CN1362151A - Nano Mayinglong pile-treating musk medicine and its preparation - Google Patents
Nano Mayinglong pile-treating musk medicine and its preparation Download PDFInfo
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- CN1362151A CN1362151A CN 01100305 CN01100305A CN1362151A CN 1362151 A CN1362151 A CN 1362151A CN 01100305 CN01100305 CN 01100305 CN 01100305 A CN01100305 A CN 01100305A CN 1362151 A CN1362151 A CN 1362151A
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Abstract
The present invention discloses a nano Mayinglong shexiang zhichuang preparation medicine. It is made up by using the Chinese medicinal materials of nano musk, nano bovine bezoar, nano pearl, nano smithsonite, nano borax and nano borneol as raw material through the processes of microwave extraction, reduced pressure concretration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation cure mainly all kinds of hemorrhoid, anal fissure, and the nano Mayinglong pile-treating musk medicine of anal eczema the invention still further relates to the method for this medication preparation.
MAYINGLONG MUSK HEMORRHOID UNGUENTUM is a kind of classical Chinese patent medicine, mainly contains effects such as antiinflammatory, analgesia, hemostasis.Be used for all kinds of hemorrhoid, anal fissure, diseases such as anal eczema.But traditional MAYINGLONG MUSK HEMORRHOID UNGUENTUM disintegrate is slower, and absorption is incomplete, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Mayinglong pile-treating musk medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Mayinglong pile-treating musk medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano musk 2-10 part nano bezoar 3-20 part nano-pearl 5-40 part
Nanometer Calamina (forging) 30-180 part nanometer Borax 30-180 part nanometer Borneolum Syntheticum 2-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano musk 3-8 part nano bezoar 5-15 part nano-pearl 10-30 part
Nanometer Calamina (forging) 50-150 part nanometer Borax 50-150 part nanometer Borneolum Syntheticum 3-8 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 10 parts of nano-pearls of 5 parts of nano bezoars of nano musk
5 parts of 100 parts of nanometer Borneolum Syntheticums of 100 parts of nanometer Boraxs of nanometer Calamina (forging)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral dropping liquid agent.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, keep the tower internal pressure-0.09 to-0.01MPa, with the instantaneous drying of hypersonic velocity jet, get Ma Yinglong Moschus hemorrhoid nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Mayinglong pile-treating musk medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Mayinglong pile-treating musk material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection of Mayinglong pile-treating musk medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, and to the treatment of rash such as anal fissure, anal eczema, clinical efficacy significantly is better than traditional MAYINGLONG MUSK HEMORRHOID UNGUENTUM.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 10 parts of nano-pearls of 5 parts of nano bezoars of nano musk
5 parts of 100 parts of nanometer Borneolum Syntheticums of 100 parts of nanometer Boraxs of nanometer Calamina (forging)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 10 parts of nano-pearls of 5 parts of nano bezoars of nano musk
5 parts of 100 parts of nanometer Borneolum Syntheticums of 100 parts of nanometer Boraxs of nanometer Calamina (forging)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer Ma Yinglong Moschus hemorrhoid powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano material by preceding method:
20 parts of 10 parts of nano-pearls of 5 parts of nano bezoars of nano musk
5 parts of 100 parts of nanometer Borneolum Syntheticums of 100 parts of nanometer Boraxs of nanometer Calamina (forging)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Ma Yinglong Moschus hemorrhoid membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano Mayinglong pile-treating musk medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nano musk 2-10 part nano bezoar 3-20 part nano-pearl 5-40 part
Nanometer Calamina (forging) 30-180 part nanometer Borax 30-180 part nanometer Borneolum Syntheticum 2-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the vacuum, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Mayinglong pile-treating musk medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano musk 3-8 part nano bezoar 5-15 part nano-pearl 10-30 part
Nanometer Calamina (forging) 50-150 part nanometer Borax 50-150 part nanometer Borneolum Syntheticum 3-8 part
3, nano Mayinglong pile-treating musk medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 10 parts of nano-pearls of 5 parts of nano bezoars of nano musk
5 parts of 100 parts of nanometer Borneolum Syntheticums of 100 parts of nanometer Boraxs of nanometer Calamina (forging)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral dropping liquid agent according to claim 1 or 2 or 3 described nano Mayinglong pile-treating musk medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Mayinglong pile-treating musk medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100305 CN1362151A (en) | 2001-01-02 | 2001-01-02 | Nano Mayinglong pile-treating musk medicine and its preparation |
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| CN 01100305 CN1362151A (en) | 2001-01-02 | 2001-01-02 | Nano Mayinglong pile-treating musk medicine and its preparation |
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| CN1362151A true CN1362151A (en) | 2002-08-07 |
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| CN 01100305 Pending CN1362151A (en) | 2001-01-02 | 2001-01-02 | Nano Mayinglong pile-treating musk medicine and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285059A (en) * | 2013-06-15 | 2013-09-11 | 彭辉容 | Medicament for treating haemorrhoids |
| CN103393724A (en) * | 2013-08-13 | 2013-11-20 | 杨海娟 | Ointment for treating perianal abscess and preparation method thereof |
| CN114652750A (en) * | 2022-03-08 | 2022-06-24 | 马应龙药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for preventing colorectal cancer |
| CN114748531A (en) * | 2022-05-26 | 2022-07-15 | 赵岩 | External itching relieving composition for hemodialysis patients and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100305 patent/CN1362151A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285059A (en) * | 2013-06-15 | 2013-09-11 | 彭辉容 | Medicament for treating haemorrhoids |
| CN103393724A (en) * | 2013-08-13 | 2013-11-20 | 杨海娟 | Ointment for treating perianal abscess and preparation method thereof |
| CN103393724B (en) * | 2013-08-13 | 2015-05-20 | 杨海娟 | Ointment for treating perianal abscess and preparation method thereof |
| CN114652750A (en) * | 2022-03-08 | 2022-06-24 | 马应龙药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for preventing colorectal cancer |
| CN114748531A (en) * | 2022-05-26 | 2022-07-15 | 赵岩 | External itching relieving composition for hemodialysis patients and preparation method thereof |
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