CN1363297A - Nano medicine 'Anluotong' and its preparing process - Google Patents
Nano medicine 'Anluotong' and its preparing process Download PDFInfo
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- CN1363297A CN1363297A CN 01100220 CN01100220A CN1363297A CN 1363297 A CN1363297 A CN 1363297A CN 01100220 CN01100220 CN 01100220 CN 01100220 A CN01100220 A CN 01100220A CN 1363297 A CN1363297 A CN 1363297A
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Abstract
A nano medicine "Anluotong" is prepared from nano Anluo marasmic extract in alcohol and nano Anluo marasmic powder through proportioning microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biologic utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Anluotong ' of a kind of dredge the meridian passage, promoting blood circulation and stopping pain, the invention still further relates to the method for this medication preparation.
The logical sheet of CNNS is a kind of classical Chinese patent medicine, mainly contains effects such as dredge the meridian passage, promoting blood circulation and stopping pain, is used for diseases such as sciatica, trigeminal neuralgia, rheumatic arthralgia.But the logical sheet disintegrate of traditional CNNS is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Anluotong ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Anluotong '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer marasmius androsaceus ethanol extraction 60-150 part nanometer Marasmius androsaceus (L.ex Fr.) Fr. mycopowder 60-150 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer marasmius androsaceus ethanol extraction 80-120 part nanometer Marasmius androsaceus (L.ex Fr.) Fr. mycopowder 80-120 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 100 parts of nanometer Marasmius androsaceus (L.ex Fr.) Fr. of nanometer marasmius androsaceus ethanol extraction mycopowder
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Anluotong ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Anluotong ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the logical tablet preparation material of common CNNS is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Anluotong ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as sciatica, trigeminal neuralgia, rheumatic arthralgia, and clinical efficacy significantly is better than the logical sheet of traditional CNNS.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Marasmius androsaceus (L.ex Fr.) Fr. of nanometer marasmius androsaceus ethanol extraction mycopowder
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Marasmius androsaceus (L.ex Fr.) Fr. of nanometer marasmius androsaceus ethanol extraction mycopowder
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the logical powder needle injection of nanometer CNNS, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Marasmius androsaceus (L.ex Fr.) Fr. of nanometer marasmius androsaceus ethanol extraction mycopowder
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the logical membrane of nanometer CNNS, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano medicine ' Anluotong ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer marasmius androsaceus ethanol extraction 60-150 part nanometer Marasmius androsaceus (L.ex Fr.) Fr. mycopowder 60-150 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Anluotong ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer marasmius androsaceus ethanol extraction 80-120 part nanometer Marasmius androsaceus (L.ex Fr.) Fr. mycopowder 80-120 part
3, nano medicine ' Anluotong ' according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 100 parts of nanometer Marasmius androsaceus (L.ex Fr.) Fr. of nanometer marasmius androsaceus ethanol extraction mycopowder
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Anluotong 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Anluotong 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100220 CN1363297A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Anluotong' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100220 CN1363297A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Anluotong' and its preparing process |
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| Publication Number | Publication Date |
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| CN1363297A true CN1363297A (en) | 2002-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100220 Pending CN1363297A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Anluotong' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005075423A1 (en) * | 2004-01-30 | 2005-08-18 | Beijing Tuolin Medicine Science And Technology Co., Ltd | Extracts of marasmins androsaceus l.es, piperdinone derivatives and the use as antihypertensive agents |
| CN100353828C (en) * | 2004-06-04 | 2007-12-12 | 毛福森 | Composite fungus product for raising human body immunity and its prepn process |
-
2001
- 2001-01-10 CN CN 01100220 patent/CN1363297A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005075423A1 (en) * | 2004-01-30 | 2005-08-18 | Beijing Tuolin Medicine Science And Technology Co., Ltd | Extracts of marasmins androsaceus l.es, piperdinone derivatives and the use as antihypertensive agents |
| US7608630B2 (en) | 2004-01-30 | 2009-10-27 | Hainan Yangpu New Special Pharmaceutical Co., Ltd. | Marasmius androsaceus L.es Fr extract, piperidone derivative, and their use for the preparation of hypertensives |
| CN100353828C (en) * | 2004-06-04 | 2007-12-12 | 毛福森 | Composite fungus product for raising human body immunity and its prepn process |
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