CN1363307A - Nano medicine 'Guiluningshen' and its preparing process - Google Patents
Nano medicine 'Guiluningshen' and its preparing process Download PDFInfo
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- CN1363307A CN1363307A CN 01100230 CN01100230A CN1363307A CN 1363307 A CN1363307 A CN 1363307A CN 01100230 CN01100230 CN 01100230 CN 01100230 A CN01100230 A CN 01100230A CN 1363307 A CN1363307 A CN 1363307A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000003292 glue Substances 0.000 claims abstract description 19
- 241000270708 Testudinidae Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 10
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000756943 Codonopsis Species 0.000 claims description 9
- 244000268590 Euryale ferox Species 0.000 claims description 9
- 235000006487 Euryale ferox Nutrition 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 240000007164 Salvia officinalis Species 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 235000005412 red sage Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 235000005903 Dioscorea Nutrition 0.000 claims description 5
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 5
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000281702 Dioscorea villosa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 239000011858 nanopowder Substances 0.000 abstract description 3
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 241000208966 Polygala Species 0.000 abstract 1
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 241000282994 Cervidae Species 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000234273 Dioscorea Species 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010057315 Daydreaming Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nano medicine "Guilu Ningshen" is prepared from the nano powders of 17 Chinese-medicinal materials including tortoise plastron gelatin, antler glue, wild jujube kernel, polygala root, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biological utilization root and high curative effect.
Description
The present invention relates to the nano medicine ' Guiluningshen ' of a kind of invigorating the spleen and benefiting QI, replenishing blood for nourishing heart, the invention still further relates to the method for this medication preparation.
The Testudinis deer ball of allaying excitement is a kind of classical Chinese patent medicine, mainly contains effects such as invigorating the spleen and benefiting QI, replenishing blood for nourishing heart, and diseases such as insomnia, absentminded, dizzy tinnitus are used to palpitate with fear.Ball absorbs not exclusively but traditional Testudinis deer is allayed excitement, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Guiluningshen ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Guiluningshen '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano tortoise plastron glue 40-80 part nano deerhorn glue 40-80 part nm acid Semen Ziziphi Spinosae 80-200 part
Nanometer Radix Polygalae 20-60 part nano Poria 120-250 part nanometer Radix Rehmanniae Preparata 500-850 part
Nano Chinese angelica 60-120 part nanometer Rhizoma Chuanxiong 120-180 part nano astragalus 120-250 part
Nanometer Radix Codonopsis 120-250 part nanometer Radix Paeoniae Alba 40-150 part nano red sage 80-250 part
Nanometer Rhizoma Atractylodis Macrocephalae 100-250 part nanometer Fructus Amomi 50-150 part nanometer Rhizoma Dioscoreae 400-650 part
Nanometer Semen Euryales 400-650 part nanometer Radix Glycyrrhizae 80-180 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano tortoise plastron glue 50-70 part nano deerhorn glue 50-70 part nm acid Semen Ziziphi Spinosae 100-150 part
Nanometer Radix Polygalae 25-50 part nano Poria 150-200 part nanometer Radix Rehmanniae Preparata 600-800 part
Nano Chinese angelica 80-100 part nanometer Rhizoma Chuanxiong 100-150 part nano astragalus 150-200 part
Nanometer Radix Codonopsis 150-200 part nanometer Radix Paeoniae Alba 50-120 part nano red sage 100-150 part
Nanometer Rhizoma Atractylodis Macrocephalae 150-200 part nanometer Fructus Amomi 70-120 part nanometer Rhizoma Dioscoreae 450-550 part
Nanometer Semen Euryales 450-550 part nanometer Radix Glycyrrhizae 100-150 part
The optimum weight proportioning of medicine of the present invention is:
123 parts of 61 parts of nm acid Semen Ziziphi Spinosaes of 61 parts of nano deerhorn glue of nano tortoise plastron glue
737 parts of 184 parts of nanometer Radix Rehmanniae Preparata of 31 parts of nano Porias of nanometer Radix Polygalae
184 parts of 123 parts of nano astragalus of 92 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
123 parts of 92 parts of nano red sages of 184 parts of nanometer Radix Paeoniae Albas of nanometer Radix Codonopsis
491 parts of 92 parts of nanometer Rhizoma Dioscoreaes of 184 parts of nanometer Fructus Amomis of the nanometer Rhizoma Atractylodis Macrocephalae
123 parts in 491 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Euryales
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Guiluningshen ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Guiluningshen ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Testudinis deer allay excitement the pill material be the micron or the millimeter above particle diameter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Guiluningshen ' etc. is had no precedent in the past.
The pharmaceutical preparation of the present invention treatment of conditions such as insomnia, absentminded, dizzy tinnitus that can be used for palpitating with fear, clinical efficacy significantly are better than traditional Testudinis deer ball of allaying excitement.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nm acid Semen Ziziphi Spinosaes of 61 parts of nano deerhorn glue of nano tortoise plastron glue
737 parts of 184 parts of nanometer Radix Rehmanniae Preparata of 31 parts of nano Porias of nanometer Radix Polygalae
184 parts of 123 parts of nano astragalus of 92 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
123 parts of 92 parts of nano red sages of 184 parts of nanometer Radix Paeoniae Albas of nanometer Radix Codonopsis
491 parts of 92 parts of nanometer Rhizoma Dioscoreaes of 184 parts of nanometer Fructus Amomis of the nanometer Rhizoma Atractylodis Macrocephalae
123 parts in 491 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Euryales
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nm acid Semen Ziziphi Spinosaes of 61 parts of nano deerhorn glue of nano tortoise plastron glue
737 parts of 184 parts of nanometer Radix Rehmanniae Preparata of 31 parts of nano Porias of nanometer Radix Polygalae
184 parts of 123 parts of nano astragalus of 92 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
123 parts of 92 parts of nano red sages of 184 parts of nanometer Radix Paeoniae Albas of nanometer Radix Codonopsis
491 parts of 92 parts of nanometer Rhizoma Dioscoreaes of 184 parts of nanometer Fructus Amomis of the nanometer Rhizoma Atractylodis Macrocephalae
123 parts in 491 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Euryales
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nanometer Testudinis deer powder needle injection of allaying excitement, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nm acid Semen Ziziphi Spinosaes of 61 parts of nano deerhorn glue of nano tortoise plastron glue
737 parts of 184 parts of nanometer Radix Rehmanniae Preparata of 31 parts of nano Porias of nanometer Radix Polygalae
184 parts of 123 parts of nano astragalus of 92 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
123 parts of 92 parts of nano red sages of 184 parts of nanometer Radix Paeoniae Albas of nanometer Radix Codonopsis
491 parts of 92 parts of nanometer Rhizoma Dioscoreaes of 184 parts of nanometer Fructus Amomis of the nanometer Rhizoma Atractylodis Macrocephalae
123 parts in 491 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Euryales
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer Testudinis deer membrane of allaying excitement, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Guiluningshen ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano tortoise plastron glue 40-80 part nano deerhorn glue 40-80 part nm acid Semen Ziziphi Spinosae 80-200 part
Nanometer Radix Polygalae 20-60 part nano Poria 120-250 part nanometer Radix Rehmanniae Preparata 500-850 part
Nano Chinese angelica 60-120 part nanometer Rhizoma Chuanxiong 120-180 part nano astragalus 120-250 part
Nanometer Radix Codonopsis 120-250 part nanometer Radix Paeoniae Alba 40-150 part nano red sage 80-250 part
Nanometer Rhizoma Atractylodis Macrocephalae 100-250 part nanometer Fructus Amomi 50-150 part nanometer Rhizoma Dioscoreae 400-650 part
Nanometer Semen Euryales 400-650 part nanometer Radix Glycyrrhizae 80-180 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Guiluningshen ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano tortoise plastron glue 50-70 part nano deerhorn glue 50-70 part nm acid Semen Ziziphi Spinosae 100-150 part
Nanometer Radix Polygalae 25-50 part nano Poria 150-200 part nanometer Radix Rehmanniae Preparata 600-800 part
Nano Chinese angelica 80-100 part nanometer Rhizoma Chuanxiong 100-150 part nano astragalus 150-200 part
Nanometer Radix Codonopsis 150-200 part nanometer Radix Paeoniae Alba 50-120 part nano red sage 100-150 part
Nanometer Rhizoma Atractylodis Macrocephalae 150-200 part nanometer Fructus Amomi 70-120 part nanometer Rhizoma Dioscoreae 450-550 part
Nanometer Semen Euryales 450-550 part nanometer Radix Glycyrrhizae 100-150 part
3, nano medicine ' Guiluningshen ' according to claim 1, wherein the weight proportion of each nano raw material is:
123 parts of 61 parts of nm acid Semen Ziziphi Spinosaes of 61 parts of nano deerhorn glue of nano tortoise plastron glue
737 parts of 184 parts of nanometer Radix Rehmanniae Preparata of 31 parts of nano Porias of nanometer Radix Polygalae
184 parts of 123 parts of nano astragalus of 92 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
123 parts of 92 parts of nano red sages of 184 parts of nanometer Radix Paeoniae Albas of nanometer Radix Codonopsis
491 parts of 92 parts of nanometer Rhizoma Dioscoreaes of 184 parts of nanometer Fructus Amomis of the nanometer Rhizoma Atractylodis Macrocephalae
123 parts in 491 parts of nanometer Radix Glycyrrhizaes of nanometer Semen Euryales
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Guiluningshen 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Guiluningshen 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100230 CN1363307A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Guiluningshen' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100230 CN1363307A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Guiluningshen' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1363307A true CN1363307A (en) | 2002-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100230 Pending CN1363307A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Guiluningshen' and its preparing process |
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| Country | Link |
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| CN (1) | CN1363307A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727652A (en) * | 2012-07-18 | 2012-10-17 | 南京中医药大学 | Traditional Chinese medicine composition for enhancing memory as well as preparation method and application of Traditional Chinese medicine composition |
| CN103816493A (en) * | 2014-03-21 | 2014-05-28 | 王建蓉 | Traditional Chinese medicine composition for treating non-consolidation of kidney-qi |
-
2001
- 2001-01-10 CN CN 01100230 patent/CN1363307A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727652A (en) * | 2012-07-18 | 2012-10-17 | 南京中医药大学 | Traditional Chinese medicine composition for enhancing memory as well as preparation method and application of Traditional Chinese medicine composition |
| CN102727652B (en) * | 2012-07-18 | 2014-04-02 | 南京中医药大学 | Traditional Chinese medicine composition for enhancing memory as well as preparation method and application of Traditional Chinese medicine composition |
| CN103816493A (en) * | 2014-03-21 | 2014-05-28 | 王建蓉 | Traditional Chinese medicine composition for treating non-consolidation of kidney-qi |
| CN103816493B (en) * | 2014-03-21 | 2016-10-05 | 刘春锋 | A kind of Chinese medicine composition treating instability of kidney QI |
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