CN102641431B - Medicament for treating vitreous opacity - Google Patents

Abstract

The invention discloses a medicament for treating vitreous opacity, which can solve the treatment problem of vitreous opacity. The medicament is characterized by being processed from a variety of traditional Chinese medicines, and the formula comprises the following raw materials in parts by weight: 6-10 parts of nostoc sphaeroids kutz, 8-15 parts of Chinese angelica, 8-15 parts of dendrobium, 6-10 parts of Chinese trumpet creeper, 6-10 parts of feather cockscomb seed, 8-15 parts of radix rehmanniae preparata, 6-10 parts of white paeony root, 8-15 parts of Chinese taxillus twig and 3-6 parts of Chinese usnea. Clinical experiments prove that the medicament disclosed by the invention has the characteristics of good curative effect and higher safety for treating vitreous opacity and is worthy of clinical application and popularization.

Description

A kind of medicine for the treatment of vitreous opacity

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat the medicine of vitreous opacity.

Background technology

The normal glass body is a transparent gelinite, increase with the age has the tendency that degeneration takes place, and mainly shows as condensing and liquefaction, also is that opaque body appears in transparent gelinite in the vitreous body, being called vitreous opacity (vitreous opacities), is the ophthalmology common disease of middle-aged and elderly people.Its symptom shows as the visual field and column of smoke shape or cloud form shadow occur, and vitreous body is dirt shape, thread, cotton-shaped, streak muddiness.Vitreous opacity is not a kind of independently disease, but the common performance of many oculopathy, this disease develops rapidly sometimes, and patient's vision is dropped rapidly to light sensation, brings huge misery and inconvenience to life.In addition, vitreous body itself had not only had blood vessel but also impassivity, and metabolism is very slow, and when muddiness occurred, often therapeutic effect was not good enough.For severe vitreous hemorrhage patient, can only adopt the therapeutic modality of vitreous excision, but complication is more and easily lose vision.

Summary of the invention

Technical assignment of the present invention is at above the deficiencies in the prior art, and the medicine of the sure treatment vitreous opacity of a kind of curative effect is provided.

The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of vitreous opacity, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Nostoc, 8 ~ 15 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of Herba Dendrobiis, 6 ~ 10 parts of Fructus Solani Lyratis, 6 ~ 10 parts of Semen Celosiae, 8 ~ 15 parts in Radix Rehmanniae Preparata, 6 ~ 10 parts of the Radix Paeoniae Albas, 8 ~ 15 parts of Herba Taxillis, 3 ~ 6 parts of Usneas.

Its optimum weight proportioning is: 8 parts of Nostoc, 10 parts of Radix Angelicae Sinensis, 10 parts of Herba Dendrobiis, 8 parts of Fructus Solani Lyratis, 8 parts of Semen Celosiae, 10 parts in Radix Rehmanniae Preparata, 8 parts of the Radix Paeoniae Albas, 10 parts of Herba Taxillis, 5 parts of Usneas.

Wherein said: Nostoc is algae Cyanophyceae nostocaceae nostoc beads algae Nostoc commune Vauch..Nature and flavor are light, and are cold.Return liver, heart channel.But the merit heat clearing away, convergence, QI invigorating makes eye bright.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, hot, temperature.Return liver, the heart, spleen channel.Merit can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Herba Dendrobii is orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., Herba Dendrobii oculati Dendrobium fimbriatum Hook. var. oculatum Hook., the fresh or dry stem of HERBA DENDROBII Dendrobium chrysanthum Wall., Herba Dendrobii Dendrobium candidum Wall. ex Lindl. or Dendrobium nobile Dendrobium nobile Lindl..Nature and flavor are sweet, are slightly cold.Return stomach, kidney channel.But the merit reinforcing stomach reg fluid, nourishing YIN and clearing away heat.

Fructus Solani Lyrati is the fruit of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sour in the mouth; Property is put down.The merit materials for improving vision; Pain relieving.

Semen Celosiae is the dry mature seed of amaranthaceous plant Herba Celosiae argenteae Celosia argentea L..The nature and flavor hardship is slightly cold.Return Liver Channel.But the merit liver heat removing makes eye bright, nebula removing.

Radix Rehmanniae Preparata is concocted through processing for the tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. and to be formed.Sweet in the mouth; Warm in nature.Return liver, kidney channel.Merit can be enriched blood moist; The benefit essence is filled out marrow.

The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor hardship, acid are slightly cold.Return liver, spleen channel.But the pain relieving of merit suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.

Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor hardship, sweet, flat.Return liver, kidney channel.But the merit invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.

Usnea is the thallus (thallus) of Usneaceae Usnea plant USNEA Usnea diffracta (women trailing plants, Herba Cucubali) Usnea diffracta Vain. or Usnea Longissima (Scolopendra Usnea, Herba Stellariae Alsines) U. longissima Ach..Nature and flavor are sweet, and are flat.But the merit heat-clearing and toxic substances removing, hemostasia and promoting granulation, pain relieving, liver heat removing and eyesight improving moves back nebula.

Composition principle: the described vitreous opacity of modern medicine, often by tunica uvea, amphiblestroid inflammation, hemorrhage, regression, and Vitrea regression etc. causes, the vitreous opacity that is equivalent to the traditional medicine record, so-called vitreous opacity refers to that an outward appearance end is good, only conscious seemingly have mosquitos and flies or cloud and mist sample shadow to dance in the air drift at the moment, even the oculopathy of poor vision." silver-colored Nereid is little " is referred to as the black flower of fly wing." Standards of Diagnosis and Treatment miscellaneous diseases seven apertures door " beginning claims vitreous opacity.Its pathological changes of primary disease is at refreshing cream, and mainly by general on the asthenic fire, blood stasis is stagnated or deficiency of both the liver and kidney, due to the asthenia of essence and blood, so eliminating evilly should stagnate and set about from clearind deficient heat, repercussive; Setting upright should be based on invigorating the liver and kidney, foster essence and blood.Nostoc is returned liver, heart channel, but the heat clearing away QI invigorating make eye bright, Fructus Solani Lyrati makes eye bright, Semen Celosiae, Usnea liver heat removing and eyesight improving nebula removing, more than all medicines go into from eliminating evil; Chinese angelica blood supplementing is invigorated blood circulation, and Radix Paeoniae Alba suppressing the hyperactive liver nourishes blood, the Herba Taxilli invigorating the liver and kidney, the Radix Rehmanniae Preparata enriching blood and replenishing vital essence is filled out marrow, the Herba Dendrobii nourishing YIN and clearing away heat, more than all medicines from set upright into.All medicines share, and play the effect that benefiting QI and nourishing blood, liver heat removing and eyesight improving, easing the affected liver the kidney invigorating, beneficial essence are filled out marrow altogether, have promoted local blood circulation, can alleviate the vitreous opacity symptom.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: Nostoc 6g, Radix Angelicae Sinensis 8g, Herba Dendrobii 8g, Fructus Solani Lyrati 6g, Semen Celosiae 6g, Radix Rehmanniae Preparata 8g, Radix Paeoniae Alba 6g, Herba Taxilli 8g, Usnea 3g.

Embodiment 2, the crude drug weight proportion: Nostoc 10g, Radix Angelicae Sinensis 15g, Herba Dendrobii 15g, Fructus Solani Lyrati 10g, Semen Celosiae 10g, Radix Rehmanniae Preparata 15g, Radix Paeoniae Alba 10g, Herba Taxilli 15g, Usnea 6g.

Embodiment 3, the crude drug weight proportion: Nostoc 8g, Radix Angelicae Sinensis 10g, Herba Dendrobii 10g, Fructus Solani Lyrati 8g, Semen Celosiae 8g, Radix Rehmanniae Preparata 10g, Radix Paeoniae Alba 8g, Herba Taxilli 10g, Usnea 5g.

During use, Chinese medicine Nostoc of the present invention, Radix Angelicae Sinensis, Herba Dendrobii, Fructus Solani Lyrati, Semen Celosiae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Usnea and Herba Taxilli are decocted with water twice, merging filtrate divides and sooner or later takes.

Effective combination of said medicine is coordinated mutually, can effectively reach the purpose for the treatment of vitreous opacity, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.

1 object and method.

1.1 the patient of the vitreous opacity that object in January, 2009 ~ 2011 year JIUYUE 90 examples (133 eyes) a variety of causes causes.Male 31 examples wherein, women 21 examples, 26 ~ 79 years old age.The cause of disease of vitreous opacity takes place: 47 of traumatic hematocele 33 examples, 40 of hemorrhage 29 examples of diabetic, 39 of hypertension retinopathy 21 examples, 7 of moderate and high myopia 7 examples.

1.2 method.

1.2.1 grouping is divided into two groups at random, matched group 46 examples (62 eyes) and treatment are organized 44 examples (71 eyes) and are observed contrast.Patient's age, sex, eye Gou Cheng not gone up no significance difference between two groups.

1.2.2 the Therapeutic Method matched group adopts 0.9% normal saline solution or 5% glucose injection 250ml to add cyclonamine injection 1.0g, vitamin C injection 3.0g, dexamethasone injection 5mg intravenous drip, bright, each the 1ml associating intramuscular injection of prolonium iodide of eye.Every day 1 time, 7 days is 1 course for the treatment of, continuous 4 courses for the treatment of; Dexamethasone changes prednisone 20mg into after first course for the treatment of, at 8 o'clock in morning every day is oral, more gradually decrement to stopping.Treatment group data scheme is that to add the embodiment of the invention 3 gained Chinese medicine decoction on the matched group basis more oral, and every day 1 time, 7 days is 1 course for the treatment of, continuous 4 courses for the treatment of.

1.2.3 capable slit lamp, ophthalmofundoscope and examination of visual acuity respectively before the observation index treatment, behind treatment 14d, the 28d, observe the curative effect difference is by ultrasound diagnosis vitreous opacity absorbing state.Vitreous opacity is by standard level Four point-score: the I level: vitreous opacity but do not influence fundus observation; The II level: the optical fundus reflection to red light is obvious, can dimly get a glimpse of optic disc and blood vessel; The III level: there is reflection to red light on the optical fundus, cannot see optical fundus blood vessel; The IV level: lesser ring of Merkel does not have reflection to red light.

1.2.4 curative effect determinate standard: efficacy evaluation with reference to mydriasis after directly ophthalmofundoscopy result and examination of visual acuity result.Produce effects: vitreous opacity obviously absorbs, and primary affection is controlled, transference cure, vision improves more than 5 row, vitreous opacity by the IV level to the II level, to the I level, high-visible to the optical fundus by the II level restoration by the III level; Effectively: vitreous opacity partially absorbs, sx, vision improves 2 ~ 5 row, vitreous opacity by the IV level to the III level, by the III level to the II level; Invalid: vitreous opacity no change or increase the weight of, symptom does not have improvement, and vision does not have raising.

1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, P＜0.05 expression has the significance meaning.

2 results: the curative effect of two groups of cases relatively sees the following form, and obvious effective rate and total effective rate treatment group obviously are better than matched group (P＜0.05).

3. conclusion: this result of study shows that the present invention treats the vitreous opacity determined curative effect, is worthy of promotion and application, and especially to basic hospital, does not have certain device and technical merit, also has those to fear operation, the more worth application of surgical contraindication patient is arranged.

Claims (2)

1. medicine for the treatment of vitreous opacity, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Nostoc, 8 ~ 15 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of Herba Dendrobiis, 6 ~ 10 parts of Fructus Solani Lyratis, 6 ~ 10 parts of Semen Celosiae, 8 ~ 15 parts in Radix Rehmanniae Preparata, 6 ~ 10 parts of the Radix Paeoniae Albas, 8 ~ 15 parts of Herba Taxillis, 3 ~ 6 parts of Usneas.

2. a kind of medicine for the treatment of vitreous opacity according to claim 1 is characterized in that its weight proportion is: 8 parts of Nostoc, 10 parts of Radix Angelicae Sinensis, 10 parts of Herba Dendrobiis, 8 parts of Fructus Solani Lyratis, 8 parts of Semen Celosiae, 10 parts in Radix Rehmanniae Preparata, 8 parts of the Radix Paeoniae Albas, 10 parts of Herba Taxillis, 5 parts of Usneas.