CN1365811A - Nano medicine 'Huixiang Juhe' and its preparing process - Google Patents
Nano medicine 'Huixiang Juhe' and its preparing process Download PDFInfo
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- CN1365811A CN1365811A CN 01102109 CN01102109A CN1365811A CN 1365811 A CN1365811 A CN 1365811A CN 01102109 CN01102109 CN 01102109 CN 01102109 A CN01102109 A CN 01102109A CN 1365811 A CN1365811 A CN 1365811A
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Abstract
A nanometre medicine "Huixiang Juhe" is prepared from the nanometre powders of 17 Chinese medicinal materials including fennel, anise, tangerine pit, psoralea fruit, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of cold expelling circulation of qi promoting, reducing swelling and alleviating pain, cure mainly the nano medicine ' Huixiang Juhe ' of colic of cold type, painful and swollen testis, the invention still further relates to the method for this medication preparation.
Huixiang juhe pill is a kind of classical Chinese patent medicine, mainly contains to alleviate gastrointestinal smooth muscular spasm, effects such as enhancing gastrointestinal motility, analgesia and antiinflammatory, is used for colic of cold type, painful and swollen testis.But traditional huixiang juhe pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Huixiang Juhe ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Huixiang Juhe '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Foeniculi 30-60 part nano star anise 30-60 part nanometer Semen Citri Reticulatae 30-60 part
Nanometer Semen Litchi 50-120 part nanometer Fructus Psoraleae 10-30 part nanometer Cortex Cinnamomi 10-30 part
Nanometer Fructus Toosendan 50-120 part nanometer Rhizoma Corydalis 30-55 part nanometer Rhizoma Curcumae 10-35 part
Nanometer Radix Aucklandiae 10-35 part nano cyperus tuber 20-65 part nanometer Pericarpium Citri Reticulatae Viride 20-65 part
Nanometer Thallus Laminariae (Thallus Eckloniae) 20-65 part nanometer Semen Arecae 20-65 part nanometer Olibanum 10-35 part
Nanometer Semen Persicae 10-30 part nanometer Squama Manis 10-35 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Foeniculi 35-50 part nano star anise 35-50 part nanometer Semen Citri Reticulatae 35-50 part
Nanometer Semen Litchi 60-100 part nanometer Fructus Psoraleae 15-25 part nanometer Cortex Cinnamomi 12-20 part
Nanometer Fructus Toosendan 60-100 part nanometer Rhizoma Corydalis 35-45 part nanometer Rhizoma Curcumae 15-25 part
Nanometer Radix Aucklandiae 15-25 part nano cyperus tuber 25-55 part nanometer Pericarpium Citri Reticulatae Viride 25-55 part
Nanometer Thallus Laminariae (Thallus Eckloniae) 25-55 part nanometer Semen Arecae 25-55 part nanometer Olibanum 15-25 part
Nanometer Semen Persicae 12-20 part nanometer Squama Manis 15-25 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 40 parts of nanometer Semen Citri Reticulataes of 40 parts of nano star anises of nanometer Fructus Foeniculi
16 parts of 20 parts of nanometer Cortex Cinnamomis of 80 parts of nanometer Fructus Psoraleaes of nanometer Semen Litchi
20 parts of 40 parts of nanometer Rhizoma Curcumae of 80 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan
40 parts on 40 parts of nanometer Pericarpium Citri Reticulatae Virides of 20 parts of nano cyperus tubers of the nanometer Radix Aucklandiae
20 parts of 40 parts of nanometer Olibanums of 40 portions of nanometer Semen Arecaes of nanometer Thallus Laminariae (Thallus Eckloniae)
20 parts of 16 parts of nanometer Squama Maniss of nanometer Semen Persicae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Huixiang Juhe ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Huixiang Juhe ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common huixiang juhe pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Huixiang Juhe ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treating orchitis, epididymis inflammation, hydrocele of testis; Have inguinal hernia, the hard pain of scrotum enlargement, pale tongue with white fur, stringy pulse or heavy tight on state treatment of conditions such as disease, clinical efficacy significantly is better than traditional huixiang juhe pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nanometer Semen Citri Reticulataes of 40 parts of nano star anises of nanometer Fructus Foeniculi
16 parts of 20 parts of nanometer Cortex Cinnamomis of 80 parts of nanometer Fructus Psoraleaes of nanometer Semen Litchi
20 parts of 40 parts of nanometer Rhizoma Curcumae of 80 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan
40 parts on 40 parts of nanometer Pericarpium Citri Reticulatae Virides of 20 parts of nano cyperus tubers of the nanometer Radix Aucklandiae
20 parts of 40 parts of nanometer Olibanums of 40 portions of nanometer Semen Arecaes of nanometer Thallus Laminariae (Thallus Eckloniae)
20 parts of 16 parts of nanometer Squama Maniss of nanometer Semen Persicae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nanometer Semen Citri Reticulataes of 40 parts of nano star anises of nanometer Fructus Foeniculi
16 parts of 20 parts of nanometer Cortex Cinnamomis of 80 parts of nanometer Fructus Psoraleaes of nanometer Semen Litchi
20 parts of 40 parts of nanometer Rhizoma Curcumae of 80 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan
40 parts on 40 parts of nanometer Pericarpium Citri Reticulatae Virides of 20 parts of nano cyperus tubers of the nanometer Radix Aucklandiae
20 parts of 40 parts of nanometer Olibanums of 40 portions of nanometer Semen Arecaes of nanometer Thallus Laminariae (Thallus Eckloniae)
20 parts of 16 parts of nanometer Squama Maniss of nanometer Semen Persicae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Fructus Foeniculi Semen Citri Reticulatae powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nanometer Semen Citri Reticulataes of 40 parts of nano star anises of nanometer Fructus Foeniculi
16 parts of 20 parts of nanometer Cortex Cinnamomis of 80 parts of nanometer Fructus Psoraleaes of nanometer Semen Litchi
20 parts of 40 parts of nanometer Rhizoma Curcumae of 80 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan
40 parts on 40 parts of nanometer Pericarpium Citri Reticulatae Virides of 20 parts of nano cyperus tubers of the nanometer Radix Aucklandiae
20 parts of 40 parts of nanometer Olibanums of 40 portions of nanometer Semen Arecaes of nanometer Thallus Laminariae (Thallus Eckloniae)
20 parts of 16 parts of nanometer Squama Maniss of nanometer Semen Persicae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Fructus Foeniculi Semen Citri Reticulatae membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part or affected part.
Claims (6)
1, a kind of nano medicine ' Huixiang Juhe ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Foeniculi 30-60 part nano star anise 30-60 part nanometer Semen Citri Reticulatae 30-60 part
Nanometer Semen Litchi 50-120 part nanometer Fructus Psoraleae 10-30 part nanometer Cortex Cinnamomi 10-30 part
Nanometer Fructus Toosendan 50-120 part nanometer Rhizoma Corydalis 30-55 part nanometer Rhizoma Curcumae 10-35 part
Nanometer Radix Aucklandiae 10-35 part nano cyperus tuber 20-65 part nanometer Pericarpium Citri Reticulatae Viride 20-65 part
Nanometer Thallus Laminariae (Thallus Eckloniae) 20-65 part nanometer Semen Arecae 20-65 part nanometer Olibanum 10-35 part
Nanometer Semen Persicae 10-30 part nanometer Squama Manis 10-35 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Huixiang Juhe ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Foeniculi 35-50 part nano star anise 35-50 part nanometer Semen Citri Reticulatae 35-50 part
Nanometer Semen Litchi 60-100 part nanometer Fructus Psoraleae 15-25 part nanometer Cortex Cinnamomi 12-20 part
Nanometer Fructus Toosendan 60-100 part nanometer Rhizoma Corydalis 35-45 part nanometer Rhizoma Curcumae 15-25 part
Nanometer Radix Aucklandiae 15-25 part nano cyperus tuber 25-55 part nanometer Pericarpium Citri Reticulatae Viride 25-55 part
Nanometer Thallus Laminariae (Thallus Eckloniae) 25-55 part nanometer Semen Arecae 25-55 part nanometer Olibanum 15-25 part
Nanometer Semen Persicae 12-20 part nanometer Squama Manis 15-25 part
3, nano medicine ' Huixiang Juhe ' according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 40 parts of nanometer Semen Citri Reticulataes of 40 parts of nano star anises of nanometer Fructus Foeniculi
16 parts of 20 parts of nanometer Cortex Cinnamomis of 80 parts of nanometer Fructus Psoraleaes of nanometer Semen Litchi
20 parts of 40 parts of nanometer Rhizoma Curcumae of 80 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan
40 parts on 40 parts of nanometer Pericarpium Citri Reticulatae Virides of 20 parts of nano cyperus tubers of the nanometer Radix Aucklandiae
20 parts of 40 parts of nanometer Olibanums of 40 portions of nanometer Semen Arecaes of nanometer Thallus Laminariae (Thallus Eckloniae)
20 parts of 16 parts of nanometer Squama Maniss of nanometer Semen Persicae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Huixiang Juhe 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Huixiang Juhe 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102109 CN1365811A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Huixiang Juhe' and its preparing process |
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| CN 01102109 CN1365811A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Huixiang Juhe' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406739A (en) * | 2011-11-09 | 2012-04-11 | 河南大学 | Traditional Chinese medicine for treating child hernia and preparation method thereof |
| CN102657840A (en) * | 2012-06-06 | 2012-09-12 | 韩源圣 | Stasis-removing and inflammation-diminishing traditional Chinese medicine composition, stasis-removing and inflammation-diminishing pills, stasis-removing and inflammation-diminishing plaster and preparation method thereof |
-
2001
- 2001-01-18 CN CN 01102109 patent/CN1365811A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406739A (en) * | 2011-11-09 | 2012-04-11 | 河南大学 | Traditional Chinese medicine for treating child hernia and preparation method thereof |
| CN102406739B (en) * | 2011-11-09 | 2013-03-20 | 河南大学 | Traditional Chinese medicine for treating child hernia and preparation method thereof |
| CN102657840A (en) * | 2012-06-06 | 2012-09-12 | 韩源圣 | Stasis-removing and inflammation-diminishing traditional Chinese medicine composition, stasis-removing and inflammation-diminishing pills, stasis-removing and inflammation-diminishing plaster and preparation method thereof |
| CN102657840B (en) * | 2012-06-06 | 2013-07-31 | 韩源圣 | Stasis-removing and inflammation-diminishing traditional Chinese medicine composition, stasis-removing and inflammation-diminishing pills, stasis-removing and inflammation-diminishing plaster and preparation method thereof |
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