CN1366974A - Nano Guilingji preparation medicine and preparation method - Google Patents
Nano Guilingji preparation medicine and preparation method Download PDFInfo
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- CN1366974A CN1366974A CN 01102170 CN01102170A CN1366974A CN 1366974 A CN1366974 A CN 1366974A CN 01102170 CN01102170 CN 01102170 CN 01102170 A CN01102170 A CN 01102170A CN 1366974 A CN1366974 A CN 1366974A
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Abstract
The present invention discloses a nano guilingji preparation medicine. It is made up by using 20 Chinese medicinal materials of nano ginseng, nano velvet deerhorn, nano sea horse, nano lycium, nano clove and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of supplementing the brain, the QI invigorating of reinforcing the kidney, appetite stimulator of keeping fit, cure mainly that the deficiency of the kidney sun is weak, hypomnesis, the smart something lost of dream at night, waist soreness, qi-asthenia cough, half congealedly just before dawn rush down, the nano Guilingji preparation medicine of inappetence, the invention still further relates to the method for this medication preparation.
Longevity powder is a kind of classical Chinese patent medicine, mainly contain hypermnesis, calm, resisting fatigue and enhancing hypoxia-bearing capability strengthen protein, nucleic acid metabolism, heart tonifying, anti-liver injury, enhance immunity, effects such as androgen sample and adrenocortical hormone sample, be used for that the deficiency of the kidney sun is weak, hypomnesis, the smart something lost of dream at night, waist soreness, qi-asthenia cough, half congealedly just before dawn rush down, inappetence.But traditional longevity powder absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Guilingji preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Guilingji preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 10-50 part nano-antler 3-20 part nanometer Hippocampus 5-50 part
Nanometer Fructus Lycii 15-50 part nano clove 10-50 part nanometer Squama Manis 5-50 part
Nanometer Medulla passeris 5-40 part nanometer Radix Achyranthis Bidentatae 10-50 part nanometer Herba Cynomorii 8-50 part
Nanometer Radix Rehmanniae Preparata 15-60 part nanometer Fructus Psoraleae 10-50 part nanometer Semen Cuscutae 10-50 part
Nanometer Cortex Eucommiae 10-50 part nanometer Fossilia Spiriferis 10-50 part nanometer Herba Cistanches 10-50 part
Nanometer Radix Glycyrrhizae 5-50 part nanometer Radix Asparagi 10-50 part nanometer Herba Epimedii 10-50 part
Nanometer halite 10-50 part nanometer Fructus Amomi 10-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 20-40 part nano-antler 5-15 part nanometer Hippocampus 10-30 part
Nanometer Fructus Lycii 25-40 part nano clove 20-40 part nanometer Squama Manis 10-30 part
Nanometer Medulla passeris 8-25 part nanometer Radix Achyranthis Bidentatae 20-40 part nanometer Herba Cynomorii 15-40 part
Nanometer Radix Rehmanniae Preparata 25-50 part nanometer Fructus Psoraleae 20-40 part nanometer Semen Cuscutae 20-40 part
Nanometer Cortex Eucommiae 20-40 part nanometer Fossilia Spiriferis 20-40 part nanometer Herba Cistanches 15-40 part
Nanometer Radix Glycyrrhizae 10-30 part nanometer Radix Asparagi 15-40 part nanometer Herba Epimedii 20-40 part
Nanometer halite 15-40 part nanometer Fructus Amomi 20-40 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 10 parts of nanometer Hippocampus of 30 parts of nano-antlers of nano ginseng
20 parts of 28 parts of nanometer Squama Maniss of 35 parts of nano cloves of nanometer Fructus Lycii
25 parts of 30 parts of nanometer Herba Cynomoriis of 15 parts of nanometer Radix Achyranthis Bidentataes of nanometer Medulla passeris
28 parts of 30 parts of nanometer Semen Cuscutae of 35 parts of nanometer Fructus Psoraleaes of nanometer Radix Rehmanniae Preparata
26 parts of 28 parts of nanometer Herba Cistanches of 28 parts of nanometer Fossilia Spiriferiss of the nanometer Cortex Eucommiae
30 parts of 25 parts of nanometer Herba Epimedii of 20 parts of nanometer Radix Asparagis of nanometer Radix Glycyrrhizae
30 parts of 25 parts of nanometer Fructus Amomis of nanometer halite
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get longevity powder preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Guilingji preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common longevity powder preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Guilingji preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for senile anemia, and the constitutional nephropathy is comprehensively demonstrate,proved, chronic respiratory tract disease, and treatment of conditions such as elder kidney asthenia is had loose bowels, constipation, clinical efficacy significantly is better than traditional longevity powder.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 10 parts of nanometer Hippocampus of 30 parts of nano-antlers of nano ginseng
20 parts of 28 parts of nanometer Squama Maniss of 35 parts of nano cloves of nanometer Fructus Lycii
25 parts of 30 parts of nanometer Herba Cynomoriis of 15 parts of nanometer Radix Achyranthis Bidentataes of nanometer Medulla passeris
28 parts of 30 parts of nanometer Semen Cuscutae of 35 parts of nanometer Fructus Psoraleaes of nanometer Radix Rehmanniae Preparata
26 parts of 28 parts of nanometer Herba Cistanches of 28 parts of nanometer Fossilia Spiriferiss of the nanometer Cortex Eucommiae
30 parts of 25 parts of nanometer Herba Epimedii of 20 parts of nanometer Radix Asparagis of nanometer Radix Glycyrrhizae
30 parts of 25 parts of nanometer Fructus Amomis of nanometer halite
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 10 parts of nanometer Hippocampus of 30 parts of nano-antlers of nano ginseng
20 parts of 28 parts of nanometer Squama Maniss of 35 parts of nano cloves of nanometer Fructus Lycii
25 parts of 30 parts of nanometer Herba Cynomoriis of 15 parts of nanometer Radix Achyranthis Bidentataes of nanometer Medulla passeris
28 parts of 30 parts of nanometer Semen Cuscutae of 35 parts of nanometer Fructus Psoraleaes of nanometer Radix Rehmanniae Preparata
26 parts of 28 parts of nanometer Herba Cistanches of 28 parts of nanometer Fossilia Spiriferiss of the nanometer Cortex Eucommiae
30 parts of 25 parts of nanometer Herba Epimedii of 20 parts of nanometer Radix Asparagis of nanometer Radix Glycyrrhizae
30 parts of 25 parts of nanometer Fructus Amomis of nanometer halite
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Guilingji membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Guilingji preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 10-50 part nano-antler 3-20 part nanometer Hippocampus 5-50 part
Nanometer Fructus Lycii 15-50 part nano clove 10-50 part nanometer Squama Manis 5-50 part
Nanometer Medulla passeris 5-40 part nanometer Radix Achyranthis Bidentatae 10-50 part nanometer Herba Cynomorii 8-50 part
Nanometer Radix Rehmanniae Preparata 15-60 part nanometer Fructus Psoraleae 10-50 part nanometer Semen Cuscutae 10-50 part
Nanometer Cortex Eucommiae 10-50 part nanometer Fossilia Spiriferis 10-50 part nanometer Herba Cistanches 10-50 part
Nanometer Radix Glycyrrhizae 5-50 part nanometer Radix Asparagi 10-50 part nanometer Herba Epimedii 10-50 part
Nanometer halite 10-50 part nanometer Fructus Amomi 10-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Guilingji preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 20-40 part nano-antler 5-15 part nanometer Hippocampus 10-30 part
Nanometer Fructus Lycii 25-40 part nano clove 20-40 part nanometer Squama Manis 10-30 part
Nanometer Medulla passeris 8-25 part nanometer Radix Achyranthis Bidentatae 20-40 part nanometer Herba Cynomorii 15-40 part
Nanometer Radix Rehmanniae Preparata 25-50 part nanometer Fructus Psoraleae 20-40 part nanometer Semen Cuscutae 20-40 part
Nanometer Cortex Eucommiae 20-40 part nanometer Fossilia Spiriferis 20-40 part nanometer Herba Cistanches 15-40 part
Nanometer Radix Glycyrrhizae 10-30 part nanometer Radix Asparagi 15-40 part nanometer Herba Epimedii 20-40 part
Nanometer halite 15-40 part nanometer Fructus Amomi 20-40 part
3, nano Guilingji preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 10 parts of nanometer Hippocampus of 30 parts of nano-antlers of nano ginseng
20 parts of 28 parts of nanometer Squama Maniss of 35 parts of nano cloves of nanometer Fructus Lycii
25 parts of 30 parts of nanometer Herba Cynomoriis of 15 parts of nanometer Radix Achyranthis Bidentataes of nanometer Medulla passeris
28 parts of 30 parts of nanometer Semen Cuscutae of 35 parts of nanometer Fructus Psoraleaes of nanometer Radix Rehmanniae Preparata
26 parts of 28 parts of nanometer Herba Cistanches of 28 parts of nanometer Fossilia Spiriferiss of the nanometer Cortex Eucommiae
30 parts of 25 parts of nanometer Herba Epimedii of 20 parts of nanometer Radix Asparagis of nanometer Radix Glycyrrhizae
30 parts of 25 parts of nanometer Fructus Amomis of nanometer halite
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Guilingji preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Guilingji preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102170 CN1366974A (en) | 2001-01-20 | 2001-01-20 | Nano Guilingji preparation medicine and preparation method |
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| CN 01102170 CN1366974A (en) | 2001-01-20 | 2001-01-20 | Nano Guilingji preparation medicine and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284115B (en) * | 2008-05-30 | 2011-01-19 | 连德峰 | Kidney-tonifying and body-strengthening pellet |
| CN108014269A (en) * | 2017-12-18 | 2018-05-11 | 高意强 | A kind of medicinal liquor of tonifying kidney and benefiting sperm |
-
2001
- 2001-01-20 CN CN 01102170 patent/CN1366974A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284115B (en) * | 2008-05-30 | 2011-01-19 | 连德峰 | Kidney-tonifying and body-strengthening pellet |
| CN108014269A (en) * | 2017-12-18 | 2018-05-11 | 高意强 | A kind of medicinal liquor of tonifying kidney and benefiting sperm |
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