CN101590114B - Medicament for treating multiple sclerosis and preparation method thereof - Google Patents

Abstract

The invention provides a medicament for treating multiple sclerosis and a preparation method thereof. The medicament contains ginseng, cornu cervi pantotrichum, tortoise plastron, tuber fleece flower root and scorpions. The medicament has the effects of regulating Yin, nourishing Yang, supplying emission and blood, benefiting bone marrows, promoting blood circulation and removing meridian obstructions. Proved by clinical tests, the Chinese medicine composition has obvious clinical effect on the multiple sclerosis.

Description

A kind of medicine of treating multiple sclerosis and preparation method thereof

Technical field

The present invention relates to a kind of medicine of treating multiple sclerosis and preparation method thereof, belong to field of Chinese herbal.

Background technology

Multiple sclerosis is a kind of common cental system demyelination of nervous system; No corresponding name of disease in the TCM Document, present age doctor family incorporates multiple sclerosis into mostly according to its clinical symptoms and is card categories such as myopathy, arthromyodynia, hemiplegia after apoplexy, dizzy, bone Shake, optic atrohic blindness, convulsive diseases.According to its primary symptom, the author thinks that primary disease belongs to Chinese medicine " myopathy " category, finds that its pathogenic characteristic and kidney superintend and direct with the channels pathological change closely relatedly, and pathogenesis is deficiency of the kidney, and brain is lost and filled, and governor vessel is hollow, network stasis of blood cervical carcinoma with cachexia." interior warp " once sayed " the kidney generating marrow and dominating bone ", and " marrow leads to brain ", " the then light many power of strength of excess of marrow-reservoir are crossed its degree certainly; Deficiency of marrow-reservoir, vertigo and tinnitus then, soreness of the shank, dizziness, order does not have finding, slack peacefully sleeping." " governor vessel ... The then nose heave height of void shakes it ..." deficiency of the kidney, brain loses that to fill be can not be autonomous with extremity, and action loses that it is strong and vigorous and walking to occur unstable, dizziness and tinnitus, blurring of vision; Deficiency of the kidney, governor vessel is hollow, and the limb muscle bones of the body collectively loses in warm moistening and supports that then to show as amyotrophy unable; It is deficient to superintend and direct sun, and warm promotion is unable, and QI-blood circulation is not smooth, and the resistance of the channels stasis of blood is so there is limbs pain; Damage of essence is superintended and directed void, and the empty cervical carcinoma with cachexia of network can have the meciless or pain of numb limbs and tense tendons.So control and work as life essence-filling, marrow-benefitting, fill superintend and direct active.

Doctor trained in Western medicine thinks that multiple sclerosis is an autoimmune disease, that is to say that our immune system mistake is destroyed myelin as foreign substance.Up to the present the medicine that effects a radical cure multiple sclerosis is still undiscovered, but still has many Therapeutic Method for the sequela that disease controlling and disease are brought.Symptom of bringing for disease such as stiff, spasm, pain, defecation disfunction etc., the treatment that merges medicine and rehabilitation all can make doing well,improving.Corticosteroid can be used to treat acute outbreak; Recent then the report order of severity when having doubly his interferon for number of times that reduces recurrence and recurrence.

Summary of the invention

The present invention provides a kind of medicine of treating multiple sclerosis, and this medicine is processed by following bulk drugs:

Radix Ginseng 90-150, Cornu Cervi Pantotrichum 70-120, Carapax et Plastrum Testudinis 100-170, Radix Polygoni Multiflori 130-210, Scorpio 40-80.

The crude drug part by weight of medicine of the present invention is preferably:

Radix Ginseng 90, Cornu Cervi Pantotrichum 70, Carapax et Plastrum Testudinis 100, Radix Polygoni Multiflori 130, Scorpio 75.

Or

Radix Ginseng 120, Cornu Cervi Pantotrichum 96, Carapax et Plastrum Testudinis 144, Radix Polygoni Multiflori 180, Scorpio 60.

Or

Radix Ginseng 150, Cornu Cervi Pantotrichum 120, Carapax et Plastrum Testudinis 170, Radix Polygoni Multiflori 210, Scorpio 45.

Or

Radix Ginseng 140, Cornu Cervi Pantotrichum 110, Carapax et Plastrum Testudinis 160, Radix Polygoni Multiflori 200, Scorpio 80.

Or

Radix Ginseng 100, Cornu Cervi Pantotrichum 80, Carapax et Plastrum Testudinis 110, Radix Polygoni Multiflori 140, Scorpio 50.

Medicine of the present invention can by above-mentioned part by weight fry in shallow oil directly that soup is taken or directly pulverize after take, also can process active component or suitably pharmaceutical dosage form take.

The active component of this medicine can be processed by the following step:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) step a) Scorpio fine powder and step b) gained dried cream powder mixing are promptly got.

Medicament form of pharmaceutical preparation of the present invention is capsule, tablet, granule, powder or pill.

The method for preparing of medicine capsule of the present invention is following:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing;

D) with step c) gained mixed powder, the adding acceptable accessories is processed capsule and is promptly got.

Be preferably:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is the extractum of 1.20-1.25, and drying is ground into dried cream powder;

C), incapsulate promptly and get with step a) Scorpio fine powder and step b) gained dried cream powder mixing.

Medicinal tablet of the present invention, granule, powder and pill are processed by the following step:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing;

D), add acceptable accessories and process tablet, granule, powder or pill with step c) gained mixed powder.

In the application of the present invention; Said Chinese medicinal composition preparation dosage form is a kind of in capsule, tablet, granule, powder or the pill preparation; For above-mentioned dosage form can be realized; Need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary; For example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc.; Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., and disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., and sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence, antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene.

Medicine of the present invention is made up of Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori, Scorpio.Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis two medicines are all the in love article of animal flesh and blood, the kind nourishing of merit, and the YIN nourishing hemopoietic, life essence-filling, marrow-benefitting, effect is concentrated one's efforts grand, monoyin and monoyang, negative and positive are also transferred.Cornu Cervi Pantotrichum spermatogenesis benefit blood, Carapax et Plastrum Testudinis is joined the usefulness that Radix Polygoni Multiflori strengthens the YIN nourishing hemopoietic.Three medicines share, with going into Liver and kidney, YIN nourishing hemopoietic, smart marrow, the governor vessel of supplementing nutrition of giving birth to of benefit.The people participates in the five internal organs, invigorating primordial QI, and gas fills and the internal organs function is vigorous, and essence and bloodization is given birth to sufficient.Scorpio returns Liver Channel, endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain.All medicines share to play altogether transfers cloudy YANG invigorating, the replenishing essence hemopoietic, and beneficial marrow fills superintends and directs, the effect of promoting blood circulation to remove obstruction in the collateral.

Western medicine is learned and is thought that multiple sclerosis is an autoimmune disease, and institute's medicament is all influential to immunologic function through pharmacological experiment study in the medicine of the present invention.Like the comprehensive raise immunity of Radix Ginseng ability, leukocyte is increased; The ginsenoside can promote the generation of mice serum IgG, IgA, IgM, promotes lymphocyte transformation.Cornu Cervi Pantotrichum has the effect that strengthens cellular immunization and humoral immunization, and Cornu Cervi Pantotrichum extract can strengthen obviously that the abdominal cavity is huge has a liking for cytophagy; The Cornu Cervi Pantotrichum ethanol extract can improve mice serum hemolytic antibody content, improves agglutinin and tires and IgG content.Obviously mouse thymus degeneration atrophy after the delay maturation of Radix Polygoni Multiflori increases thymus and spleen weight, improves spleen plaque forming cells quantity; Significantly strengthen inductive thymus of concanavalin A and splenic T lymphproliferation response; Improve the huge cytophagy ability of having a liking for, activate dried lymphocyte, improve lymhocyte transformation rate; Inducement interferon, immunity is received to press down mice has the effect that more significantly promotes cellular immunization and adjusting humoral immunization.

The consumption of Chinese medicine composition of the present invention by the crude drug gross weight, was 3～20 gram/days, but takes every day once, preferably divided and took for 2-4 time.

The specific embodiment

Following embodiment is used to illustrate the preparation of medicine of the present invention, but it can not constitute any restriction to scope of the present invention.

Embodiment 1

The preparation of capsule

Prescription:

Radix Ginseng 120g, Cornu Cervi Pantotrichum 96g, Carapax et Plastrum Testudinis 144g, Radix Polygoni Multiflori 180g, Scorpio 60g.

Method for preparing:

A) take by weighing drying by recipe quantity and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water three times by recipe quantity, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is Tianjin cream of 1.20-1.25, and drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing, 1000 capsules of packing into.

Usage and consumption: oral.One time 6～10,3 times on the one.

Embodiment 2

The preparation of tablet

Prescription:

Radix Ginseng 150g, Cornu Cervi Pantotrichum 120g, Carapax et Plastrum Testudinis 170g, Radix Polygoni Multiflori 210g, Scorpio 45g.

Method for preparing:

A) take by weighing drying by recipe quantity and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water three times by recipe quantity, 1 hour for the first time, 2 hours for the second time; 2.5 hours for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is Tianjin cream of 1.25-1.30, and drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing, add starch 200g, be pressed into 1000 by conventional formulation technology.

Embodiment 3

The preparation of powder

Prescription:

Radix Ginseng 90g, Cornu Cervi Pantotrichum 70g, Carapax et Plastrum Testudinis 100g, Radix Polygoni Multiflori 130g, Scorpio 75g.

Method for preparing:

A) take by weighing drying by recipe quantity and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water three times by recipe quantity, 1 hour for the first time, 2 hours for the second time; 2.5 hours for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is Tianjin cream of 1.25-1.30, and drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing, process powder according to conventional formulation.

Embodiment 4

The preparation of pill

Prescription:

Radix Ginseng 100g, Cornu Cervi Pantotrichum 80g, Carapax et Plastrum Testudinis 110g, Radix Polygoni Multiflori 140g, Scorpio 50g.

Method for preparing:

A) take by weighing drying by recipe quantity and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water three times by recipe quantity, 1 hour for the first time, 2 hours for the second time; 2.5 hours for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is Tianjin cream of 1.25-1.30, and drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing, process pill according to conventional formulation.

Embodiment 5

The preparation of granule

Prescription:

Radix Ginseng 140g, Cornu Cervi Pantotrichum 110g, Carapax et Plastrum Testudinis 160g, Radix Polygoni Multiflori 200g, Scorpio 80g.

Method for preparing:

A) take by weighing drying by recipe quantity and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water three times by recipe quantity, 1 hour for the first time, 2 hours for the second time; 2.5 hours for the third time, merge decocting liquid, filter; Filtrating is concentrated into and measures relative density at 60 ℃ is Tianjin cream of 1.25-1.30, and drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing, process granule according to conventional formulation.

Experimental example

For illustrating the activity of traditional Chinese medicine composition for treating multiple sclerosis of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by the foregoing description 1 method to carry out following clinical trial.

1 clinical data

1.1 diagnostic criteria: according to diagnostic criteria [the Poser CM of people's propositions such as nineteen eighty-two Washington, DC multiple sclerosis diagnosis special meeting and nineteen eighty-three Poser; Pay DW; Scheinberg L; Et al.Newdiagnostic criteria for multipie sclerosis.Guide lines for reseasch protocols [J] .Ann Neurol 1983; (3): 227～231. the standard of " clinical definite multiple sclerosis (MS) "], Chinese medical discrimination standard reference " People's Republic of China's Chinese medicine industry standard disease of tcm diagnosis criterion of therapeutical effect " is intended certainly.

1.2 the whole cases of physical data are outpatient service patients with multiple sclerosis between Hebei Yi Ling hospital January calendar year 2001～in June, 2003, are divided into 2 groups at random by prescription on individual diagnosis precedence.41 examples are organized in treatment, male's 14 examples, and women's 27 examples, men and women's ratio is 1: 1.93; 16～50 years old age, average 31.1 ± 22.6 years old; The course of disease 4～84 months, average 46.2 ± 31.4 months; Recur average 5.54 ± 0.68 times 4～13 times.Matched group 20 examples, male's 7 examples, women's 13 examples, men and women's ratio is 1: 1.86; 17～49 years old age, average 30.5 ± 22.2 years old; The course of disease 5～82 months, average 45.5 ± 29.6 months; Recur average 5.13 ± 0.64 times 5～12 times.Comparing difference does not have significance meaning (P＞0.05) between two groups, has comparability.

2 treatment and observational techniques

2.1 Therapeutic Method treatment group is taken medicine of the present invention, and each 8, every day 3 times.Wherein 16 routine patients do not wait at still oral prednisone 5～15mg/d of treatment initial stage, and after taking medicine of the present invention and treating stable disease, prednisone is decrescence to drug withdrawal.The oral prednisone 0.5mg/kg/d of matched group subtracted 5mg in per 7 days after 1 month, reduced to behind the 15mg then maintenance dose, added the azathioprine treatment simultaneously, each 50mg, days 2 times.2 groups are 1 month is 1 course of treatment, observes and treats 3 courses of treatment, the statistics curative effect.

2.2 observation item (1) clinical symptoms: limb adynamia, visual disorder, two be obstacle, sensory disturbance, walking shakiness, limbs pain, numbness, tic, dizziness, deafness and tinnitus, aversion to cold and cold limbs, soreness of the waist and knees, dizzy weak, spiritlessness and sparing of words etc. just; (2) function of nervous system's sign: vision situation, motor function, sensory function and intelligence etc.; (3) the EDSS standards of grading of MS delayed ischemic neurological deficits scoring employing Kurtzke are carried out EDSS scoring [3] to 6 function of nervous system of cone, XIAONAO, brain stem, sensation, bladder and rectum, brain of patient before and after the treatment of difference treatment group; (4) bring out current potential: VEP (VEP), brainstem evoked potential (BAEP), body bring out current potential (SEP); (5) nuclear magnetic resonance, NMR (MRI); (6) cerebrospinal fluid immunoglobulin G (lgG) and oligoclonal band; (7) recurrent number.

2.3 observational technique clinical symptoms, function of nervous system's sign each item index are unusual by normal, mile abnormality, moderate, severe is remembered 0～3 fen unusually respectively; Each inspection once before and after the treatment; Function of nervous system's sign is observed and is referred to comprise vision situation, motor function, sensory function and intelligence etc.; Concrete scoring reference literature [JohnF; Kurtzke; MD.Rating neurologic impairment in multiple sclerosis:An expandeddisability status scale (EDSS) [J] .Neurology 1983,33:1444～1452]; 6 function of nervous system such as cone, XIAONAO, brain, brain stem, sensation, bladder and rectum that the scoring of MS delayed ischemic neurological deficits adopts the EDSS standards of grading of Kurtzke that difference treatment group is treated the front and back patient carry out the EDSS scoring.

2.4 all data of statistical method all with mean ± standard deviation

expression, are carried out paired t-test (adopting the SAS statistical software) to integration before and after the treatment and recurrent number.

3 criterions of therapeutical effect and therapeutic outcome

3.1 the nimodipine method that is adopted in the efficacy assessment standard reference " new Chinese medicine treatment apoplexy clinical research guideline ": (integration before the treatment-treatment back integration)/integration * 100% before treating, represent with percent.Alleviate >=85% fully; Produce effects 50%～85%; Effective 20%～50%; Invalid＜20%.

3.2 therapeutic outcome

3.2.1 clinical efficacy: 41 examples are organized in treatment, produce effects 16 examples (39.02%); Effective 20 examples (48.78%); Invalid 5 examples (12.20%); Total effective rate 87.80%.Matched group 20 examples, produce effects 2 examples (10.00%); Effective 10 examples (50.00%); Invalid 8 examples (40.00%); Total effective rate 60.00%.Comparing difference has highly significant property meaning (P＜0.001) between group.See table 1

Table 1 treatment group and matched group curative effect be [example (%)] relatively

* compare P＜0.001 with matched group

3.2.2 two groups of patient's clinical symptoms, function of nervous system's sign and EDSS scorings are relatively before and after the treatment: two groups of patient treatments front and back self comparing differences have the significance meaning, treatment group (P＜0.01); Matched group (P＜0.05); Comparing difference has highly significant property meaning (P＜0.01) to see table 2 between group

Two groups of patient's clinical symptoms, function of nervous system's sign and EDSS scorings are relatively before and after table 2 treatment

Relatively preceding with the treatment of this group, * * P＜0.01, * P＜0.05; With comparison after the treatment of control group, △ P＜0.01

3.2.3 bring out electric potential therapy group 41 examples, VEP (VEP) before the treatment, brainstem evoked potential (BAEP), body bring out unusual person's 34 examples of current potential (SEP), 30 examples that take a turn for the better after the treatment, and basic recovery of 3 examples normally increased the weight of 2 examples, other no significant changes.Matched group 20 examples, VEP (VEP) before the treatment, brainstem evoked potential (BAEP), body are brought out unusual person's 25 examples of current potential (SEP), and 16 examples that take a turn for the better after the treatment increase the weight of 2 examples, other no significant changes.2 groups of comparing differences have highly significant property meaning (P＜0.001)

3.2.4MRI 41 examples are organized in the inspection treatment; Do MRI inspection before the treatment, all have brain with (or) the spinal cord abnormal signal, wherein have 33 examples to be multiple focus; Focus is point-like, patch shape or oval type; Not of uniform size, be more common in around the ventricles of the brain, white matter and brain stem, XIAONAO, neck marrow, breast marrow under the cerebral cortex, there are 25 routine patient MRI inspections to show that focus decreased number or scope dwindle after the treatment.Matched group 20 examples wherein have 16 examples to be multiple focus, and MRI report focus situation and treatment group are roughly the same, have 5 routine patient MRI inspection demonstration focus decreased number or scope to dwindle after the treatment.2 groups of comparing differences have significance meaning (P＜0.001)

3.2.5 41 examples are organized in cerebrospinal fluid IgG and oligoclonal band treatment; 33 routine patient cerebrospinal fluid IgG and oligoclonal bands are arranged before the treatment; Wherein 22 routine IgG raise; 16 routine oligoclonal bands are positive, and IgG rising patient in treatment back has 19 examples to recover normal, and the oligoclonal band positive patient has 13 examples to recover normal.Matched group 20 examples have 15 routine patient cerebrospinal fluid IgG and oligoclonal bands before the treatment, wherein 11 routine IgG raise, and 8 routine oligoclonal bands are positive, and IgG rising patient in treatment back has 5 examples to recover normal, and the oligoclonal band positive patient has 4 examples to recover normal.

3.2.6 recurrent number has all carried out following up a case by regular visits in 2.0～2.5 years to treatment group and matched group patient; Observe its recurrence situation; Recurrent number is 1.56 ± 0.65 times/year before the treatment of treatment group, and the treatment back is that annual 0.65 ± 0.51,2 comparing differences have highly significant property meaning (P＜0.01).Recurrent number is 1.49 ± 0.57 times/year before the treatment of control group, and the treatment back is every year 1.27 ± 0.55, and the two comparing difference does not have significance meaning (P＞0.05).

3.2.7 toxic and side effects treatment group is not found any toxic and side effects; And matched group part patient degradation side effect under had slight abnormal liver function, blood pressure, blood sugar increasing, hyperlipemia, central obesity, leukocyte, platelet after the treatment; Wherein there are 3 routine patients to descend obviously, the compelled azathioprine of stopping using because of leukocyte, platelet.

4 conclusions:

Drug therapy multiple sclerosis of the present invention can not only be improved clinical symptoms and sign effectively, recovers function of nervous system; And bring out current potential, cerebrospinal fluid IgG and oligoclonal band and MRI inspection improvement and recovery in various degree all arranged; And cross the patient is carried out following up a case by regular visits in 2.0～2.5 years, can reduce recurrent number, reduce relapse rate; And without any side effects, obviously be superior to western medicine.

Claims (10)

1. a medicine of treating multiple sclerosis is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 90-150, Cornu Cervi Pantotrichum 70-120, Carapax et Plastrum Testudinis 100-170, Radix Polygoni Multiflori 130-210, Scorpio 40-80.

2. medicine as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 90, Cornu Cervi Pantotrichum 70, Carapax et Plastrum Testudinis 100, Radix Polygoni Multiflori 130, Scorpio 75.

3. medicine as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 120, Cornu Cervi Pantotrichum 96, Carapax et Plastrum Testudinis 144, Radix Polygoni Multiflori 180, Scorpio 60.

4. medicine as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 150, Cornu Cervi Pantotrichum 120, Carapax et Plastrum Testudinis 170, Radix Polygoni Multiflori 210, Scorpio 45.

5. medicine as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 140, Cornu Cervi Pantotrichum 110, Carapax et Plastrum Testudinis 160, Radix Polygoni Multiflori 200, Scorpio 80.

6. medicine as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 100, Cornu Cervi Pantotrichum 80, Carapax et Plastrum Testudinis 110, Radix Polygoni Multiflori 140, Scorpio 50.

7. like each described medicine of claim 1-6, it is characterized in that the active component of this medicine is processed by the following step:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) step a) Scorpio fine powder and step b) gained dried cream powder mixing are promptly got.

8. like each described medicine among the claim 1-6, it is characterized in that the preparation formulation of said medicine is capsule, tablet, granule, powder or pill.

9. the method for preparing of medicine capsule as claimed in claim 8 is characterized in that, this medicine is processed by the following step:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing;

D) with step c) gained mixed powder, the adding acceptable accessories is processed capsule and is promptly got.

10. the method for preparing of medicinal tablet as claimed in claim 8, granule, powder or pill is characterized in that, this medicine is processed by the following step:

A) take by weighing drying in proportion and select clean Scorpio, be ground into fine powder;

B) take by weighing Radix Ginseng, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Radix Polygoni Multiflori decocte with water in proportion three times, each 1-3 hour, merge decocting liquid, filter, filtrating is concentrated into and measures relative densities at 60 ℃ is the extractum of 1.10-1.30, drying is ground into dried cream powder;

C) with step a) Scorpio fine powder and step b) gained dried cream powder mixing;

D), add acceptable accessories and process tablet, granule, powder or pill with step c) gained mixed powder.