CN1362226A - Nano medicine of ten medicinal plant ashes and its preparation - Google Patents
Nano medicine of ten medicinal plant ashes and its preparation Download PDFInfo
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- CN1362226A CN1362226A CN 01100725 CN01100725A CN1362226A CN 1362226 A CN1362226 A CN 1362226A CN 01100725 CN01100725 CN 01100725 CN 01100725 A CN01100725 A CN 01100725A CN 1362226 A CN1362226 A CN 1362226A
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Abstract
The present invention discloses a nano Shihui preparation medicine. It is made up by using 10 Chinese medicinal materials of nano cirsium, nano cephthalaoplos, nano madder, nano gardenia, nano moutan and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 10-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of cooling blood for hemostasis, cure mainly the nano medicine of ten medicinal plant ashes of hemorrhage, the invention still further relates to the method for this medication preparation.
SHIHUI SAN is a kind of classical Chinese patent medicine, mainly contains anastalsis, is used for haematemesis, epistaxis, metrorrhagia and all blood and goes out more than all diseases.But traditional SHIHUI SAN absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine of ten medicinal plant ashes of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine of ten medicinal plant ashes.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Cirsii Japonici 40-120 part nanometer Herba Cirsii 40-120 part nanometer Radix Rubiae 40-120 part
Nanometer Fructus Gardeniae 40-120 part nanometer Cortex Moutan 40-120 part nanometer Petiolus Trachycarpi 40-120 part
Nanometer Cacumen Platycladi 40-120 part nanometer Rhizoma Imperatae 40-120 part nano rhubarb 40-120 part
Nano-lotus leaf 40-120 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Cirsii Japonici 60-100 part nanometer Herba Cirsii 60-100 part nanometer Radix Rubiae 60-100 part
Nanometer Fructus Gardeniae 60-100 part nanometer Cortex Moutan 60-100 part nanometer Petiolus Trachycarpi 60-100 part
Nanometer Cacumen Platycladi 60-100 part nanometer Rhizoma Imperatae 60-100 part nano rhubarb 60-100 part
Nano-lotus leaf 60-100 part
The optimum weight proportioning of medicine of the present invention is:
80 parts in 80 parts of nanometer Radix Rubiaes of 80 parts of nanometer Herba Cirsiis of nanometer Radix Cirsii Japonici
80 parts on 80 parts of nanometer Petiolus Trachycarpis of 80 parts of nanometer Cortex Moutans of nanometer Fructus Gardeniae
80 parts of 80 parts of nano rhubarbs of 80 parts of nanometer Rhizoma Imperataes of nanometer Cacumen Platycladi
80 parts of nano-lotus leafs
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get ten grey preparation nano powders with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine of ten medicinal plant ashes is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common SHIHUI SAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine of ten medicinal plant ashes etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that hemoptysis of pulmonary tuberculosis, hyphema, hemoptysis caused by bronchiectasis, digestive tract ulcer are hemorrhage, the treatment of women's menorrhagia, dysfunctional uterine hemorrhage, epistaxis, hematuria and other all agnogenio hemorrhages, and clinical efficacy significantly is better than traditional SHIHUI SAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
80 parts in 80 parts of nanometer Radix Rubiaes of 80 parts of nanometer Herba Cirsiis of nanometer Radix Cirsii Japonici
80 parts on 80 parts of nanometer Petiolus Trachycarpis of 80 parts of nanometer Cortex Moutans of nanometer Fructus Gardeniae
80 parts of 80 parts of nano rhubarbs of 80 parts of nanometer Rhizoma Imperataes of nanometer Cacumen Platycladi
80 parts of nano-lotus leafs
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
80 parts in 80 parts of nanometer Radix Rubiaes of 80 parts of nanometer Herba Cirsiis of nanometer Radix Cirsii Japonici
80 parts on 80 parts of nanometer Petiolus Trachycarpis of 80 parts of nanometer Cortex Moutans of nanometer Fructus Gardeniae
80 parts of 80 parts of nano rhubarbs of 80 parts of nanometer Rhizoma Imperataes of nanometer Cacumen Platycladi
80 parts of nano-lotus leafs
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer ten grey powder needle injections, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
80 parts in 80 parts of nanometer Radix Rubiaes of 80 parts of nanometer Herba Cirsiis of nanometer Radix Cirsii Japonici
80 parts on 80 parts of nanometer Petiolus Trachycarpis of 80 parts of nanometer Cortex Moutans of nanometer Fructus Gardeniae
80 parts of 80 parts of nano rhubarbs of 80 parts of nanometer Rhizoma Imperataes of nanometer Cacumen Platycladi
80 parts of nano-lotus leafs
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer ten grey membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine of ten medicinal plant ashes is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Cirsii Japonici 40-120 part nanometer Herba Cirsii 40-120 part nanometer Radix Rubiae 40-120 part
Nanometer Fructus Gardeniae 40-120 part nanometer Cortex Moutan 40-120 part nanometer Petiolus Trachycarpi 40-120 part
Nanometer Cacumen Platycladi 40-120 part nanometer Rhizoma Imperatae 40-120 part nano rhubarb 40-120 part
Nano-lotus leaf 40-120 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine of ten medicinal plant ashes according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Cirsii Japonici 60-100 part nanometer Herba Cirsii 60-100 part nanometer Radix Rubiae 60-100 part
Nanometer Fructus Gardeniae 60-100 part nanometer Cortex Moutan 60-100 part nanometer Petiolus Trachycarpi 60-100 part
Nanometer Cacumen Platycladi 60-100 part nanometer Rhizoma Imperatae 60-100 part nano rhubarb 60-100 part
Nano-lotus leaf 60-100 part
3, nano medicine of ten medicinal plant ashes according to claim 1, wherein the weight proportion of each nano raw material is:
80 parts in 80 parts of nanometer Radix Rubiaes of 80 parts of nanometer Herba Cirsiis of nanometer Radix Cirsii Japonici
80 parts on 80 parts of nanometer Petiolus Trachycarpis of 80 parts of nanometer Cortex Moutans of nanometer Fructus Gardeniae
80 parts of 80 parts of nano rhubarbs of 80 parts of nanometer Rhizoma Imperataes of nanometer Cacumen Platycladi
80 parts of nano-lotus leafs
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine of ten medicinal plant ashes.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine of ten medicinal plant ashes; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100725 CN1362226A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of ten medicinal plant ashes and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100725 CN1362226A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of ten medicinal plant ashes and its preparation |
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| Publication Number | Publication Date |
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| CN1362226A true CN1362226A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100725 Pending CN1362226A (en) | 2001-01-08 | 2001-01-08 | Nano medicine of ten medicinal plant ashes and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106551343A (en) * | 2015-09-16 | 2017-04-05 | 哈尔滨灵椿味道食品开发有限公司 | A kind of Radix Rubiae cooling blood for hemostasis soup stock and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100725 patent/CN1362226A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106551343A (en) * | 2015-09-16 | 2017-04-05 | 哈尔滨灵椿味道食品开发有限公司 | A kind of Radix Rubiae cooling blood for hemostasis soup stock and preparation method thereof |
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