CN1360938A - Nanometer rhinitis-treaitng Qianbai medicine and its prepn - Google Patents
Nanometer rhinitis-treaitng Qianbai medicine and its prepn Download PDFInfo
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- CN1360938A CN1360938A CN 00136934 CN00136934A CN1360938A CN 1360938 A CN1360938 A CN 1360938A CN 00136934 CN00136934 CN 00136934 CN 00136934 A CN00136934 A CN 00136934A CN 1360938 A CN1360938 A CN 1360938A
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Abstract
The nano rhinitis treating Qianbai medicine is prepared with nano climbing groundsel, nano notoperygium root, nano cassia seed, nano ephedra, nano Rhizoma Ligustici Chuanxiong and other two kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, promoting blood circulation by removing wind, be used for that evil poison is stayed for a long time, the stuffy nose of qi depression to blood stasis (chronic hypertrophic rhinitis), the nanometer thousand cypress preparation for treating rhinitis medicines of allergic rhinitis with sneezing (allergic rhinitis) the invention still further relates to the method for this medication preparation.
QIANBAI BIYAN PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as antibacterial, antiallergic, is used for that evil poison is stayed for a long time, the stuffy nose of qi depression to blood stasis (chronic hypertrophic rhinitis), allergic rhinitis with sneezing (allergic rhinitis) etc.But traditional QIANBAI BIYAN PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer thousand cypress preparation for treating rhinitis medicines of increase evident in efficacy.
Another object of the present invention provides the preparation method of these nanometer thousand cypress preparation for treating rhinitis medicines.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Senecionis Scandentis 1358-3489 part nanometer Herba Selaginellae 227-580 part
The sub-136-348 part of nanometer Rhizoma Et Radix Notopterygii 9-23 part nano jueming
Nanometer Herba Ephedrae 45-116 part nanometer Rhizoma Chuanxiong 5-12 part
Nano angelica root 5-12 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Senecionis Scandentis 1940-2908 part nanometer Herba Selaginellae 324-484 part
The sub-194-290 part of nanometer Rhizoma Et Radix Notopterygii 12-20 part nano jueming
Nanometer Herba Ephedrae 65-100 part nanometer Rhizoma Chuanxiong 6-10 part
Nano angelica root 6-10 part
The best important proportioning of medicine of the present invention is:
16 parts of 404 parts of nanometer Rhizoma Et Radix Notopterygiis of 2424 parts of nanometer Herba Selaginellaes of nanometer Herba Senecionis Scandentis
8 parts of 81 parts of nanometer Rhizoma Chuanxiongs of nano jueming 242 parts of nanometer Herba Ephedraes of son
8 parts of nano angelica roots
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get QIANBAI BIYAN PIAN preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer thousand cypress preparation for treating rhinitis medicines is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common QIANBAI BIYAN PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection of nanometer thousand cypress preparation for treating rhinitis medicines etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for acute and chronic rhinitis, treatment of conditions such as sinusitis and pharyngitis, and clinical efficacy significantly is better than traditional QIANBAI BIYAN PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
16 parts of 404 parts of nanometer Rhizoma Et Radix Notopterygiis of 2424 parts of nanometer Herba Selaginellaes of nanometer Herba Senecionis Scandentis
8 parts of 81 parts of nanometer Rhizoma Chuanxiongs of nano jueming 242 parts of nanometer Herba Ephedraes of son
8 parts of nano angelica roots
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.
Embodiment 2:
Prepare nano raw material by preceding method:
16 parts of 404 parts of nanometer Rhizoma Et Radix Notopterygiis of 2424 parts of nanometer Herba Selaginellaes of nanometer Herba Senecionis Scandentis
8 parts of 81 parts of nanometer Rhizoma Chuanxiongs of nano jueming 242 parts of nanometer Herba Ephedraes of son
8 parts of nano angelica roots
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer thousand cypress rhinitis powder needle injections, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
16 parts of 404 parts of nanometer Rhizoma Et Radix Notopterygiis of 2424 parts of nanometer Herba Selaginellaes of nanometer Herba Senecionis Scandentis
8 parts of 81 parts of nanometer Rhizoma Chuanxiongs of nano jueming 242 parts of nanometer Herba Ephedraes of son
8 parts of nano angelica roots
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer thousand cypress rhinitis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, and paste the medicine position: chest, cervical region etc. is located.
Claims (6)
1, a kind of nanometer thousand cypress preparation for treating rhinitis medicines is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Senecionis Scandentis 1358-3489 part nanometer Herba Selaginellae 227-580 part
The sub-136-348 part of nanometer Rhizoma Et Radix Notopterygii 9-23 part nano jueming
Nanometer Herba Ephedrae 45-116 part nanometer Rhizoma Chuanxiong 5-12 part
Nano angelica root 5-12 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer thousand cypress preparation for treating rhinitis medicines according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Senecionis Scandentis 1940-2908 part nanometer Herba Selaginellae 324-484 part
The sub-194-290 part of nanometer Rhizoma Et Radix Notopterygii 12-20 part nano jueming
Nanometer Herba Ephedrae 65-100 part nanometer Rhizoma Chuanxiong 6-10 part
Nano angelica root 6-10 part
3, nanometer thousand cypress preparation for treating rhinitis medicines according to claim 1, wherein the weight proportion of each nano raw material is:
16 parts of 404 parts of nanometer Rhizoma Et Radix Notopterygiis of 2424 parts of nanometer Herba Selaginellaes of nanometer Herba Senecionis Scandentis
8 parts of 81 parts of nanometer Rhizoma Chuanxiongs of nano jueming 242 parts of nanometer Herba Ephedraes of son
8 parts of nano angelica roots
4, according to claim 1 or 2 or 3 described nanometer thousand cypress preparation for treating rhinitis medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer thousand cypress preparation for treating rhinitis medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136934 CN1360938A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis-treaitng Qianbai medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136934 CN1360938A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis-treaitng Qianbai medicine and its prepn |
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| CN1360938A true CN1360938A (en) | 2002-07-31 |
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| CN 00136934 Pending CN1360938A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis-treaitng Qianbai medicine and its prepn |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417385C (en) * | 2006-09-26 | 2008-09-10 | 林星 | Externally-applied preparation for treating trauma |
| CN101474381B (en) * | 2009-01-10 | 2011-10-26 | 广东顺峰药业有限公司 | Medicament for treating acute and chronic rhinitis as well as preparation method thereof and nasal cavity medicine delivery device |
-
2000
- 2000-12-29 CN CN 00136934 patent/CN1360938A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417385C (en) * | 2006-09-26 | 2008-09-10 | 林星 | Externally-applied preparation for treating trauma |
| CN101474381B (en) * | 2009-01-10 | 2011-10-26 | 广东顺峰药业有限公司 | Medicament for treating acute and chronic rhinitis as well as preparation method thereof and nasal cavity medicine delivery device |
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