distinguishing and measuring contents of perillene and perillaldehyde in giant-hyssop preparation |
| CN102743716A (en) * | 2012-06-07 | 2012-10-24 | 王晓兵 | Traditional Chinese medicine composite oral liquid for treating fever by relieving exterior syndrome with pungent and warm natured traditional Chinese medicines |
| CN102743716B (en) * | 2012-06-07 | 2016-03-09 | 王晓兵 | A kind of Traditional Chinese medicine composite oral liquid of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature treatment heating |
| CN103536705A (en) * | 2013-11-08 | 2014-01-29 | 刘艳菊 | Traditional Chinese medicine composition for treating colitis |
| CN103536705B (en) * | 2013-11-08 | 2015-11-11 | 王玲 | A kind of Chinese medicine composition for the treatment of colitis |
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