CN1368085A - Nano medicine 'Niuhuang Xiling' and its preparing process - Google Patents
Nano medicine 'Niuhuang Xiling' and its preparing process Download PDFInfo
- Publication number
- CN1368085A CN1368085A CN 01101834 CN01101834A CN1368085A CN 1368085 A CN1368085 A CN 1368085A CN 01101834 CN01101834 CN 01101834 CN 01101834 A CN01101834 A CN 01101834A CN 1368085 A CN1368085 A CN 1368085A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- nano
- part nanometer
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A nanometre (0.1-200 nm) medicine "Niuhuang Xiling" is prepared from the nanometre powders of 24 Chinese medicinal materials including bezoar, buffalo horn powder concentrate, Antelope's horn, borneol, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind ofly analgesicly to dispel the wind, the nano medicine ' Niuhuang Xiling ' of clearing heart fire, anchoring mind, the antitussive of having a respite, the invention still further relates to the method for this medication preparation.
Calculus Bovis west antelope ball is a kind of classical Chinese patent medicine, mainly contain analgesicly dispel the wind, effects such as clearing heart fire, anchoring mind, the antitussive of having a respite, be used for that flaming up of heart-fire, dizziness conjunctival congestion, dysphoria with smothery sensation are thirsty, varioliform exanthema fire-toxin, gingival swelling and pain.But the antelope ball disintegrate of traditional Calculus Bovis west is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Niuhuang Xiling ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Niuhuang Xiling '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bezoar 12-30 part nanometer Pulvis Cornus Bubali Concentratus 80-180 part nano antelope horn 6-15 part
Nanometer Cinnabaris 60-150 part nanometer Borneolum Syntheticum 12-30 part nano musk 6-18 part
Nanometer-size realgar 60-150 part nanometer Radix Ophiopogonis 60-150 part nanometer Radix Glycyrrhizae 80-180 part
Nanometer Radix Scutellariae 50-120 part nanometer Radix Paeoniae Alba 50-120 part nanometer Pericarpium Citri Reticulatae 100-200 part
Nanometer Fructus Aurantii 100-200 part nanometer Radix Saposhnikoviae 50-120 part nanometer Rhizoma Pinelliae 50-95 part
Nanometer Radix Platycodonis 100-200 part nano phellodendron bark 60-150 part nanometer coptis 100-200 part
Nano Poria 50-120 part nanometer Fructus Gardeniae 60-150 part nanometer Semen Armeniacae Amarum 50-120 part
Nanometer Fructus Trichosanthis 100-200 part nano Chinese angelica 50-90 part nanometer Caulis Akebiae 50-120 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bezoar 15-25 part nanometer Pulvis Cornus Bubali Concentratus 90-150 part nano antelope horn 8-12 part
Nanometer Cinnabaris 80-120 part nanometer Borneolum Syntheticum 15-25 part nano musk 9-15 part
Nanometer-size realgar 80-120 part nanometer Radix Ophiopogonis 80-120 part nanometer Radix Glycyrrhizae 90-150 part
Nanometer Radix Scutellariae 60-100 part nanometer Radix Paeoniae Alba 60-100 part nanometer Pericarpium Citri Reticulatae 120-180 part
Nanometer Fructus Aurantii 120-180 part nanometer Radix Saposhnikoviae 60-100 part nanometer Rhizoma Pinelliae 60-90 part
Nanometer Radix Platycodonis 120-180 part nano phellodendron bark 80-120 part nanometer coptis 120-180 part
Nano Poria 60-100 part nanometer Fructus Gardeniae 80-120 part nanometer Semen Armeniacae Amarum 60-100 part
Nanometer Fructus Trichosanthis 120-180 part nano Chinese angelica 60-80 part nanometer Caulis Akebiae 60-100 part
The optimum weight proportioning of medicine of the present invention is:
10 parts of 120 parts of nano antelope horns of 20 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano bezoar
12 parts of 20 parts of nano musks of 100 parts of nanometer Borneolum Syntheticums of nanometer Cinnabaris
120 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometer Radix Ophiopogonis of nanometer-size realgar
150 parts of 75 parts of nanometer Pericarpium Citri Reticulataes of 75 parts of nanometer Radix Paeoniae Albas of nanometer Radix Scutellariae
75 parts of 75 parts of nanometer Rhizoma Pinelliae of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Fructus Aurantii
150 parts of 100 parts of nanometer coptis of 150 parts of nano phellodendron barks of nanometer Radix Platycodonis
75 parts of 100 portions of nanometer Semen Armeniacae Amarums of 75 parts of nanometer Fructus Gardeniaes of nano Poria
75 parts of 75 parts of nanometer Caulis Akebiaes of 150 parts of nano Chinese angelicas of nanometer Fructus Trichosanthis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Niuhuang Xiling ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Niuhuang Xiling ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale; common Calculus Bovis west antelope pill material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1--200nm; the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Niuhuang Xiling ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as flaming up of heart-fire, dizziness conjunctival congestion, dysphoria with smothery sensation are thirsty, varioliform exanthema fire-toxin, gingival swelling and pain, and clinical efficacy significantly is better than traditional Calculus Bovis west antelope ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
10 parts of 120 parts of nano antelope horns of 20 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano bezoar
12 parts of 20 parts of nano musks of 100 parts of nanometer Borneolum Syntheticums of nanometer Cinnabaris
120 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometer Radix Ophiopogonis of nanometer-size realgar
150 parts of 75 parts of nanometer Pericarpium Citri Reticulataes of 75 parts of nanometer Radix Paeoniae Albas of nanometer Radix Scutellariae
75 parts of 75 parts of nanometer Rhizoma Pinelliae of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Fructus Aurantii
150 parts of 100 parts of nanometer coptis of 150 parts of nano phellodendron barks of nanometer Radix Platycodonis
75 parts of 100 portions of nanometer Semen Armeniacae Amarums of 75 parts of nanometer Fructus Gardeniaes of nano Poria
75 parts of 75 parts of nanometer Caulis Akebiaes of 150 parts of nano Chinese angelicas of nanometer Fructus Trichosanthis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
10 parts of 120 parts of nano antelope horns of 20 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano bezoar
12 parts of 20 parts of nano musks of 100 parts of nanometer Borneolum Syntheticums of nanometer Cinnabaris
120 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometer Radix Ophiopogonis of nanometer-size realgar
150 parts of 75 parts of nanometer Pericarpium Citri Reticulataes of 75 parts of nanometer Radix Paeoniae Albas of nanometer Radix Scutellariae
75 parts of 75 parts of nanometer Rhizoma Pinelliae of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Fructus Aurantii
150 parts of 100 parts of nanometer coptis of 150 parts of nano phellodendron barks of nanometer Radix Platycodonis
75 parts of 100 portions of nanometer Semen Armeniacae Amarums of 75 parts of nanometer Fructus Gardeniaes of nano Poria
75 parts of 75 parts of nanometer Caulis Akebiaes of 150 parts of nano Chinese angelicas of nanometer Fructus Trichosanthis
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard; do not add any adjuvant; make nano bezoar west antelope powder needle injection, every injection content is the 5-20 milligram; each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
10 parts of 120 parts of nano antelope horns of 20 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano bezoar
12 parts of 20 parts of nano musks of 100 parts of nanometer Borneolum Syntheticums of nanometer Cinnabaris
120 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometer Radix Ophiopogonis of nanometer-size realgar
150 parts of 75 parts of nanometer Pericarpium Citri Reticulataes of 75 parts of nanometer Radix Paeoniae Albas of nanometer Radix Scutellariae
75 parts of 75 parts of nanometer Rhizoma Pinelliae of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Fructus Aurantii
150 parts of 100 parts of nanometer coptis of 150 parts of nano phellodendron barks of nanometer Radix Platycodonis
75 parts of 100 portions of nanometer Semen Armeniacae Amarums of 75 parts of nanometer Fructus Gardeniaes of nano Poria
75 parts of 75 parts of nanometer Caulis Akebiaes of 150 parts of nano Chinese angelicas of nanometer Fructus Trichosanthis
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard; filmogen adopts polyvinyl alcohol; make nano bezoar west antelope membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Niuhuang Xiling ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bezoar 12-30 part nanometer Pulvis Cornus Bubali Concentratus 80-180 part nano antelope horn 6-15 part
Nanometer Cinnabaris 60-150 part nanometer Borneolum Syntheticum 12-30 part nano musk 6-18 part
Nanometer-size realgar 60-150 part nanometer Radix Ophiopogonis 60-150 part nanometer Radix Glycyrrhizae 80-180 part
Nanometer Radix Scutellariae 50-120 part nanometer Radix Paeoniae Alba 50-120 part nanometer Pericarpium Citri Reticulatae 100-200 part
Nanometer Fructus Aurantii 100-200 part nanometer Radix Saposhnikoviae 50-120 part nanometer Rhizoma Pinelliae 50-95 part
Nanometer Radix Platycodonis 100-200 part nano phellodendron bark 60-150 part nanometer coptis 100-200 part
Nano Poria 50-120 part nanometer Fructus Gardeniae 60-150 part nanometer Semen Armeniacae Amarum 50-120 part
Nanometer Fructus Trichosanthis 100-200 part nano Chinese angelica 50-90 part nanometer Caulis Akebiae 50-120 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Niuhuang Xiling ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bezoar 15-25 part nanometer Pulvis Cornus Bubali Concentratus 90-150 part nano antelope horn 8-12 part
Nanometer Cinnabaris 80-120 part nanometer Borneolum Syntheticum 15-25 part nano musk 9-15 part
Nanometer-size realgar 80-120 part nanometer Radix Ophiopogonis 80-120 part nanometer Radix Glycyrrhizae 90-150 part
Nanometer Radix Scutellariae 60-100 part nanometer Radix Paeoniae Alba 60-100 part nanometer Pericarpium Citri Reticulatae 120-180 part
Nanometer Fructus Aurantii 120-180 part nanometer Radix Saposhnikoviae 60-100 part nanometer Rhizoma Pinelliae 60-90 part
Nanometer Radix Platycodonis 120-180 part nano phellodendron bark 80-120 part nanometer coptis 120-180 part
Nano Poria 60-100 part nanometer Fructus Gardeniae 80-120 part nanometer Semen Armeniacae Amarum 60-100 part
Nanometer Fructus Trichosanthis 120-180 part nano Chinese angelica 60-80 part nanometer Caulis Akebiae 60-100 part
3, nano medicine ' Niuhuang Xiling ' according to claim 1, wherein the weight proportion of each nano raw material is:
10 parts of 120 parts of nano antelope horns of 20 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano bezoar
12 parts of 20 parts of nano musks of 100 parts of nanometer Borneolum Syntheticums of nanometer Cinnabaris
120 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometer Radix Ophiopogonis of nanometer-size realgar
150 parts of 75 parts of nanometer Pericarpium Citri Reticulataes of 75 parts of nanometer Radix Paeoniae Albas of nanometer Radix Scutellariae
75 parts of 75 parts of nanometer Rhizoma Pinelliae of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Fructus Aurantii
150 parts of 100 parts of nanometer coptis of 150 parts of nano phellodendron barks of nanometer Radix Platycodonis
75 parts of 100 portions of nanometer Semen Armeniacae Amarums of 75 parts of nanometer Fructus Gardeniaes of nano Poria
75 parts of 75 parts of nanometer Caulis Akebiaes of 150 parts of nano Chinese angelicas of nanometer Fructus Trichosanthis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Niuhuang Xiling 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Niuhuang Xiling 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101834 CN1368085A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Niuhuang Xiling' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101834 CN1368085A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Niuhuang Xiling' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368085A true CN1368085A (en) | 2002-09-11 |
Family
ID=4652243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01101834 Pending CN1368085A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Niuhuang Xiling' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368085A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655857A (en) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine composition for treating myelodysplastic syndrome |
| CN105267369A (en) * | 2014-07-22 | 2016-01-27 | 张世东 | Medicine for treating dreaminess |
-
2001
- 2001-02-05 CN CN 01101834 patent/CN1368085A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655857A (en) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine composition for treating myelodysplastic syndrome |
| CN105267369A (en) * | 2014-07-22 | 2016-01-27 | 张世东 | Medicine for treating dreaminess |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368193A (en) | Nano medicine 'Suoyanggujing' and its preparing process | |
| CN1368086A (en) | Nano medicine 'Niuhuang Ninggong' and its preparing process | |
| CN1366936A (en) | Nano antelope lung-clearing preparation medicine and preparation method | |
| CN1368085A (en) | Nano medicine 'Niuhuang Xiling' and its preparing process | |
| CN1368151A (en) | Nano medicine 'Hailong Gejie' and its preparing process | |
| CN1368239A (en) | Nano medicine 'Anshenyangxin' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1368318A (en) | Nano medicine 'Shugantiaoqi' and its preparing process | |
| CN1366953A (en) | Nano midday tea preparation medicine and preparation method | |
| CN1365746A (en) | Nano medicine 'Sizheng' and its preparing process | |
| CN1365749A (en) | Nano medicine 'Xiongju Shangqing' and its preparing process | |
| CN1365688A (en) | Nano medicine 'Ertong Qingfei' and its preparing process | |
| CN1365774A (en) | Nano medicine 'Niuhuang Shangqing' and its preparing process | |
| CN1368203A (en) | Nano medicine 'Zanglian' and its preparing process | |
| CN1366921A (en) | Nano Juhong preparation medicine and preparation method | |
| CN1368095A (en) | Nano medicine 'Lutai' and its preparing process | |
| CN1368161A (en) | Nano medicine 'Jieyuhegan' and its preparing process | |
| CN1365695A (en) | Nano medicine 'Xiaoer Jindan' and its preparing process | |
| CN1365758A (en) | Nano antitussive phlegm-resolving medicine and its preparing process | |
| CN1366925A (en) | Nano stomach-clearing coptis preparation medicine and preparation method | |
| CN1365775A (en) | Nano medicine 'Niuhuang Zhenjing' and its preparing process | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1368247A (en) | Nano medicine 'Fuming' and its preparing process | |
| CN1368087A (en) | Nano medicine for treating cerebral thrombus and its preparing process | |
| CN1368241A (en) | Nano medicine 'Tiaojing Zhongzi' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |