CN1362205A - Nano cough-relieving medicine and its preparation - Google Patents
Nano cough-relieving medicine and its preparation Download PDFInfo
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- CN1362205A CN1362205A CN 01100704 CN01100704A CN1362205A CN 1362205 A CN1362205 A CN 1362205A CN 01100704 CN01100704 CN 01100704 CN 01100704 A CN01100704 A CN 01100704A CN 1362205 A CN1362205 A CN 1362205A
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Abstract
The present invention discloses a nano Keke preparation medicine. It is made up by using 7 Chinese medicinal materials of nano ephedra, nano poppy husk, nano licorice, nano bitter apricot kernel, nano radish seed and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 mesh, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of cough-relieving, Dingchuan, the expectorant preparation medicine the invention still further relates to the method for this medication preparation.
KEKE JIAONANG is a kind of Chinese patent medicine of classics, is mainly used in cough, dyspnea with rapid respiration effect such as breathe hard, but traditional KEKE JIAONANG absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano cough-relieving preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano cough-relieving preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 220-260 part nanometer Pericarpium Papaveris 220-260 part nanometer Radix Glycyrrhizae 220-260 part
Nanometer Semen Armeniacae Amarum 220-260 part nanometer Semen Raphani 60-90 part nanometer Radix Platycodonis 60-90 part
Nanometer Gypsum Fibrosum 60-90 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 230-250 part nanometer Pericarpium Papaveris 230-250 part nanometer Radix Glycyrrhizae 230-250 part
Nanometer Semen Armeniacae Amarum 230-250 part nanometer Semen Raphani 70-80 part nanometer Radix Platycodonis 70-80 part
Nanometer Gypsum Fibrosum 70-80 part
The optimum weight proportioning of medicine of the present invention is:
240 parts in 240 parts of nanometer Radix Glycyrrhizaes of 240 parts of nanometer Pericarpium Papaveriss of nanometer Herba Ephedrae
75 parts of 75 parts of nanometer Radix Platycodoniss of 240 parts of nanometer Semen Raphanis of nanometer Semen Armeniacae Amarum
75 parts in nanometer Gypsum Fibrosum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get the KEKE JIAONANG nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano cough-relieving preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common KEKE JIAONANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano cough-relieving preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the Common Cold cough, upper respiratory tract infection and bronchitis _ _ waiting treatment, clinical efficacy significantly is better than traditional KEKE JIAONANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
240 parts in 240 parts of nanometer Radix Glycyrrhizaes of 240 parts of nanometer Pericarpium Papaveriss of nanometer Herba Ephedrae
75 parts of 75 parts of nanometer Radix Platycodoniss of 240 parts of nanometer Semen Raphanis of nanometer Semen Armeniacae Amarum
75 parts in nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
240 parts in 240 parts of nanometer Radix Glycyrrhizaes of 240 parts of nanometer Pericarpium Papaveriss of nanometer Herba Ephedrae
75 parts of 75 parts of nanometer Radix Platycodoniss of 240 parts of nanometer Semen Raphanis of nanometer Semen Armeniacae Amarum
75 parts in nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano cough-relieving powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
240 parts in 240 parts of nanometer Radix Glycyrrhizaes of 240 parts of nanometer Pericarpium Papaveriss of nanometer Herba Ephedrae
75 parts of 75 parts of nanometer Radix Platycodoniss of 240 parts of nanometer Semen Raphanis of nanometer Semen Armeniacae Amarum
75 parts in nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano cough-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nano cough-relieving preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer Herba Ephedrae 220-260 part nanometer Pericarpium Papaveris 220-260 part nanometer Radix Glycyrrhizae 220-260 part
Nanometer Semen Armeniacae Amarum 220-260 part nanometer Semen Raphani 60-90 part nanometer Radix Platycodonis 60-90 part
Nanometer Gypsum Fibrosum 60-90 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano cough-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 230-250 part nanometer Pericarpium Papaveris 230-250 part nanometer Radix Glycyrrhizae 230-250 part
Nanometer Semen Armeniacae Amarum 230-250 part nanometer Semen Raphani 70-80 part nanometer Radix Platycodonis 70-80 part
Nanometer Gypsum Fibrosum 70-80 part
3, nano cough-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
240 parts in 240 parts of nanometer Radix Glycyrrhizaes of 240 parts of nanometer Pericarpium Papaveriss of nanometer Herba Ephedrae
75 parts of 75 parts of nanometer Radix Platycodoniss of 240 parts of nanometer Semen Raphanis of nanometer Semen Armeniacae Amarum
75 parts in nanometer Gypsum Fibrosum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano cough-relieving preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano cough-relieving preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100704 CN1362205A (en) | 2001-01-08 | 2001-01-08 | Nano cough-relieving medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100704 CN1362205A (en) | 2001-01-08 | 2001-01-08 | Nano cough-relieving medicine and its preparation |
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| CN1362205A true CN1362205A (en) | 2002-08-07 |
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| CN 01100704 Pending CN1362205A (en) | 2001-01-08 | 2001-01-08 | Nano cough-relieving medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210748A (en) * | 2011-06-02 | 2011-10-12 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
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2001
- 2001-01-08 CN CN 01100704 patent/CN1362205A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210748A (en) * | 2011-06-02 | 2011-10-12 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
| CN102210748B (en) * | 2011-06-02 | 2013-01-02 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
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