CN1362203A - Nano cold treating medicine of antelope's horn and its preparation - Google Patents
Nano cold treating medicine of antelope's horn and its preparation Download PDFInfo
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- CN1362203A CN1362203A CN 01100701 CN01100701A CN1362203A CN 1362203 A CN1362203 A CN 1362203A CN 01100701 CN01100701 CN 01100701 CN 01100701 A CN01100701 A CN 01100701A CN 1362203 A CN1362203 A CN 1362203A
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Abstract
The present invention discloses a nano Lingyang-ganmao preparation medicine. It is made up by using 10 Chinese medicinal materials of nano antelope horn, nano arctium, naon fermented soybean, nano lonicera, nano schizonepeta and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of nano antelope common cold treating medicine of clearing away heat and expelling pathogen in the exterior, the invention still further relates to the method for this medication preparation.
Tablet of antelope horn for common cold is a kind of Chinese patent medicine of classics, is mainly used in influenza, the cough due to common cold, and dizzy heating, laryngopharynx swelling and pain, but traditional tablet of antelope horn for common cold disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antelope common cold treating medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antelope common cold treating medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano antelope horn 1-6 part nanometer Fructus Arctii 90-120 part nanometer Semen Sojae Preparatum 50-90 part
Nanometer gold Flos Lonicerae 140-180 part nanometer Herba Schizonepetae 60-100 part nanometer Fructus Forsythiae 140-180 part
Nanometer Herba Lophatheri 60-100 part nanometer Radix Platycodonis 90-110 part nanometer Mentholum 0.1-0.5 part
Nanometer Radix Glycyrrhizae 50-90 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano antelope horn 3-4 part nanometer Fructus Arctii 100-110 part nanometer Semen Sojae Preparatum 60-70 part
Nanometer gold Flos Lonicerae 160-170 part nanometer Herba Schizonepetae 80-90 part nanometer Fructus Forsythiae 160-170 part
Nanometer Herba Lophatheri 80-90 part nanometer Radix Platycodonis 100-110 part nanometer Oleum menthae 0.3-0.4 part
Nanometer Radix Glycyrrhizae 60-70 part
The optimum weight proportioning of medicine of the present invention is:
68 parts of 109 parts of nanometer Semen Sojae Preparatums of 3.4 parts of nanometer Fructus Arctiis of nano antelope horn
164 parts of 82 parts of nanometer Fructus Forsythiaes of 164 parts of nanometer Herba Schizonepetae of nanometer gold Flos Lonicerae
0.34 part of 109 portions of nanometer Oleum menthae of 82 parts of nanometer Radix Platycodoniss of nanometer Herba Lophatheri
68 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get Saigae Tataricae flu nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano antelope common cold treating medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common tablet of antelope horn for common cold preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano antelope common cold treating medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for upper respiratory tract infection, pneumonia, and measles, epidemic encephalitis type B, treatments such as pertussis, clinical efficacy significantly is better than traditional tablet of antelope horn for common cold.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
68 parts of 109 parts of nanometer Semen Sojae Preparatums of 3.4 parts of nanometer Fructus Arctiis of nano antelope horn
164 parts of 82 parts of nanometer Fructus Forsythiaes of 164 parts of nanometer Herba Schizonepetae of nanometer gold Flos Lonicerae
0.34 part of 109 portions of nanometer Oleum menthae of 82 parts of nanometer Radix Platycodoniss of nanometer Herba Lophatheri
68 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
68 parts of 109 parts of nanometer Semen Sojae Preparatums of 3.4 parts of nanometer Fructus Arctiis of nano antelope horn
164 parts of 82 parts of nanometer Fructus Forsythiaes of 164 parts of nanometer Herba Schizonepetae of nanometer gold Flos Lonicerae
0.34 part of 109 portions of nanometer Oleum menthae of 82 parts of nanometer Radix Platycodoniss of nanometer Herba Lophatheri
68 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano antelope flu powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
68 parts of 109 parts of nanometer Semen Sojae Preparatums of 3.4 parts of nanometer Fructus Arctiis of nano antelope horn
164 parts of 82 parts of nanometer Fructus Forsythiaes of 164 parts of nanometer Herba Schizonepetae of nanometer gold Flos Lonicerae
0.34 part of 109 portions of nanometer Oleum menthae of 82 parts of nanometer Radix Platycodoniss of nanometer Herba Lophatheri
68 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano antelope flu membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nano antelope common cold treating medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nano antelope horn 1-6 part nanometer Fructus Arctii 90-120 part nanometer Semen Sojae Preparatum 50-90 part
Nanometer gold Flos Lonicerae 140-180 part nanometer Herba Schizonepetae 60-100 part nanometer Fructus Forsythiae 140-180 part
Nanometer Herba Lophatheri 60-100 part nanometer Radix Platycodonis 90-110 part nanometer Mentholum 0.1-0.5 part
Nanometer Radix Glycyrrhizae 50-90 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antelope common cold treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano antelope horn 3-4 part nanometer Fructus Arctii 100-110 part nanometer Semen Sojae Preparatum 60-70 part
Nanometer gold Flos Lonicerae 160-170 part nanometer Herba Schizonepetae 80-90 part nanometer Fructus Forsythiae 160-170 part
Nanometer Herba Lophatheri 80-90 part nanometer Radix Platycodonis 100-110 part nanometer Oleum menthae 0.3-0.4 part
Nanometer Radix Glycyrrhizae 60-70 part
3, nano antelope common cold treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
68 parts of 109 parts of nanometer Semen Sojae Preparatums of 3.4 parts of nanometer Fructus Arctiis of nano antelope horn
164 parts of 82 parts of nanometer Fructus Forsythiaes of 164 parts of nanometer Herba Schizonepetae of nanometer gold Flos Lonicerae
0.34 part of 109 portions of nanometer Oleum menthae of 82 parts of nanometer Radix Platycodoniss of nanometer Herba Lophatheri
68 parts in nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antelope common cold treating medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antelope common cold treating medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100701 CN1362203A (en) | 2001-01-08 | 2001-01-08 | Nano cold treating medicine of antelope's horn and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100701 CN1362203A (en) | 2001-01-08 | 2001-01-08 | Nano cold treating medicine of antelope's horn and its preparation |
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| CN1362203A true CN1362203A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100701 Pending CN1362203A (en) | 2001-01-08 | 2001-01-08 | Nano cold treating medicine of antelope's horn and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552719A (en) * | 2010-12-24 | 2012-07-11 | 无锡济民可信山禾药业股份有限公司 | Method for adding volatile oil in preparation process of antelope cold capsule |
| CN101647547B (en) * | 2009-08-25 | 2012-08-29 | 张勇 | Burdock cooked with fermented soy beans |
| CN104606519A (en) * | 2013-11-04 | 2015-05-13 | 山东中泰药业有限公司 | Novel preparation method of antelope cold preparation |
| CN105596846A (en) * | 2016-01-27 | 2016-05-25 | 窦美芳 | Traditional Chinese medicine preparation for clinically nursing respiratory tract infection |
-
2001
- 2001-01-08 CN CN 01100701 patent/CN1362203A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647547B (en) * | 2009-08-25 | 2012-08-29 | 张勇 | Burdock cooked with fermented soy beans |
| CN102552719A (en) * | 2010-12-24 | 2012-07-11 | 无锡济民可信山禾药业股份有限公司 | Method for adding volatile oil in preparation process of antelope cold capsule |
| CN104606519A (en) * | 2013-11-04 | 2015-05-13 | 山东中泰药业有限公司 | Novel preparation method of antelope cold preparation |
| CN105596846A (en) * | 2016-01-27 | 2016-05-25 | 窦美芳 | Traditional Chinese medicine preparation for clinically nursing respiratory tract infection |
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