CN1362243A - Nano toxic expelling medicine with five ingredients and its preparation - Google Patents
Nano toxic expelling medicine with five ingredients and its preparation Download PDFInfo
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- CN1362243A CN1362243A CN 01100745 CN01100745A CN1362243A CN 1362243 A CN1362243 A CN 1362243A CN 01100745 CN01100745 CN 01100745 CN 01100745 A CN01100745 A CN 01100745A CN 1362243 A CN1362243 A CN 1362243A
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Abstract
The present invention discloses a nano Wufu toxin-diminishing preparation medicine. It is made up by using 11 Chinese medicinal materials of nano water buffalo horn concentrated powder, nano forsythia, nano indigo, nano coptis, nano arctium and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the detumescence of a kind of heat-clearing and toxic substances removing, removing heat from blood, cure mainly the children's skin infection of pyretic toxicity due to penting up, hidradenitis suppurativa, laryngopharynx swelling and pain, mouthful give birth to the nanometer five ingredients toxic expelling preparation medicine of skin ulcer, dental haemorrhage, mumps, the invention still further relates to the method for this medication preparation.
Wufu huadu pills is a kind of classical Chinese patent medicine, mainly contains antiinflammatory, resisting pathogenic microbes, antiallergic, effect such as analgesic, is used for the children's skin infection of pyretic toxicity due to penting up, hidradenitis suppurativa, laryngopharynx swelling and pain, mouthful gives birth to skin ulcer, dental haemorrhage, mumps.But traditional wufu huadu pills absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer five ingredients toxic expelling preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer five ingredients toxic expelling preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Pulvis Cornus Bubali Concentratus 5-30 part nanometer Fructus Forsythiae 30-70 part nano natural indigo 30-75 part
Nanometer coptis 30-60 part nanometer Fructus Arctii 40-80 part nanometer Radix Scrophulariae 30-60 part
Nanometer Radix Rehmanniae 30-70 part nanometer Radix Platycodonis 20-50 part nanometer Natrii Sulfas 15-40 part
Nanometer Radix Paeoniae Rubra 20-50 part nanometer Radix Glycyrrhizae 10-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Pulvis Cornus Bubali Concentratus 5-30 part nanometer Fructus Forsythiae 30-70 part nano natural indigo 30-75 part
Nanometer coptis 30-60 part nanometer Fructus Arctii 40-80 part nanometer Radix Scrophulariae 30-60 part
Nanometer Radix Rehmanniae 30-70 part nanometer Radix Platycodonis 20-50 part nanometer Natrii Sulfas 15-40 part
Nanometer Radix Paeoniae Rubra 20-50 part nanometer Radix Glycyrrhizae 10-30 part
The optimum weight proportioning of medicine of the present invention is:
55 parts of 50 parts of nano natural indigos of 10 parts of nanometer Fructus Forsythiaes of nanometer Pulvis Cornus Bubali Concentratus
40 parts of 60 portions of nanometer Radix Scrophulariaes of 45 parts of nanometer Fructus Arctiis of nanometer coptis
25 parts in 38 parts of nanometer Natrii Sulfas of 50 parts of nanometer Radix Platycodoniss of nanometer Radix Rehmanniae
20 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Paeoniae Rubra
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get five ingredients toxic expelling preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer five ingredients toxic expelling preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale; common wufu huadu pills preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1-200nm; the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nanometer five ingredients toxic expelling preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for various viruses, bacterial infection and the treatment of conditions such as disease that cause, and clinical efficacy significantly is better than traditional wufu huadu pills.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
55 parts of 50 parts of nano natural indigos of 10 parts of nanometer Fructus Forsythiaes of nanometer Pulvis Cornus Bubali Concentratus
40 parts of 60 portions of nanometer Radix Scrophulariaes of 45 parts of nanometer Fructus Arctiis of nanometer coptis
25 parts in 38 parts of nanometer Natrii Sulfas of 50 parts of nanometer Radix Platycodoniss of nanometer Radix Rehmanniae
20 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Paeoniae Rubra
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
55 parts of 50 parts of nano natural indigos of 10 parts of nanometer Fructus Forsythiaes of nanometer Pulvis Cornus Bubali Concentratus
40 parts of 60 portions of nanometer Radix Scrophulariaes of 45 parts of nanometer Fructus Arctiis of nanometer coptis
25 parts in 38 parts of nanometer Natrii Sulfas of 50 parts of nanometer Radix Platycodoniss of nanometer Radix Rehmanniae
20 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Paeoniae Rubra
Production method is as follows:
In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard; filmogen adopts polyvinyl alcohol; make nanometer five ingredients toxic expelling membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer five ingredients toxic expelling preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Pulvis Cornus Bubali Concentratus 5-30 part nanometer Fructus Forsythiae 30-70 part nano natural indigo 30-75 part
Nanometer coptis 30-60 part nanometer Fructus Arctii 40-80 part nanometer Radix Scrophulariae 30-60 part
Nanometer Radix Rehmanniae 30-70 part nanometer Radix Platycodonis 20-50 part nanometer Natrii Sulfas 15-40 part
Nanometer Radix Paeoniae Rubra 20-50 part nanometer Radix Glycyrrhizae 10-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nanometer five ingredients toxic expelling preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Pulvis Cornus Bubali Concentratus 5-30 part nanometer Fructus Forsythiae 30-70 part nano natural indigo 30-75 part
Nanometer coptis 30-60 part nanometer Fructus Arctii 40-80 part nanometer Radix Scrophulariae 30-60 part
Nanometer Radix Rehmanniae 30-70 part nanometer Radix Platycodonis 20-50 part nanometer Natrii Sulfas 15-40 part
Nanometer Radix Paeoniae Rubra 20-50 part nanometer Radix Glycyrrhizae 10-30 part
3, nanometer five ingredients toxic expelling preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
55 parts of 50 parts of nano natural indigos of 10 parts of nanometer Fructus Forsythiaes of nanometer Pulvis Cornus Bubali Concentratus
40 parts of 60 portions of nanometer Radix Scrophulariaes of 45 parts of nanometer Fructus Arctiis of nanometer coptis
25 parts in 38 parts of nanometer Natrii Sulfas of 50 parts of nanometer Radix Platycodoniss of nanometer Radix Rehmanniae
20 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Paeoniae Rubra
4, according to claim 1 or 2 or 3 described nanometer five ingredients toxic expelling preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer five ingredients toxic expelling preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100745 CN1362243A (en) | 2001-01-08 | 2001-01-08 | Nano toxic expelling medicine with five ingredients and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100745 CN1362243A (en) | 2001-01-08 | 2001-01-08 | Nano toxic expelling medicine with five ingredients and its preparation |
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| CN1362243A true CN1362243A (en) | 2002-08-07 |
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| CN 01100745 Pending CN1362243A (en) | 2001-01-08 | 2001-01-08 | Nano toxic expelling medicine with five ingredients and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027714A (en) * | 2014-07-03 | 2014-09-10 | 杨东东 | Traditional Chinese medicine for treating prickly heat |
| CN109646659A (en) * | 2018-12-28 | 2019-04-19 | 卢浩 | It is a kind of to treat cirsoid dressing |
-
2001
- 2001-01-08 CN CN 01100745 patent/CN1362243A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027714A (en) * | 2014-07-03 | 2014-09-10 | 杨东东 | Traditional Chinese medicine for treating prickly heat |
| CN109646659A (en) * | 2018-12-28 | 2019-04-19 | 卢浩 | It is a kind of to treat cirsoid dressing |
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