CN1362106A - Nano Gengnian'an medicine for treating climacteric syndrome and its preparation - Google Patents
Nano Gengnian'an medicine for treating climacteric syndrome and its preparation Download PDFInfo
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- CN1362106A CN1362106A CN 01100157 CN01100157A CN1362106A CN 1362106 A CN1362106 A CN 1362106A CN 01100157 CN01100157 CN 01100157 CN 01100157 A CN01100157 A CN 01100157A CN 1362106 A CN1362106 A CN 1362106A
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Abstract
The present invention discloses a nano Gengnian'an preparation medicine. It is made up by using 9 Chinese medicinal materials of nano cooked rehmannia, nano flowery knotweed, nano alisma, nano poria, nano schisandra and others as raw materials through the processes of microwave extraction, reduced pressure concentration and supersonic jet dspray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of nourishing YIN and clearing away heat, relieving restlessness is calmed the nerves, and is used for the nanometer GENGNIANAN preparation medicine of hectic fever that climacteric occurs, perspiration, dizzy, tinnitus, insomnia, dysphoria, unstable blood pressure, the invention still further relates to the method for this medication preparation.
GENGNIANAN PIAN is a kind of classical Chinese patent medicine, main calm, stable, memory reinforcing, the female activity of class, improve body fatigue resistance and effects such as immunologic function and antioxidation, be used for diseases such as hectic fever that climacteric occurs, perspiration, dizzy, tinnitus, insomnia, dysphoria, unstable blood pressure.But traditional GENGNIANAN PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer GENGNIANAN preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer GENGNIANAN preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae Preparata 5-60 part nanometer Radix Polygoni Multiflori 10-60 part nanometer Rhizoma Alismatis 5-50 part
The female 2-30 part of nano Poria 5-50 part nanometer Fructus Schisandrae Chinensis 10-50 part nano-pearl
Nanometer Caulis Polygoni Multiflori 5-50 part nanometer Radix Scrophulariae 5-40 part nanometer Fructus Tritici Levis 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae Preparata 10-50 part nanometer Radix Polygoni Multiflori 15-45 part nanometer Rhizoma Alismatis 10-30 part
The female 5-20 part of nano Poria 10-30 part nanometer Fructus Schisandrae Chinensis 15-45 part nano-pearl
Nanometer Caulis Polygoni Multiflori 10-30 part nanometer Radix Scrophulariae 10-30 part nanometer Fructus Tritici Levis 10-30 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 25 parts of nanometer Rhizoma Alismatis of 30 parts of nanometer Radix Polygoni Multiflori of nanometer Radix Rehmanniae Preparata
Female 10 parts of 25 parts of nano-pearls of 20 parts of nanometer Fructus Schisandrae Chinensis of nano Poria
20 parts of 15 parts of nanometer Fructus Tritici Levis of 20 parts of nanometer Radix Scrophulariae of nanometer Caulis Polygoni Multiflori
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, become the nanometer prepared slices of Chinese crude drugs under adding, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, get GENGNIANAN preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer GENGNIANAN preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common GENGNIANAN PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer GENGNIANAN preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as climacteric syndrome, and clinical efficacy significantly is better than traditional GENGNIANAN PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 25 parts of nanometer Rhizoma Alismatis of 30 parts of nanometer Radix Polygoni Multiflori of nanometer Radix Rehmanniae Preparata
Female 10 parts of 25 parts of nano-pearls of 20 parts of nanometer Fructus Schisandrae Chinensis of nano Poria
20 parts of 15 parts of nanometer Fructus Tritici Levis of 20 parts of nanometer Radix Scrophulariae of nanometer Caulis Polygoni Multiflori
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 25 parts of nanometer Rhizoma Alismatis of 30 parts of nanometer Radix Polygoni Multiflori of nanometer Radix Rehmanniae Preparata
Female 10 parts of 25 parts of nano-pearls of 20 parts of nanometer Fructus Schisandrae Chinensis of nano Poria
20 parts of 15 parts of nanometer Fructus Tritici Levis of 20 parts of nanometer Radix Scrophulariae of nanometer Caulis Polygoni Multiflori
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer GENGNIANAN powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
20 parts of 25 parts of nanometer Rhizoma Alismatis of 30 parts of nanometer Radix Polygoni Multiflori of nanometer Radix Rehmanniae Preparata
Female 10 parts of 25 parts of nano-pearls of 20 parts of nanometer Fructus Schisandrae Chinensis of nano Poria
20 parts of 15 parts of nanometer Fructus Tritici Levis of 20 parts of nanometer Radix Scrophulariae of nanometer Caulis Polygoni Multiflori
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer GENGNIANAN membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer GENGNIANAN preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae Preparata 5-60 part nanometer Radix Polygoni Multiflori 10-60 part nanometer Rhizoma Alismatis 5-50 part
The female 2-30 part of nano Poria 5-50 part nanometer Fructus Schisandrae Chinensis 10-50 part nano-pearl
Nanometer Caulis Polygoni Multiflori 5-50 part nanometer Radix Scrophulariae 5-40 part nanometer Fructus Tritici Levis 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer GENGNIANAN preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae Preparata 10-50 part nanometer Radix Polygoni Multiflori 15-45 part nanometer Rhizoma Alismatis 10-30 part
The female 5-20 part of nano Poria 10-30 part nanometer Fructus Schisandrae Chinensis 15-45 part nano-pearl
Nanometer Caulis Polygoni Multiflori 10-30 part nanometer Radix Scrophulariae 10-30 part nanometer Fructus Tritici Levis 10-30 part
3, nanometer GENGNIANAN preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 25 parts of nanometer Rhizoma Alismatis of 30 parts of nanometer Radix Polygoni Multiflori of nanometer Radix Rehmanniae Preparata
Female 10 parts of 25 parts of nano-pearls of 20 parts of nanometer Fructus Schisandrae Chinensis of nano Poria
20 parts of 15 parts of nanometer Fructus Tritici Levis of 20 parts of nanometer Radix Scrophulariae of nanometer Caulis Polygoni Multiflori
4, according to claim 1 or 2 or 3 described nanometer GENGNIANAN preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer GENGNIANAN preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100157 CN1362106A (en) | 2001-01-04 | 2001-01-04 | Nano Gengnian'an medicine for treating climacteric syndrome and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100157 CN1362106A (en) | 2001-01-04 | 2001-01-04 | Nano Gengnian'an medicine for treating climacteric syndrome and its preparation |
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| Publication Number | Publication Date |
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| CN1362106A true CN1362106A (en) | 2002-08-07 |
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| CN 01100157 Pending CN1362106A (en) | 2001-01-04 | 2001-01-04 | Nano Gengnian'an medicine for treating climacteric syndrome and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457147C (en) * | 2003-08-20 | 2009-02-04 | 山东凤凰制药股份有限公司 | Chinese medicine composition for treating climacteric metancholia for women and preparing method thereof |
-
2001
- 2001-01-04 CN CN 01100157 patent/CN1362106A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457147C (en) * | 2003-08-20 | 2009-02-04 | 山东凤凰制药股份有限公司 | Chinese medicine composition for treating climacteric metancholia for women and preparing method thereof |
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