CN107149621A - Treat external use plaster of icterus neonatorum and preparation method thereof - Google Patents
Treat external use plaster of icterus neonatorum and preparation method thereof Download PDFInfo
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- CN107149621A CN107149621A CN201710358141.4A CN201710358141A CN107149621A CN 107149621 A CN107149621 A CN 107149621A CN 201710358141 A CN201710358141 A CN 201710358141A CN 107149621 A CN107149621 A CN 107149621A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
The invention belongs to field of traditional Chinese medicine technology, and in particular to a kind of to treat external use plaster of icterus neonatorum and preparation method thereof.The external use plaster for the treatment of icterus neonatorum of the present invention, is made up of the Chinese medicine material of following parts by weight：12 15 parts of oriental wormwood, 11 15 parts of cape jasmine, 9 12 parts of radix scutellariae, 69 parts of golden cypress, 69 parts of honeysuckle, 36 parts of hickory chick.The present invention is carried out scientific compatibility, is complemented each other, with synergy, heat-clearing can be played jointly using the Chinese medicine of different drug effects, removing toxic substances, dampness removing, the effect of removing jaundice can cure mainly the jaundice caused by liver and gallbladder damp-heat, symptoms include appearance knows Huang, distending pain in the chest and hypochondrium, nausea and vomiting, dark urine；Red blood cell life span can be extended, the generation of bilirubin is reduced, promote the excretion of bilirubin；Especially newborn skin is thin, and drug absorption is good, and effect is rather good；Described preparation method, it is scientific and reasonable, simple and easy to apply.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external patch for treating neonatal jaundice and a preparation method thereof.
Background
The jaundice of the baby in the short month (within 28 days of birth) is called neonatal jaundice in medicine, which is characterized by that the blood bilirubin level is increased due to abnormal bilirubin metabolism in the neonatal period, and the neonatal jaundice is manifested in skin, mucous membrane and sclera. The disease is divided into physiological symptoms and pathological symptoms, physiological jaundice appears 2-3 days after birth, the peak is reached in 4-6 days, the premature infant subsides in 7-10 days, the duration of the premature infant is long, and no other clinical symptoms exist except slight inappetence. If jaundice occurs within 24 hours after the onset, the jaundice still does not return for 2-3 weeks, and even jaundice begins to occur after the jaundice is continuously deepened or removed or repeatedly occurs within one to several weeks after the onset, all jaundice are pathological jaundice.
The neonatal jaundice incidence rate is 60-80%, the Yinzhihuang oral liquid is a common method, the neonatal is small, the oral medicine is inconvenient to take, and the injection and the transfusion are very inconvenient.
The medicine is taken, the injection and the infusion are performed to the neonatal jaundice, great pain is brought to the patient, and the side effect brought by the injection and the infusion is great. The clinical treatment has poor curative effect and slow response, brings great pain to patients, and urgently needs an effective medicament to improve the condition.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an external patch for treating neonatal jaundice, which can reduce jaundice index, eliminate jaundice, effectively improve liver function, clear away heat and toxic materials, promote diuresis and remove jaundice; the invention also provides a preparation method thereof.
The invention relates to an external patch for treating neonatal jaundice, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12-15 parts of oriental wormwood, 11-15 parts of cape jasmine, 9-12 parts of scutellaria baicalensis, 6-9 parts of golden cypress, 6-9 parts of honeysuckle and 3-6 parts of morchella esculenta.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12-14 parts of oriental wormwood, 11-14 parts of cape jasmine, 10-12 parts of scutellaria baicalensis, 8-9 parts of golden cypress, 6-8 parts of honeysuckle and 3-6 parts of morchella esculenta.
More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of oriental wormwood, 11 parts of cape jasmine, 10 parts of scutellaria baicalensis, 9 parts of golden cypress, 6 parts of honeysuckle and 3-6 parts of morchella esculenta.
The preparation method of the external patch for treating neonatal jaundice, which is disclosed by the invention, comprises the following steps of:
(1) pulverizing herba Artemisiae Scopariae, fructus Gardeniae, Scutellariae radix, cortex Phellodendri, flos Lonicerae, and Morchella esculenta, sieving to obtain Chinese medicinal fine powder, mixing with glycerol, and soaking to obtain Chinese medicinal mixture;
(2) adding honey into the pot, heating to yellowish with slow fire, pouring the traditional Chinese medicine mixed solution obtained in the step (1) for decocting, pouring out and cooling after decocting is finished to obtain a decocted mixed solution;
(3) and (3) uniformly mixing the decocted mixed solution obtained in the step (2) with sesame oil to obtain the external patch for treating neonatal jaundice.
In the step (1), the sieving is performed by a sieve of 100-150 meshes, and the crushing of the medicament is favorable for separating out effective components, thereby improving the curative effect of the medicament. When the particle size is too large, the effective components are not separated out, and when the particle size is too small, the particles may penetrate the skin to block pores.
In the step (1), the soaking time is 24-36 hours, the medicine and the solvent are fully and uniformly mixed once every 6-8 hours in the soaking process, and the effective components are fully separated out. The time is short, the analysis amount of the effective components is less, and the drug effect is not increased after the time is too long.
In the step (1), the dosage of the glycerol is 0.3-0.5 times of the total mass of the virgate wormwood herb, the cape jasmine fruit, the baical skullcap root, the amur corktree bark, the honeysuckle flower and the morchella, and the traditional Chinese medicine powder can be fully mixed with the glycerol, is moderate in viscosity and is beneficial to being pasted and taken.
Preferably, in the step (1), the amount of the glycerol is 0.4 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the phellodendron amurense, the honeysuckle and the morchella esculenta.
In the step (2), the boiling time is 5-8 minutes, and the stirring is continuously carried out in the boiling process.
In the step (2), the dosage of the honey is 0.3-0.4 times of the total mass of the virgate wormwood herb, the cape jasmine fruit, the baical skullcap root, the amur corktree bark, the honeysuckle flower and the morchella, and the honey has the functions of detoxifying, resisting oxidation, improving the immunity of the organism and harmonizing the medicines.
Preferably, in the step (2), the amount of the honey is 0.35 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the phellodendron amurense, the honeysuckle and the morchella esculenta.
The application method and the dosage are as follows: the patch of the present invention is applied to the trunk for treatment, preferably 1cm above the umbilicus. Each patch is 50g, each patch is applied for one day, and the patch is applied in the morning for 5 days as 1 treatment course, and 3 treatment courses are used continuously.
The mechanism of the medicine in the invention is as follows:
herba Artemisiae Scopariae is the monarch drug, has effects of clearing heat and promoting diuresis, and eliminating jaundice.
Gardenia is bitter in taste and cold in nature, is a ministerial drug, and has the effects of clearing heat, promoting diuresis, purging pathogenic fire and relieving restlessness.
The scutellaria is bitter and cold and is a ministerial drug, and has the functions of clearing heat, drying dampness, purging fire and detoxifying.
Phellodendron bark, cortex Phellodendri has effects of clearing heat and eliminating dampness, purging fire and removing toxic substance, and relieving fever and steaming.
The morchella is rich in 18 amino acids, contains at least 8 vitamins, contains polysaccharide for inhibiting tumor, and active components for resisting bacteria and viruses, and has the effects of enhancing immunity of organism, resisting fatigue and viruses, inhibiting tumor and the like. The selenium contained in the product is a component of human erythrocyte glutathione peroxidase, can delay the destruction of erythrocytes, can transport a large amount of oxygen molecules to promote the excretion of bilirubin, has the functions of invigorating spleen and benefiting intestines and stomach, can treat dyspepsia such as dyspepsia, qi stagnation caused by food stagnation, abdominal distention and the like, and is a good traditional Chinese medicine for tonifying liver and kidney, nourishing brain and refreshing.
The honey has the functions of detoxifying, resisting oxidation, improving the immunity of the organism and harmonizing the medicines.
The oriental wormwood, the cape jasmine fruit, the baical skullcap root and the amur corktree bark are compatible, so that the effect of clearing damp-heat is enhanced, and the honeysuckle flower with the effect of clearing heat and detoxifying is used as adjuvant in the formula, so that the effects of clearing heat, detoxifying, promoting diuresis and removing jaundice are achieved together. The morchella can prolong the service life of red blood cells and reduce the generation of bilirubin; a large amount of essential amino acids and vitamins can help the newborn to generate protein first, and a large amount of oxygen molecules are transported by red blood cells to promote the generation of combined bilirubin, so that the excretion is facilitated; has effects of invigorating spleen, benefiting intestine and stomach, promoting gastrointestinal peristalsis, reducing enterohepatic circulation, and promoting bilirubin excretion from digestive tract.
The indications and the efficacies of the above medicines are all referred to as follows: the textbook of traditional Chinese medicine academy of medicine, traditional Chinese medicine science.
The following is a summary of clinical trials: 87 cases of neonatal jaundice are treated by clinical tests.
Neonatal jaundice symptoms:
(1) all the children patients are born 6-28 days later.
(2) Jaundice of skin, mucous membrane, sclera, and face and chest are more obvious.
(3) Jaundice index (serum bilirubin value: normal <17.1umol) is higher than normal.
The treatment scheme comprises the following steps: the patch of the present invention is applied to the trunk for treatment, preferably 1cm above the umbilicus. Each patch is 50g, each patch is applied for one day, and the patch is applied in the morning for 5 days as 1 treatment course, and 3 treatment courses are used continuously.
Treatment criteria were:
and (3) healing: jaundice disappears, the color of skin and mucosa is basically normal, and the jaundice index is normal.
The method has the following advantages: jaundice basically disappears, the skin and mucous membrane are yellowish, and the jaundice index is normal.
And (4) invalidation: jaundice does not disappear, the skin and mucous membrane are yellow, and the jaundice index is increased.
The treatment results are as follows: after 3 treatment courses of treatment, 62 cases of neonatal jaundice patients are cured, accounting for 71.3 percent; 23 cases of effectiveness account for 26.4 percent; 2 cases of no treatment, accounting for 2.3%, were organic jaundice and were treated by surgery; the total effective rate is 97.7%.
16 of the above children patients with jaundice of 18-32 index; 34 cases of jaundice index 33-80; 31 cases of jaundice index 81-160; 6 cases with jaundice index above 160.
All the children adopt gallium nitride light-emitting diodes as light sources, and give phototherapy of 24-48 hours of high-intensity narrow-spectrum blue-green light irradiation.
Several typical cases are listed below:
case 1: the infant may be born for 8 days in a male, and has significant jaundice index 122 on the face and chest due to jaundice in the skin, mucous membranes and sclera. The external application of the patch for treating neonatal jaundice is to apply 1 patch every day in the morning. After being applied for 2 courses of treatment, jaundice disappears, and jaundice index is normal.
Case 2: when a child suffers from jaundice for 5 days, the jaundice gradually worsens in 12 days, which is a certain child, the jaundice index is 137. The external application of the patch for treating neonatal jaundice is to apply 1 patch every day in the morning. After being applied for 2 courses of treatment, jaundice disappears, and jaundice index is normal.
Case 3: when a patient waits for a certain time, male, 15 days, the jaundice is found for 8 days, and after blue light irradiation and general treatment, the jaundice is ineffective and gradually worsened, and the jaundice index is increased to 172. The external application of the patch for treating neonatal jaundice is to apply 1 patch every day in the morning. After being pasted for 3 courses of treatment, jaundice disappears, and jaundice index is normal.
The clinical application of the medicine of the invention shows that the medicine has the following advantages:
(1) the Chinese herbal medicines selected by the invention all conform to the regulation of pharmacopoeia of the people's republic of China.
(2) The traditional Chinese medicine composition adopts the traditional Chinese medicinal materials with different efficacies to carry out scientific compatibility, supplements each other, has a synergistic effect, and can play the roles of clearing heat, detoxifying, promoting diuresis and removing jaundice together.
(3) The patch for treating neonatal jaundice can be mainly used for treating jaundice caused by damp-heat in liver and gallbladder, and symptoms of yellow complexion, distending pain in chest and hypochondrium, nausea and vomiting and yellow and reddish urine are seen; especially, the skin of the newborn is thin, the medicine absorption is good, and the effect is quite good.
(4) The invention adopts the traditional method for preparing the traditional Chinese medicine, is convenient to take and easy to accept, and has high patient compliance rate.
(5) The preparation method provided by the invention is scientific, reasonable, simple and feasible.
Detailed Description
The present invention is further illustrated by, but is not limited to, the following examples.
Example 1
The external patch for treating neonatal jaundice is prepared from the following traditional Chinese medicine raw materials in parts by weight:
12 parts of oriental wormwood, 11 parts of cape jasmine, 10 parts of scutellaria baicalensis, 9 parts of golden cypress, 6 parts of honeysuckle and 3 parts of morchella esculenta.
The preparation method comprises the following steps:
(1) pulverizing herba Artemisiae Scopariae, fructus Gardeniae, Scutellariae radix, cortex Phellodendri, flos Lonicerae, and Morchella esculenta, sieving with 125 mesh sieve to obtain Chinese medicinal fine powder, mixing with glycerol, soaking for 30 hr, and stirring once every 7 hr during soaking to obtain Chinese medicinal mixed solution;
(2) adding honey into the pot, heating to yellowish with slow fire, pouring the traditional Chinese medicine mixed solution obtained in the step (1), decocting for 6 minutes, pouring out and cooling after the decoction is finished, so as to obtain a decocted mixed solution;
(3) and (3) uniformly mixing the decocted mixed solution obtained in the step (2) with sesame oil to obtain the external patch for treating neonatal jaundice.
Wherein,
the dosage of the glycerol is 0.4 times of the total mass of the virgate wormwood herb, the gardenia, the baical skullcap root, the amur corktree bark, the honeysuckle and the morchella.
The amount of the honey is 0.35 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the phellodendron amurense, the honeysuckle and the morchella esculenta.
Example 2
The external patch for treating neonatal jaundice is prepared from the following traditional Chinese medicine raw materials in parts by weight:
14 parts of oriental wormwood, 14 parts of cape jasmine, 12 parts of scutellaria baicalensis, 9 parts of golden cypress, 8 parts of honeysuckle and 4 parts of morchella esculenta.
The preparation method comprises the following steps:
(1) pulverizing herba Artemisiae Scopariae, fructus Gardeniae, Scutellariae radix, cortex Phellodendri, flos Lonicerae and Morchella esculenta, sieving with 150 mesh sieve to obtain Chinese medicinal fine powder, mixing with glycerol, soaking for 24 hr while stirring every 6 hr to obtain Chinese medicinal mixed solution;
(2) adding honey into the pot, heating to yellowish with slow fire, pouring the traditional Chinese medicine mixed solution obtained in the step (1), decocting for 8 minutes, pouring out and cooling after the decoction is finished, so as to obtain a decocted mixed solution;
(3) and (3) uniformly mixing the decocted mixed solution obtained in the step (2) with sesame oil to obtain the external patch for treating neonatal jaundice.
Wherein,
the dosage of the glycerol is 0.3 times of the total mass of the virgate wormwood herb, the gardenia, the baical skullcap root, the amur corktree bark, the honeysuckle and the morchella.
The amount of the honey is 0.3 times of the total mass of the virgate wormwood herb, the gardenia, the baical skullcap root, the amur corktree bark, the honeysuckle and the morchella.
Example 3
The external patch for treating neonatal jaundice is prepared from the following traditional Chinese medicine raw materials in parts by weight:
12 parts of oriental wormwood, 11 parts of cape jasmine, 11 parts of scutellaria baicalensis, 6 parts of golden cypress, 9 parts of honeysuckle and 6 parts of morchella esculenta.
The preparation method comprises the following steps:
(1) pulverizing herba Artemisiae Scopariae, fructus Gardeniae, Scutellariae radix, cortex Phellodendri, flos Lonicerae and Morchella esculenta, sieving with 100 mesh sieve to obtain Chinese medicinal fine powder, mixing with glycerol, soaking for 36 hr while stirring every 8 hr to obtain Chinese medicinal mixed solution;
(2) adding honey into a pot, heating to yellowish with slow fire, pouring the traditional Chinese medicine mixed solution obtained in the step (1), decocting for 5 minutes, pouring out and cooling after the decoction is finished, so as to obtain a decocted mixed solution;
(3) and (3) uniformly mixing the decocted mixed solution obtained in the step (2) with sesame oil to obtain the external patch for treating neonatal jaundice.
Wherein,
the dosage of the glycerol is 0.5 times of the total mass of the virgate wormwood herb, the gardenia, the baical skullcap root, the amur corktree bark, the honeysuckle and the morchella.
The amount of the honey is 0.4 times of the total mass of the virgate wormwood herb, the gardenia, the baical skullcap root, the amur corktree bark, the honeysuckle and the morchella.
Claims (10)
1. An external patch for treating neonatal jaundice is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12-15 parts of oriental wormwood, 11-15 parts of cape jasmine, 9-12 parts of scutellaria baicalensis, 6-9 parts of golden cypress, 6-9 parts of honeysuckle and 3-6 parts of morchella esculenta.
2. The external patch for treating neonatal jaundice according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12-14 parts of oriental wormwood, 11-14 parts of cape jasmine, 10-12 parts of scutellaria baicalensis, 8-9 parts of golden cypress, 6-8 parts of honeysuckle and 3-6 parts of morchella esculenta.
3. The external patch for treating neonatal jaundice according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of oriental wormwood, 11 parts of cape jasmine, 10 parts of scutellaria baicalensis, 9 parts of golden cypress, 6 parts of honeysuckle and 3 parts of morchella esculenta.
4. A method of preparing an external patch for treating neonatal jaundice as claimed in any one of claims 1 to 3, characterized in that: the method comprises the following steps:
(1) pulverizing herba Artemisiae Scopariae, fructus Gardeniae, Scutellariae radix, cortex Phellodendri, flos Lonicerae and Morchella esculenta, sieving to obtain Chinese medicinal fine powder, mixing with glycerol, and soaking to obtain Chinese medicinal mixture;
(2) adding honey into the pot, heating to yellowish with slow fire, pouring the traditional Chinese medicine mixed solution obtained in the step (1) for decocting, pouring out and cooling after decocting is finished to obtain a decocted mixed solution;
(3) and (3) uniformly mixing the decocted mixed solution obtained in the step (2) with sesame oil to obtain the external patch for treating neonatal jaundice.
5. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 4, wherein the external patch comprises: in the step (1), the sieving is performed by a sieve of 100-150 meshes.
6. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 4, wherein the external patch comprises: in the step (1), the soaking time is 24-36 hours, and the stirring is carried out once every 6-8 hours in the soaking process.
7. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 4, wherein the external patch comprises: in the step (1), the amount of the glycerol is 0.3-0.5 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the golden cypress, the honeysuckle and the morchella esculenta.
8. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 7, wherein the external patch comprises: in the step (1), the amount of the glycerol is 0.4 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the golden cypress, the honeysuckle and the morchella.
9. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 4, wherein the external patch comprises: in the step (2), the boiling time is 5-8 minutes, and the stirring is continuously carried out in the boiling process.
10. The method of preparing an external patch for treating neonatal jaundice as claimed in claim 4, wherein the external patch comprises: in the step (2), the amount of the honey is 0.3-0.4 times of the total mass of the virgate wormwood herb, the gardenia, the scutellaria baicalensis, the golden cypress, the honeysuckle and the morchella esculenta.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578635A (en) * | 2018-04-25 | 2018-09-28 | 杭州市红十字会医院 | A kind of newborn's Chinese medicine removing jaundice shower cream and preparation method thereof |
| CN109893622A (en) * | 2019-03-14 | 2019-06-18 | 广西中医药大学附属瑞康医院 | A kind of external washout with traditional Chinese herbs side of icterus neonatorum |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362135A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation |
-
2017
- 2017-05-19 CN CN201710358141.4A patent/CN107149621A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362135A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation |
Non-Patent Citations (4)
| Title |
|---|
| 丁青艾等: "《养生保健大辞典》", 28 February 1997, 科学技术文献出版社 * |
| 于竹力等: "《常见病症简易疗法·儿童篇》", 31 January 2012, 上海世界图书出版公司 * |
| 周德生等: "《皮茎木叶花树脂和菌藻类中草药彩色图鉴》", 30 June 2016, 湖南科学技术出版社 * |
| 陶汉华: "《中医内科临证诊疗备要》", 30 April 2013, 中国医药科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578635A (en) * | 2018-04-25 | 2018-09-28 | 杭州市红十字会医院 | A kind of newborn's Chinese medicine removing jaundice shower cream and preparation method thereof |
| CN109893622A (en) * | 2019-03-14 | 2019-06-18 | 广西中医药大学附属瑞康医院 | A kind of external washout with traditional Chinese herbs side of icterus neonatorum |
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Application publication date: 20170912 |