CN1362135A - Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation - Google Patents
Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation Download PDFInfo
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- CN1362135A CN1362135A CN 01100188 CN01100188A CN1362135A CN 1362135 A CN1362135 A CN 1362135A CN 01100188 CN01100188 CN 01100188 CN 01100188 A CN01100188 A CN 01100188A CN 1362135 A CN1362135 A CN 1362135A
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Abstract
The present invention discloses a nano Yinzhihuang preparation medicine. It is made up by using the Chinese medicinal materials of nano capillaries extract, nano gardenia extract, nano scutellaria glycosici and nano lonicera extract as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, dampness removing jaundice eliminating, cure mainly icterohepatitis, acute and chronic liver-fire, chronic persistent hepatitis, the nanometer YINZHIHUANG ZHIJI medicine of neonate ABO type hemolytic jaundice and hepatitis gravis the invention still further relates to the method for this medication preparation.
Yinzhihuang Injection is a kind of classical Chinese patent medicine, mainly contain protect the liver, promoting the function of the gallbladder to alleviate jaundice, enhance immunity function and antibiotic, antiviral, antiinflammatory, effect such as analgesic, be used for icterohepatitis, acute and chronic liver-fire, chronic persistent hepatitis, neonate ABO type hemolytic jaundice and hepatitis gravis etc.But traditional Yinzhihuang Injection disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer YINZHIHUANG ZHIJI medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer YINZHIHUANG ZHIJI medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Artemisiae Scopariae extract 3-8 part nanometer Fructus Gardeniae extract 2-5 part nanometer baicalin 10-30 part
Nanometer gold silver flower extract (in chlorogenic acid) 2-6 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Artemisiae Scopariae extract 5-7 part nanometer Fructus Gardeniae extract 2-4 part nanometer baicalin 15-25 part
Nanometer gold silver flower extract (in chlorogenic acid) 3-5 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 3.2 parts of nanometer baicalins of 6 parts of nanometer Fructus Gardeniae extracts of nanometer Herba Artemisiae Scopariae extract
4 parts of nanometer gold silver flower extracts (in chlorogenic acid)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the YINZHIHUANG ZHIJI nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer YINZHIHUANG ZHIJI medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Yinzhihuang Injection preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, membrane, capsule, microcapsule, drop pill, aerosol, unguentum, medicated wine, syrup of nanometer YINZHIHUANG ZHIJI medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for infectious disease, jaundice, and the hepatitis syndrome, treatment of conditions such as hyperbilirubinemia, clinical efficacy significantly is better than traditional Yinzhihuang Injection.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 3.2 parts of nanometer baicalins of 6 parts of nanometer Fructus Gardeniae extracts of nanometer Herba Artemisiae Scopariae extract
4 parts of nanometer gold silver flower extracts (in chlorogenic acid)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 3.2 parts of nanometer baicalins of 6 parts of nanometer Fructus Gardeniae extracts of nanometer Herba Artemisiae Scopariae extract
4 parts of nanometer gold silver flower extracts (in chlorogenic acid)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer mattress Cape jasmine bloom needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
20 parts of 3.2 parts of nanometer baicalins of 6 parts of nanometer Fructus Gardeniae extracts of nanometer Herba Artemisiae Scopariae extract
4 parts of nanometer gold silver flower extracts (in chlorogenic acid)
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the yellow membrane of nanometer mattress Cape jasmine, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer YINZHIHUANG ZHIJI medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Artemisiae Scopariae extract 3-8 part nanometer Fructus Gardeniae extract 2-5 part nanometer baicalin 10-30 part
Nanometer gold silver flower extract (in chlorogenic acid) 2-6 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer YINZHIHUANG ZHIJI medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Artemisiae Scopariae extract 5-7 part nanometer Fructus Gardeniae extract 2-4 part nanometer baicalin 15-25 part
Nanometer gold silver flower extract (in chlorogenic acid) 3-5 part
3, nanometer YINZHIHUANG ZHIJI medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 3.2 parts of nanometer baicalins of 6 parts of nanometer Fructus Gardeniae extracts of nanometer Herba Artemisiae Scopariae extract
4 parts of nanometer gold silver flower extracts (in chlorogenic acid)
4, according to claim 1 or 2 or 3 described nanometer YINZHIHUANG ZHIJI medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer YINZHIHUANG ZHIJI medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100188 CN1362135A (en) | 2001-01-04 | 2001-01-04 | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100188 CN1362135A (en) | 2001-01-04 | 2001-01-04 | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation |
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| CN1362135A true CN1362135A (en) | 2002-08-07 |
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| CN 01100188 Pending CN1362135A (en) | 2001-01-04 | 2001-01-04 | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107149621A (en) * | 2017-05-19 | 2017-09-12 | 任凤兰 | Treat external use plaster of icterus neonatorum and preparation method thereof |
| CN111419923A (en) * | 2020-03-20 | 2020-07-17 | 鲁南制药集团股份有限公司 | Yinzhihuang micro capsule preparation and its preparing method |
-
2001
- 2001-01-04 CN CN 01100188 patent/CN1362135A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107149621A (en) * | 2017-05-19 | 2017-09-12 | 任凤兰 | Treat external use plaster of icterus neonatorum and preparation method thereof |
| CN111419923A (en) * | 2020-03-20 | 2020-07-17 | 鲁南制药集团股份有限公司 | Yinzhihuang micro capsule preparation and its preparing method |
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