CN1362159A - Nano shuxin syrup and preparation - Google Patents
Nano shuxin syrup and preparation Download PDFInfo
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- CN1362159A CN1362159A CN 01100314 CN01100314A CN1362159A CN 1362159 A CN1362159 A CN 1362159A CN 01100314 CN01100314 CN 01100314 CN 01100314 A CN01100314 A CN 01100314A CN 1362159 A CN1362159 A CN 1362159A
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Abstract
The present invention discloses a nano Shuxin tangjiang preparation medicine. It is made up by using 7 Chinese medicinal materials of nano codonopsis, nano astragalus, nano carthamus, nano tangkuei, nano ligusticum and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of reinforce functional activities of the heart, blood circulation promoting and blood stasis dispelling, change the function of relieving boredom, cure mainly the comfortable syrup preparation medicine of nanometer of coronary heart disease, the invention still further relates to the method for this medication preparation.
Comfortable syrup is a kind of classical Chinese patent medicine, mainly contains anoxia enduring, resists myocardial ischemia, expands effects such as coronary vasodilator, antiplatelet aggregation, be used for coronary heart disease, angina pectoris, chest pain, uncomfortable in chest, breathe hard, weak.But traditional comfortable absorption is incomplete, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the comfortable syrup preparation medicine of the nanometer of increase evident in efficacy.
Another object of the present invention provides the preparation method of the comfortable syrup preparation medicine of this nanometer.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 100-200 part nano astragalus 100-200 part nano safflower 60-140 part
Nano Chinese angelica 60-140 part nanometer Rhizoma Chuanxiong 60-140 part nanometer rhizoma sparganic 60-140 part
Nanometer Pollen Typhae 60-140 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 120-180 part nano astragalus 120-180 part nano safflower 80-120 part
Nano Chinese angelica 80-120 part nanometer Rhizoma Chuanxiong 80-120 part nanometer rhizoma sparganic 80-120 part
Nanometer Pollen Typhae 80-120 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 150 parts of nano safflowers of 150 parts of nano astragalus of nanometer Radix Codonopsis
100 parts of 100 parts of nanometer rhizoma sparganic of 100 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
100 parts of nanometer Pollen Typhaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since nano material special construction---the material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get comfortable syrup preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the comfortable syrup preparation medicine of nanometer is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common comfortable syrup preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of the comfortable syrup preparation medicine of nanometer etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as coronary heart disease, angina pectoris, coronary heart disease companion high blood viscosity, and clinical efficacy significantly is better than traditional comfortable syrup.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 150 parts of nano safflowers of 150 parts of nano astragalus of nanometer Radix Codonopsis
100 parts of 100 parts of nanometer rhizoma sparganic of 100 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
100 parts of nanometer Pollen Typhaes
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 150 parts of nano safflowers of 150 parts of nano astragalus of nanometer Radix Codonopsis
100 parts of 100 parts of nanometer rhizoma sparganic of 100 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
100 parts of nanometer Pollen Typhaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make the comfortable powder needle injection of nanometer, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method
100 parts of 150 parts of nano safflowers of 150 parts of nano astragalus of nanometer Radix Codonopsis
100 parts of 100 parts of nanometer rhizoma sparganic of 100 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
100 parts of nanometer Pollen Typhaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make the comfortable membrane of nanometer, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, the comfortable syrup preparation medicine of a kind of nanometer is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 100-200 part nano astragalus 100-200 part nano safflower 60-140 part
Nano Chinese angelica 60-140 part nanometer Rhizoma Chuanxiong 60-140 part nanometer rhizoma sparganic 60-140 part
Nanometer Pollen Typhae 60-140 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the comfortable syrup preparation medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 120-180 part nano astragalus 120-180 part nano safflower 80-120 part
Nano Chinese angelica 80-120 part nanometer Rhizoma Chuanxiong 80-120 part nanometer rhizoma sparganic 80-120 part
Nanometer Pollen Typhae 80-120 part
3, the comfortable syrup preparation medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 150 parts of nano safflowers of 150 parts of nano astragalus of nanometer Radix Codonopsis
100 parts of 100 parts of nanometer rhizoma sparganic of 100 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
100 parts of nanometer Pollen Typhaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or the comfortable syrup preparation medicine of 2 or 3 described nanometers.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the comfortable syrup preparation medicine of 2 or 3 described nanometers; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100314 CN1362159A (en) | 2001-01-02 | 2001-01-02 | Nano shuxin syrup and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100314 CN1362159A (en) | 2001-01-02 | 2001-01-02 | Nano shuxin syrup and preparation |
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| CN1362159A true CN1362159A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100314 Pending CN1362159A (en) | 2001-01-02 | 2001-01-02 | Nano shuxin syrup and preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728827A (en) * | 2016-12-20 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | It is a kind of to treat Chinese medicine preparation of angiocardiopathy and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100314 patent/CN1362159A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728827A (en) * | 2016-12-20 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | It is a kind of to treat Chinese medicine preparation of angiocardiopathy and preparation method thereof |
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