CN1368095A - Nano medicine 'Lutai' and its preparing process - Google Patents
Nano medicine 'Lutai' and its preparing process Download PDFInfo
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- CN1368095A CN1368095A CN 01101844 CN01101844A CN1368095A CN 1368095 A CN1368095 A CN 1368095A CN 01101844 CN01101844 CN 01101844 CN 01101844 A CN01101844 A CN 01101844A CN 1368095 A CN1368095 A CN 1368095A
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Abstract
A nanometre of (0.1-200 nm) medicine "Lutai" is prepared from the nanometre powders of 24 Chinese medicinal materials including deer fetus, Chinese angelica root, red ginseng, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of benefiting qi and nourishing blood, the nano medicine ' Lutai ' of the cold expelling that stimulates the menstrual flow, the invention still further relates to the method for this medication preparation.
The Embryo cervi capsule is a kind of classical Chinese patent medicine, mainly contains benefiting qi and nourishing blood, effect such as the cold expelling that stimulates the menstrual flow, and is used for insufficiency of vital energy and blood, weak thin, menoxenia, menalgia, the cold-damp leukorrhagia of winning.But traditional Embryo cervi capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Lutai ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Lutai '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Ginseng Rubra 60-150 part nano Chinese angelica 100-200 part nanometer motherwort 120-300 part
Nanometer Radix Rehmanniae Preparata 100-200 part nano cyperus tuber 35-80 part nano tortoise plastron 15-40 part
Nanometer Cortex Lycii 15-40 part nanometer Rhizoma Corydalis 10-20 part nanometer Semen Raphani 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 20-40 part nano ass hide glue 20-40 part nanometer Cortex Cinnamomi 10-20 part
Nanometer Radix Aucklandiae 10-25 part nano red sage 60-150 part nanometer Radix Paeoniae Rubra 30-60 part
Nanometer Radix Glycyrrhizae 15-40 part nanometer Fructus Foeniculi 12-30 part nanometer Radix Dipsaci 30-80 part
Nanometer Pollen Typhae 15-40 part nanometer Rhizoma Chuanxiong 15-40 part nanometer Radix Achyranthis Bidentatae 15-40 part
Nano-antler 10-20 part nano Poria 220-400 part nanometer Embryo cervi 200-400 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Ginseng Rubra 80-120 part nano Chinese angelica 120-180 part nanometer motherwort 150-250 part
Nanometer Radix Rehmanniae Preparata 120-180 part nano cyperus tuber 40-60 part nano tortoise plastron 20-30 part
Nanometer Cortex Lycii 20-30 part nanometer Rhizoma Corydalis 12-18 part nanometer Semen Raphani 20-30 part
Nanometer Rhizoma Atractylodis Macrocephalae 25-35 part nano ass hide glue 25-35 part nanometer Cortex Cinnamomi 12-18 part
Nanometer Radix Aucklandiae 12-18 part nano red sage 80-120 part nanometer Radix Paeoniae Rubra 35-50 part
Nanometer Radix Glycyrrhizae 20-30 part nanometer Fructus Foeniculi 15-25 part nanometer Radix Dipsaci 40-60 part
Nanometer Pollen Typhae 20-30 part nanometer Rhizoma Chuanxiong 20-30 part nanometer Radix Achyranthis Bidentatae 20-30 part
Nano-antler 12-18 part nano Poria 250-350 part nanometer Embryo cervi 250-350 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 150 parts of nanometer motherworts of 100 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
25 parts of 50 parts of nano tortoise plastrons of 150 parts of nano cyperus tubers of nanometer Radix Rehmanniae Preparata
25 parts of 15 parts of nanometer Semen Raphanis of 25 parts of nanometer Rhizoma Corydalis of nanometer Cortex Lycii
15 parts of 30 parts of nanometer Cortex Cinnamomis of 30 parts of nano ass hide glues of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of 100 parts of nanometer Radix Paeoniae Rubra of 15 parts of nano red sages of the nanometer Radix Aucklandiae
50 parts of 20 parts of nanometer Radix Dipsacis of 25 parts of nanometer Fructus Foeniculi of nanometer Radix Glycyrrhizae
25 parts of 25 parts of nanometer Radix Achyranthis Bidentataes of 25 parts of nanometer Rhizoma Chuanxiongs of nanometer Pollen Typhae
270 parts of 300 parts of nanometer Embryo cervi of 15 parts of nano Porias of nano-antler
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Lutai ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Lutai ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Embryo cervi capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Lutai ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for insufficiency of vital energy and blood, weak treatment of winning diseases such as thin, menoxenia, menalgia, cold-damp leukorrhagia, and clinical efficacy significantly is better than traditional Embryo cervi capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer motherworts of 100 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
25 parts of 50 parts of nano tortoise plastrons of 150 parts of nano cyperus tubers of nanometer Radix Rehmanniae Preparata
25 parts of 15 parts of nanometer Semen Raphanis of 25 parts of nanometer Rhizoma Corydalis of nanometer Cortex Lycii
15 parts of 30 parts of nanometer Cortex Cinnamomis of 30 parts of nano ass hide glues of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of 100 parts of nanometer Radix Paeoniae Rubra of 15 parts of nano red sages of the nanometer Radix Aucklandiae
50 parts of 20 parts of nanometer Radix Dipsacis of 25 parts of nanometer Fructus Foeniculi of nanometer Radix Glycyrrhizae
25 parts of 25 parts of nanometer Radix Achyranthis Bidentataes of 25 parts of nanometer Rhizoma Chuanxiongs of nanometer Pollen Typhae
270 parts of 300 parts of nanometer Embryo cervi of 15 parts of nano Porias of nano-antler
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer motherworts of 100 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
25 parts of 50 parts of nano tortoise plastrons of 150 parts of nano cyperus tubers of nanometer Radix Rehmanniae Preparata
25 parts of 15 parts of nanometer Semen Raphanis of 25 parts of nanometer Rhizoma Corydalis of nanometer Cortex Lycii
15 parts of 30 parts of nanometer Cortex Cinnamomis of 30 parts of nano ass hide glues of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of 100 parts of nanometer Radix Paeoniae Rubra of 15 parts of nano red sages of the nanometer Radix Aucklandiae
50 parts of 20 parts of nanometer Radix Dipsacis of 25 parts of nanometer Fructus Foeniculi of nanometer Radix Glycyrrhizae
25 parts of 25 parts of nanometer Radix Achyranthis Bidentataes of 25 parts of nanometer Rhizoma Chuanxiongs of nanometer Pollen Typhae
270 parts of 300 parts of nanometer Embryo cervi of 15 parts of nano Porias of nano-antler
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Embryo cervi powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer motherworts of 100 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
25 parts of 50 parts of nano tortoise plastrons of 150 parts of nano cyperus tubers of nanometer Radix Rehmanniae Preparata
25 parts of 15 parts of nanometer Semen Raphanis of 25 parts of nanometer Rhizoma Corydalis of nanometer Cortex Lycii
15 parts of 30 parts of nanometer Cortex Cinnamomis of 30 parts of nano ass hide glues of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of 100 parts of nanometer Radix Paeoniae Rubra of 15 parts of nano red sages of the nanometer Radix Aucklandiae
50 parts of 20 parts of nanometer Radix Dipsacis of 25 parts of nanometer Fructus Foeniculi of nanometer Radix Glycyrrhizae
25 parts of 25 parts of nanometer Radix Achyranthis Bidentataes of 25 parts of nanometer Rhizoma Chuanxiongs of nanometer Pollen Typhae
270 parts of 300 parts of nanometer Embryo cervi of 15 parts of nano Porias of nano-antler
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Embryo cervi membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Lutai ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Ginseng Rubra 60-150 part nano Chinese angelica 100-200 part nanometer motherwort 120-300 part
Nanometer Radix Rehmanniae Preparata 100-200 part nano cyperus tuber 35-80 part nano tortoise plastron 15-40 part
Nanometer Cortex Lycii 15-40 part nanometer Rhizoma Corydalis 10-20 part nanometer Semen Raphani 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 20-40 part nano ass hide glue 20-40 part nanometer Cortex Cinnamomi 10-20 part
Nanometer Radix Aucklandiae 10-25 part nano red sage 60-150 part nanometer Radix Paeoniae Rubra 30-60 part
Nanometer Radix Glycyrrhizae 15-40 part nanometer Fructus Foeniculi 12-30 part nanometer Radix Dipsaci 30-80 part
Nanometer Pollen Typhae 15-40 part nanometer Rhizoma Chuanxiong 15-40 part nanometer Radix Achyranthis Bidentatae 15-40 part
Nano-antler 10-20 part nano Poria 220-400 part nanometer Embryo cervi 200-400 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Lutai ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Ginseng Rubra 80-120 part nano Chinese angelica 120-180 part nanometer motherwort 150-250 part
Nanometer Radix Rehmanniae Preparata 120-180 part nano cyperus tuber 40-60 part nano tortoise plastron 20-30 part
Nanometer Cortex Lycii 20-30 part nanometer Rhizoma Corydalis 12-18 part nanometer Semen Raphani 20-30 part
Nanometer Rhizoma Atractylodis Macrocephalae 25-35 part nano ass hide glue 25-35 part nanometer Cortex Cinnamomi 12-18 part
Nanometer Radix Aucklandiae 12-18 part nano red sage 80-120 part nanometer Radix Paeoniae Rubra 35-50 part
Nanometer Radix Glycyrrhizae 20-30 part nanometer Fructus Foeniculi 15-25 part nanometer Radix Dipsaci 40-60 part
Nanometer Pollen Typhae 20-30 part nanometer Rhizoma Chuanxiong 20-30 part nanometer Radix Achyranthis Bidentatae 20-30 part
Nano-antler 12-18 part nano Poria 250-350 part nanometer Embryo cervi 250-350 part
3, nano medicine ' Lutai ' according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 150 parts of nanometer motherworts of 100 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
25 parts of 50 parts of nano tortoise plastrons of 150 parts of nano cyperus tubers of nanometer Radix Rehmanniae Preparata
25 parts of 15 parts of nanometer Semen Raphanis of 25 parts of nanometer Rhizoma Corydalis of nanometer Cortex Lycii
15 parts of 30 parts of nanometer Cortex Cinnamomis of 30 parts of nano ass hide glues of the nanometer Rhizoma Atractylodis Macrocephalae
40 parts of 100 parts of nanometer Radix Paeoniae Rubra of 15 parts of nano red sages of the nanometer Radix Aucklandiae
50 parts of 20 parts of nanometer Radix Dipsacis of 25 parts of nanometer Fructus Foeniculi of nanometer Radix Glycyrrhizae
25 parts of 25 parts of nanometer Radix Achyranthis Bidentataes of 25 parts of nanometer Rhizoma Chuanxiongs of nanometer Pollen Typhae
270 parts of 300 parts of nanometer Embryo cervi of 15 parts of nano Porias of nano-antler
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Lutai 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Lutai 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101844 CN1368095A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Lutai' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101844 CN1368095A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Lutai' and its preparing process |
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| CN1368095A true CN1368095A (en) | 2002-09-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 01101844 Pending CN1368095A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Lutai' and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425270C (en) * | 2006-03-02 | 2008-10-15 | 魏峰 | Semifluid extract of deer foetus and preparing method |
| CN101301645B (en) * | 2008-07-01 | 2012-10-31 | 杨景秋 | Carrier catalyst slurry automatic coating machine |
| CN107375605A (en) * | 2017-04-13 | 2017-11-24 | 钓鱼台医药集团吉林天强制药股份有限公司 | Semifluid extract of deer foetus and preparation method thereof |
-
2001
- 2001-02-05 CN CN 01101844 patent/CN1368095A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425270C (en) * | 2006-03-02 | 2008-10-15 | 魏峰 | Semifluid extract of deer foetus and preparing method |
| CN101301645B (en) * | 2008-07-01 | 2012-10-31 | 杨景秋 | Carrier catalyst slurry automatic coating machine |
| CN107375605A (en) * | 2017-04-13 | 2017-11-24 | 钓鱼台医药集团吉林天强制药股份有限公司 | Semifluid extract of deer foetus and preparation method thereof |
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