CN114306469A - Traditional Chinese medicine compound composition for improving sub-health - Google Patents

Abstract

The invention discloses a traditional Chinese medicine compound composition for improving sub-health, which is characterized by comprising the following components: 1-2 parts of codonopsis pilosula, 1-2 parts of mulberry, 1-2 parts of fried white peony root, 1-2 parts of poria cocos, 1-2 parts of radix astragali preparata, 1-2 parts of fried bighead atractylodes rhizome, 1-2 parts of dried orange peel, 2-3 parts of wolfberry fruit, 2-3 parts of radix polygoni multiflori preparata, 2-3 parts of prepared rehmannia root, 2-3 parts of glossy privet fruit, 2-3 parts of wine angelica, 1-2 parts of ligusticum wallichii and 1-2 parts of fried liquorice; has effects in invigorating spleen, invigorating qi, replenishing blood, invigorating kidney, dispersing stagnated liver qi, relieving qi stagnation, and regulating qi activity to improve sub-health state.

Description

Traditional Chinese medicine compound composition for improving sub-health

Technical Field

The invention belongs to the field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine compound composition for improving sub-health.

Background

The sub-health state is a clinical state proposed by the world health organization, is a modern civilization disease between health and diseases, is found by mechanical examination without positive property, has no organic lesion, and frequently appears unhealthy state; belongs to the field of 'no disease' in traditional Chinese medicine; from the point of traditional Chinese medicine syndrome differentiation, sub-health is caused by deficiency of both heart and spleen, deficiency of both kidney and liver, and the symptoms of deficiency of both heart and spleen are as follows: palpitation, amnesia, mental fatigue, poor appetite, loose stool, sallow complexion, no uneasiness, dizziness or panic, menoxenia, hematochezia, pale tongue with thin and white coating, and thready and slow pulse; the symptoms of kidney deficiency are: palpitation, night sweat, soreness of the waist and knees, red palate, dizziness, tinnitus, dysphoria with smothery sensation in the chest, insomnia, dreaminess, nocturnal emission, menoxenia, dry mouth, red tongue with little coating, and thready and rapid pulse; symptoms of liver dysfunction are: vexation, impatience, irritability, depression, oppression in chest, frequent sighing, irritability, distension and pain in breast, insomnia, dreaminess, dizziness, bitter taste in mouth, dry mouth, anorexia, abdominal distention, thin and white tongue fur, and dark pulse;

since sub-health is a state without obvious organic lesions, the treatment of the sub-health state through western medicine improvement is not from the beginning, and the sub-health state can be improved through the conditioning of traditional Chinese medicine.

Disclosure of Invention

In order to solve the technical problems, the invention provides a traditional Chinese medicine compound composition for improving sub-health, which has the effects of strengthening spleen, tonifying qi, enriching blood, tonifying kidney, soothing liver, relieving depression and regulating qi to improve sub-health;

in order to achieve the technical purpose, the invention is realized by the following technical scheme: a traditional Chinese medicine compound composition for improving sub-health is characterized by comprising the following components: 1-2 parts of codonopsis pilosula, 1-2 parts of mulberry, 1-2 parts of fried white peony root, 1-2 parts of poria cocos, 1-2 parts of radix astragali preparata, 1-2 parts of fried bighead atractylodes rhizome, 1-2 parts of dried orange peel, 2-3 parts of wolfberry fruit, 2-3 parts of radix polygoni multiflori preparata, 2-3 parts of prepared rehmannia root, 2-3 parts of glossy privet fruit, 2-3 parts of wine angelica, 1-2 parts of ligusticum wallichii and 1-2 parts of fried liquorice;

preferably, the traditional Chinese medicine comprises 2 parts of codonopsis pilosula, 2 parts of mulberry, 2 parts of fried white peony root, 2 parts of poria cocos, 2 parts of radix astragali preparata, 2 parts of fried bighead atractylodes rhizome, 2 parts of dried orange peel, 3 parts of wolfberry fruit, 3 parts of radix polygoni multiflori preparata, 3 parts of prepared rehmannia root, 3 parts of glossy privet fruit, 3 parts of wine-treated angelica, 1 part of ligusticum wallichii and 1 part of radix glycyrrhizae preparata;

preferably, the traditional Chinese medicine compound composition comprises, but is not limited to, decoction, oral liquid, granules, pills, capsules and paste;

preferably, the preparation method of the oral liquid comprises the following steps:

s1: weighing a proper amount of raw materials according to the proportion, cleaning, adding purified water 8-10 times of the raw materials, soaking for 10-20min, directly boiling with strong fire after soaking, and decocting with slow fire for 1-3 h; filtering to obtain first residue and filtrate;

s2: adding 6-8 times of purified water into the residue, boiling with strong fire, decocting with slow fire for 1-2 hr, filtering, and collecting residue and filtrate;

s3: mixing the two filtrates;

s4: concentrating the filtrate after high-speed centrifugation at the rotating speed of 15000 and 30000 until the relative density is 1-1.2;

s5: adding purified water and oligosaccharide syrup or sweetener to the concentrated solution obtained in S4 at a certain ratio to obtain oral liquid.

The pharmacological and medicinal properties of the components in the formula provided by the invention are as follows:

codonopsis pilosula: the product has mild property and sweet taste, and can enter spleen and lung channels, tonify spleen and lung qi, enrich blood, and promote fluid production;

mulberry fruit: is cold in nature and sweet in taste, has the effects of nourishing yin and supplementing blood, lubricating intestines and promoting the production of body fluid, and is used for treating yin deficiency and blood deficiency, yin deficiency and thirst, body fluid deficiency and thirst, dizziness and tinnitus, and constipation due to intestinal dryness;

parching radix Paeoniae alba: slightly cold in nature, bitter and sour in taste; it enters liver and spleen meridians. Pacify liver and alleviate pain, nourish blood and regulate menstruation, astringe yin and check sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat;

tuckahoe, poria cocos: mild in nature, sweet and bland in taste; it can be used for treating edema, oliguria, dizziness and palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia;

radix astragali Preparata: warm in nature, sweet in flavor, entering lung and spleen meridians; replenishing qi and strengthening the middle warmer, and can be used for treating qi deficiency, debilitation, anorexia and loose stool;

frying the bighead atractylodes rhizome: invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion;

dried orange peel: warm in nature, pungent and bitter in flavor; it enters spleen, stomach and lung meridians, and has the actions of regulating qi, regulating stomach, eliminating dampness and phlegm, inducing diuresis and relaxing bowels. Mainly used for treating incoordination between the spleen and the stomach, abdominal distending pain, anorexia and vomiturition; phlegm-dampness obstructing the lung, cough with excessive phlegm, fullness and stuffiness in chest and diaphragm, dizziness; edema, dysuria, constipation; acute mastitis, skin sore and tinea, fish, crab, and wine toxin;

wolfberry fruit: neutral in nature and sweet in taste, and enter liver and kidney meridians; has effects in nourishing kidney, moistening lung, nourishing liver, and improving eyesight. For treating liver and kidney yin deficiency, soreness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea;

radix polygoni multiflori preparata: is mainly used for treating symptoms of dizziness, soreness and weakness of waist and knees, insomnia and dreaminess caused by liver and kidney deficiency and essence and blood deficiency;

prepared rehmannia root: slightly warm in nature and sweet and bitter in taste; has effects in nourishing yin and tonifying blood. Treating deficiency of yin and blood, debility of waist and knees, fatigue, cough, steaming bone, nocturnal emission, metrorrhagia, menoxenia, diabetes, scanty urine, deafness, and blurred vision;

glossy privet fruit: mild in nature and sweet in taste; has the functions of nourishing yin, tonifying kidney, strengthening waist and knees and improving hearing; mainly treats liver and kidney yin deficiency, dizziness, tinnitus, early white hair, soreness and weakness of waist and knees, senile habitual constipation and the like;

wine angelica: warm in nature, sweet, pungent and bitter in flavor; tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease;

ligusticum wallichii: warm in nature and pungent in flavor; entering liver and gallbladder meridians; move qi and relieve depression, dispel wind-dryness and dampness, activate blood and alleviate pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia;

honey-fried licorice root: warm in nature and sweet in taste; entering heart, lung, stomach and spleen channels; tonify spleen and stomach, replenish qi and recover pulse.

The invention has the beneficial effects that:

the traditional Chinese medicine composition for improving sub-health provided by the invention has the effects of calming the heart and soothing the nerves, strengthening the spleen and replenishing qi, nourishing yin and clearing heat, nourishing the heart and tonifying the kidney, soothing the liver and relieving depression and conditioning the qi activity, thereby regulating and improving the sub-health state.

Detailed Description

In order to clearly and completely describe the scheme and the effect of the invention, the following embodiments are used for detailed description;

example 1

A traditional Chinese medicine compound composition for improving sub-health is characterized by comprising the following components: 2 parts of codonopsis pilosula, 2 parts of mulberry fruit, 2 parts of fried white paeony root, 2 parts of poria cocos, 2 parts of radix astragali preparata, 2 parts of fried bighead atractylodes rhizome, 2 parts of dried orange peel, 3 parts of wolfberry fruit, 3 parts of radix polygoni multiflori preparata, 3 parts of prepared rehmannia root, 3 parts of glossy privet fruit, 3 parts of wine angelica, 1 part of ligusticum wallichii and 1 part of radix glycyrrhizae preparata;

preferably, the traditional Chinese medicine compound composition comprises, but is not limited to, decoction, oral liquid, granules and pill capsules;

preferably, the preparation method of the oral liquid comprises the following steps:

s1: weighing a proper amount of raw materials according to the proportion, cleaning, adding purified water 8-10 times of the raw materials, soaking for 10-20min, directly boiling with strong fire after soaking, and decocting with slow fire for 1-3 h; filtering to obtain first residue and filtrate;

s2: adding 6-8 times of purified water into the residue, boiling with strong fire, decocting with slow fire for 1-2 hr, filtering, and collecting residue and filtrate;

s3: mixing the two filtrates;

s4: concentrating the filtrate after high-speed centrifugation at the rotating speed of 15000 and 30000 until the relative density is 1-1.2;

s5: adding purified water and oligosaccharide syrup or sweetener to the concentrated solution obtained in S4 at a certain ratio to obtain oral liquid.

Example 2

Clinical case 1: the first, male and 42 years old complain of half a month, and gradually shows fatigue after continuously staying up night, the waist and knees are weak, the fatigue cannot be relieved after sleeping or resting, but the fatigue is relieved after sports, the whole day is unclear in the head, the memory is hypomnesis, the mood is low in the morning, the patient is impatient and irritative, the sexual desire is cool, the patient does not have palpitation, the double eyelids and the lower limb edema, and the tongue is red and greasy. Western medical physical examination: clear mind, spiritual movement, fluent speech, normal muscle strength and muscle tension of limbs on both sides, and no abnormality in liver and kidney function, thyroid function and color Doppler. Prescription: 10g of codonopsis pilosula, 10g of mulberry fruit, 10g of fried white paeony root, 10g of poria cocos, 10g of radix astragali preparata, 10g of fried bighead atractylodes rhizome, 10g of dried orange peel, 15g of wolfberry fruit, 15g of prepared fleece flower root, 15g of prepared rehmannia root, 15g of glossy privet fruit, 15g of wine-treated angelica, 5g of ligusticum wallichii, 5g of honey-fried licorice root and 7 doses, wherein 1 dose is decocted in water for 500mL for 30min after breakfast and supper. And B, diagnosis: the fatigue of the patient is obviously improved, the emotion is stable day by day, the chest and the hypochondrium are more smooth, the heaviness of the two lower limbs is improved, and then 14 doses are taken. Three diagnoses: if the patient is suffering from heavy relief, the body is light and healthy, the thinking is quick, the relations between the couple and the husband are harmonious, the patient follows up for 3 months without relapse.

Example 3

96 patients treated by outpatients in 2018, 1 month to 2019, 10 months in department of traditional Chinese medicine in the hospital are selected and divided into two groups, wherein each group comprises 48 patients according to a random numerical method. The treatment groups were 28 men and 20 women; the age is 24-58 years; the course of disease is 3-50 months. 26 men and 22 women in the control group; age 22-53 years, course of disease 4-46 months. The difference of general data such as age, sex, course of disease, etc. of two groups has no statistical significance (P is more than 0.05), and has comparability;

diagnostic criteria: the health-care product meets the sub-health diagnosis standard of 'sub-health clinical traditional Chinese medicine guidelines' issued by the State administration of traditional Chinese medicine, takes fatigue as a main complaint, continuously or repeatedly attacks for more than 3 months, eliminates diseases possibly causing fatigue, and has no obvious abnormality through the conventional physical examination method and index system detection of Western medicine.

The traditional Chinese medicine syndrome diagnosis standard is as follows: the syndrome differentiation standard of the fatigue sub-health liver depression yang deficiency damp-obstruction syndrome is formulated as follows: the main symptoms are: 1) fatigue, or post-activity relief; 2) head covering or head heavy as a wrap; 3) feeling of heaviness of both lower limbs; 4) fullness in the chest and hypochondrium, distending pain, scurrying pain, or stuffiness and discomfort. The secondary symptoms are as follows: 1) a low mood, or irritability, or unstable mood; 2) sticky, greasy and uncomfortable stools, or dryness and thinness; 3) a red and swollen tongue with a greasy or yellow and greasy coating and a deep, wiry or thready pulse. If the main symptoms 1)3) or 2) or 4) are satisfied at the same time, any 2 items of the secondary symptoms can be diagnosed.

Intake and discharge criteria: inclusion criteria were: 1) the diagnosis standard of sub-health in the sub-health clinical traditional Chinese medicine guideline is met; 2) the traditional Chinese medicine distinguishes the syndrome to belong to the liver depression yang deficiency damp obstruction; 3) the age is 18-60 years, and intervention measures aiming at fatigue (including taking related anti-fatigue health care products) are not adopted in about 1 month; exclusion criteria: 1) acute diseases such as exogenous or traumatic diseases in about 1 week; 2) pregnant or lactating women; 3) those with a history of psychiatric illness or family history of psychiatric illness; 4) patients who fall off due to non-adherence to treatment.

The treatment method comprises the following steps: the treatment group gives the prescription medicine provided by the invention, 2 parts of radix codonopsitis, 2 parts of mulberry, 2 parts of fried white peony root, 2 parts of tuckahoe, 2 parts of radix astragali preparata, 2 parts of fried rhizoma atractylodis macrocephalae, 2 parts of dried orange peel, 3 parts of medlar, 3 parts of radix polygoni multiflori preparata, 3 parts of prepared rehmannia root, 3 parts of glossy privet fruit, 3 parts of wine angelica, 1 part of rhizoma ligustici wallichii and 1 part of liquorice; one dose is decocted in water for one day, the decoction is taken once a day in the morning and at night, the decoction is taken warm half an hour after meals, and the curative effect is evaluated after 2 weeks and one treatment course;

control group: taking ease pill 6g each time, 2 times daily, and evaluating the curative effect after 2 weeks as one treatment course;

the treatment results are as follows:

after treatment, the two groups of symptoms are improved, and the clinical effect of the treatment group is obvious because the control group has better total effective rate than the control group; see Table 1

TABLE 1 comparison of the clinical efficacy of the Chinese medicine in two groups of sub-healthy patients

Group of	Number of examples	Cure/example	Effective/example	Invalid/example	Total effective rate
						Treatment group	48	35	11	2	95.8％
Control group	48	10	24	14	70.8％

Claims (4)

1. A traditional Chinese medicine compound composition for improving sub-health is characterized by comprising the following components: 1-2 parts of codonopsis pilosula, 1-2 parts of mulberry fruit, 1-2 parts of fried white peony root, 1-2 parts of poria cocos, 1-2 parts of radix astragali preparata, 1-2 parts of fried bighead atractylodes rhizome, 1-2 parts of dried orange peel, 2-3 parts of wolfberry fruit, 2-3 parts of radix polygoni multiflori preparata, 2-3 parts of prepared rehmannia root, 2-3 parts of glossy privet fruit, 2-3 parts of wine angelica, 1-2 parts of ligusticum wallichii and 1-2 parts of fried liquorice.

2. The compound traditional Chinese medicine composition for improving sub-health, according to claim 1, is characterized in that the radix codonopsis pilosulae 2 parts, mulberry 2 parts, parched white peony root 2 parts, poria cocos 2 parts, radix astragali preparata 2 parts, parched white atractylodes rhizome 2 parts, dried orange peel 2 parts, wolfberry fruit 3 parts, radix polygoni multiflori preparata 3 parts, prepared rehmannia root 3 parts, glossy privet fruit 3 parts, wine angelica 3 parts, ligusticum wallichii 1 part, and moxibustion licorice 1 part.

3. The compound traditional Chinese medicine composition for improving sub-health, according to claim 1, is characterized in that the compound traditional Chinese medicine composition comprises, but is not limited to, decoction, oral liquid, granules, pills, capsules, and paste.

4. The compound traditional Chinese medicine composition for improving sub-health, according to claim 3, is characterized in that the preparation method of the oral liquid is as follows:

s1: weighing a proper amount of raw materials according to the proportion, cleaning, adding purified water 8-10 times of the raw materials, soaking for 10-20min, directly boiling with strong fire after soaking, and decocting with slow fire for 1-3 h; filtering to obtain first residue and filtrate;

s2: adding 6-8 times of purified water into the residue, boiling with strong fire, decocting with slow fire for 1-2 hr, filtering, and collecting residue and filtrate;

s3: mixing the two filtrates;

s4: concentrating the filtrate after high-speed centrifugation at the rotating speed of 15000 and 30000 until the relative density is 1-1.2;

s5: adding purified water and oligosaccharide syrup or sweetener to the concentrated solution obtained in S4 at a certain ratio to obtain oral liquid.