CN1368316A - Nano medicine 'Shuxinjangzhi' and its preparing process - Google Patents
Nano medicine 'Shuxinjangzhi' and its preparing process Download PDFInfo
- Publication number
- CN1368316A CN1368316A CN 01102694 CN01102694A CN1368316A CN 1368316 A CN1368316 A CN 1368316A CN 01102694 CN01102694 CN 01102694 CN 01102694 A CN01102694 A CN 01102694A CN 1368316 A CN1368316 A CN 1368316A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- nano
- medicine
- part nanometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Shuxin Jiangzhi" for reducing blood fat is prepared from the nanometre powders of 11 Chinese medicinal materials including violet sage root, haw, safflower, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of blood circulation promoting and blood stasis dispelling, the nano medicine ' Shuxinjangzhi ' of the turbid descending that activates yang, promoting the circulation of QI to relieve pain, the invention still further relates to the method for this medication preparation.
Comfortable tablets of reducing blood fat is a kind of classical Chinese patent medicine, mainly contains blood circulation promoting and blood stasis dispelling, effects such as the turbid descending that activates yang, promoting the circulation of QI to relieve pain, is used for that the turbid numbness resistance of QI and blood expectorant, breast low are pained, palpitation and insomnia, gastral cavity painful abdominal mass are weak, coronary heart disease, hyperlipemia are seen above-mentioned shower.But traditional comfortable tablets of reducing blood fat disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Shuxinjangzhi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Shuxinjangzhi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Salviae Miltiorrhizae 120-250 part nanometer mustard wheat pollen 20-40 part nanometer Fructus Crataegi 120-250 part
Nanometer Rhizoma Polygoni Cuspidati 20-60 part nanometer Radix Puerariae 20-50 part nano safflower 20-50 part
Nanometer Bulbus Allii Macrostemonis 20-50 part nanometer Semen Persicae 6-18 part nanometer Caulis Spatholobi 20-55 part
Nanometer Lignum Dalbergiae Odoriferae 12-30 part nanometer Radix Paeoniae Rubra 20-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Salviae Miltiorrhizae 150-210 part nanometer mustard wheat pollen 25-35 part nanometer Fructus Crataegi 150-200 part
Nanometer Rhizoma Polygoni Cuspidati 25-50 part nanometer Radix Puerariae 25-45 part nano safflower 25-45 part
Nanometer Bulbus Allii Macrostemonis 25-45 part nanometer Semen Persicae 8-15 part nanometer Caulis Spatholobi 25-45 part
Nanometer Lignum Dalbergiae Odoriferae 15-25 part nanometer Radix Paeoniae Rubra 25-45 part
The optimum weight proportioning of medicine of the present invention is:
171.4 parts of 31.4 parts of nanometer Fructus Crataegis of 183 parts of nanometer mustard of nanometer Radix Salviae Miltiorrhizae wheat pollen
34.3 parts of 34.3 parts of nano safflowers of 34.3 parts of nanometer Radix Puerariaes of nanometer Rhizoma Polygoni Cuspidati
34.3 parts of 11.4 parts of nanometer Caulis Spatholobis of 34.3 parts of nanometer Semen Persicaes of nanometer Bulbus Allii Macrostemonis
34.3 parts of 17 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Shuxinjangzhi ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Shuxinjangzhi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common comfortable tablets of reducing blood fat preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Shuxinjangzhi ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that the resistance of the turbid numbness of QI and blood expectorant, breast low are pained, palpitation and insomnia, gastral cavity painful abdominal mass are weak, coronary heart disease, hyperlipemia are seen above-mentioned shower, and clinical efficacy significantly is better than traditional comfortable tablets of reducing blood fat.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
171.4 parts of 31.4 parts of nanometer Fructus Crataegis of 183 parts of nanometer mustard of nanometer Radix Salviae Miltiorrhizae wheat pollen
34.3 parts of 34.3 parts of nano safflowers of 34.3 parts of nanometer Radix Puerariaes of nanometer Rhizoma Polygoni Cuspidati
34.3 parts of 11.4 parts of nanometer Caulis Spatholobis of 34.3 parts of nanometer Semen Persicaes of nanometer Bulbus Allii Macrostemonis
34.3 parts of 17 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
171.4 parts of 31.4 parts of nanometer Fructus Crataegis of 183 parts of nanometer mustard of nanometer Radix Salviae Miltiorrhizae wheat pollen
34.3 parts of 34.3 parts of nano safflowers of 34.3 parts of nanometer Radix Puerariaes of nanometer Rhizoma Polygoni Cuspidati
34.3 parts of 11.4 parts of nanometer Caulis Spatholobis of 34.3 parts of nanometer Semen Persicaes of nanometer Bulbus Allii Macrostemonis
34.3 parts of 17 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the comfortable blood fat reducing powder needle injection of nanometer, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
171.4 parts of 31.4 parts of nanometer Fructus Crataegis of 183 parts of nanometer mustard of nanometer Radix Salviae Miltiorrhizae wheat pollen
34.3 parts of 34.3 parts of nano safflowers of 34.3 parts of nanometer Radix Puerariaes of nanometer Rhizoma Polygoni Cuspidati
34.3 parts of 11.4 parts of nanometer Caulis Spatholobis of 34.3 parts of nanometer Semen Persicaes of nanometer Bulbus Allii Macrostemonis
34.3 parts of 17 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the comfortable blood fat reducing membrane of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Shuxinjangzhi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Salviae Miltiorrhizae 120-250 part nanometer mustard wheat pollen 20-40 part nanometer Fructus Crataegi 120-250 part
Nanometer Rhizoma Polygoni Cuspidati 20-60 part nanometer Radix Puerariae 20-50 part nano safflower 20-50 part
Nanometer Bulbus Allii Macrostemonis 20-50 part nanometer Semen Persicae 6-18 part nanometer Caulis Spatholobi 20-55 part
Nanometer Lignum Dalbergiae Odoriferae 12-30 part nanometer Radix Paeoniae Rubra 20-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Shuxinjangzhi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Salviae Miltiorrhizae 150-210 part nanometer mustard wheat pollen 25-35 part nanometer Fructus Crataegi 150-200 part
Nanometer Rhizoma Polygoni Cuspidati 25-50 part nanometer Radix Puerariae 25-45 part nano safflower 25-45 part
Nanometer Bulbus Allii Macrostemonis 25-45 part nanometer Semen Persicae 8-15 part nanometer Caulis Spatholobi 25-45 part
Nanometer Lignum Dalbergiae Odoriferae 15-25 part nanometer Radix Paeoniae Rubra 25-45 part
3, nano medicine ' Shuxinjangzhi ' according to claim 1, wherein the weight proportion of each nano raw material is:
171.4 parts of 31.4 parts of nanometer Fructus Crataegis of 183 parts of nanometer mustard of nanometer Radix Salviae Miltiorrhizae wheat pollen
34.3 parts of 34.3 parts of nano safflowers of 34.3 parts of nanometer Radix Puerariaes of nanometer Rhizoma Polygoni Cuspidati
34.3 parts of 11.4 parts of nanometer Caulis Spatholobis of 34.3 parts of nanometer Semen Persicaes of nanometer Bulbus Allii Macrostemonis
34.3 parts of 17 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Shuxinjangzhi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Shuxinjangzhi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102694 CN1368316A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shuxinjangzhi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102694 CN1368316A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shuxinjangzhi' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368316A true CN1368316A (en) | 2002-09-11 |
Family
ID=4652925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102694 Pending CN1368316A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shuxinjangzhi' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368316A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690750A (en) * | 2013-12-13 | 2014-04-02 | 昆明振华制药厂有限公司 | Heart nourishing and lipid lowering tablet and preparation method thereof |
-
2001
- 2001-02-06 CN CN 01102694 patent/CN1368316A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690750A (en) * | 2013-12-13 | 2014-04-02 | 昆明振华制药厂有限公司 | Heart nourishing and lipid lowering tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368188A (en) | Nano medicine 'Weichangan' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1362203A (en) | Nano cold treating medicine of antelope's horn and its preparation | |
| CN1368316A (en) | Nano medicine 'Shuxinjangzhi' and its preparing process | |
| CN1360914A (en) | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method | |
| CN1368061A (en) | Nano meidcine 'Xiaoshuan Tongluo' and its preparing process | |
| CN1362207A (en) | Nano healthy energy restoring agastachis medicine and its preparation | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1363341A (en) | Nano medicine 'Jiuwei Qianghuo' and its preparing process | |
| CN1362098A (en) | Nano antiphlogistic forsythiae medicine and its preparation | |
| CN1365759A (en) | Nano antalgic medicine 'Zijin' and its preparing process | |
| CN1363311A (en) | Nano medicine 'Kaixiong Shunqi' and its preparing process | |
| CN1365750A (en) | Nano medicine 'Shaofu Zhuyu' and its preparing process | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1368101A (en) | Nano medicine 'Xiaobaidu' and its preparing process | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1368259A (en) | Nano medicine 'Yangweining' and its preparing process | |
| CN1365809A (en) | Nano medicine 'Fuke Tongjing' and its preparing process | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1368230A (en) | Nano medicine 'Canegongbu' and its preparing process | |
| CN1363333A (en) | Nano medicine 'Chenxiang Huazhi' and its preparing process | |
| CN1368078A (en) | Nano medicine 'Qingshengjianfei' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |