CN1362144A - Nano urination decreasing medicine and its preparation - Google Patents
Nano urination decreasing medicine and its preparation Download PDFInfo
- Publication number
- CN1362144A CN1362144A CN 01100197 CN01100197A CN1362144A CN 1362144 A CN1362144 A CN 1362144A CN 01100197 CN01100197 CN 01100197 CN 01100197 A CN01100197 A CN 01100197A CN 1362144 A CN1362144 A CN 1362144A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- urination
- medicine
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a nano Suoquan preparatino medicine. It is made up by using the Chinese medicinal materials of nano alpinia, nano lindera and nano dioscorea as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of the kidney warming and end something lost, cure mainly the nano urination decreasing preparation medicine of frequent micturition, the enuresis, the invention still further relates to the method for this medication preparation.
Pill for Decreasing Urination is a kind of classical Chinese patent medicine, mainly contains effects such as diuresis, is used for below element deficiency and cold, frequent micturition, and disease such as bed-wetting.But traditional Pill for Decreasing Urination disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano urination decreasing preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano urination decreasing preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Alpiniae Oxyphyllae 5-50 part nanometer Radix Linderae 10-60 part nanometer Rhizoma Dioscoreae 10-70 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Alpiniae Oxyphyllae 10-30 part nanometer Radix Linderae 15-40 part nanometer Rhizoma Dioscoreae 20-50 part
The optimum weight proportioning of medicine of the present invention is:
28 parts of 25 parts of nanometer Rhizoma Dioscoreaes of 20 parts of nanometer Radixs Linderae of nanometer Fructus Alpiniae Oxyphyllae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, spring preparation nano powder must contract;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano urination decreasing preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Pill for Decreasing Urination preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano urination decreasing preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as frequent micturition, the enuresis, sialorrhea, and clinical efficacy significantly is better than traditional Pill for Decreasing Urination.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Dioscoreaes of 20 parts of nanometer Radixs Linderae of nanometer Fructus Alpiniae Oxyphyllae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Dioscoreaes of 20 parts of nanometer Radixs Linderae of nanometer Fructus Alpiniae Oxyphyllae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano urination decreasing powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Dioscoreaes of 20 parts of nanometer Radixs Linderae of nanometer Fructus Alpiniae Oxyphyllae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano urination decreasing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano urination decreasing preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Alpiniae Oxyphyllae 5-50 part nanometer Radix Linderae 10-60 part nanometer Rhizoma Dioscoreae 10-70 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano urination decreasing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Alpiniae Oxyphyllae 10-30 part nanometer Radix Linderae 15-40 part nanometer Rhizoma Dioscoreae 20-50 part
3, nano urination decreasing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
28 parts of 25 parts of nanometer Rhizoma Dioscoreaes of 20 parts of nanometer Radixs Linderae of nanometer Fructus Alpiniae Oxyphyllae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano urination decreasing preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano urination decreasing preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100197 CN1362144A (en) | 2001-01-05 | 2001-01-05 | Nano urination decreasing medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100197 CN1362144A (en) | 2001-01-05 | 2001-01-05 | Nano urination decreasing medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362144A true CN1362144A (en) | 2002-08-07 |
Family
ID=4651377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100197 Pending CN1362144A (en) | 2001-01-05 | 2001-01-05 | Nano urination decreasing medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362144A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078557A (en) * | 2011-01-19 | 2011-06-01 | 广州中医药大学 | Medicament for treating enuresis |
-
2001
- 2001-01-05 CN CN 01100197 patent/CN1362144A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078557A (en) * | 2011-01-19 | 2011-06-01 | 广州中医药大学 | Medicament for treating enuresis |
| CN102078557B (en) * | 2011-01-19 | 2012-01-11 | 广州中医药大学 | Medicament for treating enuresis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1366896A (en) | Nano hemp intestine-moistening preparation medicine and preparation method thereof | |
| CN1362144A (en) | Nano urination decreasing medicine and its preparation | |
| CN1362081A (en) | Nano tranquilizing cinnabar medicine and its preparation | |
| CN1362199A (en) | Nano girald daphne medicine and its preparation | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1364561A (en) | Nano Bitongning medicine and its preparing method | |
| CN1366978A (en) | Nane common cold-fever-abating preparation medicine and preparation method | |
| CN1362111A (en) | Nano Guzhining medicine and its preparation | |
| CN1362102A (en) | Nano shengqi medicine and its preparation | |
| CN1365771A (en) | Nano medicine 'Liuyi' and its preparing process | |
| CN1368117A (en) | Nano medicine for developing infantile intelligence and its preparing process | |
| CN1364539A (en) | Nano Yushusan medicine and its preparing method | |
| CN1362238A (en) | Nano analgesic Rhizome corydalis medicine and its preparation | |
| CN1365766A (en) | Nano medicine 'Wuji' and its preparing process | |
| CN1362135A (en) | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation | |
| CN1362248A (en) | Nano stomach-calming medicine of Aucklandiae and Amomi and its preparation | |
| CN1368215A (en) | Nano medicine 'Compound Dahuang' and its preparing process | |
| CN1366965A (en) | Nano wind-cold Ganmaoning preparation medicine and preparation method | |
| CN1365737A (en) | Nano medicine 'Jiawei Guiqi' and its preparing process | |
| CN1365768A (en) | Nano 6-component Anxiao medicine and its preparing process | |
| CN1365693A (en) | Nano medicine for treating cervical cancer and its preparing process | |
| CN1365769A (en) | Nano medicine 'Kanggan' and its preparing process | |
| CN1366954A (en) | Nano Xuanmai Ganju preparation medicine and preparation method | |
| CN1365684A (en) | Nano haw medicine and its preparing process | |
| CN1362094A (en) | Nano reinforced loquet medicine and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |