CN1362139A - Nano Pingxiao medicine and its preparation - Google Patents
Nano Pingxiao medicine and its preparation Download PDFInfo
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- CN1362139A CN1362139A CN 01100192 CN01100192A CN1362139A CN 1362139 A CN1362139 A CN 1362139A CN 01100192 CN01100192 CN 01100192 CN 01100192 A CN01100192 A CN 01100192A CN 1362139 A CN1362139 A CN 1362139A
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Abstract
The present invention discloses a nano Pingxiao preparation medicine. It is made up by using 8 Chinese medicinal materials of nano curcume, nano agrimony, nano flying squirrel's droppings, nano alum, nano niter and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of blood circulation promoting and blood stasis dispelling, pain-relieving powder for treating joint, heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors, be used to suppress the flat oral preparation for eliminating medicine of nanometer of tumor growth, the invention still further relates to the method for this medication preparation.
PINGXIAO PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as blood circulation promoting and blood stasis dispelling, pain-relieving powder for treating joint, heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors, and tumor is had certain relief of symptoms, dwindles the tumor body, suppresses tumor growth, improves body immunity, prolongs patient's vitality.But traditional PINGXIAO PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the flat oral preparation for eliminating medicine of the nanometer of increase evident in efficacy.
Another object of the present invention provides the preparation method of the flat oral preparation for eliminating medicine of this nanometer.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Curcumae 34-74 part nanometer Herba Agrimoniae 34-84 part nanometer Oletum Trogopterori 35-80 part
Nanometer Alumen 34-80 part nanometer Sal Nitri 34-84 part nanometer Resina Toxicodendri 10-30 part
Nanometer Fructus Aurantii 60-120 part nano vomiting nut powder 10-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Curcumae 44-64 part nanometer Herba Agrimoniae 44-64 part nanometer Oletum Trogopterori 45-60 part
Nanometer Alumen 44-60 part nanometer Sal Nitri 44-64 part nanometer Resina Toxicodendri 13-20 part
Nanometer Fructus Aurantii 80-100 part nano vomiting nut powder 20-50 part
The optimum weight proportioning of medicine of the present invention is:
45 parts of 54 parts of nanometer Oletum Trogopteroris of 54 parts of nanometer Herba Agrimoniaes of nanometer Radix Curcumae
18 parts of 54 parts of nanometer Resina Toxicodendri of 54 parts of nanometer Sal Nitri of nanometer Alumen
36 parts in 90 parts of nano vomiting nut powder of nanometer Fructus Aurantii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, must flat oral preparation for eliminating nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the flat oral preparation for eliminating medicine of nanometer is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common PINGXIAO PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, exhausted people's part can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of the flat oral preparation for eliminating medicine of nanometer etc. had no precedent in the past.
Pharmaceutical preparation of the present invention has certain relief of symptoms, dwindles the tumor body, suppresses tumor growth, improves body immunity, prolongs patient's vitality tumor, and clinical efficacy significantly is better than traditional PINGXIAO PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
45 parts of 54 parts of nanometer Oletum Trogopteroris of 54 parts of nanometer Herba Agrimoniaes of nanometer Radix Curcumae
18 parts of 54 parts of nanometer Resina Toxicodendri of 54 parts of nanometer Sal Nitri of nanometer Alumen
36 parts in 90 parts of nano vomiting nut powder of nanometer Fructus Aurantii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
45 parts of 54 parts of nanometer Oletum Trogopteroris of 54 parts of nanometer Herba Agrimoniaes of nanometer Radix Curcumae
18 parts of 54 parts of nanometer Resina Toxicodendri of 54 parts of nanometer Sal Nitri of nanometer Alumen
36 parts in 90 parts of nano vomiting nut powder of nanometer Fructus Aurantii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the flat powder needle injection that disappears of nanometer, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
45 parts of 54 parts of nanometer Oletum Trogopteroris of 54 parts of nanometer Herba Agrimoniaes of nanometer Radix Curcumae
18 parts of 54 parts of nanometer Resina Toxicodendri of 54 parts of nanometer Sal Nitri of nanometer Alumen
36 parts in 90 parts of nano vomiting nut powder of nanometer Fructus Aurantii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the flat membrane that disappears of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, affected part.
Claims (6)
1, the flat oral preparation for eliminating medicine of a kind of nanometer is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Curcumae 34-74 part nanometer Herba Agrimoniae 34-84 part nanometer Oletum Trogopterori 35-80 part
Nanometer Alumen 34-80 part nanometer Sal Nitri 34-84 part nanometer Resina Toxicodendri 10-30 part
Nanometer Fructus Aurantii 60-120 part nano vomiting nut powder 10-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30-60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the flat oral preparation for eliminating medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Curcumae 44-64 part nanometer Herba Agrimoniae 44-64 part nanometer Oletum Trogopterori 45-60 part
Nanometer Alumen 44-60 part nanometer Sal Nitri 44-64 part nanometer Resina Toxicodendri 13-20 part
Nanometer Fructus Aurantii 80-100 part nano vomiting nut powder 20-50 part
3, the flat oral preparation for eliminating medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
45 parts of 54 parts of nanometer Oletum Trogopteroris of 54 parts of nanometer Herba Agrimoniaes of nanometer Radix Curcumae
18 parts of 54 parts of nanometer Resina Toxicodendri of 54 parts of nanometer Sal Nitri of nanometer Alumen
36 parts in 90 parts of nano vomiting nut powder of nanometer Fructus Aurantii
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or the flat oral preparation for eliminating medicine of 2 or 3 described nanometers.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the flat oral preparation for eliminating medicine of 2 or 3 described nanometers; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100192 CN1362139A (en) | 2001-01-05 | 2001-01-05 | Nano Pingxiao medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100192 CN1362139A (en) | 2001-01-05 | 2001-01-05 | Nano Pingxiao medicine and its preparation |
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| CN1362139A true CN1362139A (en) | 2002-08-07 |
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| CN 01100192 Pending CN1362139A (en) | 2001-01-05 | 2001-01-05 | Nano Pingxiao medicine and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566281A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
-
2001
- 2001-01-05 CN CN 01100192 patent/CN1362139A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566281A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
| CN103566281B (en) * | 2012-07-27 | 2016-12-21 | 西安正大制药有限公司 | A kind of Traditional Chinese medicine composition with anti-tumor effect and preparation method |
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