CN1958061A - Technique for preparing Chinese traditional medicine and pills in use for clearing away heart-fire, dispersing phlegm, tranquilizing the mind, and reducing pressure - Google Patents
Technique for preparing Chinese traditional medicine and pills in use for clearing away heart-fire, dispersing phlegm, tranquilizing the mind, and reducing pressure Download PDFInfo
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Abstract
A Chinese medicine in the form of pill for treating hypertension and resolving phlegm is prepared from 14 Chinese-medicinal materials including borneol, mint, pearl, white peony root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation technology thereof, particularly relate to a kind of have clear away heart-fire reduce phlegm, the Chinese medicine of calm buck functionality and the preparation technology of pill thereof.
Technical background
Hypertension is a kind of serious harm health, influences a kind of disease of quality of life.Clinical manifestation has headache, mostly occurs at back brain, also dizziness can be arranged, feeling of fullness in the head, and cervical region is pulled sense, tinnitus, dim eyesight, forgetful, insomnia, unhappiness, weak, numb limbs and tense tendons, cardiopalmus etc.Also be to cause hemiplegia of limb, heart failure, cerebral infarction, cerebral hemorrhage, the major reason of renal failure, of common occurrence because of the hypertension lethal case that disables clinically, so the scholar is referred to as meaning " stealthy killer ".Aspect hypertensive treatment, the common chemical medicine mainly contains following a few class: diuretic, beta-blocker, calcium antagonist, alpha-blocking agent, angiotensin-convertion enzyme inhibitor, angiotensin ii receptor antagonist.More than the conventional antihypertensive drugs of six big classes to the hypertension acute attack, hypertensive crisis and perioperative hypertension etc. have certain therapeutic effect, in the therapeutic process of hypertension, though chemistry medicine effect is rapidly, in the blood pressure lowering process fluctuation of blood pressure big, side effect is also big, can obviously influence water, electrolyte, blood fat, the metabolism of blood glucose etc.; Organs such as the coup injury heart, brain, kidney, simultaneously these medicines are to hyperlipidemia, high blood viscosity, sclerosis of blood vessels, no improvement effects such as the damage of target organ.The Chinese medicine that some blood pressure lowerings are also arranged in the market, but its curative effect is still waiting further raising.
Summary of the invention
Technical problem to be solved by this invention provide a kind of clear away heart-fire reduce phlegm, the Chinese medicine of calm blood pressure lowering and the preparation technology of pill thereof, it is less to the side effect of human body, therapeutic effect is good, cost is low, has dual regulation, makes blood pressure drops but can not make it to be lower than normal, to dizziness and headache, being irritable and getting angry easily, symptoms such as blurring of vision, alleviation is rapid and effect is remarkable.
Medicament selection Cornu Saigae Tataricae of the present invention, Borneolum Syntheticum, Semen Cassiae, Herba Menthae, Margarita, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Curcumae, Pulvis Cornus Bubali Concentratus, Radix Codonopsis, baicalin, Calculus Bovis, the Radix Astragali, 14 kinds of medicines of Radix Et Rhizoma Nardostachyos make up; make each efficacy of drugs produce synergism these drug regimens, thus can effectively clear away heart-fire reduce phlegm, calm blood pressure lowering.
The consumption of drug component of the present invention be through the inventor carry out a large amount of grope to sum up with experimentation draw, the weight ratio of each raw material all has curative effect preferably in following weight range, then effect is particularly outstanding to adopt the made medicine of following optimum weight umber, significantly better than other consumption.
In order to solve the problems of the technologies described above; the present invention adopts following technical proposals to realize: a kind of clear away heart-fire reduce phlegm, the Chinese medicine and the preparation technology of calm blood pressure lowering, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 15-45, Borneolum Syntheticum 40-80, Semen Cassiae 200-280, Herba Menthae 5-25, Margarita 15-45, Radix Paeoniae Alba 140-220, Rhizoma Chuanxiong 15-45, Radix Curcumae 90-150, Pulvis Cornus Bubali Concentratus 25-70, Radix Codonopsis 55-95, baicalin 150-250, Calculus Bovis 40-80, Radix Astragali 55-95, Radix Et Rhizoma Nardostachyos 15-45.
Described Chinese medicine, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 25-35, Borneolum Syntheticum 50-70, Semen Cassiae 220-260, Herba Menthae 10-20, Margarita 25-35, Radix Paeoniae Alba 160-200, Rhizoma Chuanxiong 25-35, Radix Curcumae 110-130, Pulvis Cornus Bubali Concentratus 35-55, Radix Codonopsis 65-85, baicalin 180-220, Calculus Bovis 50-70, Radix Astragali 65-85, Radix Et Rhizoma Nardostachyos 25-35.
Described Chinese medicine, raw material and the optimum weight umber of making effective ingredient are: Cornu Saigae Tataricae 30, Borneolum Syntheticum 60, Semen Cassiae 240, Herba Menthae 15, Margarita 30, the Radix Paeoniae Alba 180, Rhizoma Chuanxiong 30, Radix Curcumae 120, Pulvis Cornus Bubali Concentratus 45, Radix Codonopsis 75, baicalin 200, Calculus Bovis 60, the Radix Astragali 75, Radix Et Rhizoma Nardostachyos 30.
The present invention can adopt the conventional method of Chinese medicine preparation to make any conventional oral formulations; as dosage forms such as tablet, capsule, powder, granule, oral liquid, syrup, Emulsion, suspensoids; but in order better to keep the effective ingredient of medicine; the present invention preferably makes pill, but this can not be used to limit protection scope of the present invention.
A kind of described clear away heart-fire reduce phlegm, the preparation technology of the medicine pill of calm blood pressure lowering, it is to be prepared from by following step:
Get and meet described parts by weight Margarita water and fly or be ground into impalpable powder; the Cornu Saigae Tataricae file is ground into fine powder; Semen Cassiae, Herba Menthae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Curcumae, Radix Codonopsis, baicalin, the Radix Astragali, Radix Et Rhizoma Nardostachyos are ground into fine powder; with Calculus Bovis, Borneolum Syntheticum, Pulvis Cornus Bubali Concentratus porphyrize; with above-mentioned powder facing-up, sieve mixing; every 100g powder adds refined honey 80～140g and makes honeyed pill, promptly.
Described Borneolum Syntheticum porphyrize is the fine powder that the Borneolum Syntheticum list is ground into 100 sieves.
Advantage of the present invention and effect are as follows:
Have 14 flavor medicines in the medicine of the present invention, the detoxifcation of reducing phlegm, have one's ideas straightened out of principal agent clear away heart-fire; And strengthened the effect of principal agent as Margarita, the Borneolum Syntheticum of accessory drugs, play the arresting convulsion of calming the nerves, heat radiation analgesic effect; Radix Astragali QI invigorating, the Radix Paeoniae Alba yin fluid astringing that nourishes blood, the effect of Here it is Chinese medicine and pharmacy said " reinforcing body resistance ".It can regulate human physiological functions, improves immunity, and above composition comprehensively can be treated vigorous, the excessive rising of liver-YANG of liver-fire, just the hypertension of common people's said " string, aphtha of the mouth and tongue on the endogenous fire " and phlegm-heat type.This side has the QI invigorating centralizing function concurrently in the suppressing the hyperactive liver blood pressure lowering, hypotensive effect is soft, and relief of symptoms is obvious, is applicable to the hypertension of traditional Chinese medical science liver-heat yang-excess type.Be characterized in having dual regulation, make blood pressure drops but can not make it to be lower than normal.Medicine of the present invention is to dizziness and headache, being irritable and getting angry easily, and symptoms such as blurring of vision are alleviated rapidly.Calculus Bovis can clear away heart-fire and reduces phlegm in the medicine of the present invention, and cool liver arresting convulsion has calmness, convulsion and renal hypertensive rat is had remarkable and persistent hypotensive effect.Cornu Saigae Tataricae can suppressing the hyperactive liver and subsiding YANG, and cool liver arresting convulsion has blood pressure lowering, analgesic, maincenter inhibition, convulsion, enhancing animal hypoxia-bearing capability and analgesic activity.Effects such as " make eye bright, QI invigorating play the moon, removes stagnant blood ... the gas of feeling at ease " that Shennong's Herbal carries it to be had.The Borneolum Syntheticum awakening consciousness, clearing away heat to alleviate pain, its main component Borneolum Syntheticum, isoborneol all have anoxia enduring, sedation.Margarita can be calmed the frightened by heat clearing and tranquillizing, and to malaise, the palpitation and insomnia person is effective.The heat clearing away of Cornu Bubali energy, removing heat from blood, detoxifcation, blood pressure lowering.The Rhizoma Chuanxiong awakening consciousness has obvious and persistent hypotensive effect.The Radix Paeoniae Alba yin fluid astringing that can nourish blood, suppressing liver-YANG.Semen Cassiae energy blood pressure lowering, blood fat reducing, relieving constipation, liver heat removing and eyesight improving, for the hypertension excessive rising of liver-YANG, flaming up of liver-fire, the performance headache is dizzy, and eyes is dry and astringent, and big dry stool person is very suitable.The baicalin antiinflammatory, blood pressure lowering, diuresis, blood vessel dilating, blood fat reducing, and energy function of gallbladder promoting, spasmolytic, calmness.The Radix Curcumae soothing liver-QI for relieving depression, to stagnation of QI due to depression of the liver, mood is not smooth, can make its smooth and easy wide separating.The Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, relieving stagnation and activating the spleen has calmness, stable, hypotensive effect.Each medicine cooperates in the side, makes blood pressure steadily drop to normal value, and alleviates each simultaneous phenomenon.
Medicine of the present invention is specially adapted to one, the second stage of hypertensive treatment, cures mainly hypertension, and Chinese medical discrimination belongs to liver-Yang sthenia type and phlegm-fire is stopped up the Sheng type.Total effective rate reaches 98.6%, and symptoms such as dizzy, headache are obviously alleviated, and blood, urine, just routine examination is normal.Comprehensive adjustment, steadily blood pressure lowering, treating both the principal and secondary aspects of a disease, can gradually reduce part Western medicine antihypertensive can be to untoward reaction such as kidney, liver, hearts.
Below further set forth the beneficial effect of medicine of the present invention by clinical experiment.
Hypertension therapy clinical experiment report of the present invention:
Medicine of the present invention is the hypertensive Chinese patent medicine of treatment, and function is to clear away heart-fire to reduce phlegm, and calm blood pressure lowering cures mainly: the hypertension due to the overabundant liver-fire.To the Zhenju Jiangya Tablet group, medicine group of the present invention (castrate yellow) is observed clinical case 250 examples altogether, Zhenju Jiangya Tablet 150 examples wherein, medicine 100 examples of the present invention.The result shows: aspect efficacy of antihypertensive treatment, and Zhenju Jiangya Tablet produce effects 44 examples, effective 73 examples, invalid 33 examples, total effective rate 78.00%; Medicine produce effects 51 examples of the present invention, effective 39 examples, invalid 10 examples, total effective rate 90%; Curative effect is learned processing by statistics between two groups, and significant difference is arranged, P＜0.05.Aspect the disease curative effect, Zhenju Jiangya Tablet (matched group) produce effects 43 examples, effective 60 examples, invalid 47 examples, total effective rate 68.7%; Medicine of the present invention (test group) produce effects 58 examples, effective 40 examples, invalid 2 examples, total effective rate 98%; Curative effect is learned processing by statistics between two groups, and significant difference is arranged, and P＜0.01 now is summarized as follows clinical trial data:
Physical data:
Traditional Chinese medical science severity extent was relatively learned by statistics and is handled P＞0.05 before each organized main symptom before patient's source, sex, age, hypertension clinical stages, hypertensive disease distribution situation, treatment, treatment, and difference does not have the significance meaning, has comparability.
Test method:
Diagnostic criteria:
(1), the dialectical standard of traditional Chinese medical science hyperactivity of liver-fire: dizziness and headache, flushing conjunctival congestion, being irritable and getting angry easily, dry mouth with bitter taste, constipation is urinated red, red tongue with yellow fur, wiry and frequent pulse.
(2) Western medicine diagnose standard: slightly (standard of working out with reference to national cardiovascular epidemiology in 1979 and crowd prevention and treatment forum)
1, systolic pressure is equal to or higher than 160 (21.3), and diastolic pressure is equal to or higher than 95, and both have one can make a definite diagnosis through examining.
2, clinical stages, belonged to for 1 phase.(still with reference to above-mentioned standard)
3, clinical stages belongs to the phase patients with hypertension, and a following person is arranged: X ray examination, Electrocardioscopy are seen left ventricular hypertrophy; Examination of ocular fundus is seen has tremulous pulse general or part in optical fundus to narrow down.
(3) test case standard:
1, include the case standard in:
The patient who meets the dizzy and dialectical standard of hyperactivity of liver-fire of the traditional Chinese medical science; The patient who meets the doctor trained in Western medicine hypertension phase.
2, get rid of the case standard:
The hypertension classification belongs to the patient of III phase; Be associated with the serious primary disease of Liver and kidney and hemopoietic system, the psychotic; Age is under-18s and gestation and women breast-feeding their children more than 70 years old; Serious diarrhoea person; Do not meet the standard of including in, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
(4) clinical implementation scheme:
1, EXPERIMENTAL DESIGN: this test adopts single at random blind contrast method to be divided into two treatment groups, adopts single blind counter point, is respectively Zhenju Jiangya Tablet 150 examples, and medicine group 100 examples of the present invention require inpatient to be no less than 2/3, the strict control of clinic case variable factor.
2, the course of treatment and consumption: two groups is a course of treatment to take medicine all around all, promptly finishes to observe.Dose is each 1-2 ball, every day 1 time.
3, statistical procedures method: measurement data adopts the t check; Significance test adopts X
2Check, clinical scale relatively adopt Ridit to analyze.
4, curative effect judging standard:
Efficacy of antihypertensive treatment evaluation criteria: (standard of formulating with reference to national cardiovascular epidemiology in 1979 and crowd prevention and treatment forum)
Produce effects: more than the diastolic pressure decline 10mm Hg (1.3Kpa), and reach normal range.Though diastolic pressure is not reduced to normally, descended more than the 20mmHg (2.7Kpa).Must possess wherein one.
Effectively: diastolic pressure descends not as good as 10mm Hg (1.3Kpa), but has reached normal range.Diastolic pressure is the preceding decline 10-19mmHg (1.3-2.5Kpa) of treatment, but does not reach normal range.Systolic pressure is more than the preceding decline 30mmHg (4Kpa) of treatment.
Invalid: as not reach above standard person.
5, clinical disease curative effect judging standard:
Produce effects: main symptom disappears, and accompanied symptoms disappears substantially, and score reduces more than 70%.
Effectively: the main symptom accompanied symptoms alleviates, and score reduces between 30%-70%.
Invalid: main symptom accompanied symptoms no change, score reduces＜30%.
Experimental result:
1. respectively organize the comparison sheet 1 of blood pressure curative effect: each organizes the comparison of blood pressure curative effect
| Group | Total routine number | Produce effects | Effectively | Invalid | Total effective rate | X |
| Example (%) | Example (%) | Example (%) | ％ | |||
| Zhenju Jiangya Tablet group medicine group of the present invention | 150 100 | 44(29.3) 51(51) | 73(48.7) 39(39) | 33(22) 10(10) | 78 90 | |
Statistical procedures result's (Ridit analysis):
Zhenju Jiangya Tablet, medicine group of the present invention be X relatively
2=6.49p＜0.05, difference has the significance meaning.
2, respectively organize the comparison of I, II phase hypertension curative effect
Table 2: each organizes the comparison of I, II phase hypertension curative effect
| Group | By stages | Total routine number | Produce effects | Effectively | Invalid | Total effective rate |
| Example (%) | Example (%) | Example (%) | ％ | |||
| Zhenju Jiangya Tablet | The group I phase | 38 | 9(23.7) | 22(57.9) | 7(18.4) | 81.6 |
| Medicine of the present invention | The II phase I phase II phase | 112 33 67 | 54(48.2) 28(84.8) 32(47.8) | 48(42.9) 4(12.1) 34(50.7) | 10(8.9) 1(3.0) 1(1.4) | 91.1 97 98.6 |
Statistical procedures result: Zhenju Jiangya Tablet group I, II phase be u=0.21 P＜0.05 relatively, medicine group I of the present invention, II phase be u=0.39 P＜0.05 relatively, the result shows, between each group to patient's curative effect difference in various degree, I phase hypertension is compared u=137.64 p＜0.01 for two groups, to two groups of II phase hypertension u=1.63p＜0.05 relatively, the result shows between each group has the significance meaning to patient's curative effect difference in various degree.
3, respectively organize the comparison of clinical therapeutic effect of syndrome
Table 3: each organizes the comparison of clinical therapeutic effect of syndrome
| Group | Total routine number | Produce effects example (%) | Effectively routine (%) | Invalid example (%) | Total effective rate % |
| Precious chrysanthemum group Calculus Bovis group | 150 100 | 43(28.7) 58(58) | 60(40) 40(40) | 47(31.3) 2(2) | 68.7 98 |
Statistical procedures result: two groups of u=136.8 relatively, P＜0.01, the result shows, to patient's curative effect difference in various degree, the significance meaning arranged between each group
4, respectively organize the relation of state of an illness classification and curative effect
Table 4 is respectively organized the relation of state of an illness classification and curative effect
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| Example (%) | Example (%) | Example (%) | ％ | ||
| Group is heavy in the precious light chrysanthemum | 26 89 35 | 7(26.9) 27(30.3) 7(20) | 8(30.7) 30(33.7) 23(65.7) | 11(42.4) 32(36) 5(14.3) | 51.6 64 85.7 |
| This light bright middle group is heavy | 8 64 28 | 4(50) 19(29.7) 14(51.9) | 4(50) 30(46.9) 13(46.4) | 0(0) 1(1.4) 1(3.7) | 100 98.6 96.3 |
Statistical procedures result: two groups are slightly compared X
2=11.76 P＜0.05; Two groups of moderates compare X
2=126.36 P＜0.01; Two groups of severes compare X
2=136.30 P＜0.01; The result shows, to patient's curative effect difference in various degree, the significance meaning arranged between each group
5, the symptom curative effect relatively
Table 5: each organizes the comparison of symptom tongue arteries and veins curative effect
| Symptom | Group | The example number | Treat the precedent number | Treat the routine number in back | Disappearance rate | X 2P |
| Dizzy | Precious chrysanthemum group test group | 150 100 | 132(88) 97(97) | 102(12) 12(12) | 0.05 P＜0.01 | |
| Headache | Precious chrysanthemum group test group | 150 100 | 123(82) 83(83) | 31(18) 10(10) | 0.01 P＜0.01 | |
| Flushing | Precious chrysanthemum group test group | 150 100 | 93(62) 60(60) | 62(41.3) 6(6) | 0.01 P＜0.01 | |
| Conjunctival congestion | Precious chrysanthemum group test group | 150 100 | 37(24.7) 29(29) | 20(13.3) 1(1) | 0.009 P＜0.01 | |
| Xerostomia | Precious chrysanthemum group test group | 150 100 | 112(74.7) 72(72) | 86(57.3) 7(7) | 3.414 P＜0.01 | |
| Bitter taste | Precious chrysanthemum group test group | 150 100 | 88(58.7) 60(60) | 60(40) 8(8) | 3.274 P＜0.01 | |
| Constipation | Precious chrysanthemum group test group | 150 100 | 111(74) 65(65) | 34(22.7) 7(7) | 0.404 P＜0.01 | |
| Dysphoria | Precious chrysanthemum group test group | 150 100 | 83(55.3) 35(35) | 32(21.3) 1(1) | 0.583 P＜0.01 | |
| It is red to urinate | Precious chrysanthemum group test group | 150 100 | 61(40.7) 42(42) | 27(18) 3(3) | 1.418 P＜0.01 | |
| Picture of the tongue | Precious chrysanthemum group test group | 150 100 | 120(66.7) 80(80) | 91(60.7) 12(12) | 0.5 P＜0.01 | |
| Pulse condition | Precious chrysanthemum group test group | 150 100 | 139(92.7) 82(82) | 127(84.7) 73(73) | 0.031 P＜0.01 |
Statistical procedures result: each is organized the symptom curative effect and learns more by statistics and handle P＜0.01, the two group curative effect to symptom significant difference is arranged.
6, the variation of blood fat is compared before and after each group treatment
Table 6: the variation of blood fat relatively before and after each group treatment
| Index | Group | Before the treatment | After the treatment |
| The cholesterol triglyceride | The precious chrysanthemum group of precious chrysanthemum group test group test group | 5.10±0.82 5.73±1.65 1.82±0.66 1.95±1.18 | 4.94±0.82 t＝1.69 5.43±1.24 t＝1.45 P＞0.05 1.17±0.64 t＝1.47 1.84±1.02 t＝0.71 P＞0.05 |
Statistical procedures result: Blood Lipid is learned by statistics and is handled P＞0.05, no significance meaning difference before and after three groups of treatments.
7, safety evaluatio:
Each organizes the variation before and after the treatment of patient safety index
Table 7 is respectively organized patient's blood, urine, the just variation of conventional therapy front and back
| Group | Precious chrysanthemum group | The Calculus Bovis group | |||
| Normally | Unusually | Normally | Unusually | ||
| Blood R urinates just electrocardiogram GPT C | Before and after treatment | 150 150 144 146 150 150 75 76 150 150 135 135 | 0 0 6 4 0 0 75 74 0 0 0 0 | 100 100 84 86 100 100 39 41 100 100 78 79 | 0 0 16 14 0 0 61 59 0 0 6 5 |
| BUN | After treating before treating | 147 150 | 3 0 | 91 94 | 9 6 |
As seen from Table 7: each organize patient take medicine the back every index do not occur unusually.
In medicine group case observation of the present invention, 30 routine patients have been carried out the urine arsenic content the results are shown in Table 8:
The variation of urine arsenic before and after table 8 medicine of the present invention is taken medicine
| Group | The example number | Before the treatment | After the treatment |
| Medicine of the present invention | 30 | 0.0185±0.00096 | 0.0255±0.012 t＝2.507 P＜0.05 |
Take as seen from Table 8 and be significant difference medicine of the present invention is urinated arsenic content and taken medicine after January before, but because of all low in normal value, so in clinical, do not see human body generation toxic and side effects.
Discuss:
Medicine of the present invention is the Chinese patent medicine of treatment hypertension, having clears away heart-fire reduces phlegm, the effect of calm blood pressure lowering, for further its therapeutic effect of checking and observe this medicine after carrying out the single medicinal material adjustment to the influence of its therapeutic effect with have no side effect, the method of clinical employing random experiment, Zhenju Jiangya Tablet and medicine of the present invention have been carried out the clinical observation on the therapeutic effect of treatment hypertension (hyperactivity of liver-fire), observe hypertension (hyperactivity of liver-fire) 250 examples altogether, wherein hypertension I phases 71 example accounts for 28.4% of case sum, hypertension II phases 149 example, account for 71.6% of case sum, in 250 examples were observed, Zhenju Jiangya Tablet was observed case 150 examples, observed drug 100 examples of the present invention, the result shows: aspect efficacy of antihypertensive treatment, and Zhenju Jiangya Tablet produce effects 44 examples, effective 73 examples, invalid 33 examples, total effective rate 78.00%; Medicine produce effects 51 examples of the present invention, effective 39 examples, invalid 10 examples, total effective rate 90%; Curative effect is learned processing by statistics between two groups, and significant difference is arranged, P＜0.05.Aspect the disease curative effect, Zhenju Jiangya Tablet produce effects 43 examples, effective 60 examples, invalid 47 examples, total effective rate 68.7%; Medicine produce effects 58 examples of the present invention, effective 40 examples, invalid 2 examples, total effective rate 98%; Curative effect is learned processing by statistics between two groups, significant difference is arranged, P＜0.01, observed result shows: medicine of the present invention is to the disease curative effect highly significant of hypertension (hyperactivity of liver-fire), disease curative effect to the state of an illness in various degree (slight, moderate, severe) patient is all better, learn by statistics and handle, its difference has the significance meaning.The antihypertensive effect of proof Calculus Bovis blood pressure lowering is better, under observation notices.
Conclusion:
Clinically pass through 250 routine hypertension (hyperactivity of liver-fire) treatments and sum up and show, aspect efficacy of antihypertensive treatment, aspect efficacy of antihypertensive treatment, Zhenju Jiangya Tablet produce effects 44 examples, effective 73 examples, invalid 33 examples, total effective rate 78.00%; Medicine produce effects 51 examples of the present invention, effective 39 examples, invalid 10 examples, total effective rate 90%; Curative effect is learned processing by statistics between two groups, and significant difference is arranged, P＜0.05.Aspect the disease curative effect, Zhenju Jiangya Tablet produce effects 43 examples, effective 60 examples, invalid 47 examples, total effective rate 68.7%; Medicine produce effects 58 examples of the present invention, effective 40 examples, invalid 2 examples, total effective rate 98%; Curative effect is learned processing by statistics between two groups, and significant difference is arranged, P＜0.01.Observed result shows, medicine of the present invention all has better curative effect aspect the hypertension disease reducing hypertension and improve, and is a kind of determined curative effect, and the Chinese medicine preparation of treatment hypertension easy to carry is not found obvious toxic and side effects in the observation.
The specific embodiment
Embodiment one
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 30, Borneolum Syntheticum 60, Semen Cassiae 240, Herba Menthae 15, Margarita 30, the Radix Paeoniae Alba 180, Rhizoma Chuanxiong 30, Radix Curcumae 120, Pulvis Cornus Bubali Concentratus 45, Radix Codonopsis 75, baicalin 200, Calculus Bovis 60, the Radix Astragali 75, Radix Et Rhizoma Nardostachyos 30.
The preparation technology who said medicine is made medicine pill is as follows:
Get and meet described parts by weight Margarita water and fly or be ground into impalpable powder; the Cornu Saigae Tataricae file is ground into fine powder; Semen Cassiae, Herba Menthae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Curcumae, Radix Codonopsis, baicalin, the Radix Astragali, Radix Et Rhizoma Nardostachyos are ground into fine powder; the Borneolum Syntheticum porphyrize is the fine powder that the Borneolum Syntheticum list is ground into 100 sieves, with Calculus Bovis, Pulvis Cornus Bubali Concentratus porphyrize, with above-mentioned powder facing-up; sieve; mixing, every 100g powder add refined honey 80～140g and make honeyed pill, promptly.
Embodiment two
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are:
Cornu Saigae Tataricae 15, Borneolum Syntheticum 40, Semen Cassiae 200, Herba Menthae 5, Margarita 15, the Radix Paeoniae Alba 140, Rhizoma Chuanxiong 15, Radix Curcumae 90, Pulvis Cornus Bubali Concentratus 25, Radix Codonopsis 55, baicalin 150, Calculus Bovis 40, the Radix Astragali 55, Radix Et Rhizoma Nardostachyos 15.
Its preparation method is with embodiment one.
Embodiment three
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are:
Cornu Saigae Tataricae 45, Borneolum Syntheticum 80, Semen Cassiae 280, Herba Menthae 25, Margarita 45, the Radix Paeoniae Alba 220, Rhizoma Chuanxiong 45, Radix Curcumae 150, Pulvis Cornus Bubali Concentratus 70, Radix Codonopsis 95, baicalin 250, Calculus Bovis 80, the Radix Astragali 95, Radix Et Rhizoma Nardostachyos 45.
Its preparation method is with embodiment one.
Embodiment four
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are:
Cornu Saigae Tataricae 25, Borneolum Syntheticum 50, Semen Cassiae 220, Herba Menthae 10, Margarita 25, the Radix Paeoniae Alba 160, Rhizoma Chuanxiong 25, Radix Curcumae 110, Pulvis Cornus Bubali Concentratus 35, Radix Codonopsis 65, baicalin 180, Calculus Bovis 50, the Radix Astragali 65, Radix Et Rhizoma Nardostachyos 25.
Its preparation method is with embodiment one.
Embodiment five
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 35, Borneolum Syntheticum 70, Semen Cassiae 260, Herba Menthae 20, Margarita 35, the Radix Paeoniae Alba 200, Rhizoma Chuanxiong 35, Radix Curcumae 130, Pulvis Cornus Bubali Concentratus 55, Radix Codonopsis 85, baicalin 220, Calculus Bovis 70, the Radix Astragali 85, Radix Et Rhizoma Nardostachyos 35.
Its preparation method is with embodiment one.
Embodiment six
Medicine of the present invention clear away heart-fire reduce phlegm, calm Chinese hypotensor, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 30, Borneolum Syntheticum 8, Semen Cassiae 240, Herba Menthae 18, Margarita 40, the Radix Paeoniae Alba 220, Rhizoma Chuanxiong 25, Radix Curcumae 120, Pulvis Cornus Bubali Concentratus 60, Radix Codonopsis 80, baicalin 200, Calculus Bovis 80, the Radix Astragali 65, Radix Et Rhizoma Nardostachyos 40.
Its preparation method is with embodiment one.
Claims (5)
1, a kind of clear away heart-fire reduce phlegm, the Chinese medicine and the preparation technology of calm blood pressure lowering, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 15-45, Borneolum Syntheticum 40-80, Semen Cassiae 200-280, Herba Menthae 5-25, Margarita 15-45, Radix Paeoniae Alba 140-220, Rhizoma Chuanxiong 15-45, Radix Curcumae 90-150, Pulvis Cornus Bubali Concentratus 25-70, Radix Codonopsis 55-95, baicalin 150-250, Calculus Bovis 40-80, Radix Astragali 55-95, Radix Et Rhizoma Nardostachyos 15-45.
2, according to claim 1 clear away heart-fire reduce phlegm, the Chinese medicine of calm blood pressure lowering is characterized in that described Chinese medicine, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 25-35, Borneolum Syntheticum 50-70, Semen Cassiae 220-260, Herba Menthae 10-20, Margarita 25-35, Radix Paeoniae Alba 160-200, Rhizoma Chuanxiong 25-35, Radix Curcumae 110-130, Pulvis Cornus Bubali Concentratus 35-55, Radix Codonopsis 65-85, baicalin 180-220, Calculus Bovis 50-70, Radix Astragali 65-85, Radix Et Rhizoma Nardostachyos 25-35.
3, according to claim 1 clear away heart-fire reduce phlegm, the Chinese medicine of calm blood pressure lowering is characterized in that described Chinese medicine, raw material and the parts by weight of making effective ingredient are: Cornu Saigae Tataricae 30, Borneolum Syntheticum 60, Semen Cassiae 240, Herba Menthae 15, Margarita 30, the Radix Paeoniae Alba 180, Rhizoma Chuanxiong 30, Radix Curcumae 120, Pulvis Cornus Bubali Concentratus 45, Radix Codonopsis 75, baicalin 200, Calculus Bovis 60, the Radix Astragali 75, Radix Et Rhizoma Nardostachyos 30.
4, a kind of claim 1 described clear away heart-fire reduce phlegm, the preparation technology of the medicine pill of calm blood pressure lowering, it is characterized in that it is to be prepared from by following step:
Get and meet described parts by weight Margarita water and fly or be ground into impalpable powder; the Cornu Saigae Tataricae file is ground into fine powder; Semen Cassiae, Herba Menthae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Curcumae, Radix Codonopsis, baicalin, the Radix Astragali, Radix Et Rhizoma Nardostachyos are ground into fine powder; with Calculus Bovis, Borneolum Syntheticum, Pulvis Cornus Bubali Concentratus porphyrize; with above-mentioned powder facing-up, sieve mixing; every 100g powder adds refined honey 80～140g and makes honeyed pill, promptly.
5, according to claim 4 described clear away heart-fire reduce phlegm, the preparation technology of the medicine pill of calm blood pressure lowering, it is characterized in that described Borneolum Syntheticum porphyrize is the fine powders that the Borneolum Syntheticum list are ground into 100 sieves.
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| CN200610134191A CN100581581C (en) | 2006-11-07 | 2006-11-07 | Technique for preparing Chinese traditional medicine and pills for clearing away heart-fire, dispersing phlegm, tranquilizing the mind, and reducing blood pressure |
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| CN200610134191A CN100581581C (en) | 2006-11-07 | 2006-11-07 | Technique for preparing Chinese traditional medicine and pills for clearing away heart-fire, dispersing phlegm, tranquilizing the mind, and reducing blood pressure |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664505B (en) * | 2008-09-03 | 2012-01-04 | 李玉根 | Blood pressure lowering soup |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664505B (en) * | 2008-09-03 | 2012-01-04 | 李玉根 | Blood pressure lowering soup |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
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