CN1366977A - Nano Guloushan dieda preparation medicine and preparation method - Google Patents
Nano Guloushan dieda preparation medicine and preparation method Download PDFInfo
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- CN1366977A CN1366977A CN 01102184 CN01102184A CN1366977A CN 1366977 A CN1366977 A CN 1366977A CN 01102184 CN01102184 CN 01102184 CN 01102184 A CN01102184 A CN 01102184A CN 1366977 A CN1366977 A CN 1366977A
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Abstract
The present ivnention discloses a nano gulouyou dieda preparation medicine. It is made up by using 32 Chinese medicinal materials of nano anomalous artemisia, nano corydalis, nano cinnamon twig, nano frankincense, nano drynaria and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano Guloushan dieda medicine of a kind of relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain, the invention still further relates to the method for this medication preparation.
The Guloushan dieda ball is a kind of classical Chinese patent medicine, mainly contains effects such as relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain, is used for that traumatic injury, alluvial swell and ache, muscles and bones is turned round pain, the waist diseases such as damage of being overworked for a very long period.But traditional Guloushan dieda ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Guloushan dieda medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Guloushan dieda medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Artemisia anomah S. Moore 15-40 part nanometer Rhizoma Corydalis 12-30 part nanometer Ramulus Cinnamomi 25-50 part
Nanometer Olibanum 6-18 part nanometer Rhizoma Drynariae 15-40 part nano amber 6-20 part
Nano angelica root 15-40 part nanometer Rhizoma Alpiniae Officinarum 15-40 part nanometer Radix Dipsaci 15-40 part
Nanometer Radix Achyranthis Bidentatae 15-40 part nano cyperus tuber 15-40 part nanometer Fructus Psoraleae 15-40 part
Nano Chinese angelica tail 8-20 part nanometer Semen Persicae 25-50 part nanometer Radix Curcumae 10-35 part
Nanometer Pyritum 10-30 part nanometer Myrrha 8-25 part nanometer Lignum Aquilariae Resinatum 8-20 part
Nanometer Rhizoma Curcumae 15-40 part nanometer Rhizoma Chuanxiong 15-40 part nanometer Herba Lycopi 15-40 part
Nano safflower 15-40 part nanometer Fructus Chaenomelis 15-40 part nanometer Cortex Eucommiae 15-40 part
Nanometer rhizoma sparganic 15-40 part nanometer Radix Platycodonis 15-40 part nanometer Sanguis Draxonis 6-20 part
Nanometer Radix Notoginseng 5-9 part nanometer Radix Glycyrrhizae 8-25 part nanometer Fructus Aurantii 15-40 part
Nanometer Radix Clematidis 15-40 part nanometer Fructus Amomi Rotundus 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Artemisia anomah S. Moore 20-30 part nanometer Rhizoma Corydalis 15-25 part nanometer Ramulus Cinnamomi 30-40 part
Nanometer Olibanum 8-15 part nanometer Rhizoma Drynariae 20-30 part nano amber 8-15 part
Nano angelica root 20-30 part nanometer Rhizoma Alpiniae Officinarum 20-30 part nanometer Radix Dipsaci 20-30 part
Nanometer Radix Achyranthis Bidentatae 20-30 part nano cyperus tuber 20-30 part nanometer Fructus Psoraleae 20-30 part
Nano Chinese angelica tail 10-15 part nanometer Semen Persicae 30-40 part nanometer Radix Curcumae 15-25 part
Nanometer Pyritum 15-25 part nanometer Myrrha 10-15 part nanometer Lignum Aquilariae Resinatum 10-15 part
Nanometer Rhizoma Curcumae 20-30 part nanometer Rhizoma Chuanxiong 20-30 part nanometer Herba Lycopi 20-30 part
Nano safflower 20-30 part nanometer Fructus Chaenomelis 20-30 part nanometer Cortex Eucommiae 20-30 part
Nanometer rhizoma sparganic 20-30 part nanometer Radix Platycodonis 20-30 part nanometer Sanguis Draxonis 8-15 part
Nanometer Radix Notoginseng 6-8 part nanometer Radix Glycyrrhizae 10-15 part nanometer Fructus Aurantii 20-30 part
Nanometer Radix Clematidis 20-30 part nanometer Fructus Amomi Rotundus 20-30 part
The optimum weight proportioning of medicine of the present invention is:
36 parts of 20 parts of nanometer Ramulus Cinnamomi of 24 parts of nanometer Rhizoma Corydalis of nanometer Artemisia anomah S. Moore
12 parts of 24 parts of nano ambers of 12 parts of nanometer Rhizoma Drynariae of nanometer Olibanum
24 parts of 24 parts of nanometer Radix Dipsacis of 24 portions of nanometer Rhizoma Alpiniae Officinarums of nano angelica root
24 parts of 24 parts of nanometer Fructus Psoraleaes of 24 parts of nano cyperus tubers of nanometer Radix Achyranthis Bidentatae
20 parts of 36 parts of nanometer Radix Curcumaes of 12 parts of nanometer Semen Persicaes of nano Chinese angelica tail
12 parts of 12 parts of nanometer Lignum Aquilariae Resinatum of 20 parts of nanometer Myrrhas of nanometer Pyritum
24 parts of 24 parts of nanometer Herba Lycopi of 24 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Curcumae
24 parts of 24 parts of nanometer Cortexs Eucommiae of 24 parts of nanometer Fructus Chaenomeliss of nano safflower
10 parts of 24 parts of nanometer Sanguis Draxonis of 24 parts of nanometer Radix Platycodoniss of nanometer rhizoma sparganic
24 parts of 12 parts of nanometer Fructus Aurantiis of 7 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Notoginseng
24 parts in 24 parts of nanometer Fructus Amomi Rotunduss of nanometer Radix Clematidis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Guloushan dieda nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Guloushan dieda medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Guloushan dieda pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Guloushan dieda medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that traumatic injury, alluvial swell and ache, muscles and bones is turned round pain, the waist treatment of conditions such as damage of being overworked for a very long period, and clinical efficacy significantly is better than traditional Guloushan dieda ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
36 parts of 20 parts of nanometer Ramulus Cinnamomi of 24 parts of nanometer Rhizoma Corydalis of nanometer Artemisia anomah S. Moore
12 parts of 24 parts of nano ambers of 12 parts of nanometer Rhizoma Drynariae of nanometer Olibanum
24 parts of 24 parts of nanometer Radix Dipsacis of 24 portions of nanometer Rhizoma Alpiniae Officinarums of nano angelica root
24 parts of 24 parts of nanometer Fructus Psoraleaes of 24 parts of nano cyperus tubers of nanometer Radix Achyranthis Bidentatae
20 parts of 36 parts of nanometer Radix Curcumaes of 12 parts of nanometer Semen Persicaes of nano Chinese angelica tail
12 parts of 12 parts of nanometer Lignum Aquilariae Resinatum of 20 parts of nanometer Myrrhas of nanometer Pyritum
24 parts of 24 parts of nanometer Herba Lycopi of 24 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Curcumae
24 parts of 24 parts of nanometer Cortexs Eucommiae of 24 parts of nanometer Fructus Chaenomeliss of nano safflower
10 parts of 24 parts of nanometer Sanguis Draxonis of 24 parts of nanometer Radix Platycodoniss of nanometer rhizoma sparganic
24 parts of 12 parts of nanometer Fructus Aurantiis of 7 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Notoginseng
24 parts in 24 parts of nanometer Fructus Amomi Rotunduss of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
36 parts of 20 parts of nanometer Ramulus Cinnamomi of 24 parts of nanometer Rhizoma Corydalis of nanometer Artemisia anomah S. Moore
12 parts of 24 parts of nano ambers of 12 parts of nanometer Rhizoma Drynariae of nanometer Olibanum
24 parts of 24 parts of nanometer Radix Dipsacis of 24 portions of nanometer Rhizoma Alpiniae Officinarums of nano angelica root
24 parts of 24 parts of nanometer Fructus Psoraleaes of 24 parts of nano cyperus tubers of nanometer Radix Achyranthis Bidentatae
20 parts of 36 parts of nanometer Radix Curcumaes of 12 parts of nanometer Semen Persicaes of nano Chinese angelica tail
12 parts of 12 parts of nanometer Lignum Aquilariae Resinatum of 20 parts of nanometer Myrrhas of nanometer Pyritum
24 parts of 24 parts of nanometer Herba Lycopi of 24 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Curcumae
24 parts of 24 parts of nanometer Cortexs Eucommiae of 24 parts of nanometer Fructus Chaenomeliss of nano safflower
10 parts of 24 parts of nanometer Sanguis Draxonis of 24 parts of nanometer Radix Platycodoniss of nanometer rhizoma sparganic
24 parts of 12 parts of nanometer Fructus Aurantiis of 7 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Notoginseng
24 parts in 24 parts of nanometer Fructus Amomi Rotunduss of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Guloushan dieda powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
36 parts of 20 parts of nanometer Ramulus Cinnamomi of 24 parts of nanometer Rhizoma Corydalis of nanometer Artemisia anomah S. Moore
12 parts of 24 parts of nano ambers of 12 parts of nanometer Rhizoma Drynariae of nanometer Olibanum
24 parts of 24 parts of nanometer Radix Dipsacis of 24 portions of nanometer Rhizoma Alpiniae Officinarums of nano angelica root
24 parts of 24 parts of nanometer Fructus Psoraleaes of 24 parts of nano cyperus tubers of nanometer Radix Achyranthis Bidentatae
20 parts of 36 parts of nanometer Radix Curcumaes of 12 parts of nanometer Semen Persicaes of nano Chinese angelica tail
12 parts of 12 parts of nanometer Lignum Aquilariae Resinatum of 20 parts of nanometer Myrrhas of nanometer Pyritum
24 parts of 24 parts of nanometer Herba Lycopi of 24 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Curcumae
24 parts of 24 parts of nanometer Cortexs Eucommiae of 24 parts of nanometer Fructus Chaenomeliss of nano safflower
10 parts of 24 parts of nanometer Sanguis Draxonis of 24 parts of nanometer Radix Platycodoniss of nanometer rhizoma sparganic
24 parts of 12 parts of nanometer Fructus Aurantiis of 7 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Notoginseng
24 parts in 24 parts of nanometer Fructus Amomi Rotunduss of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Guloushan dieda membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano Guloushan dieda medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Artemisia anomah S. Moore 15-40 part nanometer Rhizoma Corydalis 12-30 part nanometer Ramulus Cinnamomi 25-50 part
Nanometer Olibanum 6-18 part nanometer Rhizoma Drynariae 15-40 part nano amber 6-20 part
Nano angelica root 15-40 part nanometer Rhizoma Alpiniae Officinarum 15-40 part nanometer Radix Dipsaci 15-40 part
Nanometer Radix Achyranthis Bidentatae 15-40 part nano cyperus tuber 15-40 part nanometer Fructus Psoraleae 15-40 part
Nano Chinese angelica tail 8-20 part nanometer Semen Persicae 25-50 part nanometer Radix Curcumae 10-35 part
Nanometer Pyritum 10-30 part nanometer Myrrha 8-25 part nanometer Lignum Aquilariae Resinatum 8-20 part
Nanometer Rhizoma Curcumae 15-40 part nanometer Rhizoma Chuanxiong 15-40 part nanometer Herba Lycopi 15-40 part
Nano safflower 15-40 part nanometer Fructus Chaenomelis 15-40 part nanometer Cortex Eucommiae 15-40 part
Nanometer rhizoma sparganic 15-40 part nanometer Radix Platycodonis 15-40 part nanometer Sanguis Draxonis 6-20 part
Nanometer Radix Notoginseng 5-9 part nanometer Radix Glycyrrhizae 8-25 part nanometer Fructus Aurantii 15-40 part
Nanometer Radix Clematidis 15-40 part nanometer Fructus Amomi Rotundus 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Guloushan dieda medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Artemisia anomah S. Moore 20-30 part nanometer Rhizoma Corydalis 15-25 part nanometer Ramulus Cinnamomi 30-40 part
Nanometer Olibanum 8-15 part nanometer Rhizoma Drynariae 20-30 part nano amber 8-15 part
Nano angelica root 20-30 part nanometer Rhizoma Alpiniae Officinarum 20-30 part nanometer Radix Dipsaci 20-30 part
Nanometer Radix Achyranthis Bidentatae 20-30 part nano cyperus tuber 20-30 part nanometer Fructus Psoraleae 20-30 part
Nano Chinese angelica tail 10-15 part nanometer Semen Persicae 30-40 part nanometer Radix Curcumae 15-25 part
Nanometer Pyritum 15-25 part nanometer Myrrha 10-15 part nanometer Lignum Aquilariae Resinatum 10-15 part
Nanometer Rhizoma Curcumae 20-30 part nanometer Rhizoma Chuanxiong 20-30 part nanometer Herba Lycopi 20-30 part
Nano safflower 20-30 part nanometer Fructus Chaenomelis 20-30 part nanometer Cortex Eucommiae 20-30 part
Nanometer rhizoma sparganic 20-30 part nanometer Radix Platycodonis 20-30 part nanometer Sanguis Draxonis 8-15 part
Nanometer Radix Notoginseng 6-8 part nanometer Radix Glycyrrhizae 10-15 part nanometer Fructus Aurantii 20-30 part
Nanometer Radix Clematidis 20-30 part nanometer Fructus Amomi Rotundus 20-30 part
3, nano Guloushan dieda medicine according to claim 1, wherein the weight proportion of each nano raw material is:
36 parts of 20 parts of nanometer Ramulus Cinnamomi of 24 parts of nanometer Rhizoma Corydalis of nanometer Artemisia anomah S. Moore
12 parts of 24 parts of nano ambers of 12 parts of nanometer Rhizoma Drynariae of nanometer Olibanum
24 parts of 24 parts of nanometer Radix Dipsacis of 24 portions of nanometer Rhizoma Alpiniae Officinarums of nano angelica root
24 parts of 24 parts of nanometer Fructus Psoraleaes of 24 parts of nano cyperus tubers of nanometer Radix Achyranthis Bidentatae
20 parts of 36 parts of nanometer Radix Curcumaes of 12 parts of nanometer Semen Persicaes of nano Chinese angelica tail
12 parts of 12 parts of nanometer Lignum Aquilariae Resinatum of 20 parts of nanometer Myrrhas of nanometer Pyritum
24 parts of 24 parts of nanometer Herba Lycopi of 24 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Curcumae
24 parts of 24 parts of nanometer Cortexs Eucommiae of 24 parts of nanometer Fructus Chaenomeliss of nano safflower
10 parts of 24 parts of nanometer Sanguis Draxonis of 24 parts of nanometer Radix Platycodoniss of nanometer rhizoma sparganic
24 parts of 12 parts of nanometer Fructus Aurantiis of 7 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Notoginseng
24 parts in 24 parts of nanometer Fructus Amomi Rotunduss of nanometer Radix Clematidis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Guloushan dieda medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Guloushan dieda medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| CN 01102184 CN1366977A (en) | 2001-01-20 | 2001-01-20 | Nano Guloushan dieda preparation medicine and preparation method |
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| CN 01102184 CN1366977A (en) | 2001-01-20 | 2001-01-20 | Nano Guloushan dieda preparation medicine and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943635B (en) * | 2006-10-27 | 2010-04-21 | 王德振 | Chinese traditional medicinal preparation for treating bone injuries and osteonosus |
| CN102755597A (en) * | 2012-07-23 | 2012-10-31 | 董璞 | Chinese medicine for treating acute soft tissue injury |
-
2001
- 2001-01-20 CN CN 01102184 patent/CN1366977A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943635B (en) * | 2006-10-27 | 2010-04-21 | 王德振 | Chinese traditional medicinal preparation for treating bone injuries and osteonosus |
| CN102755597A (en) * | 2012-07-23 | 2012-10-31 | 董璞 | Chinese medicine for treating acute soft tissue injury |
| CN102755597B (en) * | 2012-07-23 | 2014-01-08 | 刘杰 | Chinese medicine for treating acute soft tissue injury |
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