CN104587443A - Traditional Chinese medicine preparation for primary antiphospholipid syndrome and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for a primary antiphospholipid syndrome. The traditional Chinese medicine preparation is prepared by the following steps: taking astragalus membranaceus, American ginseng, radix rehmanniae, white paeony root, radix cyathulae, fried peach kernel, safflower, angelica sinensis, ligusticum wallichii, rhizoma corydalis, turmeric, trogopterus dung, woodlouse, drynaria rhizome, sangusis draconis, artemisia anomala, dried ginger, prepared kusnezoff monkshood root, fleece-flower root, mulberry, caulis spatholobi, hippocampus japonicus, rhizoma polygonati and prepared liquorice as raw materials, preparing in proportion according to different properties of each traditional Chinese medicine after cleaning and dicing pretreatment and making by adopting a special method. The traditional Chinese medicine preparation has the effects of soothing liver and regulating the flow of Qi, activating blood and removing stasis, replenishing qi and stimulating menstrual flow. The traditional Chinese medicine preparation and the preparation method thereof disclosed by the invention are special, and through clinical verification, the traditional Chinese medicine preparation is obvious in treatment effect, short in treatment period and low in cost and has no adverse reaction and no any toxic or side effects, thereby having wide market application prospect.

Description

A kind of Chinese medicine preparation for primary anti-phospholipid syndrome and preparation method

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for primary anti-phospholipid syndrome, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Primary anti-phospholipid syndrome is the one of anti-phospholipid syndrome.Anti-phospholipid syndrome (APS) is a kind of with the illness of tremulous pulse or phlebothrombosis, morbid state gestation and anti-phospholipid antibody (APL) lasting masculin repeatedly.APS can be secondary to systemic lupus erythematosus (sle) or other autoimmune diseases, but also can occur separately (former APS).The no matter APS of former or secondary, its clinical manifestation and lab testing indifference.Women's sickness rate is obviously more than male.Family's tendency of APS is also not obvious, but the anti-phospholipid antibody inspection of patients' relatives is often positive.Owing to only having some patients to occur clinical manifestation in the crowd of the APL positive, therefore the generation of APS is also relevant with other factors.There are these antibody of research prompting can suppress to be reacted by the blood coagulation waterfall with the catalysis of negative charge phospholipid.These reactions comprise the activation of factor X, the conversion of prothrombin-thrombin, the activation of PROTEIN C, and the inactivation of the factor Ⅴ a caused by PROTEIN C activated.APL Profilin C activates or the effect of neutralization to factor Ⅴ a inactivation, and patient can be made to be in " Pre-thrombosis State ".Prove that anticardiolipin antibody (ACL) and the cross reaction of Phosphatidylserine make it be combined with platelet and activate platelet, also can cause thrombosis.The thromboxane that other possible mechanism also comprise platelet synthesis increases, and suppresses the synthesis of prostacyclin, and stimulation produces tissue factor by endotheliocyte.In the thrombosis of APL mediation, a kind of by name beta2 Glycoprotein 1(β 2GP1) plasma protein very concerned.Think at present APL by and the anticoagulation of β 2GP1 cause thrombosis.Autoimmunity APL, by being combined with electronegative phospholipid in conjunction with β 2GP1 or other cardiolipin binding protein, is β 2GP1 dependency APL.But, the infection such as syphilis, non-syphilitic leptospira, Borrelia burgdoyferi, HIV (human immunodeficiency virus) (HIV), leptospira and parasite, and the anti-phospholipid antibody of medicine and malignant tumor induced synthesis directly can be combined with phospholipid usually, be β 2GP1 dependent/non-dependent antibody.

The traditional Chinese medical science thinks that blood stasis blocks channels, and QI-blood circulation is obstructed, and gushes network broken and see hemorrhage with hyperamization.Because blood stasis stops not removing in aggressiveness, blocking venation, or be again hemorrhage reason, therefore its hemorrhage feature out to stop, repeatedly endlessly; Blood-stasis internal-depression, QI-blood circulation is not smooth, failure of skin and muscle to be nourished, therefore darkish complexion, and pachylosis is as scute, and even lip onyx is purple dark.

Doctor trained in Western medicine many uses heparin or warfarin are treated clinically at present, long-term or the short time uses this type of medicine to treat, obesity can be caused, hirsutism, acne, blood glucose raises, hypertension, edema, intestine gastric ulcer, orthostatic hypotension, feel sick, vomiting, dizzy, constipation etc. series of side effects symptom, after drug withdrawal, primary affection knock-on increases the weight of the side effect with secondary, patient can be made to produce very large misery, therapeutic process again and again, DeGrain, expense is high, and tcm clinical practice is to the method for the treatment of of primary disease, Chinese medicine used is touched upon dissipating depression of QI depressed liver-energy dispersing and QI regulating more, or adopt massage diet care method, in conjunction with TCM psychotherapy, convince by patient analysis with speech, to remove psychological burden, unfold feelings will, harmonizing the functional activities of vital QI.But it is long that above treatment all exists the cycle, slow curative effect has the shortcomings such as side effect to health, thus give patient cause larger pressure at heart and ailing pressure.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation being used for the treatment of primary anti-phospholipid syndrome, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment primary anti-phospholipid syndrome, healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of primary anti-phospholipid syndrome repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

The effect of Chinese medicine of the present invention:

Wherein:

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Panacis Quinquefolii: be the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Nature and flavor: sweet, micro-hardship are cool.GUIXIN, lung, kidney channel.Effect: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.Record in " book on Chinese herbal medicine asks former ": lung heat clearing kidney, cool heart spleen, with pathogenic fire reducing, is relieved summer heat, relieved the effect of alcohol.Record in " Records of Tradition Chinese and Western Medicine in Combination ": can edema caused by disorder of QI be subsidized, and can tonification blood system.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.

The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Record in " herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Radix Cyathulae: be the dry root of Sichuan amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..Nature and flavor: bitter, sour are flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.Record in " Traditional Chinese Medicine in Sichuan will ": expelling wind and removing dampness, stimulate the menstrual flow loose blood.Control cold-damp waist thigh bone pain, flaccidity of the lower limbs clonic spasm of the muscle, women's amenorrhea and lump in the abdomen, gonorrhea, hematuria, impotence, mistake are drowned.

Semen Persicae (parched): the parched medicinal material being Semen Persicae.Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.

Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, supports fresh blood and main Disorder addiction.

Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.

Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Record in " Japan hanako materia medica ": except wind, control gas, warm waist knee joint, broken disease addiction, flutter damage blood stasis, fall tire, and sudden and violent lumbago.

Rhizoma Curcumae Longae: the dry rhizome nature and flavor for zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L.: pungent, bitter, temperature.Return spleen, Liver Channel.Effect: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.Record in Tang Materia Medica: main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.Power is strong in Radix Curcumae.

Oletum Trogopterori: be flying squirrel section animal trogopterus xanthipes Trogopterus Xanthipes Milne-Edwards or the dry feces flying murine little flying squirrel Pteromys volans L..Nature and flavor: sweet, temperature.Effect: promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.Record in " Amplification on Materia Medica addendum ": can promoting the circulation of blood hemostasis.Control trusted subordinate's cold air, married woman is pained, pricking caused by the stagnation of QI and blood.

Eupolyphaga Seu Steleophaga: be Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Steleophaga plancyi(Boleny) female worm dry body.Nature and flavor: salty, cold; Slightly poisonous.Return Liver Channel.Effect: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.

Rhizoma Drynariae: be the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J. Sm..Nature and flavor: bitter, temperature.Return kidney, Liver Channel.Effect: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.Record in " Kaibao Bencao ": main removing blood stasis, hemostasis, benefit is traumaticd fracture.

Sanguis Draxonis: the resin oozed out for babassu Sanguis Draxonis Daemonorops draco Blume. fruit is through being processed into.Nature and flavor: sweet, salty are flat.GUIXIN, Liver Channel.Effect: removing blood stasis and relieving pain, hemostasia and promoting granulation.Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.Record in " Haiyao Bencao, Oversea Materia Medica ": leadingly traumatic fracture damage, all pain, tonify deficiency and vim and vigour stir thorn, and interior blood trouble is gathered, and should wine clothes.

Herba Artemisiae Anomalae: be the herb of feverfew artemisia anomalas.Nature and flavor: bitter, temperature.GUIXIN, spleen channel.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.Record in Tang Materia Medica: main removing blood stasis, lower swollen.

Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Effect: Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Record in " detailed outline ": Rhizoma Zingiberis, can draw that blood medicine enters blood system, gas medicine enters edema caused by disorder of QI.Can go again to dislike and support newly, have the meaning of Yin grows while yang is generating.

Radix Aconiti Kusnezoffii Preparata: be the Preparation process product of Radix Aconiti Kusnezoffii.Radix Aconiti Kusnezoffii is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitum kusnezoffii Reichb..Nature and flavor: pungent, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.Effect: expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.

Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., its rattan claims " Caulis Polygoni Multiflori ".Nature and flavor: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Effect: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.Record in " book on Chinese herbal medicine is stated ": control apoplexy, headache, migratory arthralgia, the arthroncus of knee, epilepsy syndrome, jaundice.

Fructus Mori: be the fruit ear of moraceae plants Mulberry.Nature and flavor: sweet, sour, cold in nature.Return liver, kidney channel.Effect: nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.

Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus (Caulis Sargentodoxae, Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) Spatholobus suberectus Dunn.Nature and flavor: bitter, sweet, temperature.Return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.Record in " decoction pieces is newly joined ": blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.

Hippocampus: be the dry body of Syngnathidae animal strain line Hippocampus Hippocampus kelloggi Jordan et Snyder, HIPPOCAMPUS Hippocampus histrix Kaup, Hippocampus Kuda Hippocampus kuda Bleeker, hippocampus trimaculatus Leacs Hippocampus trimaculatus Leach or little Hippocampus (HAIQU) Hippocampus japonicus Kaup.Nature and flavor: sweet, temperature.Return liver, kidney channel.Effect: warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.For sexual impotence, the enuresis, suffers from a deficiency of the kidney and breathes heavily, lump in the abdomen, injury from falling down; External treatment carbuncle furuncle.Record in " detailed outline ": warm water is hidden, and tonifying YANG road, the abdominal mass that disappears block, controls furuncle swelling toxin.

Rhizoma Polygonati: be the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.Record in " Bencao Congxin ": put down and fill blood and moisten.

Radix Glycyrrhizae Preparata: be the Preparation process product of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Side's solution of the present invention is: in side, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Cyathulae, Semen Persicae (parched), Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Oletum Trogopterori, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Sanguis Draxonis, Radix Aconiti Kusnezoffii Preparata, Radix Polygoni Multiflori, Fructus Mori, Caulis Spatholobi, Hippocampus all return Liver Channel, there is depressed liver-energy dispersing and QI regulating, promoting blood circulation to restore menstrual flow effect.Primary anti-phospholipid syndrome pathological changes endogenous cause of ill is that blood follows row and receives caused by obstruction, and namely blood is obstructed, and it is stagnant to follow the walking retardation in children.Thus initiation primary disease.Liver is viscus attriguted to wind and wood, main catharsis and store blood, and its gas lift is sent out, and happiness bar reaches and dislikes depression, and liver take blood as body, with gas for cloudy with, body and with positive, integrates yang blood and qi, becomes the body of negative and positive unification.Therefore its pathological change easily forms irritability depression, thus hold this disease raw.Above ten seven flavor medicines are as monarch drug in side, first fundamentally depressed liver-energy dispersing and QI regulating, and promoting blood circulation to restore menstrual flow, makes disease obtain basic control.The Radix Astragali, Radix Panacis Quinquefolii, Rhizoma Zingiberis, Rhizoma Polygonati, Radix Glycyrrhizae Preparata return lung meridian invigorating vital QI.Lung governing qi, the main blood of liver, gas and blood have mutual dependence for existence, mutual promotion, the substantial connection of refinforcing each other, and thus when there is pathological changes, QI and blood often can influence each other, and both sees disorder of QI, sees disorders of blood again, is QI and blood being ill simultaneously.Above Six-element medicine, as ministerial drug, assists monarch drug monarch's depressed liver-energy dispersing and QI regulating on the one hand, promoting blood circulation to restore menstrual flow; On the other hand to health invigorating vital QI, promote health blood circulation.The all medicines of this side share, and the monarch and his subjects pull together, and have depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, the effect of the effect that QI invigorating is stimulated the menstrual flow, and can effectively treat primary anti-phospholipid syndrome.

Present Medical Technology research proves: Radix Paeoniae Alba extract paeoniflorin can expand coronary vasodilator and extremity vascular, has hypotensive activity; Carthamus yellow has the platelet aggregation suppressing ADP induction very significantly, and also has obviously depolymerisation to the platelet that ADP has assembled; Have after Radix Angelicae Sinensis extract (containing ligustilide) and reduce blood viscosity effect; Ligustrazine has depolymerisation to the platelet of having assembled; Rhizoma Corydalis ethanol extract has to show to be expanded coronary vasodilator, reduces coronary resistance and the effect increasing blood flow; Curcumin has a significant effect to platelet aggregation and blood viscosity.

Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, wherein be rich in aminoacid in Radix Panacis Quinquefolii and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: the Radix Astragali 28 ~ 32 parts, Radix Panacis Quinquefolii 10 ~ 14 parts, Radix Rehmanniae 16 ~ 20 parts, the Radix Paeoniae Alba 13 ~ 17 parts, Radix Cyathulae 16 ~ 20 parts, Semen Persicae (parched) 10 ~ 14 parts, 7 ~ 11 parts, Flos Carthami, Radix Angelicae Sinensis 18 ~ 22 parts, Rhizoma Chuanxiong 13 ~ 17 parts, Rhizoma Corydalis 16 ~ 20 parts, 13 ~ 17 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 10 ~ 14 parts, Eupolyphaga Seu Steleophaga 4 ~ 8 parts, Rhizoma Drynariae 16 ~ 20 parts, Sanguis Draxonis 1 ~ 5 part, Herba Artemisiae Anomalae 18 ~ 22 parts, Rhizoma Zingiberis 16 ~ 20 parts, Radix Aconiti Kusnezoffii Preparata 7 ~ 11 parts, Radix Polygoni Multiflori 18 ~ 22 parts, Fructus Mori 16 ~ 22 parts, Caulis Spatholobi 18 ~ 22 parts, Hippocampus 10 ~ 14 parts, Rhizoma Polygonati 16 ~ 20 parts, Radix Glycyrrhizae Preparata 4 ~ 8 parts.

Wherein be preferably: the Radix Astragali 30 parts, Radix Panacis Quinquefolii 12 parts, Radix Rehmanniae 18 parts, the Radix Paeoniae Alba 15 parts, Radix Cyathulae 18 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Corydalis 18 parts, 15 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Rhizoma Drynariae 18 parts, Sanguis Draxonis 3 parts, Herba Artemisiae Anomalae 20 parts, Rhizoma Zingiberis 18 parts, Radix Aconiti Kusnezoffii Preparata 9 parts, Radix Polygoni Multiflori 20 parts, Fructus Mori 18 parts, Caulis Spatholobi 20 parts, Hippocampus 12 parts, Rhizoma Polygonati 18 parts, Radix Glycyrrhizae Preparata 6 parts.

A kind of preparation method of the Chinese medicine preparation for primary anti-phospholipid syndrome is as follows:

Step one: by weight of the present invention, gets Sanguis Draxonis and cleans grinding, cross 120 mesh sieves, for subsequent use;

Step 2: by weight of the present invention, gets Radix Paeoniae Alba sheet respectively, puts in pot and fries to micro-yellow with slow fire, take out, cool; Get clean Radix Cyathulae section, put in pot and make popular, spray 50% ~ 60% yellow wine, fry to micro-dry, taking-up cools; Clean Oletum Trogopterori is put micro-stir-fry in pot, sprays edible rice vinegar, then fry to micro-dry, surperficial glossy time take out, dry; First clean Eupolyphaga Seu Steleophaga with clear water, then with drying after 1% salt decocting in water or low baking temperature oven dry; All the other medical materials removing impurity, cleans, runs through, section, dry, for subsequent use;

Step 3: by weight proportion of the present invention, by the Radix Astragali in step one, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Cyathulae, Semen Persicae (parched), Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Oletum Trogopterori, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Rhizoma Zingiberis, Radix Aconiti Kusnezoffii Preparata, Radix Polygoni Multiflori, Caulis Spatholobi, Hippocampus, Rhizoma Polygonati, Radix Glycyrrhizae Preparata medical material is placed in marmite, add the water of 8 times of volumes, intense fire infusion 10 ~ 15 minutes, fiery infusion of larding speech with literary allusions is filtered for 20 ~ 30 minutes, add the water of 2 times of volumes again, by Herba Artemisiae Anomalae, Fructus Mori drops in marmite, slow fire infusion obtains filtrate in 15 ~ 20 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use,

Step 4: by weight proportion of the present invention, gets Radix Panacis Quinquefolii and is placed in marmite, adds 3 times of volume water, slow fire infusion 10 ~ 15 minutes, and infusion merges gained filtrate three times repeatedly, for subsequent use;

Step 5: combining step three and step 4 gained filtrate, pours into the warm medicinal liquid decocted in proportion in step one and is placed with in the bowl of medicated powder, take after mixing it with water, both Chinese medicine decoction of the present invention.

Using method of the present invention: get decoction after meal warm, pours in the bowl being placed with Sanguis Draxonis medicated powder, takes after mixing it with water.Every day 3 times.It within 7 days, is a course for the treatment of.

Chinese medicine Radix Cyathulae of the present invention with wine processing in order to strengthen Radix Cyathulae blood circulation promoting and blood stasis dispelling effect; Oletum Trogopterori vinegar concocts the abnormal flavour but also enhancing Oletum Trogopterori blood stasis dispelling effect of not only removing Oletum Trogopterori; And the process of preparing Chinese medicine of Eupolyphaga Seu Steleophaga saline is the effect strengthening Eupolyphaga Seu Steleophaga blood circulation promoting and blood stasis dispelling.

Medicine of the present invention has depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, the effect that QI invigorating is stimulated the menstrual flow, and effective, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced Western medicine and the injury of operation to patient body, alleviate the slight illness of patient, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one: the Radix Astragali 30 parts, Radix Panacis Quinquefolii 12 parts, Radix Rehmanniae 18 parts, the Radix Paeoniae Alba 15 parts, Radix Cyathulae 18 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Corydalis 18 parts, 15 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Rhizoma Drynariae 18 parts, Sanguis Draxonis 3 parts, Herba Artemisiae Anomalae 20 parts, Rhizoma Zingiberis 18 parts, Radix Aconiti Kusnezoffii Preparata 9 parts, Radix Polygoni Multiflori 20 parts, Fructus Mori 18 parts, Caulis Spatholobi 20 parts, Hippocampus 12 parts, Rhizoma Polygonati 18 parts, Radix Glycyrrhizae Preparata 6 parts.

Embodiment two: the Radix Astragali 28 parts, Radix Panacis Quinquefolii 12 parts, Radix Rehmanniae 18 parts, the Radix Paeoniae Alba 15 parts, Radix Cyathulae 20 parts, Semen Persicae (parched) 12 parts, 8 parts, Flos Carthami, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Corydalis 18 parts, 15 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Rhizoma Drynariae 18 parts, Sanguis Draxonis 3 parts, Herba Artemisiae Anomalae 20 parts, Rhizoma Zingiberis 16 parts, Radix Aconiti Kusnezoffii Preparata 9 parts, Radix Polygoni Multiflori 20 parts, Fructus Mori 18 parts, Caulis Spatholobi 20 parts, Hippocampus 12 parts, Rhizoma Polygonati 18 parts, Radix Glycyrrhizae Preparata 6 parts.

Embodiment three: the Radix Astragali 30 parts, Radix Panacis Quinquefolii 13 parts, Radix Rehmanniae 19 parts, the Radix Paeoniae Alba 15 parts, Radix Cyathulae 18 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 19 parts, Rhizoma Chuanxiong 16 parts, Rhizoma Corydalis 18 parts, 16 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Rhizoma Drynariae 18 parts, Sanguis Draxonis 3 parts, Herba Artemisiae Anomalae 21 parts, Rhizoma Zingiberis 18 parts, Radix Aconiti Kusnezoffii Preparata 8 parts, Radix Polygoni Multiflori 20 parts, Fructus Mori 20 parts, Caulis Spatholobi 20 parts, Hippocampus 13 parts, Rhizoma Polygonati 18 parts, Radix Glycyrrhizae Preparata 6 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept patient 240 example for medical treatment, patient is divided at random observation group and each 120 examples of matched group, wherein male 24 example, women 216 example, M-F 1:9, max age 38 years old, minimal ages 18 years old, the several thoughtful some months of the course of disease is not etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).

Two, diagnostic criteria

1, clinical criteria

(1) blood vessel embolism

The artery and vein of any tissue or organ and thin vessels generation thrombosis >=1 time.

(2) abnormal pregnancy

1) the gestation normal foetal death of unaccountable morphology in more than 10 weeks or 10 weeks is betided for >=1 time, or 2) >=betide the serious preeclampsia of the cause of pregnant 34 weeks, eclamposia or the normal neonate premature labor of the morphology caused by clear and definite placental insufficiency for 1 time, or 3) >=betide unaccountable spontaneous abortion before pregnant 10 weeks for 3 times, must get rid of parent dissect or hormone abnormality and parental chromosomes abnormal.

2. laboratory standard

(1) lupus anticoagulant at least 2 positives, interval at least 12 week.

(2) medium/high titre IgG/IgM type ACL at least detects 2 times, interval at least 12 week.

(3) IgG/IgM type anti-β 2GP1 antibody at least detects 2 times, interval at least 12 week.Diagnosis APS must meet at least 1 clinical criteria and 1 laboratory standard.

Three, Therapeutic Method:

1, observation group is according to Medications Example one of the present invention, weighting raw materials (daily dose), by the treatment of invention implementation method, gets decoction warm, every day 3 times.It within 7 days, is a course for the treatment of.

2, matched group adopts conventional warfarin treatment method, and the Ureteral Calculus phase is 7 days.

Four, efficacy assessment standard:

1, cure: pain disappears completely, thrombosis disappears, and platelet is normal, not in generation pain in 3 months.

2, take a turn for the better: pain can obviously alleviate, and thrombosis diminishes, and platelet recovers normal substantially, treat after 1 month and recover normal.

3, invalid: thrombosis and platelet change are very unobvious, even increase the weight of.

Five, therapeutic outcome statistics:

Matched group result is added up

Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of

Wherein: total effective rate=cure rate+improvement rate

Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness on treatment primary anti-phospholipid syndrome, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.

Model case and curative effect:

Case one, patient Wang, man, 28 years old, people from Qingdao City, came here and goes to a doctor on January 18th, 2013.Main cause: kidney position checks there is thrombosis.Before patient half a year there is two lumbocrural pain in unknown cause, walks for a long time, to stand and after stair activity, pain increases the weight of, after having a rest and night antalgesic do not alleviate, through examination in hospital, find anticardiolipin antibody ACA positive, B2-GP1 is also positive, is diagnosed as primary anti-phospholipid syndrome.Hospital adopts warfarin to treat patient, and effect is not remarkable, treats by recommending here.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur for 1 year.

Case two, patient Lee, female, 29 years old, people from Qingzhou in Shandong province.Come here on May 14th, 2013 to go to a doctor, symptom is as follows after diagnosing: after each gestation, latter half of gestation is miscarried.Be that Placenta Hominis thrombosis causes on inspection, be diagnosed as primary anti-phospholipid syndrome through hospital.Adopt warfarin treatment 3 years, symptom still exists, and marries and does not educate so far for 5 years.Here treatment afterwards adopts made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and after 2 years, Effect of follow-up visit by telephone has given birth to a youngster, family life also gets a promotion because of the arrival of baby, and mother-in-law and daughter-in-law's relation is harmonious further.

Case three: Song, female, 32 years old, family's Yishui, Shandong, JIUYUE in 2013 first visit on the 22nd.Main suit: marriage in 2005 is not educated so far, and each later stage of pregnancy all miscarries.Make a round of visits everywhere and ask doctor.Be primary anti-phospholipid syndrome by hospital diagnosis.Adopt warfarin treatment 4 years, symptom still exists, and does not educate so far.Marital relations once worsened.Carry out here treatment after being introduced, adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and after 2 years, Effect of follow-up visit by telephone has given birth to a youngster, and one's wedded life obtains firmly, family life also gets a promotion because of the arrival of baby, and mother-in-law and daughter-in-law's relation is harmonious further.

Claims (4)

1. the Chinese medicine preparation for primary anti-phospholipid syndrome, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: the Radix Astragali 28 ~ 32 parts, Radix Panacis Quinquefolii 10 ~ 14 parts, Radix Rehmanniae 16 ~ 20 parts, the Radix Paeoniae Alba 13 ~ 17 parts, Radix Cyathulae 16 ~ 20 parts, Semen Persicae (parched) 10 ~ 14 parts, 7 ~ 11 parts, Flos Carthami, Radix Angelicae Sinensis 18 ~ 22 parts, Rhizoma Chuanxiong 13 ~ 17 parts, Rhizoma Corydalis 16 ~ 20 parts, 13 ~ 17 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 10 ~ 14 parts, Eupolyphaga Seu Steleophaga 4 ~ 8 parts, Rhizoma Drynariae 16 ~ 20 parts, Sanguis Draxonis 1 ~ 5 part, Herba Artemisiae Anomalae 18 ~ 22 parts, Rhizoma Zingiberis 16 ~ 20 parts, Radix Aconiti Kusnezoffii Preparata 7 ~ 11 parts, Radix Polygoni Multiflori 18 ~ 22 parts, Fructus Mori 16 ~ 22 parts, Caulis Spatholobi 18 ~ 22 parts, Hippocampus 10 ~ 14 parts, Rhizoma Polygonati 16 ~ 20 parts, Radix Glycyrrhizae Preparata 4 ~ 8 parts.

2. a kind of Chinese medicine preparation for primary anti-phospholipid syndrome according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: the Radix Astragali 30 parts, Radix Panacis Quinquefolii 12 parts, Radix Rehmanniae 18 parts, the Radix Paeoniae Alba 15 parts, Radix Cyathulae 18 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Corydalis 18 parts, 15 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Rhizoma Drynariae 18 parts, Sanguis Draxonis 3 parts, Herba Artemisiae Anomalae 20 parts, Rhizoma Zingiberis 18 parts, Radix Aconiti Kusnezoffii Preparata 9 parts, Radix Polygoni Multiflori 20 parts, Fructus Mori 18 parts, Caulis Spatholobi 20 parts, Hippocampus 12 parts, Rhizoma Polygonati 18 parts, Radix Glycyrrhizae Preparata 6 parts.

3. a kind of Chinese medicine preparation for primary anti-phospholipid syndrome according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. for a preparation method for the Chinese medicine preparation of primary anti-phospholipid syndrome, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, gets Sanguis Draxonis and cleans, grinding, cross 120 mesh sieves, for subsequent use; Step 2: by weight of the present invention, gets Radix Paeoniae Alba sheet respectively, puts in pot and fries to micro-yellow with slow fire, take out, cool; Get clean Radix Cyathulae section, put in pot and make popular, spray 50% ~ 60% yellow wine, fry to micro-dry, taking-up cools; Clean Oletum Trogopterori is put micro-stir-fry in pot, sprays edible rice vinegar, then fry to micro-dry, surperficial glossy time take out, dry; First clean Eupolyphaga Seu Steleophaga with clear water, then with drying after 1% salt decocting in water or low baking temperature oven dry; All the other medical materials removing impurity, cleans, runs through, section, dry, for subsequent use; Step 3: by weight proportion of the present invention, the Radix Astragali, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Cyathulae, Semen Persicae (parched), Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Oletum Trogopterori, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Rhizoma Zingiberis, Radix Aconiti Kusnezoffii Preparata, Radix Polygoni Multiflori, Caulis Spatholobi, Hippocampus, Rhizoma Polygonati, Radix Glycyrrhizae Preparata medical material are placed in marmite, add the water of 8 times of volumes, intense fire infusion 10 ~ 15 minutes, fiery infusion of larding speech with literary allusions is filtered for 20 ~ 30 minutes, add the water of 2 times of volumes again, Herba Artemisiae Anomalae, Fructus Mori are dropped in marmite, slow fire infusion obtains filtrate in 15 ~ 20 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use; Step 4: by weight proportion of the present invention, gets Radix Panacis Quinquefolii and is placed in marmite, adds 3 times of volume water, slow fire infusion 10 ~ 15 minutes, and infusion merges gained filtrate three times repeatedly, for subsequent use; Step 5: combining step three and step 4 gained filtrate, pours into the warm medicinal liquid decocted in proportion in step one and is placed with in the bowl of medicated powder, both Chinese medicine decoction of the present invention.