CN1362123A - Nano meridian passage-dredging and blood circulation promoting medicine and its preparation - Google Patents
Nano meridian passage-dredging and blood circulation promoting medicine and its preparation Download PDFInfo
- Publication number
- CN1362123A CN1362123A CN 01100176 CN01100176A CN1362123A CN 1362123 A CN1362123 A CN 1362123A CN 01100176 CN01100176 CN 01100176 CN 01100176 A CN01100176 A CN 01100176A CN 1362123 A CN1362123 A CN 1362123A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- blood circulation
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Shujin-huoxue preparation medicine. It is made u pby using 10 Chinese medicinal materials of nano carthamus, nano cyperus, nano cibotium, nano Chinese silkvine root bark, nano star jasmine stem dand others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of relaxing muscles and tendons and activating QI and blood in the collateral, the nanometer relaxing muscles and tendons to promote blood circulation preparation medicine of promoting blood circulation to remove blood stasis the invention still further relates to the method for this medication preparation.
Tablet for relieving rigidity of muscles and promoting blood circulation is a kind of classical Chinese patent medicine, mainly contains effects such as relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation to remove blood stasis, is used for bones and muscles pain, limbs contracture, aching pain in waist and back, traumatic injury.But traditional tablet for relieving rigidity of muscles and promoting blood circulation disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer relaxing muscles and tendons to promote blood circulation preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer relaxing muscles and tendons to promote blood circulation preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano safflower 44.8-115.2 part nano cyperus tuber 180-420 part nanometer Rhizoma Cibotii 224-576 part
Nanometer Cortex Periplocae 112-288 part nanometer Caulis Trachelospermi 180-420 part nanometer Herba Lycopodii 180-420 part
Nanometer herba lycopi 180-420 part nanometer Herba Visci 224-576 part nanometer Caulis Spatholobi 180-420 part
Nanometer Pyritum 28-72 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano safflower 64-96 part nano cyperus tuber 250-350 part nanometer Rhizoma Cibotii 320-480 part
Nanometer Cortex Periplocae 160-240 part nanometer Caulis Trachelospermi 250-350 part nanometer Herba Lycopodii 250-350 part
Nanometer herba lycopi 250-350 part nanometer Herba Visci 320-480 part nanometer Caulis Spatholobi 250-350 part
Nanometer Pyritum (forging) 40-60 part
The optimum weight proportioning of medicine of the present invention is:
400 parts of 300 parts of nanometer Rhizoma Cibotii of 80 parts of nano cyperus tubers of nano safflower
300 parts of 300 parts of nanometer Herba Lycopodiis of 200 parts of nanometer Caulis Trachelospermis of nanometer Cortex Periplocae
300 parts of 400 parts of nanometer Caulis Spatholobis of 300 parts of nanometer Herba Viscis of nanometer herba lycopi
50 parts of nanometer Pyritums
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, get relaxing muscles and tendons to promote blood circulation tablet preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer relaxing muscles and tendons to promote blood circulation preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common tablet for relieving rigidity of muscles and promoting blood circulation preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer relaxing muscles and tendons to promote blood circulation preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for bones and muscles pain, the limbs contracture, and aching pain in waist and back, treatment of conditions such as traumatic injury, clinical efficacy significantly is better than tablet for relieving rigidity of muscles and promoting blood circulation.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
400 parts of 300 parts of nanometer Rhizoma Cibotii of 80 parts of nano cyperus tubers of nano safflower
300 parts of 300 parts of nanometer Herba Lycopodiis of 200 parts of nanometer Caulis Trachelospermis of nanometer Cortex Periplocae
300 parts of 400 parts of nanometer Caulis Spatholobis of 300 parts of nanometer Herba Viscis of nanometer herba lycopi
50 parts of nanometer Pyritums
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
400 parts of 300 parts of nanometer Rhizoma Cibotii of 80 parts of nano cyperus tubers of nano safflower
300 parts of 300 parts of nanometer Herba Lycopodiis of 200 parts of nanometer Caulis Trachelospermis of nanometer Cortex Periplocae
300 parts of 400 parts of nanometer Caulis Spatholobis of 300 parts of nanometer Herba Viscis of nanometer herba lycopi
50 parts of nanometer Pyritums
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer relaxing muscles and tendons to promote blood circulation powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
400 parts of 300 parts of nanometer Rhizoma Cibotii of 80 parts of nano cyperus tubers of nano safflower
300 parts of 300 parts of nanometer Herba Lycopodiis of 200 parts of nanometer Caulis Trachelospermis of nanometer Cortex Periplocae
300 parts of 400 parts of nanometer Caulis Spatholobis of 300 parts of nanometer Herba Viscis of nanometer herba lycopi
50 parts of nanometer Pyritums
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer relaxing muscles and tendons to promote blood circulation membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, cervical region and affected part.
Claims (6)
1, a kind of nanometer relaxing muscles and tendons to promote blood circulation preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano safflower 45-115 part nano cyperus tuber 180-420 part nanometer Rhizoma Cibotii 224-576 part
Nanometer Cortex Periplocae 112-288 part nanometer Caulis Trachelospermi 180-420 part nanometer Herba Lycopodii 180-420 part
Nanometer herba lycopi 180-420 part nanometer Herba Visci 224-576 part nanometer Caulis Spatholobi 180-420 part
Nanometer Pyritum 28-72 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer relaxing muscles and tendons to promote blood circulation preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano safflower 64-96 part nano cyperus tuber 250-350 part nanometer Rhizoma Cibotii 320-480 part
Nanometer Cortex Periplocae 160-240 part nanometer Caulis Trachelospermi 250-350 part nanometer Herba Lycopodii 250-350 part
Nanometer herba lycopi 250-350 part nanometer Herba Visci 320-480 part nanometer Caulis Spatholobi 250-350 part
Nanometer Pyritum 40-60 part
3, nanometer relaxing muscles and tendons to promote blood circulation preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
400 parts of 300 parts of nanometer Rhizoma Cibotii of 80 parts of nano cyperus tubers of nano safflower
300 parts of 300 parts of nanometer Herba Lycopodiis of 200 parts of nanometer Caulis Trachelospermis of nanometer Cortex Periplocae
300 parts of 400 parts of nanometer Caulis Spatholobis of 300 parts of nanometer Herba Viscis of nanometer herba lycopi
50 parts of nanometer Pyritums
4, according to claim 1 or 2 or 3 described nanometer relaxing muscles and tendons to promote blood circulation preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer relaxing muscles and tendons to promote blood circulation preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100176 CN1362123A (en) | 2001-01-04 | 2001-01-04 | Nano meridian passage-dredging and blood circulation promoting medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100176 CN1362123A (en) | 2001-01-04 | 2001-01-04 | Nano meridian passage-dredging and blood circulation promoting medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362123A true CN1362123A (en) | 2002-08-07 |
Family
ID=4651356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100176 Pending CN1362123A (en) | 2001-01-04 | 2001-01-04 | Nano meridian passage-dredging and blood circulation promoting medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362123A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198209A (en) * | 2011-05-18 | 2011-09-28 | 杭州华东医药集团康润制药有限公司 | Tendon-relaxing and blood-activating capsules and preparation process thereof |
| CN110051767A (en) * | 2019-05-08 | 2019-07-26 | 汤合燕 | A kind of external medicinal liquid and preparation method thereof with blood circulation invigorating efficacies |
-
2001
- 2001-01-04 CN CN 01100176 patent/CN1362123A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198209A (en) * | 2011-05-18 | 2011-09-28 | 杭州华东医药集团康润制药有限公司 | Tendon-relaxing and blood-activating capsules and preparation process thereof |
| CN102198209B (en) * | 2011-05-18 | 2012-12-05 | 杭州华东医药集团康润制药有限公司 | Tendon-relaxing and blood-activating capsules and preparation process thereof |
| CN110051767A (en) * | 2019-05-08 | 2019-07-26 | 汤合燕 | A kind of external medicinal liquid and preparation method thereof with blood circulation invigorating efficacies |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368188A (en) | Nano medicine 'Weichangan' and its preparing process | |
| CN1368181A (en) | Nano medicine 'Shufeng Dingtong' and its preparing process | |
| CN1362123A (en) | Nano meridian passage-dredging and blood circulation promoting medicine and its preparation | |
| CN1368063A (en) | Nano medicine 'Yushangling' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1360912A (en) | Nanometer spur treating medicine and its prepn | |
| CN1360930A (en) | Nanometer traumatic injury-treating medicine and its prepn | |
| CN1360914A (en) | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method | |
| CN1368192A (en) | Nano medicine for treating menalgia and its preparing process | |
| CN1368244A (en) | Nano universal gynecologic medicine and its preparing process | |
| CN1366918A (en) | Nano navel-warming preparation medicine and preparation method | |
| CN1366958A (en) | Nano Dieda Huoxue preparation medicine for curing traumatic injuries and preparation method | |
| CN1365759A (en) | Nano antalgic medicine 'Zijin' and its preparing process | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1365811A (en) | Nano medicine 'Huixiang Juhe' and its preparing process | |
| CN1366923A (en) | Nano kindey-benefiting preparation medicine and preparation method | |
| CN1368087A (en) | Nano medicine for treating cerebral thrombus and its preparing process | |
| CN1362116A (en) | Nano Chinese flowing quine medicine and its preparation | |
| CN1364484A (en) | Nano eleven ingredient Nengxiao medicine and its preparing method | |
| CN1368191A (en) | Nano medicine 'Qufengshujin' and its preparing process | |
| CN1362204A (en) | Nanometer medicine for invigorating gallbadder and exhausting stone and its preparation | |
| CN1364490A (en) | Nano sixteen ingredient Dongqingque medicine and its preparing method | |
| CN1362222A (en) | Nanometer blood-nourishing and transquilizing medicine and its preparation | |
| CN1368362A (en) | Nano medicine for treating lumbocrural pain and its preparing process | |
| CN1362120A (en) | Nano wound-healing motoginseng medicine and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |