CN1362239A - Nano Yixuesheng medicine for benefiting hemopoiesis and its preparation - Google Patents
Nano Yixuesheng medicine for benefiting hemopoiesis and its preparation Download PDFInfo
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- CN1362239A CN1362239A CN 01100739 CN01100739A CN1362239A CN 1362239 A CN1362239 A CN 1362239A CN 01100739 CN01100739 CN 01100739 CN 01100739 A CN01100739 A CN 01100739A CN 1362239 A CN1362239 A CN 1362239A
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Abstract
The present invention discloses a nano Yixuesheng preparation medicine. It is made up by using 22 Chinese medicinal materials of nano ass hide glue, nano tortoise plastron gule, nano deerhorn glue, nano deer's blood, nano cattle marrow and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The nano blood tonifying that the present invention relates to a kind of spleen invigorating hemopoietic, kidney tonifying, essence replenishing is given birth to preparation medicine, the invention still further relates to the method for this medication preparation.
Benefit blood rubber capsule is a kind of classical Chinese patent medicine, mainly contains effects such as spleen invigorating hemopoietic, kidney tonifying, essence replenishing, is used for blood deficiency all disease, various anemia and the thrombocytopenia of spleen kidney two due to losing.. but traditional beneficial blood rubber capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully, and the nano blood tonifying of increase evident in efficacy is given birth to preparation medicine.
Another object of the present invention provides this nano blood tonifying to give birth to the preparation method of preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ass hide glue 10-20 part nano tortoise plastron glue 10-20 part nano deerhorn glue 10-20 part
Nanometer Sanguis cervi 10-20 part nanometer Medulla Bovis seu Bubali 15-35 part nanometer Placenta Hominis 5-15 part
Nano-antler 1-5 part nano Poria 15-35 part nano astragalus 12-30 part
Nanometer Radix Paeoniae Alba 12-30 part nano Chinese angelica 10-20 part nanometer Radix Codonopsis 10-20 part
Nanometer Radix Rehmanniae Preparata 10-20 nanometer Rhizoma Atractylodis Macrocephalae 10-20 part nanometer system fleece-flower root-5-15
Nanometer Fructus Jujubae 5-15 part nanometer Fructus Crataegi 10-20 part nanometer Fructus Hordei Germinatus 10-20 part
Nanometer Endothelium Corneum Gigeriae Galli 5-15 part nanometer Rhizoma Anemarrhenae 2-8 part nano rhubarb 2-8 part
Nanometer Testa arachidis hypogaeae 1-5
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ass hide glue 12-18 part nano tortoise plastron glue 12-18 part nano deerhorn glue 12-18 part
Nanometer Sanguis cervi 12-18 part nanometer Medulla Bovis seu Bubali 20-30 part nanometer Placenta Hominis 8-12 part
Nano-antler 2-4 part nano Poria 20-30 part nano astragalus 16-24 part
Nanometer Radix Paeoniae Alba 16-24 part nano Chinese angelica 12-18 part nanometer Radix Codonopsis 12-18 part
Nanometer Radix Rehmanniae Preparata 12-18 part nanometer Rhizoma Atractylodis Macrocephalae 12-18 part nanometer system fleece-flower root 8-12 part
Nanometer Fructus Jujubae 8-12 part nanometer Fructus Crataegi 12-18 part nanometer Fructus Hordei Germinatus 12-18 part
Nanometer Endothelium Corneum Gigeriae Galli 8-12 part nanometer Rhizoma Anemarrhenae 4-6 part nano rhubarb 4-6 part
Nanometer Testa arachidis hypogaeae 2-3 part
The optimum weight proportioning of medicine of the present invention is:
15 parts in 15 parts of nano deerhorn glue of 5 parts of nano tortoise plastron glue of nano ass hide glue
10 parts of 25 parts of nanometer Placenta Hominiss of 15 parts of nanometer Medulla Bovis seu Bubali of nanometer Sanguis cervi
20 parts of 25 parts of nano astragalus of 3 parts of nano Porias of nano-antler
15 parts of 15 parts of nanometer Radix Codonopsis of 20 parts of nano Chinese angelicas of the nanometer Radix Paeoniae Alba
10 parts of 15 parts of nanometer system fleece-flower roots of 15 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Rehmanniae Preparata
15 parts in 15 parts of nanometer Fructus Hordei Germinatus of 10 parts of nanometer Fructus Crataegis of nanometer Fructus Jujubae
5 parts of 5 parts of nano rhubarbs of 10 parts of nanometer Rhizoma Anemarrhenaes of nanometer Endothelium Corneum Gigeriae Galli
2.5 parts of nanometer Testa arachidis hypogaeaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, benefit blood is given birth to the preparation nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common beneficial blood rubber capsule preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
The pharmacological effect that above-mentioned two kinds of methods are made the living preparation medicine of nano blood tonifying is identical.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created nano blood tonifying and has given birth to the new drug formulation that the pill of preparation medicine, powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution etc. are had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for spleen kidney two treatment of conditions such as all diseases of blood deficiency, various anemia and thrombocytopenia due to losing, and clinical efficacy significantly is better than traditional beneficial blood rubber capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
15 parts in 15 parts of nano deerhorn glue of 5 parts of nano tortoise plastron glue of nano ass hide glue
10 parts of 25 parts of nanometer Placenta Hominiss of 15 parts of nanometer Medulla Bovis seu Bubali of nanometer Sanguis cervi
20 parts of nano-antler 25 parts of nano astragalus of 3 parts of nano Porias (processed with honey)
15 parts of 15 parts of nanometer Radix Codonopsis of 20 parts of nano Chinese angelicas of the nanometer Radix Paeoniae Alba
10 parts of 15 parts of nanometer system fleece-flower roots of 15 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Rehmanniae Preparata
15 parts in 15 parts of nanometer Fructus Hordei Germinatus of 10 parts of nanometer Fructus Crataegis of nanometer Fructus Jujubae
5 parts of 5 parts of nano rhubarbs of 10 parts of nanometer Rhizoma Anemarrhenaes of nanometer Endothelium Corneum Gigeriae Galli
2.5 parts of nanometer Testa arachidis hypogaeaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
15 parts in 15 parts of nano deerhorn glue of 5 parts of nano tortoise plastron glue of nano ass hide glue
10 parts of 25 parts of nanometer Placenta Hominiss of 15 parts of nanometer Medulla Bovis seu Bubali of nanometer Sanguis cervi
20 parts of 25 parts of nano astragalus of 3 parts of nano Porias of nano-antler
15 parts of 15 parts of nanometer Radix Codonopsis of 20 parts of nano Chinese angelicas of the nanometer Radix Paeoniae Alba
10 parts of 15 parts of nanometer system fleece-flower roots of 15 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Rehmanniae Preparata
15 parts in 15 parts of nanometer Fructus Hordei Germinatus of 10 parts of nanometer Fructus Crataegis of nanometer Fructus Jujubae
5 parts of 5 parts of nano rhubarbs of 10 parts of nanometer Rhizoma Anemarrhenaes of nanometer Endothelium Corneum Gigeriae Galli
2.5 parts of nanometer Testa arachidis hypogaeaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nano blood tonifying fecula needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
15 parts in 15 parts of nano deerhorn glue of 5 parts of nano tortoise plastron glue of nano ass hide glue
10 parts of 25 parts of nanometer Placenta Hominiss of 15 parts of nanometer Medulla Bovis seu Bubali of nanometer Sanguis cervi
20 parts of 25 parts of nano astragalus of 3 parts of nano Porias of nano-antler
15 parts of 15 parts of nanometer Radix Codonopsis of 20 parts of nano Chinese angelicas of the nanometer Radix Paeoniae Alba
10 parts of 15 parts of nanometer system fleece-flower roots of 15 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Rehmanniae Preparata
15 parts in 15 parts of nanometer Fructus Hordei Germinatus of 10 parts of nanometer Fructus Crataegis of nanometer Fructus Jujubae
5 parts of 5 parts of nano rhubarbs of 10 parts of nanometer Rhizoma Anemarrhenaes of nanometer Endothelium Corneum Gigeriae Galli
2.5 parts of nanometer Testa arachidis hypogaeaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nano blood tonifying and give birth to membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano blood tonifying is given birth to preparation medicine, it is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ass hide glue 10-20 part nano tortoise plastron glue 10-20 part nano deerhorn glue 10-20 part
Nanometer Sanguis cervi 10-20 part nanometer Medulla Bovis seu Bubali 15-35 part nanometer Placenta Hominis 5-15 part
Nano-antler 1-5 part nano Poria 15-35 part nano astragalus 12-30 part
Nanometer Radix Paeoniae Alba 12-30 part nano Chinese angelica 10-20 part nanometer Radix Codonopsis 10-20 part
Nanometer Radix Rehmanniae Preparata 10-20 nanometer Rhizoma Atractylodis Macrocephalae 10-20 part nanometer system fleece-flower root-5-15
Nanometer Fructus Jujubae 5-15 part nanometer Fructus Crataegi 10-20 part nanometer Fructus Hordei Germinatus 10-20 part
Nanometer Endothelium Corneum Gigeriae Galli 5-15 part nanometer Rhizoma Anemarrhenae 2-8 part nano rhubarb 2-8 part
Nanometer Testa arachidis hypogaeae 1-5
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano blood tonifying according to claim 1 is given birth to preparation medicine, and wherein the weight proportion of each nano raw material is:
Nano ass hide glue 12-18 part nano tortoise plastron glue 12-18 part nano deerhorn glue 12-18 part
Nanometer Sanguis cervi 12-18 part nanometer Medulla Bovis seu Bubali 20-30 part nanometer Placenta Hominis 8-12 part
Nano-antler 2-4 part nano Poria 20-30 part nano astragalus 16-24 part
Nanometer Radix Paeoniae Alba 16-24 part nano Chinese angelica 12-18 part nanometer Radix Codonopsis 12-18 part
Nanometer Radix Rehmanniae Preparata 12-18 part nanometer Rhizoma Atractylodis Macrocephalae 12-18 part nanometer system fleece-flower root 8-12 part
Nanometer Fructus Jujubae 8-12 part nanometer Fructus Crataegi 12-18 part nanometer Fructus Hordei Germinatus 12-18 part
Nanometer Endothelium Corneum Gigeriae Galli 8-12 part nanometer Rhizoma Anemarrhenae 4-6 part nano rhubarb 4-6 part
Nanometer Testa arachidis hypogaeae 2-3 part
3, nano blood tonifying according to claim 1 is given birth to preparation medicine, and wherein the weight proportion of each nano raw material is:
15 parts in 15 parts of nano deerhorn glue of 5 parts of nano tortoise plastron glue of nano ass hide glue
10 parts of 25 parts of nanometer Placenta Hominiss of 15 parts of nanometer Medulla Bovis seu Bubali of nanometer Sanguis cervi
20 parts of 25 parts of nano astragalus of 3 parts of nano Porias of nano-antler
15 parts of 15 parts of nanometer Radix Codonopsis of 20 parts of nano Chinese angelicas of the nanometer Radix Paeoniae Alba
10 parts of 15 parts of nanometer system fleece-flower roots of 15 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Rehmanniae Preparata
15 parts in 15 parts of nanometer Fructus Hordei Germinatus of 10 parts of nanometer Fructus Crataegis of nanometer Fructus Jujubae
5 parts of 5 parts of nano rhubarbs of 10 parts of nanometer Rhizoma Anemarrhenaes of nanometer Endothelium Corneum Gigeriae Galli
2.5 parts of nanometer Testa arachidis hypogaeaes
4, give birth to preparation medicine according to claim 1 or 2 or 3 described nano blood tonifyings, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the living preparation medicine of 2 or 3 described nano blood tonifyings; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100739 CN1362239A (en) | 2001-01-08 | 2001-01-08 | Nano Yixuesheng medicine for benefiting hemopoiesis and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100739 CN1362239A (en) | 2001-01-08 | 2001-01-08 | Nano Yixuesheng medicine for benefiting hemopoiesis and its preparation |
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| CN1362239A true CN1362239A (en) | 2002-08-07 |
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| CN 01100739 Pending CN1362239A (en) | 2001-01-08 | 2001-01-08 | Nano Yixuesheng medicine for benefiting hemopoiesis and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101671619B (en) * | 2009-03-18 | 2012-07-25 | 四川金皇乐爽鹿业有限公司 | Preparation method of deer blood wine |
| CN103251856A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN103355679A (en) * | 2013-07-23 | 2013-10-23 | 山东省农业科学院农产品研究所 | Making method of chewable tablet with effect of enriching blood |
-
2001
- 2001-01-08 CN CN 01100739 patent/CN1362239A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101671619B (en) * | 2009-03-18 | 2012-07-25 | 四川金皇乐爽鹿业有限公司 | Preparation method of deer blood wine |
| CN103251856A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN103251856B (en) * | 2013-05-08 | 2015-07-22 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN103355679A (en) * | 2013-07-23 | 2013-10-23 | 山东省农业科学院农产品研究所 | Making method of chewable tablet with effect of enriching blood |
| CN103355679B (en) * | 2013-07-23 | 2014-12-03 | 山东省农业科学院农产品研究所 | Making method of chewable tablet with effect of enriching blood |
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