CN1695730A - Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method - Google Patents

Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method Download PDF

Info

Publication number
CN1695730A
CN1695730A CN 200510011731 CN200510011731A CN1695730A CN 1695730 A CN1695730 A CN 1695730A CN 200510011731 CN200510011731 CN 200510011731 CN 200510011731 A CN200510011731 A CN 200510011731A CN 1695730 A CN1695730 A CN 1695730A
Authority
CN
China
Prior art keywords
radix
chinese medicine
ganoderma
medicine composition
raw material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN 200510011731
Other languages
Chinese (zh)
Other versions
CN1330345C (en
Inventor
黄生田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangxi Wuzhou Pharmaceutical Group Co Ltd
Original Assignee
Guangxi Wuzhou Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangxi Wuzhou Pharmaceutical Group Co Ltd filed Critical Guangxi Wuzhou Pharmaceutical Group Co Ltd
Priority to CNB2005100117317A priority Critical patent/CN1330345C/en
Publication of CN1695730A publication Critical patent/CN1695730A/en
Application granted granted Critical
Publication of CN1330345C publication Critical patent/CN1330345C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

A Chinese medicine in the form of tablet, capsule, pill, drpping pill, etc for treating hyperlipemia is prepared from 6 Chinese-medicinal materials including haw, red sage root, pilose asiabell rot, ganoderma, etc. Its preparing process is also disclosed.

Description

A kind of Chinese medicine composition for the treatment of hyperlipidemia and preparation method thereof
Invention field
The present invention relates to a kind of Chinese medicine composition, specifically is a kind of Chinese medicine composition for the treatment of hyperlipidemia, the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Hyperlipidemia is the medical problem of a universality, is because people's dietary structure changes, and reasons such as total fat and animal proteinum Excessive Intake cause.The consequence of hyperlipidemia development is an atherosclerosis, and this is one of main basic pathological changes of many blood vessels and organ disease such as coronary heart disease, hypertension, diabetes etc., discovers that hypertriglyceridemia is the independent risk factor of above-mentioned disease.The control of hyperlipemia generally needs to carry out for a long time even throughout one's life, required appropriate litigation fees costliness, and present all fat-reducing medicaments of doctor trained in Western medicine all have certain toxic and side effects, part Study data result shows that pharmaceutical intervention (being non-that spit of fland class lipid lowerers especially) can not make crowd's general mortality rate reduce.
Theory of Chinese medical science thinks that blood operation is among blood vessels, and circulation is more than, flows round without stopping." Longevity and Life Preservation " said: " with the passing of time qi being the governor of blood, the stagnation of QI reach blood.Gas has one expiration and inspiration not transport, and it is not all right that then blood has one expiration and inspiration ".So syndrome of blood stasis involves gas inevitably, can cause not promoting the circulation of blood of gas because of the deficiency of vital energy or the stagnation of QI, high blood viscosity can reduce real these deficiency syndrome of mark thus.Mark is real to be mark with expectorant, the stasis of blood, and deficiency in origin is a basis with weakened body resistance (deficiency of vital energy, suffer from a deficiency of the kidney).
The traditional Chinese medical science is passed through clinical observation for many years to the treatment of primary disease, adopts retrograde treatment, consolidates and takes stopgap measures, represent prescription with " function of invigorating circulation and reducing blood fat fat-reducing soup " (blood fat reducing series) for it, dialectical opinion is controlled, specific aim treatment blood high viscosity syndrome, hyperlipemia, start with from the kidney invigorating, QI invigorating, hold concurrently with blood stasis dispersing and phlegm expelling.
The applicant is on the basis of research tradition Chinese herbal medicine, and through test for many years, the Chinese medicine proved recipe from the Guangxi folklore screens multiple formulations, has found that therapeutic effect is good, the several drugs that has no side effect and finished the present invention.
Summary of the invention
Purpose of the present invention just provides a kind of Chinese medicine composition for the treatment of hyperlipidemia.Another object of the present invention just provides the preparation method of this Chinese medicine composition.
The traditional Chinese medical science thinks that hyperlipidemia card is many by eating and drinking without temperance, consults the food delicious food, and spleen fortune is strong, lipid fortuneization mistake department, and the unfavorable store essential substances liquid of deficiency of the kidney yin, and Vent is in blood, in the raising blood due to the lipid concentration.And deficiency of kidney yin, the edema with the liver involved mistake is supported, and embarrass and dredge Vent, so that the lipid metabolism imbalance, stay with fixed attention in blood, to amass down for a long time, QI-blood circulation is obstructed and stasis of blood formation with fixed attention.QI-blood circulation is obstructed, and influences the five internal organs again and is in harmonious proportion, and further causes blood fat to increase and causes disease to develop and development.Therefore regulating qi to disperse stagnation suitably, promoting blood circulation to remove obstruction in the collateral is able to spleen, kidney, liver fortuneization smoothly.On the basis of this traditional Chinese medical science understanding, establishing the treatment rule is turbid, the supplementing QI and nourishing YIN of spleen invigoratingization, blood circulation promoting and blood stasis dispelling.Compositions of the present invention is exactly under the guidance of this treatment rule, selects for use the Chinese crude drug reasonable formula to be prepared from.
The effective ingredient of Chinese medicine composition disclosed in this invention is to be that feedstock production forms by Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae, and wherein with Fructus Crataegi cuneatae circulation of qi promoting dissipating blood stasis, intestinal stasis relieving is good for the stomach; The Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow; Rhizoma Alismatis is wet clearly, change turbid, convenient, colleague spleen invigoratingization turbid, the merit of blood circulation promoting and blood stasis dispelling is the monarch drug in the raw material prescription altogether.The Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting; The Ganoderma replenishing QI to invigorate the spleen, eliminating phlegm and relieving asthma, the merit of concurrence supplementing QI and nourishing YIN; Ministerial drug in the side of being all.The beneficial will and Radix Polygalae is calmed the nerves, eliminating phlegm for diminishing swelling is adjuvant in the side.The consumption of these preparation raw materials is (weight ratio): Fructus Crataegi cuneatae 6-18, Rhizoma Alismatis 5-15, Radix Salviae Miltiorrhizae 5-14, Radix Codonopsis 4-12, Ganoderma 4-12, Radix Polygalae 2-6.The preparation raw material weight ratio of the effective ingredient of preferred Chinese medicine composition of the present invention is: Fructus Crataegi cuneatae 10-15, Rhizoma Alismatis 9-11, Radix Salviae Miltiorrhizae 8-10, Radix Codonopsis 7-9, Ganoderma 7-9, Radix Polygalae 3-5.More preferably the preparation raw material weight ratio of the effective ingredient of Chinese medicine composition of the present invention is: Fructus Crataegi cuneatae 12, Rhizoma Alismatis 10, Radix Salviae Miltiorrhizae 9, Radix Codonopsis 8, Ganoderma 8, Radix Polygalae 4.
Below be the crude drug source of Chinese medicine preparation of the present invention:
Fructus Crataegi cuneatae: derive from rosaceous plant Crataegi cuneatae Crataegus cuneata Sieb.etZucc..
Rhizoma Alismatis: derive from Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..
Radix Salviae Miltiorrhizae: derive from labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
Radix Codonopsis: derive from campanulaceae plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., plain flower Radix Codonopsis Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..
Ganoderma: derive from Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum (Leyss.exFr.) Karst. or Ganoderma Ganoderma sinense Zhao, Xu et Zhang.
Radix Polygalae: derive from milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L..
The preparation of the effective ingredient of Chinese medicine composition of the present invention can be that above-mentioned raw material of Chinese medicine is directly pulverized, or the decocting after-filtration obtains the water extract of described raw material together, continues to be condensed into clear paste; Or above-mentioned raw material of Chinese medicine one reinstated the alcohol extract that ethanol extraction obtains described raw material, continue to be condensed into clear paste; Or will add ethanol in the above-mentioned water extract, and precipitation, supernatant reclaims ethanol, and debris continues the concentrated clear paste that makes.
The effective ingredient of Chinese medicine composition of the present invention is preferably as follows preparation: Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae are directly pulverized, or decocting 2 times together, each is 3 hours, collecting decoction, filter, concentrate the condensed water extract that obtains described raw material, continue to be condensed into the clear paste that relative density is 1.10~1.25 (70 ℃); Or Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae one reinstated ethanol extraction 2 times, and each 2 hours, merge, obtain the alcohol extract of described raw material, continue to be condensed into the clear paste that relative density is 1.10~1.25 (70 ℃); Or with above-mentioned water extract ethanol precipitation, supernatant liquid reclaims ethanol, and the debris continuation concentrates and makes the clear paste that relative density is 1.10~1.15 (70 ℃), promptly.
Chinese medicine composition of the present invention can be made various common formulations together with its effective ingredient and/or pharmaceutically acceptable carrier, as tablet, capsule, pill, drop pill, granule, medicinal tea, mixture, syrup, powder etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to: excipient, as starch and derivant thereof, dextrin, calcium hydrogen phosphate, magnesium stearate, differential silica gel etc.; Disintegrating agent is as sodium carboxymethyl cellulose, hydroxypropyl cellulose etc.; Lubricant is as magnesium stearate etc.; The sugar coating material is as sucrose, Pulvis Talci, gelatin, pigment, river wax etc.; Thin film coating material is as stomach dissolution type water, pure coating material etc.
It is turbid that Chinese medicine composition of the present invention has spleen invigoratingization, supplementing QI and nourishing YIN, and the effect of blood circulation promoting and blood stasis dispelling makes the strong fortune of taste department, kidney storing essence liquid, the liver and gall bar reaches, and mechanism of qi must be opened; Blood is dredged freely, thereby makes lipid biochemistry active.Compress transforms strong, and draining has.Therefore, we are applicable to the hepatic and renal YIN deficiency, dampness-heat in the liver and gallbladder, the hyperlipidemia that the taste imbalance causes.Disease is seen vertigo and tinnitus, and is uncomfortable in chest indigestion and loss of appetite, shortness of breath and palpitation etc.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.
Embodiment 1: the preparation of tablet of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 180g, Rhizoma Alismatis 130g, Radix Salviae Miltiorrhizae 90g, Radix Codonopsis 80g, Ganoderma 80g, Radix Polygalae 40g.
With Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each 3 hours, collecting decoction, filter, obtain the water extract of described raw material, continue to be condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), drying, get 1 part of dry extract, make particle drying with the starch portion, add sodium carboxymethyl cellulose 0.3%, magnesium stearate 0.3%, tabletting, or directly pack, promptly get tablet of the present invention.
Embodiment 2: the preparation of granule of the present invention, medicinal tea
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 120g, Rhizoma Alismatis 100g, Radix Salviae Miltiorrhizae 90g, Radix Codonopsis 80g, Ganoderma 80g, Radix Polygalae 40g.
Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae are added 60% ethanol extraction 2 times together, each 2 hours, merge extractive liquid.Filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.10~1.25 (70 ℃), and drying is also made dried cream powder.Get 1 part of dry extract, 2.4 parts of sucrose, 1 part in dextrin is made soft material with 70% ethanol, crosses the 12-14 mesh sieve and makes granule, and drying promptly gets granule; Or be pressed into bulk, make medicinal tea.
Embodiment 3: the preparation of the watered pill of the present invention, honeyed pill
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 180g, Rhizoma Alismatis 150g, Radix Salviae Miltiorrhizae 100g, Radix Codonopsis 100g, Ganoderma 120g, Radix Polygalae 60g.
Get Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae powder and be broken into fine powder, admix 20~80% Mel or water again, make water-honeyed pill, concentrated pill, honeyed pill, the watered pill etc.
Embodiment 4: the preparation of drop pill of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 180g, Rhizoma Alismatis 130g, Radix Salviae Miltiorrhizae 140g, Radix Codonopsis 120g, Ganoderma 120g, Radix Polygalae 60g.
Pulverizing medicinal materials such as Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae are become coarse powder, add 60% ethanol heating extraction twice, each 2 hours.Merge extractive liquid, reclaims ethanol and is concentrated into the clear paste that relative density is 1.10-1.25 (60 ℃), and with the poloxamer mixing of 5 times of amounts (by weight), heating makes fusion, drips and makes drop pill, promptly.
Embodiment 5: the preparation of capsule of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 100g, Rhizoma Alismatis 80g, Radix Salviae Miltiorrhizae 80g, Radix Codonopsis 40g, Ganoderma 50g, Radix Polygalae 20g.
With Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each 3 hours, collecting decoction, filter, obtain the water extract of described raw material, add ethanol again, extremely pure content reaches 60%, precipitation, supernatant reclaims ethanol and is condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), makes granule with starch, dry, add magnesium stearate, encapsulated, promptly obtain product.
Embodiment 6: the preparation of mixture of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 60g, Rhizoma Alismatis 50g, Radix Salviae Miltiorrhizae 60g, Radix Codonopsis 50g, Ganoderma 40g, Radix Polygalae 20g.
With Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each is 3 hours, collecting decoction filters, and obtains the water extract of described raw material, add ethanol to pure content again and reach 60%, precipitation, supernatant reclaims ethanol and is condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), adds 10~55% sucrose, 0.1~1% potassium sorbate, 0.1~0.3% ethyl hydroxybenzoate again, mix homogeneously promptly obtains product.
Embodiment 7: the preparation of syrup of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 70g, Rhizoma Alismatis 60g, Radix Salviae Miltiorrhizae 50g, Radix Codonopsis 50g, Ganoderma 50g, Radix Polygalae 30g.
With Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each is 3 hours, collecting decoction, filter, obtain the water extract of described raw material, add ethanol to pure content again and reach 60%, precipitation, supernatant reclaims ethanol and is condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), adds sucrose 40~70%, potassium sorbate preservative 0.1~1%, ethyl hydroxybenzoate 0.1~0.3% merging again, makes syrup.
Embodiment 8: the preparation of powder of the present invention
Take by weighing following raw materials in weight: Fructus Crataegi cuneatae 80g, Rhizoma Alismatis 60g, Radix Salviae Miltiorrhizae 70g, Radix Codonopsis 60g, Ganoderma 60g, Radix Polygalae 40g.
With Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each 3 hours, collecting decoction, filter, obtain the water extract of described raw material, add ethanol again, extremely pure content reaches 60%, precipitation, supernatant reclaims ethanol and is condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), drying under reduced pressure, be ground into fine powder, sieve, mixing is made powder.
Below set forth the effect of this Chinese medicine composition by test.Test material: medicine: granule of the present invention is provided by Guangxi Wuzhou Pharmaceutical Group Plc.Face the solution that is made into respective concentration with preceding water.
Animal: the wistar rat provides by Guangxi tumor institute animal.
Experimental example 1:High fat feeding experiment
Choose healthy wistar rat, male, body weight 310.36 ± 29.28g, 50, be divided into 5 groups at random, 10 every group, after healthy one week of observation, each treated animal is all fed and (is contained cholesterol 2%, animal oil 15%, multidimensional sugar 10% with high lipid food, yolk powder 5%, methylthiouracil 0.2%) from the 7th day of hello high lipid food, begin gastric infusion, wherein 3 groups of filling stomach dosage are respectively 10g/kg, 5g/kg, 2g/kg B.W.Positive controls is irritated stomach inositol niacinate 0.1g/kg B.W.Negative control group is irritated isopyknic normal saline, and once a day, after 2 weeks, the high lipid food of nursing composition is changed into cholesterol 1%, animal oil 10%, and multidimensional sugar 10%, yolk powder 5%, methylthiouracil 0.2% continues 2 weeks of administration again.The next day that administration finishes, get blood from the eyeball rear vein beard, separation of serum is with the content of sulfur ferrophosphorus reagent method mensuration serum cholesterol (SCH); Measure serum beta lipoprotein (SBLP) content with the turbid method of heparin-manganese; Method with isopropyl alcohol extracting-acetylacetone,2,4-pentanedione colour developing is measured serum triglycerides (STG) content.
The result is shown in following table 1 and table 2
Table one, the present invention are to the influence of rat fat
Group Number of animals ??SCH(mg%) ??SBLP(mg%) ??STG(mg%)
Negative control group ??10 ??488.28±82.32 ??455.76±95.40 ??288.64±68.81
Positive controls ??10 ??382.41±49.50 ??283.90±64.00 ??128.90±52.33
The 2g/kg group ??10 ??391.87±53.30 ??384.87±81.60 ??152.63±49.12
The 5g/kg group ??10 ??353.71±42.00 ??270.33±60.30 ??112.60±53.40
The 10g/kg group ??10 ??341.50±42.10 ??256.17±70.29 ??113.21±61.60
Table two, significance are relatively
Group Number of animals Compare (P value) with negative control
??SCH ??SBLP ??STG
Negative control group ??10
Positive controls ??10 ??P<0.01 ??P<0.001 ??P<0.001
The 2g/kg group ??10 ??P<0.01 ??P<0.05 ??P<0.01
The 5g/kg group ??10 ??P<0.001 ??P<0.001 ??P<0.001
The 10g/kg group ??10 ??P<0.001 ??P<0.001 ??P<0.001
The result from table one, table two as seen, dosage among the present invention (5g/kg) group, heavy dose of (10g/kg) group all have the reduction effect (P<0.001) of highly significant to the SCH in the rat blood serum, SBLP, STG content; Low dose of (2g/kg) group also has significant reduction effect (P<0.01) to the SCH in the rat blood serum, STG content, to the effect of SBLP then a little less than, with matched group relatively, group difference meaningful (P<0.05).Illustrate that the present composition truly has good effect for reducing blood fat.
Experimental example 2:Clinical experiment
Owing to be subjected to the restriction of historical conditions, there is not hyperlipidemia and some diseases name of disease of issuing licence in motherland's medical literature, the present invention is with reference to the documents and materials of reporting in the last few years, clinical practice situation in conjunction with hyperlipidemia, the cardinal symptom of determining hyperlipidemia is that dizziness and headache, tinnitus are forgetful, soreness of the waist and knees, cardiopalmus is uncomfortable in chest, bitter taste is indigestion and loss of appetite, vomiting and nausea expectorant is turbid, conjunctival congestion yellowish urine, being irritable and getting angry easily etc., divide into groups according to these symptoms, and entrust the institute of oncology, Guangxi to carry out hundreds of routine clinical experiments according to following criterion, the results are shown in Table three.
Curative effect judging standard:
1, clinical recovery: the hyperlipidemia symptom all disappears, and blood lipids index drops to normal value, i.e. serum total cholesterol≤220mg%, or triglyceride≤120mg%, or beta lipoprotein≤450mg%.
2, produce effects: the hyperlipidemia cardinal symptom is improved more than 2~3 and is disappeared, and blood lipids index descends 〉=15%.
3, effective: the hyperlipidemia cardinal symptom is improved more than 1~2 and is disappeared, and blood lipids index descends 5%~15%.
4, invalid: as not reach These parameters person.
Symptom variation before and after table three, the present invention treat
Symptom Before the treatment (example) Treatment back (example) Effective percentage (%)
Dizzy ??224 ??23 ??89.7
Headache ??145 ??9 ??93.8
Nose heave ??62 ??5 ??91.9
Feeling of fullness in the head ??132 ??38 ??71.2
Being irritable and getting angry easily ??163 ??14 ??91.4
Sleep less ??137 ??14 ??89.7
Dreaminess ??149 ??56 ??62.4
Uncomfortable in chest ??185 ??42 ??77.2
Cardiopalmus ?141 ??44 ??68.8
Vexed ?110 ??14 ??87.2
Vomiting and nausea expectorant is turbid ?45 ??11 ??75.5
Tinnitus ?67 ??15 ??77.6
Forgetful ?106 ??29 ??72.6
Soreness of the waist and knees ?84 ??15 ??82.1
Bitter taste ?145 ??33 ??77.2
Indigestion and loss of appetite ?67 ??15 ??77.6
Conjunctival congestion ?32 ??0 ??100.0
Yellowish urine ?128 ??43 ??66.4
Drowsirness ?45 ??17 ??62.2
The result can draw from table three, the present invention is forgetful to the symptom of hyperlipidemia such as dizziness and headache, tinnitus, soreness of the waist and knees, cardiopalmus is uncomfortable in chest, bitter taste is indigestion and loss of appetite, vomiting and nausea expectorant is turbid, conjunctival congestion yellowish urine, being irritable and getting angry easily etc. have obvious effect, most of symptoms all can improve or disappear (healing) after the medication, and are especially obvious for the doing well,improving of the hepatic and renal YIN deficiency, excessive rising of liver-YANG, dampness-heat in the liver and gallbladder, stagnation of turbid phlegm in middle-JIAO card.

Claims (10)

1. Chinese medicine composition for the treatment of hyperlipidemia, it is made up of effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that its contained effective ingredient is to be made by the following weight proportion raw material: Fructus Crataegi cuneatae 6-18, Rhizoma Alismatis 5-15, Radix Salviae Miltiorrhizae 5-14, Radix Codonopsis 4-12, Ganoderma 4-12, Radix Polygalae 2-6.
2, according to the described Chinese medicine composition of claim 1, wherein said raw material weight ratio is: Fructus Crataegi cuneatae 10-15, Rhizoma Alismatis 9-11, Radix Salviae Miltiorrhizae 8-10, Radix Codonopsis 7-9, Ganoderma 7-9, Radix Polygalae 3-5.
3, according to the described Chinese medicine composition of claim 1, wherein said raw material weight ratio is: Fructus Crataegi cuneatae 12, Rhizoma Alismatis 10, Radix Salviae Miltiorrhizae 9, Radix Codonopsis 8, Ganoderma 8, Radix Polygalae 4.
4, according to the described Chinese medicine composition of claim 1, it is pharmaceutics of Chinese drugs common formulations such as tablet, capsule, pill, drop pill, granule, medicinal tea, mixture, syrup or powder.
5, the preparation method of each described Chinese medicine composition of claim 1-4, it comprises directly pulverizes described raw material of Chinese medicine, or the decocting after-filtration obtains the water extract of described raw material together, continues to be condensed into clear paste, mixes again and/or with pharmaceutically acceptable carrier.
6, the preparation method of the described Chinese medicine composition of claim 5, it comprises Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each is 3 hours, collecting decoction, filter, continue to be condensed into clear paste (70 ℃, relative density 1.10~1.25), mix again and/or with pharmaceutically acceptable carrier.
7, the preparation method of each described Chinese medicine composition of claim 1-4, it comprises reinstates 20%~80% ethanol extraction with described raw material of Chinese medicine one, reclaims solvent then and is condensed into clear paste, mixes again and/or with pharmaceutically acceptable carrier.
8, the preparation method of the described Chinese medicine composition of claim 7, it comprises Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae is added 20%~80% ethanol extraction 2 times together, each is 2 hours, merge extractive liquid,, filter, reclaim solvent and concentrate the alcohol extract that obtains described raw material, continue to be condensed into the clear paste that relative density is 1.10~1.25 (70 ℃), mix again and/or with pharmaceutically acceptable carrier.
9, the preparation method of each described Chinese medicine composition of claim 1-4, it comprises Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting after-filtration together, obtain the water extract of described raw material, use 20%~80% ethanol precipitation then, supernatant reclaims ethanol and concentrates and makes clear paste, mixes again and/or with pharmaceutically acceptable carrier.
10, the preparation method of the described Chinese medicine composition of claim 9, it comprises Fructus Crataegi cuneatae, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Ganoderma, Radix Polygalae decocting together 2 times, each is 3 hours, collecting decoction, filter, concentrate the condensed water extract that obtains described raw material, back with 20%~80% ethanol precipitation, supernatant reclaims ethanol and concentrates and makes the clear paste that relative density is 1.10~1.25 (70 ℃), mixes again and/or with pharmaceutically acceptable carrier.
CNB2005100117317A 2005-05-17 2005-05-17 Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method Active CN1330345C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNB2005100117317A CN1330345C (en) 2005-05-17 2005-05-17 Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2005100117317A CN1330345C (en) 2005-05-17 2005-05-17 Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method

Publications (2)

Publication Number Publication Date
CN1695730A true CN1695730A (en) 2005-11-16
CN1330345C CN1330345C (en) 2007-08-08

Family

ID=35348719

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005100117317A Active CN1330345C (en) 2005-05-17 2005-05-17 Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method

Country Status (1)

Country Link
CN (1) CN1330345C (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895393B (en) * 2006-06-27 2010-05-12 吕海章 Health-care composition for regulating blood fat
CN104606404A (en) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 Traditional Chinese medicine composition for treating hyperlipidemia and preparation method of traditional Chinese medicine composition
CN104971269A (en) * 2015-07-22 2015-10-14 江西中医药大学附属医院 Granules for strengthening spleen, dissolving turbidity and regulating fat and preparation method thereof
CN108627510A (en) * 2018-06-06 2018-10-09 临安卡尔生物技术有限公司 High-density lipoprotein cholesterol detection kit
CN110226651A (en) * 2019-05-31 2019-09-13 熊发翠 Health protection tea composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1150942C (en) * 2002-08-13 2004-05-26 马金堂 Capsule for cleaning blood and reducing fat

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895393B (en) * 2006-06-27 2010-05-12 吕海章 Health-care composition for regulating blood fat
CN104606404A (en) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 Traditional Chinese medicine composition for treating hyperlipidemia and preparation method of traditional Chinese medicine composition
CN104971269A (en) * 2015-07-22 2015-10-14 江西中医药大学附属医院 Granules for strengthening spleen, dissolving turbidity and regulating fat and preparation method thereof
CN104971269B (en) * 2015-07-22 2018-06-05 江西中医药大学附属医院 A kind of turbid lipid-regulating grain of invigorating the spleenization and preparation method thereof
CN108627510A (en) * 2018-06-06 2018-10-09 临安卡尔生物技术有限公司 High-density lipoprotein cholesterol detection kit
CN110226651A (en) * 2019-05-31 2019-09-13 熊发翠 Health protection tea composition

Also Published As

Publication number Publication date
CN1330345C (en) 2007-08-08

Similar Documents

Publication Publication Date Title
CN1857690A (en) Gynecopathy treating preparation and its preparing process
WO2010135858A1 (en) Pharmaceutical composition and use for preparing medicament thereof
CN102293927B (en) Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof
CN106266558A (en) A kind of Halth-care composition of resisting fatigue and preparation method thereof
CN1330345C (en) Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method
CN101053621A (en) Traditional Chinese medicinal composition for treating obesity and its preparation method
CN101856405B (en) Medicinal composition for treating type II diabetes mellitus and preparation method thereof
CN101085039B (en) Composition for preventing and treating diabetes (hyperglycaemia) and its preparation method
CN101461932B (en) Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof
CN100571740C (en) The Chinese medicine composition of a kind of blood sugar lowering, blood fat reducing and method for making and application
CN1927324A (en) Preparation method of traditional medicine preparation for treating women's menoxenia
CN1709326A (en) Method for preparing concentrated pill for treating mammary gland proliferation disease
CN106309729B (en) A kind of Chinese medicine composition adjusting chronic hepatitis immune function
CN1943756A (en) A Chinese traditional medicinal composite used for treatment of hypertension and its preparation method
CN102552861A (en) Ginseng Sini granules and preparing method thereof
CN103006891B (en) Medicine composition for treating chronic renal failure
CN111000969A (en) Pharmaceutical composition for treating simple obesity and preparation method thereof
CN105727089A (en) Application of medicine composition containing folium artemisiae argyi to preparing medicine for treating irritable bowel syndrome
CN110664905A (en) Traditional Chinese medicine preparation for expelling wind and clearing away cold and preparation method thereof
CN105412424A (en) Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation
CN1053111C (en) Chinese medical composite preparation with such functions as dispelling toxicity, detoxicating, recuperating, health preserving and face nursing
CN105055851A (en) Chinese medicinal composition for treatment of diabetes, preparation and application thereof
CN1579523A (en) Infant's Runtu granulars and preparation method
CN1943755A (en) A Chinese traditional medicinal composition for treatment of hypertension and its preparation method
CN115487260B (en) Traditional Chinese medicine composition for treating hypercholesterolemia or atherosclerosis and application thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP02 Change in the address of a patent holder

Address after: 543002 No. 1, Industrial Avenue, Wuzhou Industrial Park, the Guangxi Zhuang Autonomous Region

Patentee after: Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd.

Address before: 543002, Wuzhou 3, No. two, the Guangxi Zhuang Autonomous Region, Guangxi, Wuzhou Pharmaceutical (Group) Limited by Share Ltd

Patentee before: Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd.