CN1362175A - Nano Naoliqing medicine and its preparation - Google Patents
Nano Naoliqing medicine and its preparation Download PDFInfo
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- CN1362175A CN1362175A CN 01100330 CN01100330A CN1362175A CN 1362175 A CN1362175 A CN 1362175A CN 01100330 CN01100330 CN 01100330 CN 01100330 A CN01100330 A CN 01100330A CN 1362175 A CN1362175 A CN 1362175A
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Abstract
The present invention discloses a nano Naoliqing preparation medicine. It is made up by using 10 Chinese medicinal materials of nano loadstone, nano cooked distiller's yeast, nano borneol, nano achyranthes, nano mother-of-pearl and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in the therapeutic effect.
Description
The present invention relates to a kind of suppressing the hyperactive liver and subsiding YANG, refreshment and tranquilization, cure mainly that excessive rising of liver-YANG causes have a dizzy spell, the tinnitus bitter taste, vexed difficulty is slept and the nanometer NAOLIQING preparation medicine of disease such as hypertension, the invention still further relates to the method for this medication preparation.
The NAOLIQING capsule is a kind of classical Chinese patent medicine, mainly contains effects such as calmness, blood pressure lowering, be used for that excessive rising of liver-YANG causes have a dizzy spell, the tinnitus bitter taste, vexed difficulty is slept and disease such as hypertension.But traditional NAOLIQING capsule disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer NAOLIQING preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer NAOLIQING preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The ripe distillers yeast 20-60 of nano magnetite 20-50 part nanometer part
Nanometer Borneolum Syntheticum 5-20 part nanometer Radix Achyranthis Bidentatae 20-50 part
The female 10-40 part of nano-pearl nanometer distillers yeast 20-60 part
Nanometer Mentholum 5-30 part nanometer Haematitum 40-120 part
Nano pinellia 20-60 part nanometer Fel Sus domestica 30-120 part
The formula optimization weight proportion scope of medicine of the present invention is:
The ripe distillers yeast 35-45 of nano magnetite 35-45 part nanometer part
Nanometer Borneolum Syntheticum 8-15 part nanometer Radix Achyranthis Bidentatae 35-45 part
The female 15-25 part of nano-pearl nanometer distillers yeast 35-45 part
Nanometer Mentholum 8-15 part nanometer Haematitum 60-80 part
Nano pinellia 35-45 part nanometer Fel Sus domestica 60-80 part
The optimum weight proportioning of medicine of the present invention is:
42.4 parts in the ripe distillers yeast of 42.4 parts of nanometers of nano magnetite
42.4 parts of 10.8 parts of nanometer Radix Achyranthis Bidentataes of nanometer Borneolum Syntheticum
42.4 parts in the female 20.8 parts of nanometer distillers yeast of nano-pearl
73.3 parts of 10.8 parts of nanometer Haematitums of nanometer Mentholum
74 parts of 42.4 parts of nanometer Fel Sus domestica of nano pinellia
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get NAOLIQING preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer NAOLIQING preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common NAOLIQING capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer NAOLIQING preparation medicine etc. is had no precedent in the past.
Treatment of conditions such as that pharmaceutical preparation of the present invention can be used for is dizzy, apoplexy and hypertension, clinical efficacy significantly is better than traditional NAOLIQING capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
42.4 parts in the ripe distillers yeast of 42.4 parts of nanometers of nano magnetite
42.4 parts of 10.8 parts of nanometer Radix Achyranthis Bidentataes of nanometer Borneolum Syntheticum
42.4 parts in the female 20.8 parts of nanometer distillers yeast of nano-pearl
73.3 parts of 10.8 parts of nanometer Haematitums of nanometer Mentholum
74 parts of 42.4 parts of nanometer Fel Sus domestica of nano pinellia
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
42.4 parts in the ripe distillers yeast of 42.4 parts of nanometers of nano magnetite
42.4 parts of 10.8 parts of nanometer Radix Achyranthis Bidentataes of nanometer Borneolum Syntheticum
42.4 parts in the female 20.8 parts of nanometer distillers yeast of nano-pearl
73.3 parts of 10.8 parts of nanometer Haematitums of nanometer Mentholum
74 parts of 42.4 parts of nanometer Fel Sus domestica of nano pinellia
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer NAOLIQING powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
42.4 parts in the ripe distillers yeast of 42.4 parts of nanometers of nano magnetite
42.4 parts of 10.8 parts of nanometer Radix Achyranthis Bidentataes of nanometer Borneolum Syntheticum
42.4 parts in the female 20.8 parts of nanometer distillers yeast of nano-pearl
73.3 parts of 10.8 parts of nanometer Haematitums of nanometer Mentholum
74 parts of 42.4 parts of nanometer Fel Sus domestica of nano pinellia
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer NAOLIQING membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest, cervical region.
Claims (6)
1, a kind of nanometer NAOLIQING preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The ripe distillers yeast 20-60 of nano magnetite 20-50 part nanometer part
Nanometer Borneolum Syntheticum 5-20 part nanometer Radix Achyranthis Bidentatae 20-50 part
The female 10-40 part of nano-pearl nanometer distillers yeast 20-60 part
Nanometer Mentholum 5-30 part nanometer Haematitum 40-120 part
Nano pinellia 20-60 part nanometer Fel Sus domestica 30-120 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer NAOLIQING preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The ripe distillers yeast 35-45 of nano magnetite 35-45 part nanometer part
Nanometer Borneolum Syntheticum 8-15 part nanometer Radix Achyranthis Bidentatae 35-45 part
The female 15-25 part of nano-pearl nanometer distillers yeast 35-45 part
Nanometer Mentholum 8-15 part nanometer Haematitum 60-80 part
Nano pinellia 35-45 part nanometer Fel Sus domestica 60-80 part
3, nanometer NAOLIQING preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
42.4 parts in the ripe distillers yeast of 42.4 parts of nanometers of nano magnetite
42.4 parts of 10.8 parts of nanometer Radix Achyranthis Bidentataes of nanometer Borneolum Syntheticum
42.4 parts in the female 20.8 parts of nanometer distillers yeast of nano-pearl
73.3 parts of 10.8 parts of nanometer Haematitums of nanometer Mentholum
74 parts of 42.4 parts of nanometer Fel Sus domestica of nano pinellia
4, according to claim 1 or 2 or 3 described nanometer NAOLIQING preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer NAOLIQING preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MP pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100330 CN1362175A (en) | 2001-01-02 | 2001-01-02 | Nano Naoliqing medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100330 CN1362175A (en) | 2001-01-02 | 2001-01-02 | Nano Naoliqing medicine and its preparation |
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| Publication Number | Publication Date |
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| CN1362175A true CN1362175A (en) | 2002-08-07 |
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| CN 01100330 Pending CN1362175A (en) | 2001-01-02 | 2001-01-02 | Nano Naoliqing medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888415A (en) * | 2020-07-27 | 2020-11-06 | 南京同仁堂药业有限责任公司 | A Chinese medicinal pill with effects of suppressing hyperactive liver, subsiding yang, tranquilizing mind and tranquilizing mind, and its preparation method |
-
2001
- 2001-01-02 CN CN 01100330 patent/CN1362175A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888415A (en) * | 2020-07-27 | 2020-11-06 | 南京同仁堂药业有限责任公司 | A Chinese medicinal pill with effects of suppressing hyperactive liver, subsiding yang, tranquilizing mind and tranquilizing mind, and its preparation method |
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