CN1368064A - Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process - Google Patents
Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process Download PDFInfo
- Publication number
- CN1368064A CN1368064A CN 01101812 CN01101812A CN1368064A CN 1368064 A CN1368064 A CN 1368064A CN 01101812 CN01101812 CN 01101812 CN 01101812 A CN01101812 A CN 01101812A CN 1368064 A CN1368064 A CN 1368064A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- nano
- chinese
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A nanometre (0.1-200 nm) medicine for nourishing kidney and bone is prpared from the nanometre powders of 12 Chinese medicinal materials including fleece flower root, tuckahoe, white peony root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of nourishing the liver and kidney, strong muscles and bones, cure mainly the nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone of deficiency of the liver and kindey, impairment caused by overstrain lumbago, muscles and bones folding wound, the invention still further relates to the method for this medication preparation.
Yishenbugu liquid is a kind of classical Chinese patent medicine, mainly contains effects such as nourishing the liver and kidney, strong muscles and bones, is used for deficiency of the liver and kindey, impairment caused by overstrain lumbago, muscles and bones folding wound.But traditional yishenbugu liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Drynariae 25-60 part nanometer Radix Polygoni Multiflori 80-180 part nano Poria 40-90 part
Nanometer Radix Dipsaci 40-90 part nanometer Radix Paeoniae Alba 25-80 part nano Chinese angelica 40-90 part
Nanometer Radix Codonopsis 50-95 part nanometer Radix Rehmanniae Preparata 40-90 part nanometer Rhizoma Polygonati 40-90 part
Nanometer Fructus Lycii 40-90 part nanometer Pyritum 25-80 part nanometer Pericarpium Citri Reticulatae 10-25 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Drynariae 30-50 part nanometer Radix Polygoni Multiflori 100-150 part nano Poria 50-80 part
Nanometer Radix Dipsaci 50-80 part nanometer Radix Paeoniae Alba 30-60 part nano Chinese angelica 50-80 part
Nanometer Radix Codonopsis 60-90 part nanometer Radix Rehmanniae Preparata 50-80 part nanometer Rhizoma Polygonati 50-80 part
Nanometer Fructus Lycii 50-80 part nanometer Pyritum 30-60 part nanometer Pericarpium Citri Reticulatae 12-20 part
The optimum weight proportioning of medicine of the present invention is:
63 parts of 126 parts of nano Porias of 45 parts of nanometer Radix Polygoni Multiflori of nanometer Rhizoma Drynariae
63 parts of 44 parts of nano Chinese angelicas of 63 parts of nanometer Radix Paeoniae Albas of nanometer Radix Dipsaci
63 parts of 63 parts of nanometer Rhizoma Polygonatis of 75 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
16 parts of 45 parts of nanometer Pericarpium Citri Reticulataes of 63 parts of nanometer Pyritums of nanometer Fructus Lycii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the ' yishenbugu ' for tonifying kidney and strengthening bone nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common yishenbugu liquid formulation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as deficiency of the liver and kindey, impairment caused by overstrain lumbago, muscles and bones folding wound, and clinical efficacy significantly is better than traditional yishenbugu liquid.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
63 parts of 126 parts of nano Porias of 45 parts of nanometer Radix Polygoni Multiflori of nanometer Rhizoma Drynariae
63 parts of 44 parts of nano Chinese angelicas of 63 parts of nanometer Radix Paeoniae Albas of nanometer Radix Dipsaci
63 parts of 63 parts of nanometer Rhizoma Polygonatis of 75 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
16 parts of 45 parts of nanometer Pericarpium Citri Reticulataes of 63 parts of nanometer Pyritums of nanometer Fructus Lycii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
63 parts of 126 parts of nano Porias of 45 parts of nanometer Radix Polygoni Multiflori of nanometer Rhizoma Drynariae
63 parts of 44 parts of nano Chinese angelicas of 63 parts of nanometer Radix Paeoniae Albas of nanometer Radix Dipsaci
63 parts of 63 parts of nanometer Rhizoma Polygonatis of 75 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
16 parts of 45 parts of nanometer Pericarpium Citri Reticulataes of 63 parts of nanometer Pyritums of nanometer Fructus Lycii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer yishenbugu powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
63 parts of 126 parts of nano Porias of 45 parts of nanometer Radix Polygoni Multiflori of nanometer Rhizoma Drynariae
63 parts of 44 parts of nano Chinese angelicas of 63 parts of nanometer Radix Paeoniae Albas of nanometer Radix Dipsaci
63 parts of 63 parts of nanometer Rhizoma Polygonatis of 75 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
16 parts of 45 parts of nanometer Pericarpium Citri Reticulataes of 63 parts of nanometer Pyritums of nanometer Fructus Lycii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer yishenbugu membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Drynariae 25-60 part nanometer Radix Polygoni Multiflori 80-180 part nano Poria 40-90 part
Nanometer Radix Dipsaci 40-90 part nanometer Radix Paeoniae Alba 25-80 part nano Chinese angelica 40-90 part
50 95 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis 40-90 part nanometer Rhizoma Polygonati 40-90 part
Nanometer Fructus Lycii 40-90 part nanometer Pyritum 25-80 part nanometer Pericarpium Citri Reticulatae 10-25 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Drynariae 30-50 part nanometer Radix Polygoni Multiflori 100-150 part nano Poria 50-80 part
Nanometer Radix Dipsaci 50-80 part nanometer Radix Paeoniae Alba 30-60 part nano Chinese angelica 50-80 part
Nanometer Radix Codonopsis 60-90 part nanometer Radix Rehmanniae Preparata 50-80 part nanometer Rhizoma Polygonati 50-80 part
Nanometer Fructus Lycii 50-80 part nanometer Pyritum 30-60 part nanometer Pericarpium Citri Reticulatae 12-20 part
3, nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone according to claim 1, wherein the weight proportion of each nano raw material is:
63 parts of 126 parts of nano Porias of 45 parts of nanometer Radix Polygoni Multiflori of nanometer Rhizoma Drynariae
63 parts of 44 parts of nano Chinese angelicas of 63 parts of nanometer Radix Paeoniae Albas of nanometer Radix Dipsaci
63 parts of 63 parts of nanometer Rhizoma Polygonatis of 75 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
16 parts of 45 parts of nanometer Pericarpium Citri Reticulataes of 63 parts of nanometer Pyritums of nanometer Fructus Lycii
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' yishenbugu ' for tonifying kidney and strengthening bone; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101812 CN1368064A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101812 CN1368064A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368064A true CN1368064A (en) | 2002-09-11 |
Family
ID=4652222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01101812 Pending CN1368064A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368064A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785814A (en) * | 2010-03-17 | 2010-07-28 | 玉林市骨科医院 | Oral liquid medicament for tonifying kidney and strengthening bone and method for producing same |
| CN101095933B (en) * | 2007-07-05 | 2010-11-03 | 中国人民解放军第四一一医院 | Chinese traditional medicine compound recipe for healing bones and treating wound |
| CN103675190A (en) * | 2013-12-18 | 2014-03-26 | 吉林修正药业新药开发有限公司 | Quality control method of Chinese patent medicine of kidney tonifying and bone reinforcing solution |
| CN106281878A (en) * | 2016-08-10 | 2017-01-04 | 贵州省仁怀市雨花中药材种植有限公司 | A kind of yishenbugu health promoting wine and preparation method thereof |
| CN108210727A (en) * | 2018-03-16 | 2018-06-29 | 广东力集团制药股份有限公司 | A kind of yishenbugu liquid and preparation method thereof |
-
2001
- 2001-02-05 CN CN 01101812 patent/CN1368064A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095933B (en) * | 2007-07-05 | 2010-11-03 | 中国人民解放军第四一一医院 | Chinese traditional medicine compound recipe for healing bones and treating wound |
| CN101785814A (en) * | 2010-03-17 | 2010-07-28 | 玉林市骨科医院 | Oral liquid medicament for tonifying kidney and strengthening bone and method for producing same |
| CN101785814B (en) * | 2010-03-17 | 2012-02-08 | 玉林市骨科医院 | Oral liquid medicament for tonifying kidney and strengthening bone and method for producing same |
| CN103675190A (en) * | 2013-12-18 | 2014-03-26 | 吉林修正药业新药开发有限公司 | Quality control method of Chinese patent medicine of kidney tonifying and bone reinforcing solution |
| CN106281878A (en) * | 2016-08-10 | 2017-01-04 | 贵州省仁怀市雨花中药材种植有限公司 | A kind of yishenbugu health promoting wine and preparation method thereof |
| CN108210727A (en) * | 2018-03-16 | 2018-06-29 | 广东力集团制药股份有限公司 | A kind of yishenbugu liquid and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368064A (en) | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process | |
| CN1368353A (en) | Nano medicine 'Zibushengfa' and its preparing process | |
| CN1368239A (en) | Nano medicine 'Anshenyangxin' and its preparing process | |
| CN1365810A (en) | Nano medicine 'Guishao Dihuang' and its preparing process | |
| CN1368203A (en) | Nano medicine 'Zanglian' and its preparing process | |
| CN1366953A (en) | Nano midday tea preparation medicine and preparation method | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1368274A (en) | Nano medicine 'Zhibao Lingzhi' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1368320A (en) | Nano medicine 'Shengerfa' and its preparing process | |
| CN1368101A (en) | Nano medicine 'Xiaobaidu' and its preparing process | |
| CN1365717A (en) | Nano medicine 'Jianer Xiaoshi' and its preparing process | |
| CN1368265A (en) | Nano medicine 'Xingsu' and its preparing process | |
| CN1368195A (en) | Nano medicine 'Buxuedanggui' and its preparing process | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1365801A (en) | Nano medicine 'Shenrong Guben' and its preparing process | |
| CN1368224A (en) | Nano medicine 'Chaishaoliujun' and its preparing process | |
| CN1365777A (en) | Nano medicine 'Qipi' and its preparing process | |
| CN1364525A (en) | Nano body strengthening and brain invigorating medicine and its preparing method | |
| CN1368339A (en) | Nano emdicine 'Wubishan' and its preparing process | |
| CN1368259A (en) | Nano medicine 'Yangweining' and its preparing process | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1368264A (en) | Nano medicine 'Renshenbu' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |