CN1362136A - Nano Jingfukang medicine and its preparation - Google Patents
Nano Jingfukang medicine and its preparation Download PDFInfo
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- CN1362136A CN1362136A CN 01100189 CN01100189A CN1362136A CN 1362136 A CN1362136 A CN 1362136A CN 01100189 CN01100189 CN 01100189 CN 01100189 A CN01100189 A CN 01100189A CN 1362136 A CN1362136 A CN 1362136A
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Abstract
The present ivnention discloses a nano Jingfukang preparation medicine. It is made up by using 21 Chinese medicinal materials of nano astragalus, nano codonopsis, nano salvia, nano white peony, nano dried/fresh rehmannia and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of promoting blood circulation to remove obstruction in the collateral, the wind pain relieving of loosing, be used for the cerebral blood supply insufficiency that cervical spondylosis causes, dizziness, neck stiffness, aching pain in should and back, the nanometer Jingfukang preparation medicine of disease of hand the invention still further relates to the method for this medication preparation.
JINGFUKANG KELI is a kind of classical Chinese patent medicine, mainly contains effects such as promoting blood circulation to remove obstruction in the collateral, diffusing wind pain relieving, is used for the cerebral blood supply insufficiency that cervical spondylosis causes, dizziness, neck stiffness, aching pain in should and back, diseases such as disease of hand.But traditional JINGFUKANG KELI absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer Jingfukang preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer Jingfukang preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano astragalus 5-70 part nanometer Radix Codonopsis 10-50 part nano red sage 5-50 part
Nanometer Radix Paeoniae Alba 5-60 part nanometer Radix Rehmanniae 5-50 part nano abalone shell 10-70 part
Nanometer Radix Clematidis 5-50 part nanometer Ophicalcitum 10-50 part nanometer Radix Puerariae 10-70 part
Nano phellodendron bark 10-70 part nanometer Radix Gentianae Macrophyllae 5-50 part nanometer Semen Vaccariae 10-60 part
Nanometer Rhizoma Chuanxiong 5-70 part nanometer Rhizoma Atractylodis 5-50 part nanometer Rhizoma Et Radix Notopterygii 5-50 part
Nanometer Semen Persicae 5-40 part nanometer Olibanum 5-40 part nanometer Myrrha 5-50 part
Nano safflower 10-60 part nanometer earthworm 5-60 part nanometer Eupolyphaga Seu Steleophaga 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano astragalus 15-50 part nanometer Radix Codonopsis 20-40 part nano red sage 10-40 part
Nanometer Radix Paeoniae Alba 10-40 part nanometer Radix Rehmanniae 10-40 part nano abalone shell 20-50 part
Nanometer Radix Clematidis 15-40 part nanometer Ophicalcitum 20-40 part nanometer Radix Puerariae 15-50 part
Nano phellodendron bark 15-50 part nanometer Radix Gentianae Macrophyllae 10-40 part nanometer Semen Vaccariae 15-50 part
Nanometer Rhizoma Chuanxiong 10-50 part nanometer Rhizoma Atractylodis 10-40 part nanometer Rhizoma Et Radix Notopterygii 10-40 part
Nanometer Semen Persicae 10-30 part nanometer Olibanum 10-30 part nanometer Myrrha 10-40 part
Nano safflower 15-40 part nanometer earthworm 10-50 part nanometer Eupolyphaga Seu Steleophaga 10-30 part
The optimum weight proportioning of medicine of the present invention is:
25 parts of 30 parts of nano red sages of 25 parts of nanometer Radix Codonopsis of nano astragalus
30 parts of 20 parts of nano abalone shells of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
25 parts of 30 parts of nanometer Radix Puerariaes of 25 parts of nanometer Ophicalcitums of nanometer Radix Clematidis
30 parts of 20 parts of nanometer Semen Vaccariae of 25 portions of nanometer Radix Gentianae Macrophyllae of nano phellodendron bark
25 parts of 20 parts of nanometer Rhizoma Et Radix Notopterygiis of 15 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Chuanxiong
20 parts of 20 parts of nanometer Myrrhas of 15 parts of nanometer Olibanums of nanometer Semen Persicae
20 parts of 30 parts of nanometer Eupolyphaga Seu Steleophagas of 25 parts of nanometer earthworms of nano safflower
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Jingfukang preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer Jingfukang preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common JINGFUKANG KELI preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer Jingfukang preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the cerebral blood supply insufficiency that cervical spondylosis causes, dizziness, and neck stiffness, aching pain in should and back, treatment of conditions such as disease of hand, clinical efficacy significantly is better than traditional JINGFUKANG KELI.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 30 parts of nano red sages of 25 parts of nanometer Radix Codonopsis of nano astragalus
30 parts of 20 parts of nano abalone shells of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
25 parts of 30 parts of nanometer Radix Puerariaes of 25 parts of nanometer Ophicalcitums of nanometer Radix Clematidis
30 parts of 20 parts of nanometer Semen Vaccariae of 25 portions of nanometer Radix Gentianae Macrophyllae of nano phellodendron bark
25 parts of 20 parts of nanometer Rhizoma Et Radix Notopterygiis of 15 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Chuanxiong
20 parts of 20 parts of nanometer Myrrhas of 15 parts of nanometer Olibanums of nanometer Semen Persicae
20 parts of 30 parts of nanometer Eupolyphaga Seu Steleophagas of 25 parts of nanometer earthworms of nano safflower
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 30 parts of nano red sages of 25 parts of nanometer Radix Codonopsis of nano astragalus
30 parts of 20 parts of nano abalone shells of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
25 parts of 30 parts of nanometer Radix Puerariaes of 25 parts of nanometer Ophicalcitums of nanometer Radix Clematidis
30 parts of 20 parts of nanometer Semen Vaccariae of 25 portions of nanometer Radix Gentianae Macrophyllae of nano phellodendron bark
25 parts of 20 parts of nanometer Rhizoma Et Radix Notopterygiis of 15 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Chuanxiong
20 parts of 20 parts of nanometer Myrrhas of 15 parts of nanometer Olibanums of nanometer Semen Persicae
20 parts of 30 parts of nanometer Eupolyphaga Seu Steleophagas of 25 parts of nanometer earthworms of nano safflower
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer JINGFUKANG powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
25 parts of 30 parts of nano red sages of 25 parts of nanometer Radix Codonopsis of nano astragalus
30 parts of 20 parts of nano abalone shells of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
25 parts of 30 parts of nanometer Radix Puerariaes of 25 parts of nanometer Ophicalcitums of nanometer Radix Clematidis
30 parts of 20 parts of nanometer Semen Vaccariae of 25 portions of nanometer Radix Gentianae Macrophyllae of nano phellodendron bark
25 parts of 20 parts of nanometer Rhizoma Et Radix Notopterygiis of 15 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Chuanxiong
20 parts of 20 parts of nanometer Myrrhas of 15 parts of nanometer Olibanums of nanometer Semen Persicae
20 parts of 30 parts of nanometer Eupolyphaga Seu Steleophagas of 25 parts of nanometer earthworms of nano safflower
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer JINGFUKANG membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: cervical region.
Claims (6)
1, a kind of nanometer Jingfukang preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano astragalus 5-70 part nanometer Radix Codonopsis 10-50 part nano red sage 5-50 part
Nanometer Radix Paeoniae Alba 5-60 part nanometer Radix Rehmanniae 5-50 part nano abalone shell 10-70 part
Nanometer Radix Clematidis 5-50 part nanometer Ophicalcitum 10-50 part nanometer Radix Puerariae 10-70 part
Nano phellodendron bark 10-70 part nanometer Radix Gentianae Macrophyllae 5-50 part nanometer Semen Vaccariae 10-60 part
Nanometer Rhizoma Chuanxiong 5-70 part nanometer Rhizoma Atractylodis 5-50 part nanometer Rhizoma Et Radix Notopterygii 5-50 part
Nanometer Semen Persicae 5-40 part nanometer Olibanum 5-40 part nanometer Myrrha 5-50 part
Nano safflower 10-60 part nanometer earthworm 5-60 part nanometer Eupolyphaga Seu Steleophaga 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Jingfukang preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano astragalus 15-50 part nanometer Radix Codonopsis 20-40 part nano red sage 10-40 part
Nanometer Radix Paeoniae Alba 10-40 part nanometer Radix Rehmanniae 10-40 part nano abalone shell 20-50 part
Nanometer Radix Clematidis 15-40 part nanometer Ophicalcitum 20-40 part nanometer Radix Puerariae 15-50 part
Nano phellodendron bark 15-50 part nanometer Radix Gentianae Macrophyllae 10-40 part nanometer Semen Vaccariae 15-50 part
Nanometer Rhizoma Chuanxiong 10-50 part nanometer Rhizoma Atractylodis 10-40 part nanometer Rhizoma Et Radix Notopterygii 10-40 part
Nanometer Semen Persicae 10-30 part nanometer Olibanum 10-30 part nanometer Myrrha 10-40 part
Nano safflower 15-40 part nanometer earthworm 10-50 part nanometer Eupolyphaga Seu Steleophaga 10-30 part
3, nanometer Jingfukang preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 30 parts of nano red sages of 25 parts of nanometer Radix Codonopsis of nano astragalus
30 parts of 20 parts of nano abalone shells of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
25 parts of 30 parts of nanometer Radix Puerariaes of 25 parts of nanometer Ophicalcitums of nanometer Radix Clematidis
30 parts of 20 parts of nanometer Semen Vaccariae of 25 portions of nanometer Radix Gentianae Macrophyllae of nano phellodendron bark
25 parts of 20 parts of nanometer Rhizoma Et Radix Notopterygiis of 15 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Chuanxiong
20 parts of 20 parts of nanometer Myrrhas of 15 parts of nanometer Olibanums of nanometer Semen Persicae
20 parts of 30 parts of nanometer Eupolyphaga Seu Steleophagas of 25 parts of nanometer earthworms of nano safflower
4, according to claim 1 or 2 or 3 described nanometer Jingfukang preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer Jingfukang preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100189 CN1362136A (en) | 2001-01-04 | 2001-01-04 | Nano Jingfukang medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100189 CN1362136A (en) | 2001-01-04 | 2001-01-04 | Nano Jingfukang medicine and its preparation |
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| CN1362136A true CN1362136A (en) | 2002-08-07 |
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| CN 01100189 Pending CN1362136A (en) | 2001-01-04 | 2001-01-04 | Nano Jingfukang medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040926B (en) * | 2007-04-20 | 2010-05-26 | 朱强 | Chinese traditional medicine compound took orally for treating cervical spondylosis |
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2001
- 2001-01-04 CN CN 01100189 patent/CN1362136A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040926B (en) * | 2007-04-20 | 2010-05-26 | 朱强 | Chinese traditional medicine compound took orally for treating cervical spondylosis |
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