CN1362181A - Nano fritillary-loquat medicine and its preparation - Google Patents
Nano fritillary-loquat medicine and its preparation Download PDFInfo
- Publication number
- CN1362181A CN1362181A CN 01100336 CN01100336A CN1362181A CN 1362181 A CN1362181 A CN 1362181A CN 01100336 CN01100336 CN 01100336 CN 01100336 A CN01100336 A CN 01100336A CN 1362181 A CN1362181 A CN 1362181A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- fritillary
- medicine
- loquat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano chuanbei-piba preparation medicine. It is made up by using the Chinese medicinal materials of nano sichuan fritillaria, nano platycodon, nano loquat leaf and nano mentha camphor as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size dis 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, cure mainly the nano fritillary-loquat preparation medicine of cold cough, the invention still further relates to the method for this medication preparation.
Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae is a kind of classical Chinese patent medicine, mainly contains cough-relieving, reduces phlegm, relievings asthma, effect such as antibacterial, analgesic, is used for cold cough and bronchitis.But traditional Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano fritillary-loquat preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano fritillary-loquat preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 30-70 part of nano Sichuan fritillary bulb nanometer Radix Platycodonis 30-70 part nanometer Folium Eriobotryae 200-400 part
Nanometer Mentholum 02-0.5 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 40-60 part of nano Sichuan fritillary bulb nanometer Radix Platycodonis 40-60 part nanometer Folium Eriobotryae 250-350 part
Nanometer Mentholum 0.3-0.4 part
The optimum weight proportioning of medicine of the present invention is:
300 parts of 45 parts of nanometer Folium Eriobotryaes of the female 45 parts of nanometer Radix Platycodonis of nano Sichuan fritillary bulb
0.34 part of nanometer Mentholum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material--the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get fritillary-loquat preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano fritillary-loquat preparation medicine is identical
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of nano fritillary-loquat preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough, asthma, and clinical efficacy significantly is better than traditional Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
300 parts of 45 parts of nanometer Folium Eriobotryaes of the female 45 parts of nanometer Radix Platycodonis of nano Sichuan fritillary bulb
0.34 part of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
300 parts of 45 parts of nanometer Folium Eriobotryaes of the female 45 parts of nanometer Radix Platycodonis of nano Sichuan fritillary bulb
0.34 part of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make the nano fritillary-loquat powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
300 parts of 45 parts of nanometer Folium Eriobotryaes of the female 45 parts of nanometer Radix Platycodonis of nano Sichuan fritillary bulb
0.34 part of nanometer Mentholum
Prepare nano raw material by preceding method
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make the nano fritillary-loquat membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position:: back, chest.
Claims (6)
1, a kind of nano fritillary-loquat preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 30-70 part of nano Sichuan fritillary bulb nanometer Radix Platycodonis 30-70 part nanometer Folium Eriobotryae 200-400 part
Nanometer Mentholum 02-0.5 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano fritillary-loquat preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The female 40-60 part of nano Sichuan fritillary bulb nanometer Radix Platycodonis 40-60 part nanometer Folium Eriobotryae 250-350 part
Nanometer Mentholum 0.3-0.4 part
3, nano fritillary-loquat preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
300 parts of 45 parts of nanometer Folium Eriobotryaes of the female 45 parts of nanometer Radix Platycodonis of nano Sichuan fritillary bulb
0.34 part of nanometer Mentholum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano fritillary-loquat preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano fritillary-loquat preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100336 CN1362181A (en) | 2001-01-02 | 2001-01-02 | Nano fritillary-loquat medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100336 CN1362181A (en) | 2001-01-02 | 2001-01-02 | Nano fritillary-loquat medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362181A true CN1362181A (en) | 2002-08-07 |
Family
ID=4651505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100336 Pending CN1362181A (en) | 2001-01-02 | 2001-01-02 | Nano fritillary-loquat medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362181A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358562C (en) * | 2004-11-26 | 2008-01-02 | 北京正大绿洲医药科技有限公司 | Tendril-leaved fritillary bulb loquat drop pills and preparation method thereof |
| CN101204510B (en) * | 2006-12-21 | 2011-04-20 | 杨文龙 | Preparation and detection method of Chinese traditional medicine preparation |
| CN101219200B (en) * | 2007-01-08 | 2012-10-17 | 杨文龙 | Traditional Chinese medicine soft capsule and preparing method thereof |
| CN104689035A (en) * | 2015-03-06 | 2015-06-10 | 云南中烟工业有限责任公司 | Aerosol precursor containing pharmacodynamic ingredients of Chuanbei Pipa syrup and method for dispersing aerosol precursor into nano-scale frog drops |
| CN113951510A (en) * | 2021-02-19 | 2022-01-21 | 北京鹤年堂中医医院管理(集团)有限公司 | Snow pear paste and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100336 patent/CN1362181A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358562C (en) * | 2004-11-26 | 2008-01-02 | 北京正大绿洲医药科技有限公司 | Tendril-leaved fritillary bulb loquat drop pills and preparation method thereof |
| CN101204510B (en) * | 2006-12-21 | 2011-04-20 | 杨文龙 | Preparation and detection method of Chinese traditional medicine preparation |
| CN101219200B (en) * | 2007-01-08 | 2012-10-17 | 杨文龙 | Traditional Chinese medicine soft capsule and preparing method thereof |
| CN104689035A (en) * | 2015-03-06 | 2015-06-10 | 云南中烟工业有限责任公司 | Aerosol precursor containing pharmacodynamic ingredients of Chuanbei Pipa syrup and method for dispersing aerosol precursor into nano-scale frog drops |
| CN113951510A (en) * | 2021-02-19 | 2022-01-21 | 北京鹤年堂中医医院管理(集团)有限公司 | Snow pear paste and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1362181A (en) | Nano fritillary-loquat medicine and its preparation | |
| CN1362170A (en) | Nano body resistance-strengthening Zhenqi medicine and its preparation | |
| CN1364538A (en) | Nano bronchitis treating medicine and its preparing method | |
| CN1366942A (en) | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method | |
| CN1362081A (en) | Nano tranquilizing cinnabar medicine and its preparation | |
| CN1364568A (en) | Nano cough relieving medicine and its preparing method | |
| CN1364543A (en) | Nano apricot kernel and perilla antitussive medicine and its preparing method | |
| CN1364482A (en) | Nano wild jujube seed mecicine and its preparing method | |
| CN1365794A (en) | Nano medicine 'Xingnaojing' and its preparing process | |
| CN1365757A (en) | Nano antitussive asthma-relieving medicine and its preparing process | |
| CN1368092A (en) | Nano medicine 'Mahuangzhike' and its preparing process | |
| CN1368117A (en) | Nano medicine for developing infantile intelligence and its preparing process | |
| CN1362238A (en) | Nano analgesic Rhizome corydalis medicine and its preparation | |
| CN1364472A (en) | Nano five ingredient musk medicine and its preparing method | |
| CN1366978A (en) | Nane common cold-fever-abating preparation medicine and preparation method | |
| CN1362102A (en) | Nano shengqi medicine and its preparation | |
| CN1365724A (en) | Nano compound antitussive platycodon root medicine and its preparing process | |
| CN1362094A (en) | Nano reinforced loquet medicine and its preparation | |
| CN1362145A (en) | Nano snake bile-fritillary-loquat medicine and its preparation | |
| CN1362097A (en) | Nano Guilong Kechuanning medicine and its preparation | |
| CN1365745A (en) | Nano 4-component elecampane inula medicine and its preparing process | |
| CN1368218A (en) | Nano compound medicine for treating hepatitides and its preparing process | |
| CN1362119A (en) | Nano natural indigo medicine and its preparation | |
| CN1362118A (en) | Nano liushen medicine and its preparation | |
| CN1362219A (en) | Nano Zhichuanling medicine for treating asthma and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |