CN1364555A - Nano middle warmer claming six ingredient medicine and its preparing method - Google Patents
Nano middle warmer claming six ingredient medicine and its preparing method Download PDFInfo
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- CN1364555A CN1364555A CN 01100822 CN01100822A CN1364555A CN 1364555 A CN1364555 A CN 1364555A CN 01100822 CN01100822 CN 01100822 CN 01100822 A CN01100822 A CN 01100822A CN 1364555 A CN1364555 A CN 1364555A
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Abstract
The nano middle warmer calming Liuhe medicine is prepared with nano cabin pacholi, nano perilla leaf, nano elslholtzia, nano aucklandia root, nano bean of white hyacinth and other nine kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of drive away summer heat dehumidifying and in help digestion, it is wet to cure mainly the summer Sunstroke, dyspepsia is stagnated, the cold and heat headache is uncomfortable in chestly felt sick, preparation medicine during the nanometer six directions of the stomachache of vomiting and diarrhoea is fixed the invention still further relates to the method for this medication preparation.
Liuhe dingzhong pills is a kind of classical Chinese patent medicine, mainly containing drive away summer heat dehumidifying and in effect such as help digestion, it is wet to be used for the summer Sunstroke, dyspepsia is stagnated, the cold and heat headache is uncomfortable in chestly felt sick the stomachache of vomiting and diarrhoea.But traditional liuhe dingzhong pills disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully, preparation medicine during the nanometer six directions of increase evident in efficacy is fixed.
Another object of the present invention provides the preparation method of the fixed middle preparation medicine of this nanometer six directions.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Pogostemonis 13-33 part nanometer Folium Perillae 13-33 part nanometer Herba Moslae 13-33 part
Nanometer Radix Aucklandiae 32-76 part nanometer Semen Lablab Album 13-33 part nanometer Lignum Santali Albi 32-76 part
Nano Poria 41-103 part nanometer Radix Platycodonis 41-103 part nanometer Fructus Aurantii 41-103 part
Nanometer Fructus Chaenomelis 41-103 part nanometer Pericarpium Citri Reticulatae 41-103 part nanometer Fructus Crataegi 41-103 part
Nanometer Fructus Setariae Germinatus 162-414 part nanometer Massa Medicata Fermentata 162-414 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Pogostemonis 18-28 part nanometer Folium Perillae 18-28 part nanometer Herba Moslae 18-28 part
Nanometer Radix Aucklandiae 44-64 part nanometer Semen Lablab Album 18-28 part nanometer Lignum Santali Albi 44-64 part
Nano Poria 58-86 part nanometer Radix Platycodonis 58-86 part nanometer Fructus Aurantii 58-86 part
Nanometer Fructus Chaenomelis 58-86 part nanometer Pericarpium Citri Reticulatae 58-86 part nanometer Fructus Crataegi 58-86 part
Nanometer Fructus Setariae Germinatus 231-345 part nanometer Massa Medicata Fermentata 231-345 part
The optimum weight proportioning of medicine of the present invention is:
24 parts of 24 parts of nanometer Herba Moslaes of 24 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
54 parts in 24 parts of nanometer Lignum Santali Albis of 54 portions of nanometer Semen Lablab Albums of the nanometer Radix Aucklandiae
72 parts of 72 parts of nanometer Fructus Aurantiis of 72 parts of nanometer Radix Platycodoniss of nano Poria
72 parts of 72 parts of nanometer Fructus Crataegis of 72 parts of nanometer Pericarpium Citri Reticulataes of nanometer Fructus Chaenomelis
288 parts of 288 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Setariae Germinatus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the fixed middle preparation nano powder of the six directions with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the fixed middle preparation medicine of the nanometer six directions is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common liuhe dingzhong pills preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention also created the nanometer six directions fixed in the new drug formulation had no precedent in the past of the suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution etc. of preparation medicine.
It is wet that pharmaceutical preparation of the present invention can be used for the summer Sunstroke, and dyspepsia is stagnated, and the cold and heat headache is uncomfortable in chest nauseating, treatment of conditions such as the stomachache of vomiting and diarrhoea, and clinical efficacy significantly is better than traditional liuhe dingzhong pills.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
24 parts of 24 parts of nanometer Herba Moslaes of 24 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
54 parts in 24 parts of nanometer Lignum Santali Albis of 54 portions of nanometer Semen Lablab Albums of the nanometer Radix Aucklandiae
72 parts of 72 parts of nanometer Fructus Aurantiis of 72 parts of nanometer Radix Platycodoniss of nano Poria
72 parts of 72 parts of nanometer Fructus Crataegis of 72 parts of nanometer Pericarpium Citri Reticulataes of nanometer Fructus Chaenomelis
288 parts of 288 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Setariae Germinatus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
24 parts of 24 parts of nanometer Herba Moslaes of 24 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
54 parts in 24 parts of nanometer Lignum Santali Albis of 54 portions of nanometer Semen Lablab Albums of the nanometer Radix Aucklandiae
72 parts of 72 parts of nanometer Fructus Aurantiis of 72 parts of nanometer Radix Platycodoniss of nano Poria
72 parts of 72 parts of nanometer Fructus Crataegis of 72 parts of nanometer Pericarpium Citri Reticulataes of nanometer Fructus Chaenomelis
288 parts of 288 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Setariae Germinatus
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nanometer six directions fixed in powder needle injection, every injection content be the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
24 parts of 24 parts of nanometer Herba Moslaes of 24 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
54 parts in 24 parts of nanometer Lignum Santali Albis of 54 portions of nanometer Semen Lablab Albums of the nanometer Radix Aucklandiae
72 parts of 72 parts of nanometer Fructus Aurantiis of 72 parts of nanometer Radix Platycodoniss of nano Poria
72 parts of 72 parts of nanometer Fructus Crataegis of 72 parts of nanometer Pericarpium Citri Reticulataes of nanometer Fructus Chaenomelis
288 parts of 288 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Setariae Germinatus
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the fixed middle membrane of the nanometer six directions, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer six directions fixed in preparation medicine, it is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Pogostemonis 13-33 part nanometer Folium Perillae 13-33 part nanometer Herba Moslae 13-33 part
Nanometer Radix Aucklandiae 32-76 part nanometer Semen Lablab Album 13-33 part nanometer Lignum Santali Albi 32-76 part
Nano Poria 41-103 part nanometer Radix Platycodonis 41-103 part nanometer Fructus Aurantii 41-103 part
Nanometer Fructus Chaenomelis 41-103 part nanometer Pericarpium Citri Reticulatae 41-103 part nano Fructus Crataegi 41-103 part
Nanometer Fructus Setariae Germinatus 162-414 part nanometer Massa Medicata Fermentata 162-414 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the fixed middle preparation medicine of the nanometer six directions according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Pogostemonis 18-28 part nanometer Folium Perillae 18-28 part nanometer Herba Moslae 18-28 part
Nanometer Radix Aucklandiae 44-64 part nanometer Semen Lablab Album 8-28 part nanometer Lignum Santali Albi 44-64 part
Nano Poria 58-86 part nanometer Radix Platycodonis 58-86 part nanometer Fructus Aurantii 58-86 part
Nanometer Fructus Chaenomelis 58-86 part nanometer Pericarpium Citri Reticulatae 58-86 part nanometer Fructus Crataegi 58-86 part
Nanometer Fructus Setariae Germinatus 231-345 part nanometer Massa Medicata Fermentata 231-345 part
3, the fixed middle preparation medicine of the nanometer six directions according to claim 1, wherein the weight proportion of each nano raw material is:
24 parts of 24 parts of nanometer Herba Moslaes of 24 parts of nanometer Folium Perillaes of nanometer Herba Pogostemonis
54 parts in 24 parts of nanometer Lignum Santali Albis of 54 portions of nanometer Semen Lablab Albums of the nanometer Radix Aucklandiae
72 parts of 72 parts of nanometer Fructus Aurantiis of 72 parts of nanometer Radix Platycodoniss of nano Poria
72 parts of 72 parts of nanometer Fructus Crataegis of 72 parts of nanometer Pericarpium Citri Reticulataes of nanometer Fructus Chaenomelis
288 parts of 288 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Setariae Germinatus
4, according to claim 1 or the fixed middle preparation medicine of the 2 or 3 described nanometer six directions, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the fixed middle preparation medicine of the 2 or 3 described nanometer six directions; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100822 CN1364555A (en) | 2001-01-11 | 2001-01-11 | Nano middle warmer claming six ingredient medicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100822 CN1364555A (en) | 2001-01-11 | 2001-01-11 | Nano middle warmer claming six ingredient medicine and its preparing method |
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| CN1364555A true CN1364555A (en) | 2002-08-21 |
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| CN 01100822 Pending CN1364555A (en) | 2001-01-11 | 2001-01-11 | Nano middle warmer claming six ingredient medicine and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402054C (en) * | 2005-12-29 | 2008-07-16 | 徐明学 | Medicine for treating heatstroke and its preparation method |
| CN101947298A (en) * | 2010-09-16 | 2011-01-19 | 陕西中药研究所 | Method for preparing stomach-regulating pills |
-
2001
- 2001-01-11 CN CN 01100822 patent/CN1364555A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402054C (en) * | 2005-12-29 | 2008-07-16 | 徐明学 | Medicine for treating heatstroke and its preparation method |
| CN101947298A (en) * | 2010-09-16 | 2011-01-19 | 陕西中药研究所 | Method for preparing stomach-regulating pills |
| CN101947298B (en) * | 2010-09-16 | 2011-09-28 | 陕西中药研究所 | Method for preparing stomach-regulating pills |
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