CN1363311A - Nano medicine 'Kaixiong Shunqi' and its preparing process - Google Patents
Nano medicine 'Kaixiong Shunqi' and its preparing process Download PDFInfo
- Publication number
- CN1363311A CN1363311A CN 01100234 CN01100234A CN1363311A CN 1363311 A CN1363311 A CN 1363311A CN 01100234 CN01100234 CN 01100234 CN 01100234 A CN01100234 A CN 01100234A CN 1363311 A CN1363311 A CN 1363311A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- nano
- part nanometer
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A nano medicine "Kaixiong Shunqi" is prepared from the nano powders of 12 Chinese-medicinal materials including areca seed, immature bitter orange, green tangerine peel, aucklandia root, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of pleasant the chest stuffiness relieving, the stagnant nano medicine ' Kaixiong Shunqi ' of removing food stagnancyization, the invention still further relates to the method for this medication preparation.
Kaixiong Shunqi Wan is a kind of classical Chinese patent medicine, mainly contain aid digestion, regulate gastrointestinal function and effect such as antibacterial, be used for eating and drinking without temperance, gas to the caused septum pectorale feeling of fullness of pent-up, diseases such as the acute gastroenteritis that distension uncomfortable in chest, stomach wrist pain, constipation and depression of QI cause, bacillary dysentery.But traditional Kaixiong Shunqi Wan disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Kaixiong Shunqi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Kaixiong Shunqi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Semen Arecae 10-50 part nanometer Fructus Aurantii Immaturus 10-50 part nanometer Pericarpium Citri Reticulatae Viride 8-50 part
Nanometer Radix Aucklandiae 10-50 part nanometer Cortex Magnoliae Officinalis 8-40 part nano rhubarb 5-40 part
Nanometer Radix Linderae 8-50 part nanometer Fructus Crataegi 10-50 part nanometer Massa Medicata Fermentata 10-50 part
Nanometer Fructus Hordei Germinatus 5-40 part nanometer Radix Glycyrrhizae 3-30 part nanometer Semen Raphani 5-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Semen Arecae 20-40 part nanometer Fructus Aurantii Immaturus 20-40 part nanometer Pericarpium Citri Reticulatae Viride 15-35 part
Nanometer Radix Aucklandiae 20-40 part nanometer Cortex Magnoliae Officinalis 15-35 part nano rhubarb 10-30 part
Nanometer Radix Linderae 15-35 part nanometer Fructus Crataegi 20-40 part nanometer Massa Medicata Fermentata 20-40 part
Nanometer Fructus Hordei Germinatus 10-30 part nanometer Radix Glycyrrhizae 8-25 part nanometer Semen Raphani 10-30 part
The optimum weight proportioning of medicine of the present invention is:
25 parts on 28 parts of nanometer Pericarpium Citri Reticulatae Virides of 30 parts of nanometer Fructus Aurantii Immaturuss of nanometer Semen Arecae
20 parts of 25 parts of nano rhubarbs of 30 parts of nanometer Cortex Magnoliae Officinalis of the nanometer Radix Aucklandiae
28 parts of 30 parts of nanometer Massa Medicata Fermentata of 25 parts of nanometer Fructus Crataegis of the nanometer Radix Linderae
20 parts of 15 parts of nanometer Semen Raphanis of 20 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Kaixiong Shunqi ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Kaixiong Shunqi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Kaixiong Shunqi Wan preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Kaixiong Shunqi ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as dyspepsia, acute gastroenteritis, bacillary dysentery, and clinical efficacy significantly is better than traditional Kaixiong Shunqi Wan.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts on 28 parts of nanometer Pericarpium Citri Reticulatae Virides of 30 parts of nanometer Fructus Aurantii Immaturuss of nanometer Semen Arecae
20 parts of 25 parts of nano rhubarbs of 30 parts of nanometer Cortex Magnoliae Officinalis of the nanometer Radix Aucklandiae
28 parts of 30 parts of nanometer Massa Medicata Fermentata of 25 parts of nanometer Fructus Crataegis of the nanometer Radix Linderae
20 parts of 15 parts of nanometer Semen Raphanis of 20 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts on 28 parts of nanometer Pericarpium Citri Reticulatae Virides of 30 parts of nanometer Fructus Aurantii Immaturuss of nanometer Semen Arecae
20 parts of 25 parts of nano rhubarbs of 30 parts of nanometer Cortex Magnoliae Officinalis of the nanometer Radix Aucklandiae
28 parts of 30 parts of nanometer Massa Medicata Fermentata of 25 parts of nanometer Fructus Crataegis of the nanometer Radix Linderae
20 parts of 15 parts of nanometer Semen Raphanis of 20 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer and open the pleasant powder needle injection of breast, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
25 parts on 28 parts of nanometer Pericarpium Citri Reticulatae Virides of 30 parts of nanometer Fructus Aurantii Immaturuss of nanometer Semen Arecae
20 parts of 25 parts of nano rhubarbs of 30 parts of nanometer Cortex Magnoliae Officinalis of the nanometer Radix Aucklandiae
28 parts of 30 parts of nanometer Massa Medicata Fermentata of 25 parts of nanometer Fructus Crataegis of the nanometer Radix Linderae
20 parts of 15 parts of nanometer Semen Raphanis of 20 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer and open the pleasant membrane of breast, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano medicine ' Kaixiong Shunqi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Semen Arecae 10-50 part nanometer Fructus Aurantii Immaturus 10-50 part nanometer Pericarpium Citri Reticulatae Viride 8-50 part
Nanometer Radix Aucklandiae 10-50 part nanometer Cortex Magnoliae Officinalis 8-40 part nano rhubarb 5-40 part
Nanometer Radix Linderae 8-50 part nanometer Fructus Crataegi 10-50 part nanometer Massa Medicata Fermentata 10-50 part
Nanometer Fructus Hordei Germinatus 5-40 part nanometer Radix Glycyrrhizae 3-30 part nanometer Semen Raphani 5-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Kaixiong Shunqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Semen Arecae 20-40 part nanometer Fructus Aurantii Immaturus 20-40 part nanometer Pericarpium Citri Reticulatae Viride 15-35 part
Nanometer Radix Aucklandiae 20-40 part nanometer Cortex Magnoliae Officinalis 15-35 part nano rhubarb 10-30 part
Nanometer Radix Linderae 15-35 part nanometer Fructus Crataegi 20-40 part nanometer Massa Medicata Fermentata 20-40 part
Nanometer Fructus Hordei Germinatus 10-30 part nanometer Radix Glycyrrhizae 8-25 part nanometer Semen Raphani 10-30 part
3, nano medicine ' Kaixiong Shunqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts on 28 parts of nanometer Pericarpium Citri Reticulatae Virides of 30 parts of nanometer Fructus Aurantii Immaturuss of nanometer Semen Arecae
20 parts of 25 parts of nano rhubarbs of 30 parts of nanometer Cortex Magnoliae Officinalis of the nanometer Radix Aucklandiae
28 parts of 30 parts of nanometer Massa Medicata Fermentata of 25 parts of nanometer Fructus Crataegis of the nanometer Radix Linderae
20 parts of 15 parts of nanometer Semen Raphanis of 20 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Kaixiong Shunqi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Kaixiong Shunqi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100234 CN1363311A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Kaixiong Shunqi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100234 CN1363311A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Kaixiong Shunqi' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1363311A true CN1363311A (en) | 2002-08-14 |
Family
ID=4651410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100234 Pending CN1363311A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Kaixiong Shunqi' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1363311A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797365A (en) * | 2010-04-21 | 2010-08-11 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN108686153A (en) * | 2017-04-06 | 2018-10-23 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating functional dyspepsia FD |
-
2001
- 2001-01-10 CN CN 01100234 patent/CN1363311A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797365A (en) * | 2010-04-21 | 2010-08-11 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN101797365B (en) * | 2010-04-21 | 2011-09-28 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN108686153A (en) * | 2017-04-06 | 2018-10-23 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating functional dyspepsia FD |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368188A (en) | Nano medicine 'Weichangan' and its preparing process | |
| CN1363311A (en) | Nano medicine 'Kaixiong Shunqi' and its preparing process | |
| CN1362184A (en) | Nano tonic ginsneg medicine and its preparation | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1368061A (en) | Nano meidcine 'Xiaoshuan Tongluo' and its preparing process | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1363341A (en) | Nano medicine 'Jiuwei Qianghuo' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1365717A (en) | Nano medicine 'Jianer Xiaoshi' and its preparing process | |
| CN1364489A (en) | Nano ten powerful tonics medicine and its preparing method | |
| CN1362248A (en) | Nano stomach-calming medicine of Aucklandiae and Amomi and its preparation | |
| CN1368343A (en) | Nano medicine 'Kanglebiyan' and its preparing process | |
| CN1362222A (en) | Nanometer blood-nourishing and transquilizing medicine and its preparation | |
| CN1368106A (en) | Nano medicine 'Xiaoer Xiaoshijianwei' and its preparing process | |
| CN1363333A (en) | Nano medicine 'Chenxiang Huazhi' and its preparing process | |
| CN1368316A (en) | Nano medicine 'Shuxinjangzhi' and its preparing process | |
| CN1362229A (en) | Nano Maiwei Rehmannine Praeparatae medicine and its preparation | |
| CN1362128A (en) | Nano tranquilizing and brain nourishing medicine and its preparation | |
| CN1365680A (en) | Nano medicine 'Suzi Jingqi' and its preparing process | |
| CN1362106A (en) | Nano Gengnian'an medicine for treating climacteric syndrome and its preparation | |
| CN1368170A (en) | Nano medicine 'Shenshu' and its preparing process | |
| CN1362177A (en) | Nano xiaozhiling medicine for treaitng piles and its preparation | |
| CN1362223A (en) | Nano Xinmaitong medicine and its preparation | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |