CN1360937A - Nanometer rhinitis treating medicine and its prepn - Google Patents
Nanometer rhinitis treating medicine and its prepn Download PDFInfo
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- CN1360937A CN1360937A CN 00136933 CN00136933A CN1360937A CN 1360937 A CN1360937 A CN 1360937A CN 00136933 CN00136933 CN 00136933 CN 00136933 A CN00136933 A CN 00136933A CN 1360937 A CN1360937 A CN 1360937A
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Abstract
The nano rhinitis treating medicine is prepared with nano Flos Chrysanthemi Indici, nano Fructus Xanthii, nano Rhizoma Paridis, nano selfheal, nano Codonopsis Pilosulae and other three kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, the nanometer rhinitis treating preparation medicine of chronic rhinitis the invention still further relates to the method for this medication preparation.
The rhinitis treating electuary is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, is used for scorchingly hot nasopharynx, the nasopharyngeal sore pain of penting up, and disease such as secretions increase after the nasopharynx part chronic inflammatory disease, nasopharyngeal carcinoma radiotherapy.But traditional rhinitis treating electuary disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer rhinitis treating preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer rhinitis treating preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Flos Chrysanthemi Indici 10-50 part nanometer Fructus Xanthii 5-40 part nanometer Rhizoma Paridis 5-50 part
Nanometer Rubus Parvifolius L. 5-500 part nanometer Radix Zanthoxyli 5-40 part nanometer Spica Prunellae 5-50 part
Nanometer Radix Gentianae 3-50 part nanometer Radix Codonopsis 3-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Flos Chrysanthemi Indici 20-40 part nanometer Fructus Xanthii 10-30 part nanometer Rhizoma Paridis 15-40 part
Nanometer Rubus Parvifolius L. 15-40 part nanometer Radix Zanthoxyli 10-30 part nanometer Spica Prunellae 10-30 part
Nanometer Radix Gentianae 8-30 part nanometer Radix Codonopsis 8-30 part
The best important proportioning of medicine of the present invention is:
25 parts of 20 parts of nanometer Rhizoma Paridis of 30 parts of nanometer Fructus Xanthii of nanometer Flos Chrysanthemi Indici
20 parts of 20 parts of nanometer Spica Prunellaes of 25 parts of nanometer Radix Zanthoxylis of nanometer Rubus Parvifolius L.
15 parts of 15 parts of nanometer Radix Codonopsis of nanometer Radix Gentianae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the special construction of nano material------material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, get rhinitis treating preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nanometer rhinitis treating preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common rhinitis treating electuary preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nanometer rhinitis treating preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for scorchingly hotly penting up nasopharynx, nasopharyngeal sore pain, and treatment of conditions such as secretions increase after the nasopharynx part chronic inflammatory disease, nasopharyngeal carcinoma radiotherapy, and clinical efficacy significantly is better than traditional rhinitis treating granule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 20 parts of nanometer Rhizoma Paridis of 30 parts of nanometer Fructus Xanthii of nanometer Flos Chrysanthemi Indici
20 parts of 20 parts of nanometer Spica Prunellaes of 25 parts of nanometer Radix Zanthoxylis of nanometer Rubus Parvifolius L.
15 parts of 15 parts of nanometer Radix Codonopsis of nanometer Radix Gentianae
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 20 parts of nanometer Rhizoma Paridis of 30 parts of nanometer Fructus Xanthii of nanometer Flos Chrysanthemi Indici
20 parts of 20 parts of nanometer Spica Prunellaes of 25 parts of nanometer Radix Zanthoxylis of nanometer Rubus Parvifolius L.
15 parts of 15 parts of nanometer Radix Codonopsis of nanometer Radix Gentianae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nanometer rhinitis treating powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
25 parts of 20 parts of nanometer Rhizoma Paridis of 30 parts of nanometer Fructus Xanthii of nanometer Flos Chrysanthemi Indici
20 parts of 20 parts of nanometer Spica Prunellaes of 25 parts of nanometer Radix Zanthoxylis of nanometer Rubus Parvifolius L.
15 parts of 15 parts of nanometer Radix Codonopsis of nanometer Radix Gentianae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer rhinitis treating membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, and paste the medicine position: back, chest, cervical region etc. are located.
Claims (6)
1, a kind of nanometer rhinitis treating preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Flos Chrysanthemi Indici 10-50 part nanometer Fructus Xanthii 5-40 part nanometer Rhizoma Paridis 5-50 part
Nanometer Rubus Parvifolius L. 5-500 part nanometer Radix Zanthoxyli 5-40 part nanometer Spica Prunellae 5-50 part
Nanometer Radix Gentianae 3-50 part nanometer Radix Codonopsis 3-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer rhinitis treating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Flos Chrysanthemi Indici 20-40 part nanometer Fructus Xanthii 10-30 part nanometer Rhizoma Paridis 15-40 part
Nanometer Rubus Parvifolius L. 15-40 part nanometer Radix Zanthoxyli 10-30 part nanometer Spica Prunellae 10-30 part
Nanometer Radix Gentianae 8-30 part nanometer Radix Codonopsis 8-30 part
3, nanometer rhinitis treating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 20 parts of nanometer Rhizoma Paridis of 30 parts of nanometer Fructus Xanthii of nanometer Flos Chrysanthemi Indici
20 parts of 20 parts of nanometer Spica Prunellaes of 25 parts of nanometer Radix Zanthoxylis of nanometer Rubus Parvifolius L.
15 parts of 15 parts of nanometer Radix Codonopsis of nanometer Radix Gentianae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nanometer rhinitis treating preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer rhinitis treating preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136933 CN1360937A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis treating medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136933 CN1360937A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis treating medicine and its prepn |
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| CN1360937A true CN1360937A (en) | 2002-07-31 |
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| CN 00136933 Pending CN1360937A (en) | 2000-12-29 | 2000-12-29 | Nanometer rhinitis treating medicine and its prepn |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105166308A (en) * | 2015-08-27 | 2015-12-23 | 济南舜祥医药科技有限公司 | Ginger-flavored chewing gum and preparation method thereof |
| CN118286342A (en) * | 2024-05-22 | 2024-07-05 | 广州白云山和记黄埔中药有限公司 | Application of nasopharynx toxicity-removing preparation in resisting klebsiella pneumoniae |
-
2000
- 2000-12-29 CN CN 00136933 patent/CN1360937A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105166308A (en) * | 2015-08-27 | 2015-12-23 | 济南舜祥医药科技有限公司 | Ginger-flavored chewing gum and preparation method thereof |
| CN118286342A (en) * | 2024-05-22 | 2024-07-05 | 广州白云山和记黄埔中药有限公司 | Application of nasopharynx toxicity-removing preparation in resisting klebsiella pneumoniae |
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